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CACNG8 (calcium voltage-gated channel auxiliary subunit gamma 8)

Gene

Calcium voltage-gated channel auxiliary subunit gamma 8

CACNG8

19q13.42

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]

Show/Hide all(210)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019066	hsa-miR-335-5p	Microarray	18185580
MIRT037799	hsa-miR-92b-5p	CLASH	23622248
MIRT039482	hsa-miR-652-3p	CLASH	23622248
MIRT051710	hsa-let-7d-5p	CLASH	23622248
MIRT051755	hsa-let-7c-5p	CLASH	23622248
MIRT052055	hsa-let-7b-5p	CLASH	23622248
MIRT442428	hsa-miR-6848-3p	PAR-CLIP	22100165
MIRT442428	hsa-miR-6848-3p	PAR-CLIP	23708386
MIRT442428	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT442429	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT442429	hsa-miR-2114-3p	PAR-CLIP	23708386
MIRT442430	hsa-miR-6843-3p	PAR-CLIP	22100165
MIRT442430	hsa-miR-6843-3p	PAR-CLIP	23708386
MIRT442430	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT442431	hsa-miR-6131	PAR-CLIP	22100165
MIRT442431	hsa-miR-6131	PAR-CLIP	23708386
MIRT442431	hsa-miR-6131	HITS-CLIP	23824327
MIRT442432	hsa-miR-3663-5p	PAR-CLIP	22100165
MIRT442432	hsa-miR-3663-5p	PAR-CLIP	23708386
MIRT442432	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT442433	hsa-miR-372-5p	PAR-CLIP	22100165
MIRT442433	hsa-miR-372-5p	PAR-CLIP	23708386
MIRT442434	hsa-miR-371a-5p	PAR-CLIP	22100165
MIRT442434	hsa-miR-371a-5p	PAR-CLIP	23708386
MIRT442435	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT442435	hsa-miR-616-5p	PAR-CLIP	23708386
MIRT442436	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT442436	hsa-miR-373-5p	PAR-CLIP	23708386
MIRT442437	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT442437	hsa-miR-371b-5p	PAR-CLIP	23708386
MIRT442438	hsa-miR-7109-3p	PAR-CLIP	22100165
MIRT442438	hsa-miR-7109-3p	PAR-CLIP	23708386
MIRT450406	hsa-miR-578	PAR-CLIP	22100165
MIRT450407	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT450408	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450409	hsa-miR-4635	PAR-CLIP	22100165
MIRT450410	hsa-miR-95-5p	PAR-CLIP	22100165
MIRT450411	hsa-miR-429	PAR-CLIP	22100165
MIRT450412	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT450413	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT570112	hsa-miR-6749-3p	PAR-CLIP	20371350
MIRT570113	hsa-miR-422a	PAR-CLIP	20371350
MIRT570114	hsa-miR-378i	PAR-CLIP	20371350
MIRT570115	hsa-miR-378f	PAR-CLIP	20371350
MIRT570116	hsa-miR-378h	PAR-CLIP	20371350
MIRT570117	hsa-miR-378e	PAR-CLIP	20371350
MIRT570118	hsa-miR-378d	PAR-CLIP	20371350
MIRT570119	hsa-miR-378c	PAR-CLIP	20371350
MIRT570120	hsa-miR-378b	PAR-CLIP	20371350
MIRT570121	hsa-miR-378a-3p	PAR-CLIP	20371350
MIRT570122	hsa-miR-4254	PAR-CLIP	20371350
MIRT570123	hsa-miR-3690	PAR-CLIP	20371350
MIRT570124	hsa-miR-7108-3p	PAR-CLIP	20371350
MIRT570125	hsa-miR-4258	PAR-CLIP	20371350
MIRT611823	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT611823	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT611823	hsa-miR-6514-3p	HITS-CLIP	27418678
MIRT611823	hsa-miR-6514-3p	HITS-CLIP	28735896
MIRT611824	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT611824	hsa-miR-6894-3p	HITS-CLIP	23313552
MIRT611824	hsa-miR-6894-3p	HITS-CLIP	27418678
MIRT611824	hsa-miR-6894-3p	HITS-CLIP	28735896
MIRT611825	hsa-miR-466	HITS-CLIP	23824327
MIRT611825	hsa-miR-466	HITS-CLIP	27418678
MIRT611825	hsa-miR-466	HITS-CLIP	28735896
MIRT611826	hsa-miR-4672	HITS-CLIP	23824327
MIRT611826	hsa-miR-4672	HITS-CLIP	27418678
MIRT611826	hsa-miR-4672	HITS-CLIP	28735896
MIRT611827	hsa-miR-3941	HITS-CLIP	23824327
MIRT611827	hsa-miR-3941	HITS-CLIP	27418678
MIRT611827	hsa-miR-3941	HITS-CLIP	28735896
MIRT611828	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT611828	hsa-miR-4680-3p	HITS-CLIP	23313552
MIRT611829	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT611829	hsa-miR-3140-5p	HITS-CLIP	23313552
MIRT611829	hsa-miR-3140-5p	HITS-CLIP	28735896
MIRT611830	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT611830	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT611830	hsa-miR-216b-3p	HITS-CLIP	27418678
MIRT611830	hsa-miR-216b-3p	HITS-CLIP	28735896
MIRT611831	hsa-miR-603	HITS-CLIP	23824327
MIRT611831	hsa-miR-603	HITS-CLIP	23313552
MIRT611831	hsa-miR-603	HITS-CLIP	27418678
MIRT611831	hsa-miR-603	HITS-CLIP	28735896
MIRT611832	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611832	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT611832	hsa-miR-362-3p	HITS-CLIP	28735896
MIRT611833	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611833	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT611833	hsa-miR-329-3p	HITS-CLIP	28735896
MIRT611834	hsa-miR-8485	HITS-CLIP	23824327
MIRT611834	hsa-miR-8485	HITS-CLIP	27418678
MIRT611834	hsa-miR-8485	HITS-CLIP	28735896
MIRT611835	hsa-miR-3615	HITS-CLIP	23824327
MIRT614508	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT624474	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT624475	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624476	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624477	hsa-miR-4452	HITS-CLIP	23824327
MIRT624478	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT624479	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624480	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624481	hsa-miR-623	HITS-CLIP	23824327
MIRT624482	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT624483	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT624484	hsa-miR-3182	HITS-CLIP	23824327
MIRT624485	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624486	hsa-miR-3938	HITS-CLIP	23824327
MIRT626693	hsa-miR-1248	HITS-CLIP	23824327
MIRT629930	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT629931	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT629932	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT629933	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629934	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629935	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT633890	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT636676	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT636677	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT637826	hsa-miR-640	HITS-CLIP	23824327
MIRT637827	hsa-miR-4665-3p	HITS-CLIP	23824327
MIRT637828	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT637829	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT637830	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT637831	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT637832	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT637833	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT637834	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT637835	hsa-miR-8079	HITS-CLIP	23824327
MIRT637836	hsa-miR-1245a	HITS-CLIP	23824327
MIRT641462	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT641463	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT641464	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT641465	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT649223	hsa-miR-4279	HITS-CLIP	23824327
MIRT649224	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT649225	hsa-miR-4697-3p	HITS-CLIP	23824327
MIRT649226	hsa-miR-223-3p	HITS-CLIP	23824327
MIRT649227	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT649228	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT649229	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT649230	hsa-miR-5193	HITS-CLIP	23824327
MIRT649231	hsa-miR-935	HITS-CLIP	23824327
MIRT649231	hsa-miR-935	HITS-CLIP	23313552
MIRT649231	hsa-miR-935	HITS-CLIP	27418678
MIRT678690	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT678691	hsa-miR-1226-3p	HITS-CLIP	23824327
MIRT678692	hsa-miR-1911-3p	HITS-CLIP	23824327
MIRT679449	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679449	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT685449	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT685450	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT685451	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT685452	hsa-miR-3689c	HITS-CLIP	23313552
MIRT685453	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT685454	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT685455	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT685456	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT685457	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT685458	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT685459	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT685460	hsa-miR-203b-3p	HITS-CLIP	23313552
MIRT685461	hsa-miR-7158-3p	HITS-CLIP	23313552
MIRT685462	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT685463	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT685464	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT685465	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT685466	hsa-miR-1827	HITS-CLIP	23313552
MIRT685467	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT685468	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT685469	hsa-miR-665	HITS-CLIP	23313552
MIRT685470	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT685471	hsa-miR-4459	HITS-CLIP	23313552
MIRT685472	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT685473	hsa-miR-5690	HITS-CLIP	23313552
MIRT685474	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT685475	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT685476	hsa-miR-4478	HITS-CLIP	23313552
MIRT685477	hsa-miR-4419b	HITS-CLIP	23313552
MIRT685478	hsa-miR-3929	HITS-CLIP	23313552
MIRT685479	hsa-miR-940	HITS-CLIP	23313552
MIRT685480	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT685481	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT685482	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT685483	hsa-miR-510-5p	HITS-CLIP	23313552
MIRT685484	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT685485	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT685486	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT685487	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT685488	hsa-miR-5095	HITS-CLIP	23313552
MIRT685489	hsa-miR-4252	HITS-CLIP	23313552
MIRT685490	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT685491	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT685492	hsa-miR-4438	HITS-CLIP	23313552
MIRT695878	hsa-miR-1303	HITS-CLIP	23313552
MIRT695879	hsa-miR-5096	HITS-CLIP	23313552
MIRT695880	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT695881	hsa-miR-4435	HITS-CLIP	23313552
MIRT695882	hsa-miR-588	HITS-CLIP	23313552
MIRT695883	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT695884	hsa-miR-548s	HITS-CLIP	23313552
MIRT695885	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT695886	hsa-miR-6832-5p	HITS-CLIP	23313552
MIRT695887	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT695888	hsa-miR-1279	HITS-CLIP	23313552
MIRT695889	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT762666	hsa-miR-143-5p	PAR-CLIP	27292025
MIRT766248	hsa-miR-3650	PAR-CLIP	27292025
MIRT772981	hsa-miR-500b-3p	PAR-CLIP	27292025
MIRT774749	hsa-miR-5586-3p	PAR-CLIP	27292025
MIRT776213	hsa-miR-6499-3p	PAR-CLIP	27292025

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IBA	21873635
GO:0005245	Function	Voltage-gated calcium channel activity	NAS	11170751
GO:0005246	Function	Calcium channel regulator activity	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	NAS	11170751
GO:0006816	Process	Calcium ion transport	NAS	11170751
GO:0014069	Component	Postsynaptic density	ISS
GO:0016247	Function	Channel regulator activity	IBA	21873635
GO:0019226	Process	Transmission of nerve impulse	IBA	21873635
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0032281	Component	AMPA glutamate receptor complex	IBA	21873635
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0061337	Process	Cardiac conduction	TAS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA	21873635
GO:0098943	Process	Neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA	21873635
GO:0098970	Process	Postsynaptic neurotransmitter receptor diffusion trapping	IBA	21873635
GO:0099590	Process	Neurotransmitter receptor internalization	IBA	21873635
GO:1990454	Component	L-type voltage-gated calcium channel complex	ISS
GO:2000311	Process	Regulation of AMPA receptor activity	IBA	21873635
GO:2000311	Process	Regulation of AMPA receptor activity	IDA	20805473, 21172611

MIM	HGNC	e!Ensembl
606900	13628	ENSG00000142408

Protein

UniProt ID

Q8WXS5

Protein name

Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)

Protein function

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00822	PMP22_Claudin	17 → 223	PMP-22/EMP/MP20/Claudin family	Family

Sequence

MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV

Sequence length

425

Interactions

View interactions

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