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CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2)

Gene

10369

Calcium voltage-gated channel auxiliary subunit gamma 2

CACNG2

MRD10

22q12.3

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels

Show/Hide all(132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT659915	hsa-miR-8080	HITS-CLIP	23824327
MIRT659914	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT659913	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT659912	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT659911	hsa-miR-2117	HITS-CLIP	23824327
MIRT659910	hsa-miR-520d-5p	HITS-CLIP	23824327
MIRT659909	hsa-miR-524-5p	HITS-CLIP	23824327
MIRT659908	hsa-miR-4273	HITS-CLIP	23824327
MIRT659907	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT624489	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT624488	hsa-miR-3163	HITS-CLIP	23824327
MIRT624487	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT659915	hsa-miR-8080	HITS-CLIP	23824327
MIRT659914	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT659913	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT659912	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT659911	hsa-miR-2117	HITS-CLIP	23824327
MIRT659910	hsa-miR-520d-5p	HITS-CLIP	23824327
MIRT659909	hsa-miR-524-5p	HITS-CLIP	23824327
MIRT659908	hsa-miR-4273	HITS-CLIP	23824327
MIRT659907	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT624489	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT624488	hsa-miR-3163	HITS-CLIP	23824327
MIRT624487	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT858016	hsa-miR-1205	CLIP-seq
MIRT858017	hsa-miR-1229	CLIP-seq
MIRT858018	hsa-miR-134	CLIP-seq
MIRT858019	hsa-miR-1343	CLIP-seq
MIRT858020	hsa-miR-150	CLIP-seq
MIRT858021	hsa-miR-1915	CLIP-seq
MIRT858022	hsa-miR-27a	CLIP-seq
MIRT858023	hsa-miR-27b	CLIP-seq
MIRT858024	hsa-miR-3118	CLIP-seq
MIRT858025	hsa-miR-3144-5p	CLIP-seq
MIRT858026	hsa-miR-3155	CLIP-seq
MIRT858027	hsa-miR-3155b	CLIP-seq
MIRT858028	hsa-miR-3166	CLIP-seq
MIRT858029	hsa-miR-3192	CLIP-seq
MIRT858030	hsa-miR-339-5p	CLIP-seq
MIRT858031	hsa-miR-342-3p	CLIP-seq
MIRT858032	hsa-miR-34a	CLIP-seq
MIRT858033	hsa-miR-34c-5p	CLIP-seq
MIRT858034	hsa-miR-3649	CLIP-seq
MIRT858035	hsa-miR-3657	CLIP-seq
MIRT858036	hsa-miR-3661	CLIP-seq
MIRT858037	hsa-miR-3678-3p	CLIP-seq
MIRT858038	hsa-miR-3690	CLIP-seq
MIRT858039	hsa-miR-4254	CLIP-seq
MIRT858040	hsa-miR-4267	CLIP-seq
MIRT858041	hsa-miR-4284	CLIP-seq
MIRT858042	hsa-miR-4418	CLIP-seq
MIRT858043	hsa-miR-4494	CLIP-seq
MIRT858044	hsa-miR-449a	CLIP-seq
MIRT858045	hsa-miR-449b	CLIP-seq
MIRT858046	hsa-miR-4532	CLIP-seq
MIRT858047	hsa-miR-4653-3p	CLIP-seq
MIRT858048	hsa-miR-4669	CLIP-seq
MIRT858049	hsa-miR-4677-3p	CLIP-seq
MIRT858050	hsa-miR-4713-5p	CLIP-seq
MIRT858051	hsa-miR-4726-3p	CLIP-seq
MIRT858052	hsa-miR-4729	CLIP-seq
MIRT858053	hsa-miR-4760-5p	CLIP-seq
MIRT858054	hsa-miR-4765	CLIP-seq
MIRT858055	hsa-miR-4771	CLIP-seq
MIRT858056	hsa-miR-484	CLIP-seq
MIRT858057	hsa-miR-486-3p	CLIP-seq
MIRT858058	hsa-miR-492	CLIP-seq
MIRT858059	hsa-miR-509-3-5p	CLIP-seq
MIRT858060	hsa-miR-509-5p	CLIP-seq
MIRT858061	hsa-miR-5096	CLIP-seq
MIRT858062	hsa-miR-513a-5p	CLIP-seq
MIRT858063	hsa-miR-532-3p	CLIP-seq
MIRT858064	hsa-miR-579	CLIP-seq
MIRT858065	hsa-miR-586	CLIP-seq
MIRT858066	hsa-miR-627	CLIP-seq
MIRT858067	hsa-miR-631	CLIP-seq
MIRT858068	hsa-miR-924	CLIP-seq
MIRT1954827	hsa-miR-1257	CLIP-seq
MIRT1954828	hsa-miR-1290	CLIP-seq
MIRT1954829	hsa-miR-129-5p	CLIP-seq
MIRT1954830	hsa-miR-193a-5p	CLIP-seq
MIRT1954831	hsa-miR-3611	CLIP-seq
MIRT1954832	hsa-miR-361-3p	CLIP-seq
MIRT1954833	hsa-miR-3667-3p	CLIP-seq
MIRT1954834	hsa-miR-3689a-3p	CLIP-seq
MIRT1954835	hsa-miR-3689c	CLIP-seq
MIRT1954836	hsa-miR-4728-5p	CLIP-seq
MIRT1954837	hsa-miR-637	CLIP-seq
MIRT2192359	hsa-miR-128	CLIP-seq
MIRT1954829	hsa-miR-129-5p	CLIP-seq
MIRT858018	hsa-miR-134	CLIP-seq
MIRT858019	hsa-miR-1343	CLIP-seq
MIRT858021	hsa-miR-1915	CLIP-seq
MIRT1954830	hsa-miR-193a-5p	CLIP-seq
MIRT2192360	hsa-miR-202	CLIP-seq
MIRT2192361	hsa-miR-224	CLIP-seq
MIRT2192362	hsa-miR-2278	CLIP-seq
MIRT858024	hsa-miR-3118	CLIP-seq
MIRT858025	hsa-miR-3144-5p	CLIP-seq
MIRT2192363	hsa-miR-3150b-3p	CLIP-seq
MIRT858032	hsa-miR-34a	CLIP-seq
MIRT858033	hsa-miR-34c-5p	CLIP-seq
MIRT1954833	hsa-miR-3667-3p	CLIP-seq
MIRT2192364	hsa-miR-376c	CLIP-seq
MIRT858042	hsa-miR-4418	CLIP-seq
MIRT858044	hsa-miR-449a	CLIP-seq
MIRT858045	hsa-miR-449b	CLIP-seq
MIRT2192365	hsa-miR-451b	CLIP-seq
MIRT858046	hsa-miR-4532	CLIP-seq
MIRT2192366	hsa-miR-4667-3p	CLIP-seq
MIRT2192367	hsa-miR-4689	CLIP-seq
MIRT2192368	hsa-miR-4784	CLIP-seq
MIRT858057	hsa-miR-486-3p	CLIP-seq
MIRT858059	hsa-miR-509-3-5p	CLIP-seq
MIRT858060	hsa-miR-509-5p	CLIP-seq
MIRT2192369	hsa-miR-642a	CLIP-seq
MIRT2192370	hsa-miR-939	CLIP-seq
MIRT1954828	hsa-miR-1290	CLIP-seq
MIRT2385463	hsa-miR-1291	CLIP-seq
MIRT2385464	hsa-miR-328	CLIP-seq
MIRT2385465	hsa-miR-4488	CLIP-seq
MIRT2385466	hsa-miR-4651	CLIP-seq
MIRT2385467	hsa-miR-4697-5p	CLIP-seq
MIRT2385468	hsa-miR-608	CLIP-seq
MIRT1954837	hsa-miR-637	CLIP-seq
MIRT1954830	hsa-miR-193a-5p	CLIP-seq
MIRT2495755	hsa-miR-3613-3p	CLIP-seq
MIRT2495756	hsa-miR-371b-5p	CLIP-seq
MIRT2495757	hsa-miR-4661-5p	CLIP-seq
MIRT2495755	hsa-miR-3613-3p	CLIP-seq
MIRT2495756	hsa-miR-371b-5p	CLIP-seq
MIRT2495757	hsa-miR-4661-5p	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	20805473, 32296183
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	IEA
GO:0006612	Process	Protein targeting to membrane	IEA
GO:0007528	Process	Neuromuscular junction development	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016247	Function	Channel regulator activity	IBA	21873635
GO:0019226	Process	Transmission of nerve impulse	IBA	21873635
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0032281	Component	AMPA glutamate receptor complex	IBA	21873635
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0035255	Function	Ionotropic glutamate receptor binding	IEA
GO:0036477	Component	Somatodendritic compartment	IEA
GO:0044300	Component	Cerebellar mossy fiber	IEA
GO:0051592	Process	Response to calcium ion	IEA
GO:0051899	Process	Membrane depolarization	TAS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0060081	Process	Membrane hyperpolarization	IEA
GO:0060082	Process	Eye blink reflex	IEA
GO:0061337	Process	Cardiac conduction	TAS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA	21873635
GO:0098943	Process	Neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA	21873635
GO:0098970	Process	Postsynaptic neurotransmitter receptor diffusion trapping	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099061	Component	Integral component of postsynaptic density membrane	IEA
GO:0099590	Process	Neurotransmitter receptor internalization	IBA	21873635
GO:1904510	Process	Positive regulation of protein localization to basolateral plasma membrane	IEA
GO:2000311	Process	Regulation of AMPA receptor activity	IBA	21873635
GO:2000311	Process	Regulation of AMPA receptor activity	ISS
GO:2000969	Process	Positive regulation of AMPA receptor activity	IEA

MIM	HGNC	e!Ensembl
602911	1406	ENSG00000166862

Protein

UniProt ID

Q9Y698

Protein name

Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2)

Protein function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation a

PDB

6DLZ , 6DM0 , 6DM1 , 6O9G , 6TNO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00822	PMP22_Claudin	6 → 197	PMP-22/EMP/MP20/Claudin family	Family

Sequence

MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH
SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL
CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF
YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS
SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH
NCIQKENKDSLHSNTANRRTTPV

Sequence length

323

Interactions

View interactions

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