CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3)

Gene

• Entrez ID: 784
• Gene name: Calcium voltage-gated channel auxiliary subunit beta 3
• Gene symbol: CACNB3
• Synonyms: CAB3, CACNLB3
• Chromosome: 12
• Chromosome location: 12q13.12
• Summary: This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regul

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016710	hsa-miR-335-5p	Microarray	18185580
MIRT042695	hsa-miR-196b-5p	CLASH	23622248
MIRT857899	hsa-miR-1	CLIP-seq
MIRT857900	hsa-miR-206	CLIP-seq
MIRT857901	hsa-miR-3064-3p	CLIP-seq
MIRT857902	hsa-miR-3673	CLIP-seq
MIRT857903	hsa-miR-4300	CLIP-seq
MIRT857904	hsa-miR-432	CLIP-seq
MIRT857905	hsa-miR-4474-3p	CLIP-seq
MIRT857906	hsa-miR-4764-5p	CLIP-seq
MIRT857907	hsa-miR-604	CLIP-seq
MIRT857908	hsa-miR-613	CLIP-seq
MIRT857909	hsa-miR-619	CLIP-seq
MIRT857910	hsa-miR-647	CLIP-seq
MIRT857911	hsa-miR-920	CLIP-seq
MIRT1954778	hsa-miR-1202	CLIP-seq
MIRT1954779	hsa-miR-1275	CLIP-seq
MIRT1954780	hsa-miR-1291	CLIP-seq
MIRT1954781	hsa-miR-1294	CLIP-seq
MIRT1954782	hsa-miR-134	CLIP-seq
MIRT1954783	hsa-miR-140-3p	CLIP-seq
MIRT1954784	hsa-miR-183	CLIP-seq
MIRT1954785	hsa-miR-219-5p	CLIP-seq
MIRT1954786	hsa-miR-3118	CLIP-seq
MIRT1954787	hsa-miR-3194-5p	CLIP-seq
MIRT1954788	hsa-miR-330-3p	CLIP-seq
MIRT1954789	hsa-miR-34a	CLIP-seq
MIRT1954790	hsa-miR-34c-5p	CLIP-seq
MIRT1954791	hsa-miR-3612	CLIP-seq
MIRT1954792	hsa-miR-3620	CLIP-seq
MIRT1954793	hsa-miR-3649	CLIP-seq
MIRT1954794	hsa-miR-371-3p	CLIP-seq
MIRT1954795	hsa-miR-371b-3p	CLIP-seq
MIRT1954796	hsa-miR-3972	CLIP-seq
MIRT1954797	hsa-miR-4260	CLIP-seq
MIRT1954798	hsa-miR-4274	CLIP-seq
MIRT1954799	hsa-miR-4292	CLIP-seq
MIRT1954800	hsa-miR-4308	CLIP-seq
MIRT857904	hsa-miR-432	CLIP-seq
MIRT1954801	hsa-miR-4443	CLIP-seq
MIRT1954802	hsa-miR-4445	CLIP-seq
MIRT1954803	hsa-miR-4488	CLIP-seq
MIRT1954804	hsa-miR-449a	CLIP-seq
MIRT1954805	hsa-miR-449b	CLIP-seq
MIRT1954806	hsa-miR-4514	CLIP-seq
MIRT1954807	hsa-miR-4656	CLIP-seq
MIRT1954808	hsa-miR-4659a-5p	CLIP-seq
MIRT1954809	hsa-miR-4659b-5p	CLIP-seq
MIRT1954810	hsa-miR-4663	CLIP-seq
MIRT1954811	hsa-miR-4665-5p	CLIP-seq
MIRT1954812	hsa-miR-4692	CLIP-seq
MIRT1954813	hsa-miR-4697-5p	CLIP-seq
MIRT1954814	hsa-miR-4782-3p	CLIP-seq
MIRT1954815	hsa-miR-508-3p	CLIP-seq
MIRT1954816	hsa-miR-515-3p	CLIP-seq
MIRT1954817	hsa-miR-519e	CLIP-seq
MIRT1954818	hsa-miR-637	CLIP-seq
MIRT1954819	hsa-miR-650	CLIP-seq
MIRT1954787	hsa-miR-3194-5p	CLIP-seq
MIRT2446042	hsa-miR-147	CLIP-seq
MIRT2446043	hsa-miR-1914	CLIP-seq
MIRT2446044	hsa-miR-3150b-3p	CLIP-seq
MIRT2446045	hsa-miR-3689a-3p	CLIP-seq
MIRT2446046	hsa-miR-3689c	CLIP-seq
MIRT2446047	hsa-miR-3911	CLIP-seq
MIRT2446048	hsa-miR-4648	CLIP-seq
MIRT2446049	hsa-miR-4654	CLIP-seq
MIRT2446050	hsa-miR-4728-5p	CLIP-seq
MIRT2446051	hsa-miR-4769-5p	CLIP-seq
MIRT2446052	hsa-miR-4784	CLIP-seq
MIRT2446053	hsa-miR-486-3p	CLIP-seq
MIRT2446054	hsa-miR-516a-3p	CLIP-seq
MIRT2446055	hsa-miR-644	CLIP-seq
MIRT2446056	hsa-miR-765	CLIP-seq
MIRT2446042	hsa-miR-147	CLIP-seq
MIRT2446043	hsa-miR-1914	CLIP-seq
MIRT2446044	hsa-miR-3150b-3p	CLIP-seq
MIRT2446045	hsa-miR-3689a-3p	CLIP-seq
MIRT2446046	hsa-miR-3689c	CLIP-seq
MIRT2446047	hsa-miR-3911	CLIP-seq
MIRT2446048	hsa-miR-4648	CLIP-seq
MIRT2446049	hsa-miR-4654	CLIP-seq
MIRT2446050	hsa-miR-4728-5p	CLIP-seq
MIRT2446051	hsa-miR-4769-5p	CLIP-seq
MIRT2446052	hsa-miR-4784	CLIP-seq
MIRT2446053	hsa-miR-486-3p	CLIP-seq
MIRT2446054	hsa-miR-516a-3p	CLIP-seq
MIRT2446055	hsa-miR-644	CLIP-seq
MIRT2446056	hsa-miR-765	CLIP-seq
MIRT2495744	hsa-miR-1227	CLIP-seq
MIRT857901	hsa-miR-3064-3p	CLIP-seq
MIRT1954792	hsa-miR-3620	CLIP-seq
MIRT1954799	hsa-miR-4292	CLIP-seq
MIRT2495745	hsa-miR-4455	CLIP-seq
MIRT2495746	hsa-miR-4715-3p	CLIP-seq
MIRT2495747	hsa-miR-545	CLIP-seq
MIRT2495748	hsa-miR-609	CLIP-seq
MIRT1954818	hsa-miR-637	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IDA	11160515
GO:0005246	Function	Calcium channel regulator activity	ISS
GO:0005515	Function	Protein binding	IPI	18535142, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	IBA	21873635
GO:0005891	Component	Voltage-gated calcium channel complex	IDA	11160515
GO:0006816	Process	Calcium ion transport	IDA	11160515
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007528	Process	Neuromuscular junction development	IBA	21873635
GO:0008331	Function	High voltage-gated calcium channel activity	IBA	21873635
GO:0008331	Function	High voltage-gated calcium channel activity	ISS	25527503
GO:0016020	Component	Membrane	IDA	16525042
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050966	Process	Detection of mechanical stimulus involved in sensory perception of pain	IEA
GO:0051899	Process	Membrane depolarization	TAS
GO:0060402	Process	Calcium ion transport into cytosol	ISS	25527503
GO:0061337	Process	Cardiac conduction	TAS
GO:0061577	Process	Calcium ion transmembrane transport via high voltage-gated calcium channel	ISS	25527503
GO:0072659	Process	Protein localization to plasma membrane	ISS	25527503
GO:0090314	Process	Positive regulation of protein targeting to membrane	IEA
GO:0090650	Process	Cellular response to oxygen-glucose deprivation	IEA
GO:0098903	Process	Regulation of membrane repolarization during action potential	ISS	25527503
GO:1901385	Process	Regulation of voltage-gated calcium channel activity	IBA	21873635
GO:1901386	Process	Negative regulation of voltage-gated calcium channel activity	IEA
GO:1901843	Process	Positive regulation of high voltage-gated calcium channel activity	ISS
GO:1902630	Process	Regulation of membrane hyperpolarization	IEA
GO:1905788	Process	Negative regulation of detection of mechanical stimulus involved in sensory perception of touch	IEA
GO:1990454	Component	L-type voltage-gated calcium channel complex	ISS	25527503
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	IEA

Other IDs

• MIM: 601958
• HGNC: 1403
• e!Ensembl: ENSG00000167535

Protein

• UniProt ID: P54284
• Protein name: Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)
• Protein function: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity
• PDB: 7MIX, 7MIY, 7UHF, 7UHG, 8E59, 8E5A, 8E5B, 8EPL, 8FHS, 8WE6, 8WE7, 8WE8, 8WE9, 8X90, 8X91, 8X93
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12052	VGCC_beta4Aa_N	16 → 58	Voltage gated calcium channel subunit beta domain 4Aa N terminal	Domain
  PF00625	Guanylate_kin	176 → 356	Guanylate kinase	Domain

• Sequence:

  MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPV
  AFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPS
  PQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPV
  VLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER
  SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVL
  QRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRAT
  HHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQR
  SSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWP
  KDSY

• Sequence length: 484