CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1)

Gene

• Entrez ID: 782
• Gene name: Calcium voltage-gated channel auxiliary subunit beta 1
• Gene symbol: CACNB1
• Synonyms: CAB1, CACNLB1, CCHLB1
• Chromosome: 17
• Chromosome location: 17q12
• Summary: The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021151	hsa-miR-186-5p	Sequencing	20371350
MIRT716946	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT716945	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT716944	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT716943	hsa-miR-1470	HITS-CLIP	19536157
MIRT716942	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT716941	hsa-miR-6803-3p	HITS-CLIP	19536157
MIRT716940	hsa-miR-4469	HITS-CLIP	19536157
MIRT716939	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT716938	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT716937	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT716936	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT716935	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT487424	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT487423	hsa-miR-1324	PAR-CLIP	23592263
MIRT487421	hsa-miR-4270	PAR-CLIP	23592263
MIRT487422	hsa-miR-4441	PAR-CLIP	23592263
MIRT487420	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT487419	hsa-miR-7515	PAR-CLIP	23592263
MIRT487418	hsa-miR-3202	PAR-CLIP	23592263
MIRT487417	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT487416	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT487415	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487414	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487413	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487412	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487410	hsa-miR-4271	PAR-CLIP	23592263
MIRT487411	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487409	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487408	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT487407	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487406	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487405	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT716946	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT716945	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT716944	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT716943	hsa-miR-1470	HITS-CLIP	19536157
MIRT716942	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT716941	hsa-miR-6803-3p	HITS-CLIP	19536157
MIRT716940	hsa-miR-4469	HITS-CLIP	19536157
MIRT716939	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT716938	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT716937	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT716936	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT716935	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT487424	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT487423	hsa-miR-1324	PAR-CLIP	23592263
MIRT487421	hsa-miR-4270	PAR-CLIP	23592263
MIRT487422	hsa-miR-4441	PAR-CLIP	23592263
MIRT487420	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT487419	hsa-miR-7515	PAR-CLIP	23592263
MIRT487418	hsa-miR-3202	PAR-CLIP	23592263
MIRT487417	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT487416	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT487415	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487414	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487413	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487412	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487410	hsa-miR-4271	PAR-CLIP	23592263
MIRT487411	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487409	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487408	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT487407	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487406	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487405	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT857843	hsa-miR-15a	CLIP-seq
MIRT857844	hsa-miR-15b	CLIP-seq
MIRT857845	hsa-miR-16	CLIP-seq
MIRT857846	hsa-miR-1827	CLIP-seq
MIRT857847	hsa-miR-195	CLIP-seq
MIRT857848	hsa-miR-2277-3p	CLIP-seq
MIRT857849	hsa-miR-3173-3p	CLIP-seq
MIRT857850	hsa-miR-331-3p	CLIP-seq
MIRT857851	hsa-miR-3612	CLIP-seq
MIRT857852	hsa-miR-3689a-3p	CLIP-seq
MIRT857853	hsa-miR-3689c	CLIP-seq
MIRT857854	hsa-miR-3943	CLIP-seq
MIRT857855	hsa-miR-424	CLIP-seq
MIRT857856	hsa-miR-4254	CLIP-seq
MIRT857857	hsa-miR-4308	CLIP-seq
MIRT857858	hsa-miR-4313	CLIP-seq
MIRT857859	hsa-miR-4419a	CLIP-seq
MIRT857860	hsa-miR-4510	CLIP-seq
MIRT857861	hsa-miR-4690-5p	CLIP-seq
MIRT857862	hsa-miR-4779	CLIP-seq
MIRT857863	hsa-miR-497	CLIP-seq
MIRT857864	hsa-miR-650	CLIP-seq
MIRT1954748	hsa-miR-129-3p	CLIP-seq
MIRT857846	hsa-miR-1827	CLIP-seq
MIRT1954749	hsa-miR-214	CLIP-seq
MIRT1954750	hsa-miR-2355-5p	CLIP-seq
MIRT1954751	hsa-miR-3619-5p	CLIP-seq
MIRT1954752	hsa-miR-3622b-5p	CLIP-seq
MIRT1954753	hsa-miR-3929	CLIP-seq
MIRT1954754	hsa-miR-4419b	CLIP-seq
MIRT1954755	hsa-miR-4478	CLIP-seq
MIRT1954756	hsa-miR-4649-3p	CLIP-seq
MIRT1954757	hsa-miR-4651	CLIP-seq
MIRT1954758	hsa-miR-4660	CLIP-seq
MIRT1954759	hsa-miR-4802-5p	CLIP-seq
MIRT1954760	hsa-miR-518a-3p	CLIP-seq
MIRT1954761	hsa-miR-518b	CLIP-seq
MIRT1954762	hsa-miR-518c	CLIP-seq
MIRT1954763	hsa-miR-518d-3p	CLIP-seq
MIRT1954764	hsa-miR-518f	CLIP-seq
MIRT1954765	hsa-miR-608	CLIP-seq
MIRT1954766	hsa-miR-646	CLIP-seq
MIRT1954767	hsa-miR-761	CLIP-seq
MIRT2192329	hsa-miR-1233	CLIP-seq
MIRT2192330	hsa-miR-1252	CLIP-seq
MIRT2192331	hsa-miR-1266	CLIP-seq
MIRT2192332	hsa-miR-1271	CLIP-seq
MIRT1954748	hsa-miR-129-3p	CLIP-seq
MIRT857843	hsa-miR-15a	CLIP-seq
MIRT857844	hsa-miR-15b	CLIP-seq
MIRT857845	hsa-miR-16	CLIP-seq
MIRT857847	hsa-miR-195	CLIP-seq
MIRT2192333	hsa-miR-2278	CLIP-seq
MIRT2192334	hsa-miR-3150b-3p	CLIP-seq
MIRT2192335	hsa-miR-361-3p	CLIP-seq
MIRT2192336	hsa-miR-3667-3p	CLIP-seq
MIRT2192337	hsa-miR-3689d	CLIP-seq
MIRT857854	hsa-miR-3943	CLIP-seq
MIRT857855	hsa-miR-424	CLIP-seq
MIRT2192338	hsa-miR-4258	CLIP-seq
MIRT2192339	hsa-miR-4454	CLIP-seq
MIRT2192340	hsa-miR-4459	CLIP-seq
MIRT2192341	hsa-miR-4518	CLIP-seq
MIRT1954758	hsa-miR-4660	CLIP-seq
MIRT2192342	hsa-miR-4683	CLIP-seq
MIRT2192343	hsa-miR-4691-5p	CLIP-seq
MIRT2192344	hsa-miR-4710	CLIP-seq
MIRT2192345	hsa-miR-4784	CLIP-seq
MIRT2192346	hsa-miR-4797-5p	CLIP-seq
MIRT2192347	hsa-miR-483-3p	CLIP-seq
MIRT857863	hsa-miR-497	CLIP-seq
MIRT2192348	hsa-miR-635	CLIP-seq
MIRT2192349	hsa-miR-644	CLIP-seq
MIRT1954766	hsa-miR-646	CLIP-seq
MIRT2192350	hsa-miR-663b	CLIP-seq
MIRT2192351	hsa-miR-96	CLIP-seq
MIRT2192329	hsa-miR-1233	CLIP-seq
MIRT1954748	hsa-miR-129-3p	CLIP-seq
MIRT2192336	hsa-miR-3667-3p	CLIP-seq
MIRT2385462	hsa-miR-378g	CLIP-seq
MIRT2192338	hsa-miR-4258	CLIP-seq
MIRT2192343	hsa-miR-4691-5p	CLIP-seq
MIRT2192349	hsa-miR-644	CLIP-seq
MIRT2192350	hsa-miR-663b	CLIP-seq
MIRT857843	hsa-miR-15a	CLIP-seq
MIRT857844	hsa-miR-15b	CLIP-seq
MIRT857845	hsa-miR-16	CLIP-seq
MIRT857847	hsa-miR-195	CLIP-seq
MIRT2192333	hsa-miR-2278	CLIP-seq
MIRT857855	hsa-miR-424	CLIP-seq
MIRT857863	hsa-miR-497	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IGI	21883149
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007528	Process	Neuromuscular junction development	IBA	21873635
GO:0008331	Function	High voltage-gated calcium channel activity	IBA	21873635
GO:0042383	Component	Sarcolemma	IEA
GO:0045202	Component	Synapse	IEA
GO:0061337	Process	Cardiac conduction	TAS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:1901385	Process	Regulation of voltage-gated calcium channel activity	IBA	21873635
GO:1902514	Process	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IGI	21883149
GO:1904646	Process	Cellular response to amyloid-beta	IGI	21883149

Other IDs

• MIM: 114207
• HGNC: 1401
• e!Ensembl: ENSG00000067191

Protein

• UniProt ID: Q02641
• Protein name: Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)
• Protein function: Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type cal
• PDB: 7VFS, 7VFU, 7VFV, 7VFW, 7XLQ, 7YG5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12052	VGCC_beta4Aa_N	58 → 99	Voltage gated calcium channel subunit beta domain 4Aa N terminal	Domain
  PF00625	Guanylate_kin	228 → 408	Guanylate kinase	Domain

• Sequence:

  MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA
  ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP
  VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR
  LGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK
  GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA
  EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG
  KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP
  NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYP
  SSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGT
  PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR

• Sequence length: 598