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CACNA1C (calcium voltage-gated channel subunit alpha1 C)

Gene

Calcium voltage-gated channel subunit alpha1 C

CACNA1C

CACH2, CACN2, CACNA1C-IT2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, NEDHLSS, TS, TS. LQT8

12

12p13.33

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through

Show/Hide all(47)

SNP ID	Visualize variation	Clinical significance	Consequence
rs56394008	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs79891110	G>A,T	Pathogenic, not-provided	Stop gained, coding sequence variant, intron variant, missense variant
rs80315385	G>A,C	Pathogenic, not-provided, uncertain-significance	Coding sequence variant, intron variant, missense variant
rs111606207	C>A,T	Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance	Coding sequence variant, synonymous variant, missense variant
rs121912775	G>A	Conflicting-interpretations-of-pathogenicity, benign, likely-benign, pathogenic	Coding sequence variant, missense variant
rs121912776	C>T	Pathogenic, not-provided	Coding sequence variant, missense variant
rs141633456	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs184684058	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs186741807	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs200330469	C>T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs200800133	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs201258230	C>A,T	Likely-benign, benign-likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs201345843	C>T	Benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs201756421	T>C	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs367895193	G>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Intron variant, missense variant, coding sequence variant
rs369079645	A>G	Conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs370576211	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs372702466	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs374857905	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, synonymous variant
rs375534041	A>G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs398123517	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs527741368	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs545511851	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs575583988	GAG>-	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Coding sequence variant, inframe deletion
rs587782933	G>A	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant, intron variant
rs730880056	G>A,C	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs747654175	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs750459136	C>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs750835733	C>G,T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs750998195	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs754527651	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs758786846	C>G,T	Pathogenic	Missense variant, coding sequence variant, stop gained
rs760888275	C>T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs773528195	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs786205745	G>A,C	Pathogenic	Intron variant, missense variant, coding sequence variant
rs786205748	C>T	Pathogenic	Missense variant, coding sequence variant
rs786205753	G>A	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs794727587	C>G	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs797044881	T>C	Pathogenic	Missense variant, coding sequence variant
rs886042224	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, intron variant, missense variant
rs1057517711	G>A	Uncertain-significance, likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs1467561684	A>G,T	Likely-pathogenic	Missense variant, coding sequence variant
rs1555672574	G>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1555836187	A>G,T	Pathogenic	Missense variant, stop gained, coding sequence variant
rs1555968941	G>A,C	Not-provided, likely-pathogenic	Missense variant, coding sequence variant
rs1568469857	C>A	Pathogenic	Missense variant, coding sequence variant
rs1569139160	C>G	Pathogenic	Missense variant, coding sequence variant

Show/Hide all(193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001203	hsa-miR-133a-3p	Luciferase reporter assay, Western blot	19136465
MIRT568987	hsa-miR-4270	PAR-CLIP	20371350
MIRT568986	hsa-miR-4441	PAR-CLIP	20371350
MIRT568984	hsa-miR-6754-5p	PAR-CLIP	20371350
MIRT568985	hsa-miR-4487	PAR-CLIP	20371350
MIRT568983	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT568982	hsa-miR-4505	PAR-CLIP	20371350
MIRT568981	hsa-miR-5787	PAR-CLIP	20371350
MIRT568980	hsa-miR-4300	PAR-CLIP	20371350
MIRT568979	hsa-miR-5591-5p	PAR-CLIP	20371350
MIRT568978	hsa-miR-6726-5p	PAR-CLIP	20371350
MIRT568977	hsa-miR-920	PAR-CLIP	20371350
MIRT568976	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT568975	hsa-miR-4492	PAR-CLIP	20371350
MIRT568974	hsa-miR-4498	PAR-CLIP	20371350
MIRT568972	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT568973	hsa-miR-762	PAR-CLIP	20371350
MIRT568971	hsa-miR-3175	PAR-CLIP	20371350
MIRT568970	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT568969	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT568968	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT568967	hsa-miR-4489	PAR-CLIP	20371350
MIRT568966	hsa-miR-4283	PAR-CLIP	20371350
MIRT568965	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT568964	hsa-miR-4425	PAR-CLIP	20371350
MIRT568963	hsa-miR-3147	PAR-CLIP	20371350
MIRT568962	hsa-miR-2110	PAR-CLIP	20371350
MIRT568961	hsa-miR-6810-5p	PAR-CLIP	20371350
MIRT568960	hsa-miR-3150a-3p	PAR-CLIP	20371350
MIRT568959	hsa-miR-6763-5p	PAR-CLIP	20371350
MIRT568958	hsa-miR-6857-5p	PAR-CLIP	20371350
MIRT568957	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT568956	hsa-miR-6778-5p	PAR-CLIP	20371350
MIRT568955	hsa-miR-6791-5p	PAR-CLIP	20371350
MIRT444938	hsa-miR-3938	PAR-CLIP	22100165
MIRT444936	hsa-miR-4780	PAR-CLIP	22100165
MIRT444937	hsa-miR-6780b-3p	PAR-CLIP	22100165
MIRT444935	hsa-miR-623	PAR-CLIP	22100165
MIRT444934	hsa-miR-204-5p	PAR-CLIP	22100165
MIRT444933	hsa-miR-211-5p	PAR-CLIP	22100165
MIRT444932	hsa-miR-4755-5p	PAR-CLIP	22100165
MIRT444931	hsa-miR-5006-3p	PAR-CLIP	22100165
MIRT732349	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27341015
MIRT732349	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27341015
MIRT568987	hsa-miR-4270	PAR-CLIP	20371350
MIRT568986	hsa-miR-4441	PAR-CLIP	20371350
MIRT568984	hsa-miR-6754-5p	PAR-CLIP	20371350
MIRT568985	hsa-miR-4487	PAR-CLIP	20371350
MIRT568983	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT568982	hsa-miR-4505	PAR-CLIP	20371350
MIRT568981	hsa-miR-5787	PAR-CLIP	20371350
MIRT568980	hsa-miR-4300	PAR-CLIP	20371350
MIRT568979	hsa-miR-5591-5p	PAR-CLIP	20371350
MIRT568978	hsa-miR-6726-5p	PAR-CLIP	20371350
MIRT568977	hsa-miR-920	PAR-CLIP	20371350
MIRT568976	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT568975	hsa-miR-4492	PAR-CLIP	20371350
MIRT568974	hsa-miR-4498	PAR-CLIP	20371350
MIRT568972	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT568973	hsa-miR-762	PAR-CLIP	20371350
MIRT568971	hsa-miR-3175	PAR-CLIP	20371350
MIRT568970	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT568969	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT568968	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT568967	hsa-miR-4489	PAR-CLIP	20371350
MIRT568966	hsa-miR-4283	PAR-CLIP	20371350
MIRT568965	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT568964	hsa-miR-4425	PAR-CLIP	20371350
MIRT568963	hsa-miR-3147	PAR-CLIP	20371350
MIRT568962	hsa-miR-2110	PAR-CLIP	20371350
MIRT568961	hsa-miR-6810-5p	PAR-CLIP	20371350
MIRT568960	hsa-miR-3150a-3p	PAR-CLIP	20371350
MIRT568959	hsa-miR-6763-5p	PAR-CLIP	20371350
MIRT568958	hsa-miR-6857-5p	PAR-CLIP	20371350
MIRT568957	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT568956	hsa-miR-6778-5p	PAR-CLIP	20371350
MIRT568955	hsa-miR-6791-5p	PAR-CLIP	20371350
MIRT444938	hsa-miR-3938	PAR-CLIP	22100165
MIRT444936	hsa-miR-4780	PAR-CLIP	22100165
MIRT444937	hsa-miR-6780b-3p	PAR-CLIP	22100165
MIRT444935	hsa-miR-623	PAR-CLIP	22100165
MIRT444934	hsa-miR-204-5p	PAR-CLIP	22100165
MIRT444933	hsa-miR-211-5p	PAR-CLIP	22100165
MIRT444932	hsa-miR-4755-5p	PAR-CLIP	22100165
MIRT444931	hsa-miR-5006-3p	PAR-CLIP	22100165
MIRT857479	hsa-miR-1197	CLIP-seq
MIRT857480	hsa-miR-1252	CLIP-seq
MIRT857481	hsa-miR-29a	CLIP-seq
MIRT857482	hsa-miR-29b	CLIP-seq
MIRT857483	hsa-miR-29c	CLIP-seq
MIRT857484	hsa-miR-3065-3p	CLIP-seq
MIRT857485	hsa-miR-3153	CLIP-seq
MIRT857486	hsa-miR-3165	CLIP-seq
MIRT857487	hsa-miR-3183	CLIP-seq
MIRT857488	hsa-miR-3190	CLIP-seq
MIRT857489	hsa-miR-3202	CLIP-seq
MIRT857490	hsa-miR-3915	CLIP-seq
MIRT857491	hsa-miR-3928	CLIP-seq
MIRT857492	hsa-miR-4299	CLIP-seq
MIRT857493	hsa-miR-4312	CLIP-seq
MIRT857494	hsa-miR-4317	CLIP-seq
MIRT857495	hsa-miR-4326	CLIP-seq
MIRT857496	hsa-miR-4434	CLIP-seq
MIRT857497	hsa-miR-4476	CLIP-seq
MIRT857498	hsa-miR-4516	CLIP-seq
MIRT857499	hsa-miR-4531	CLIP-seq
MIRT857500	hsa-miR-4533	CLIP-seq
MIRT857501	hsa-miR-4534	CLIP-seq
MIRT857502	hsa-miR-4641	CLIP-seq
MIRT857503	hsa-miR-4652-3p	CLIP-seq
MIRT857504	hsa-miR-4712-3p	CLIP-seq
MIRT857505	hsa-miR-4723-3p	CLIP-seq
MIRT857506	hsa-miR-4747-5p	CLIP-seq
MIRT857507	hsa-miR-4765	CLIP-seq
MIRT857508	hsa-miR-508-5p	CLIP-seq
MIRT857509	hsa-miR-550a	CLIP-seq
MIRT857510	hsa-miR-619	CLIP-seq
MIRT857511	hsa-miR-1827	CLIP-seq
MIRT857512	hsa-miR-3189-5p	CLIP-seq
MIRT857513	hsa-miR-4268	CLIP-seq
MIRT857514	hsa-miR-4467	CLIP-seq
MIRT857515	hsa-miR-4469	CLIP-seq
MIRT857516	hsa-miR-4655-3p	CLIP-seq
MIRT857517	hsa-miR-4660	CLIP-seq
MIRT857518	hsa-miR-4736	CLIP-seq
MIRT857519	hsa-miR-4758-3p	CLIP-seq
MIRT857520	hsa-miR-4778-3p	CLIP-seq
MIRT857521	hsa-miR-4793-5p	CLIP-seq
MIRT857522	hsa-miR-940	CLIP-seq
MIRT857523	hsa-miR-1228	CLIP-seq
MIRT857524	hsa-miR-1286	CLIP-seq
MIRT857525	hsa-miR-28-5p	CLIP-seq
MIRT857526	hsa-miR-3125	CLIP-seq
MIRT857527	hsa-miR-3126-3p	CLIP-seq
MIRT857528	hsa-miR-3139	CLIP-seq
MIRT857485	hsa-miR-3153	CLIP-seq
MIRT857486	hsa-miR-3165	CLIP-seq
MIRT857488	hsa-miR-3190	CLIP-seq
MIRT857489	hsa-miR-3202	CLIP-seq
MIRT857529	hsa-miR-34a	CLIP-seq
MIRT857530	hsa-miR-34c-5p	CLIP-seq
MIRT857531	hsa-miR-3616-3p	CLIP-seq
MIRT857532	hsa-miR-377	CLIP-seq
MIRT857533	hsa-miR-3916	CLIP-seq
MIRT857534	hsa-miR-4271	CLIP-seq
MIRT857535	hsa-miR-4419a	CLIP-seq
MIRT857536	hsa-miR-4436a	CLIP-seq
MIRT857537	hsa-miR-4436b-3p	CLIP-seq
MIRT857538	hsa-miR-448	CLIP-seq
MIRT857539	hsa-miR-449a	CLIP-seq
MIRT857540	hsa-miR-449b	CLIP-seq
MIRT857541	hsa-miR-4510	CLIP-seq
MIRT857500	hsa-miR-4533	CLIP-seq
MIRT857542	hsa-miR-4667-5p	CLIP-seq
MIRT857543	hsa-miR-4700-5p	CLIP-seq
MIRT857544	hsa-miR-4725-3p	CLIP-seq
MIRT857545	hsa-miR-4728-5p	CLIP-seq
MIRT857546	hsa-miR-4733-3p	CLIP-seq
MIRT857506	hsa-miR-4747-5p	CLIP-seq
MIRT857547	hsa-miR-4789-5p	CLIP-seq
MIRT857548	hsa-miR-4795-5p	CLIP-seq
MIRT857549	hsa-miR-516b	CLIP-seq
MIRT857550	hsa-miR-602	CLIP-seq
MIRT857551	hsa-miR-708	CLIP-seq
MIRT857552	hsa-miR-877	CLIP-seq
MIRT857553	hsa-miR-939	CLIP-seq
MIRT857511	hsa-miR-1827	CLIP-seq
MIRT1954673	hsa-miR-3646	CLIP-seq
MIRT1954674	hsa-miR-3679-3p	CLIP-seq
MIRT1954675	hsa-miR-4649-3p	CLIP-seq
MIRT1954676	hsa-miR-4659a-3p	CLIP-seq
MIRT1954677	hsa-miR-4659b-3p	CLIP-seq
MIRT857508	hsa-miR-508-5p	CLIP-seq
MIRT1954678	hsa-miR-544b	CLIP-seq
MIRT857522	hsa-miR-940	CLIP-seq
MIRT857511	hsa-miR-1827	CLIP-seq
MIRT2192271	hsa-miR-3942-3p	CLIP-seq
MIRT857520	hsa-miR-4778-3p	CLIP-seq
MIRT2436020	hsa-miR-1297	CLIP-seq
MIRT2436021	hsa-miR-26a	CLIP-seq
MIRT2436022	hsa-miR-26b	CLIP-seq
MIRT2436023	hsa-miR-3140-5p	CLIP-seq
MIRT2436024	hsa-miR-3661	CLIP-seq
MIRT2436025	hsa-miR-421	CLIP-seq
MIRT2436026	hsa-miR-4452	CLIP-seq
MIRT2436027	hsa-miR-4465	CLIP-seq
MIRT1954676	hsa-miR-4659a-3p	CLIP-seq
MIRT1954677	hsa-miR-4659b-3p	CLIP-seq
MIRT2436028	hsa-miR-4680-3p	CLIP-seq
MIRT2436029	hsa-miR-4709-5p	CLIP-seq
MIRT2436030	hsa-miR-4738-3p	CLIP-seq
MIRT2436031	hsa-miR-494	CLIP-seq
MIRT2436032	hsa-miR-631	CLIP-seq

Show/Hide all(52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002520	Process	Immune system development	IMP	15454078
GO:0005245	Function	Voltage-gated calcium channel activity	IBA	21873635
GO:0005245	Function	Voltage-gated calcium channel activity	IDA	8392192, 12130699
GO:0005245	Function	Voltage-gated calcium channel activity	IMP	24728418
GO:0005515	Function	Protein binding	IPI	11438518, 15140941, 18535142
GO:0005516	Function	Calmodulin binding	IPI	15140941
GO:0005737	Component	Cytoplasm	IDA	11206130
GO:0005886	Component	Plasma membrane	IDA	11206130
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0005891	Component	Voltage-gated calcium channel complex	IDA	12130699, 17224476
GO:0006816	Process	Calcium ion transport	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	12130699
GO:0007507	Process	Heart development	IMP	15454078
GO:0008331	Function	High voltage-gated calcium channel activity	IBA	21873635
GO:0008331	Function	High voltage-gated calcium channel activity	IDA	15454078
GO:0008331	Function	High voltage-gated calcium channel activity	TAS	11576544
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	TAS	11576544
GO:0014069	Component	Postsynaptic density	IDA	14140941
GO:0016021	Component	Integral component of membrane	IDA	8392192
GO:0016032	Process	Viral process	IEA
GO:0030018	Component	Z disc	ISS
GO:0030425	Component	Dendrite	IEA
GO:0035115	Process	Embryonic forelimb morphogenesis	IMP	15454078
GO:0035585	Process	Calcium-mediated signaling using extracellular calcium source	TAS	11576544
GO:0043010	Process	Camera-type eye development	IMP	15454078
GO:0043204	Component	Perikaryon	IEA
GO:0045762	Process	Positive regulation of adenylate cyclase activity	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050796	Process	Regulation of insulin secretion	TAS
GO:0051393	Function	Alpha-actinin binding	IPI	17110593
GO:0060402	Process	Calcium ion transport into cytosol	ISS
GO:0060402	Process	Calcium ion transport into cytosol	TAS	19095005
GO:0061337	Process	Cardiac conduction	IMP	24728418
GO:0061337	Process	Cardiac conduction	TAS
GO:0061577	Process	Calcium ion transmembrane transport via high voltage-gated calcium channel	IDA	15454078
GO:0070509	Process	Calcium ion import	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IDA	15454078
GO:0070588	Process	Calcium ion transmembrane transport	IMP	24728418
GO:0086002	Process	Cardiac muscle cell action potential involved in contraction	IMP	15454078
GO:0086007	Function	Voltage-gated calcium channel activity involved in cardiac muscle cell action potential	IMP	15454078
GO:0086007	Function	Voltage-gated calcium channel activity involved in cardiac muscle cell action potential	IMP	17224476
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	IMP	15454078
GO:0086045	Process	Membrane depolarization during AV node cell action potential	IMP	26253506
GO:0086056	Function	Voltage-gated calcium channel activity involved in AV node cell action potential	IMP	26253506
GO:0086064	Process	Cell communication by electrical coupling involved in cardiac conduction	TAS	11576544
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IMP	15454078, 15863612, 17224476, 26253506
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098911	Process	Regulation of ventricular cardiac muscle cell action potential	IMP	15454078, 26253506
GO:0098912	Process	Membrane depolarization during atrial cardiac muscle cell action potential	IMP	17224476
GO:1990454	Component	L-type voltage-gated calcium channel complex	IDA	15454078

MIM	HGNC	e!Ensembl
114205	1390	ENSG00000151067

Protein

UniProt ID

Protein name

Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)

Protein function

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:2472841

PDB

1T0J , 2BE6 , 2F3Y , 2F3Z , 2LQC , 3G43 , 3OXQ , 5V2P , 5V2Q , 6C0A , 6DAD , 6DAE , 6DAF , 6U39 , 6U3A , 6U3B , 6U3D , 7L8V , 8EOG , 8EOI , 8FD7 , 8FHS , 8HLP , 8HMA , 8HMB , 8UKO , 8UKP , 8WE6 , 8WE7 , 8WE8 , 8WE9 , 8WEA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	123 → 416	Ion transport protein	Family
PF00520	Ion_trans	523 → 764	Ion transport protein	Family
PF00520	Ion_trans	899 → 955	Ion transport protein	Family
PF00520	Ion_trans	951 → 1197	Ion transport protein	Family
PF00520	Ion_trans	1238 → 1324	Ion transport protein	Family
PF00520	Ion_trans	1320 → 1535	Ion transport protein	Family
PF16905	GPHH	1544 → 1597	Voltage-dependent L-type calcium channel, IQ-associated	Family
PF08763	Ca_chan_IQ	1607 → 1681	Voltage gated calcium channel IQ domain	Domain
PF16885	CAC1F_C	1701 → 1819	Voltage-gated calcium channel subunit alpha, C-term	Family
PF16885	CAC1F_C	2080 → 2190	Voltage-gated calcium channel subunit alpha, C-term	Family

Sequence

MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR
QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISI
VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIA
YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR
VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN
QEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI
TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD
FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVA
GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLT
IASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGI
LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL
FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG
GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR
TASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNP
ETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDT
IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVF
TSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVL
RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSD
SSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPEL
LYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC
ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH
YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVIL
SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR
VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTE
INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFA
VFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRI
KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRI
KTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFK
KRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASE
DDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDST
FTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLS
SNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETY
EVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRA
SFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPA
TPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLM
VPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESA
ADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSS
L

Sequence length

2221

Interactions

View interactions

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