C5AR1 (complement C5a receptor 1)

Gene

• Entrez ID: 728
• Gene name: Complement C5a receptor 1
• Gene symbol: C5AR1
• Synonyms: C5A, C5AR, C5R1, CD88
• Chromosome: 19
• Chromosome location: 19q13.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019124	hsa-miR-335-5p	Microarray	18185580
MIRT030190	hsa-miR-26b-5p	Microarray	19088304
MIRT848590	hsa-miR-1262	CLIP-seq
MIRT848591	hsa-miR-1343	CLIP-seq
MIRT848592	hsa-miR-3179	CLIP-seq
MIRT848593	hsa-miR-339-5p	CLIP-seq
MIRT848594	hsa-miR-3689a-3p	CLIP-seq
MIRT848595	hsa-miR-3689c	CLIP-seq
MIRT848596	hsa-miR-3907	CLIP-seq
MIRT848597	hsa-miR-3945	CLIP-seq
MIRT848598	hsa-miR-4253	CLIP-seq
MIRT848599	hsa-miR-4447	CLIP-seq
MIRT848600	hsa-miR-4450	CLIP-seq
MIRT848601	hsa-miR-4472	CLIP-seq
MIRT848602	hsa-miR-4503	CLIP-seq
MIRT848603	hsa-miR-4505	CLIP-seq
MIRT848604	hsa-miR-4651	CLIP-seq
MIRT848605	hsa-miR-4667-5p	CLIP-seq
MIRT848606	hsa-miR-4700-5p	CLIP-seq
MIRT848607	hsa-miR-4701-3p	CLIP-seq
MIRT848608	hsa-miR-4713-3p	CLIP-seq
MIRT848609	hsa-miR-4728-5p	CLIP-seq
MIRT848610	hsa-miR-4731-3p	CLIP-seq
MIRT848611	hsa-miR-4793-5p	CLIP-seq
MIRT848612	hsa-miR-4801	CLIP-seq
MIRT848613	hsa-miR-485-5p	CLIP-seq
MIRT848614	hsa-miR-608	CLIP-seq
MIRT848590	hsa-miR-1262	CLIP-seq
MIRT1951754	hsa-miR-150	CLIP-seq
MIRT848592	hsa-miR-3179	CLIP-seq
MIRT848597	hsa-miR-3945	CLIP-seq
MIRT848598	hsa-miR-4253	CLIP-seq
MIRT1951755	hsa-miR-4438	CLIP-seq
MIRT848603	hsa-miR-4505	CLIP-seq
MIRT848607	hsa-miR-4701-3p	CLIP-seq
MIRT848610	hsa-miR-4731-3p	CLIP-seq
MIRT848612	hsa-miR-4801	CLIP-seq
MIRT848613	hsa-miR-485-5p	CLIP-seq
MIRT1951756	hsa-miR-5095	CLIP-seq
MIRT1951757	hsa-miR-579	CLIP-seq
MIRT1951758	hsa-miR-664	CLIP-seq
MIRT2189639	hsa-miR-1208	CLIP-seq
MIRT2189640	hsa-miR-1224-3p	CLIP-seq
MIRT848590	hsa-miR-1262	CLIP-seq
MIRT2189641	hsa-miR-145	CLIP-seq
MIRT2189642	hsa-miR-197	CLIP-seq
MIRT2189643	hsa-miR-24	CLIP-seq
MIRT2189644	hsa-miR-2681	CLIP-seq
MIRT848592	hsa-miR-3179	CLIP-seq
MIRT2189645	hsa-miR-4269	CLIP-seq
MIRT2189646	hsa-miR-4284	CLIP-seq
MIRT2189647	hsa-miR-4420	CLIP-seq
MIRT1951755	hsa-miR-4438	CLIP-seq
MIRT2189648	hsa-miR-4466	CLIP-seq
MIRT848603	hsa-miR-4505	CLIP-seq
MIRT848607	hsa-miR-4701-3p	CLIP-seq
MIRT848610	hsa-miR-4731-3p	CLIP-seq
MIRT848612	hsa-miR-4801	CLIP-seq
MIRT2189649	hsa-miR-483-5p	CLIP-seq
MIRT848613	hsa-miR-485-5p	CLIP-seq
MIRT1951756	hsa-miR-5095	CLIP-seq
MIRT2189650	hsa-miR-640	CLIP-seq
MIRT2189651	hsa-miR-675	CLIP-seq
MIRT2189652	hsa-miR-935	CLIP-seq
MIRT848590	hsa-miR-1262	CLIP-seq
MIRT848592	hsa-miR-3179	CLIP-seq
MIRT848603	hsa-miR-4505	CLIP-seq
MIRT848607	hsa-miR-4701-3p	CLIP-seq
MIRT848610	hsa-miR-4731-3p	CLIP-seq
MIRT848612	hsa-miR-4801	CLIP-seq
MIRT848613	hsa-miR-485-5p	CLIP-seq
MIRT2189648	hsa-miR-4466	CLIP-seq
MIRT2189651	hsa-miR-675	CLIP-seq
MIRT2189644	hsa-miR-2681	CLIP-seq
MIRT2493288	hsa-miR-4301	CLIP-seq
MIRT2189648	hsa-miR-4466	CLIP-seq
MIRT2493289	hsa-miR-4775	CLIP-seq
MIRT2493290	hsa-miR-590-3p	CLIP-seq
MIRT2189651	hsa-miR-675	CLIP-seq
MIRT2676954	hsa-miR-129-5p	CLIP-seq
MIRT2189648	hsa-miR-4466	CLIP-seq
MIRT2493289	hsa-miR-4775	CLIP-seq
MIRT2493290	hsa-miR-590-3p	CLIP-seq
MIRT2189651	hsa-miR-675	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	TAS	7649993
GO:0001774	Process	Microglial cell activation	ISS
GO:0001856	Function	Complement component C5a binding	IEA
GO:0002430	Process	Complement receptor mediated signaling pathway	IBA	21873635
GO:0004875	Function	Complement receptor activity	IBA	21873635
GO:0004878	Function	Complement component C5a receptor activity	IBA	21873635
GO:0004878	Function	Complement component C5a receptor activity	IDA	10571060, 22496247
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	IPI	10571060
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	2007135
GO:0006915	Process	Apoptotic process	IEA
GO:0006935	Process	Chemotaxis	TAS	10352266
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	TAS	9590258
GO:0006968	Process	Cellular defense response	TAS	8779720
GO:0007165	Process	Signal transduction	TAS	2007135, 8702752
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007202	Process	Activation of phospholipase C activity	TAS	7649993
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007606	Process	Sensory perception of chemical stimulus	TAS	9590258
GO:0009986	Component	Cell surface	IEA
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IEA
GO:0010759	Process	Positive regulation of macrophage chemotaxis	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	22960554
GO:0021534	Process	Cell proliferation in hindbrain	IEA
GO:0030449	Process	Regulation of complement activation	TAS
GO:0030593	Process	Neutrophil chemotaxis	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031100	Process	Animal organ regeneration	IEA
GO:0032494	Process	Response to peptidoglycan	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0038178	Process	Complement component C5a signaling pathway	IDA	10571060
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	22496247
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0045177	Component	Apical part of cell	IDA	22496247
GO:0045766	Process	Positive regulation of angiogenesis	IEA
GO:0048143	Process	Astrocyte activation	ISS
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IDA	22496247
GO:0050830	Process	Defense response to Gram-positive bacterium	IEA
GO:0050890	Process	Cognition	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	22496247
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	IEA
GO:0097242	Process	Amyloid-beta clearance	ISS
GO:0099172	Process	Presynapse organization	ISS
GO:1902947	Process	Regulation of tau-protein kinase activity	ISS

Other IDs

• MIM: 113995
• HGNC: 1338
• e!Ensembl: ENSG00000197405

Protein

• UniProt ID: P21730
• Protein name: C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)
• Protein function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the rece
• PDB: 2K3U, 5O9H, 6C1Q, 6C1R, 7Y64, 7Y65, 7Y66, 7Y67, 8GO8, 8GOO, 8HK5, 8I0N, 8I0Z, 8IA2, 8JZP, 8JZZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	54 → 300	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
  VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
  YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
  YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
  LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
  VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV

• Sequence length: 350