C4B (complement C4B (Chido/Rodgers blood group))

Gene

• Entrez ID: 721
• Gene name: Complement C4B (Chido/Rodgers blood group)
• Gene symbol: C4B
• Synonyms: C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and g

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2493124	hsa-miR-1206	CLIP-seq
MIRT2493125	hsa-miR-146b-3p	CLIP-seq
MIRT2493126	hsa-miR-1915	CLIP-seq
MIRT2493127	hsa-miR-2115	CLIP-seq
MIRT2493128	hsa-miR-3117-5p	CLIP-seq
MIRT2493129	hsa-miR-3173-5p	CLIP-seq
MIRT2493130	hsa-miR-4267	CLIP-seq
MIRT2493131	hsa-miR-4281	CLIP-seq
MIRT2493132	hsa-miR-433	CLIP-seq
MIRT2493133	hsa-miR-4517	CLIP-seq
MIRT2493134	hsa-miR-4519	CLIP-seq
MIRT2493135	hsa-miR-4726-3p	CLIP-seq
MIRT2493136	hsa-miR-516a-3p	CLIP-seq
MIRT2493137	hsa-miR-520f	CLIP-seq
MIRT2493138	hsa-miR-874	CLIP-seq
MIRT2493139	hsa-miR-889	CLIP-seq
MIRT2493124	hsa-miR-1206	CLIP-seq
MIRT2493127	hsa-miR-2115	CLIP-seq
MIRT2493130	hsa-miR-4267	CLIP-seq
MIRT2493132	hsa-miR-433	CLIP-seq
MIRT2493134	hsa-miR-4519	CLIP-seq
MIRT2493136	hsa-miR-516a-3p	CLIP-seq
MIRT2493137	hsa-miR-520f	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	9574539

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001848	Function	Complement binding	IDA	2395880
GO:0004866	Function	Endopeptidase inhibitor activity	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	2395880
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0006956	Process	Complement activation	IBA	21873635
GO:0006956	Process	Complement activation	IGI	19302245
GO:0006956	Process	Complement activation	TAS
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0008228	Process	Opsonization	TAS	22333221
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0030246	Function	Carbohydrate binding	IDA	2395880
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030449	Process	Regulation of complement activation	TAS
GO:0032490	Process	Detection of molecule of bacterial origin	IDA	22333221
GO:0044216	Component	Other organism cell	IDA	22333221
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:2000427	Process	Positive regulation of apoptotic cell clearance	IGI	19302245

Other IDs

• MIM: 120820
• HGNC: 1324
• e!Ensembl: ENSG00000224389