C4A (complement C4A (Chido/Rodgers blood group))

Gene

• Entrez ID: 720
• Gene name: Complement C4A (Chido/Rodgers blood group)
• Gene symbol: C4A
• Synonyms: C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. Th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2493108	hsa-miR-1206	CLIP-seq
MIRT2493109	hsa-miR-146b-3p	CLIP-seq
MIRT2493110	hsa-miR-1915	CLIP-seq
MIRT2493111	hsa-miR-2115	CLIP-seq
MIRT2493112	hsa-miR-3117-5p	CLIP-seq
MIRT2493113	hsa-miR-3173-5p	CLIP-seq
MIRT2493114	hsa-miR-4267	CLIP-seq
MIRT2493115	hsa-miR-4281	CLIP-seq
MIRT2493116	hsa-miR-433	CLIP-seq
MIRT2493117	hsa-miR-4517	CLIP-seq
MIRT2493118	hsa-miR-4519	CLIP-seq
MIRT2493119	hsa-miR-4726-3p	CLIP-seq
MIRT2493120	hsa-miR-516a-3p	CLIP-seq
MIRT2493121	hsa-miR-520f	CLIP-seq
MIRT2493122	hsa-miR-874	CLIP-seq
MIRT2493123	hsa-miR-889	CLIP-seq
MIRT2493108	hsa-miR-1206	CLIP-seq
MIRT2493111	hsa-miR-2115	CLIP-seq
MIRT2493114	hsa-miR-4267	CLIP-seq
MIRT2493116	hsa-miR-433	CLIP-seq
MIRT2493118	hsa-miR-4519	CLIP-seq
MIRT2493120	hsa-miR-516a-3p	CLIP-seq
MIRT2493121	hsa-miR-520f	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	9574539

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001849	Function	Complement component C1q complex binding	IDA	2395880
GO:0004866	Function	Endopeptidase inhibitor activity	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0006956	Process	Complement activation	IBA	21873635
GO:0006956	Process	Complement activation	IGI	19302245
GO:0006956	Process	Complement activation	TAS
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0030424	Component	Axon	IDA	26814963
GO:0030425	Component	Dendrite	IDA	26814963
GO:0030449	Process	Regulation of complement activation	TAS
GO:0043025	Component	Neuronal cell body	IDA	26814963
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IDA	26814963
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:2000427	Process	Positive regulation of apoptotic cell clearance	IGI	19302245

Other IDs

• MIM: 120810
• HGNC: 1323
• e!Ensembl: ENSG00000244731