GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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BGN (biglycan)

Gene

633

Biglycan

BGN

DSPG1, MRLS, PG-S1, PGI, SEMDX, SLRR1A

Xq28

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and

Show/Hide all(7)

SNP ID	Visualize variation	Clinical significance	Consequence
rs879255604	A>G	Pathogenic	Missense variant, coding sequence variant
rs879255605	G>T	Pathogenic	Missense variant, coding sequence variant
rs886037823	G>A	Pathogenic	Stop gained, coding sequence variant
rs886037824	A>C	Pathogenic	Missense variant, coding sequence variant
rs886037825	G>A	Pathogenic	Missense variant, coding sequence variant
rs1602981402	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1602981441	->AA	Likely-pathogenic	Coding sequence variant, frameshift variant

Show/Hide all(244)

miRTarBase ID	miRNA	Experiments	Reference
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT635492	hsa-miR-6828-5p	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	24906430
MIRT517400	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT517399	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT517398	hsa-miR-3125	PAR-CLIP	22012620
MIRT517396	hsa-miR-3916	PAR-CLIP	22012620
MIRT517397	hsa-miR-6859-5p	PAR-CLIP	22012620
MIRT517395	hsa-miR-4476	PAR-CLIP	22012620
MIRT517394	hsa-miR-6876-5p	PAR-CLIP	22012620
MIRT517393	hsa-miR-4533	PAR-CLIP	22012620
MIRT517400	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT517399	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT517398	hsa-miR-3125	PAR-CLIP	23446348
MIRT517396	hsa-miR-3916	PAR-CLIP	23446348
MIRT517397	hsa-miR-6859-5p	PAR-CLIP	23446348
MIRT517395	hsa-miR-4476	PAR-CLIP	23446348
MIRT517394	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT517393	hsa-miR-4533	PAR-CLIP	23446348
MIRT517398	hsa-miR-3125	PAR-CLIP	27292025
MIRT517396	hsa-miR-3916	PAR-CLIP	27292025
MIRT517395	hsa-miR-4476	PAR-CLIP	27292025
MIRT517393	hsa-miR-4533	PAR-CLIP	27292025
MIRT517400	hsa-miR-6758-5p	PAR-CLIP	27292025
MIRT517399	hsa-miR-6856-5p	PAR-CLIP	27292025
MIRT517397	hsa-miR-6859-5p	PAR-CLIP	27292025
MIRT517394	hsa-miR-6876-5p	PAR-CLIP	27292025
MIRT517398	hsa-miR-3125	HITS-CLIP	27418678
MIRT517398	hsa-miR-3125	HITS-CLIP	27418678
MIRT517398	hsa-miR-3125	HITS-CLIP	27418678
MIRT517398	hsa-miR-3125	HITS-CLIP	27418678
MIRT517396	hsa-miR-3916	HITS-CLIP	27418678
MIRT517396	hsa-miR-3916	HITS-CLIP	27418678
MIRT517396	hsa-miR-3916	HITS-CLIP	27418678
MIRT517396	hsa-miR-3916	HITS-CLIP	27418678
MIRT614284	hsa-miR-4311	HITS-CLIP	27418678
MIRT517395	hsa-miR-4476	HITS-CLIP	27418678
MIRT517395	hsa-miR-4476	HITS-CLIP	27418678
MIRT517395	hsa-miR-4476	HITS-CLIP	27418678
MIRT517395	hsa-miR-4476	HITS-CLIP	27418678
MIRT517393	hsa-miR-4533	HITS-CLIP	27418678
MIRT517393	hsa-miR-4533	HITS-CLIP	27418678
MIRT517393	hsa-miR-4533	HITS-CLIP	27418678
MIRT517393	hsa-miR-4533	HITS-CLIP	27418678
MIRT517400	hsa-miR-6758-5p	HITS-CLIP	27418678
MIRT517400	hsa-miR-6758-5p	HITS-CLIP	27418678
MIRT517400	hsa-miR-6758-5p	HITS-CLIP	27418678
MIRT517400	hsa-miR-6758-5p	HITS-CLIP	27418678
MIRT517399	hsa-miR-6856-5p	HITS-CLIP	27418678
MIRT517399	hsa-miR-6856-5p	HITS-CLIP	27418678
MIRT517399	hsa-miR-6856-5p	HITS-CLIP	27418678
MIRT517399	hsa-miR-6856-5p	HITS-CLIP	27418678
MIRT517397	hsa-miR-6859-5p	HITS-CLIP	27418678
MIRT517397	hsa-miR-6859-5p	HITS-CLIP	27418678
MIRT517397	hsa-miR-6859-5p	HITS-CLIP	27418678
MIRT517397	hsa-miR-6859-5p	HITS-CLIP	27418678
MIRT517394	hsa-miR-6876-5p	HITS-CLIP	27418678
MIRT517394	hsa-miR-6876-5p	HITS-CLIP	27418678
MIRT517394	hsa-miR-6876-5p	HITS-CLIP	27418678
MIRT517394	hsa-miR-6876-5p	HITS-CLIP	27418678
MIRT607442	hsa-miR-8485	HITS-CLIP	27418678
MIRT736304	hsa-miR-206	Luciferase reporter assay, RNA-seq, qRT-PCR	32129700
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT635492	hsa-miR-6828-5p	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT614284	hsa-miR-4311	HITS-CLIP	23824327
MIRT607442	hsa-miR-8485	HITS-CLIP	23824327
MIRT517400	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT517399	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT517398	hsa-miR-3125	PAR-CLIP	22012620
MIRT517396	hsa-miR-3916	PAR-CLIP	22012620
MIRT517397	hsa-miR-6859-5p	PAR-CLIP	22012620
MIRT517395	hsa-miR-4476	PAR-CLIP	22012620
MIRT517394	hsa-miR-6876-5p	PAR-CLIP	22012620
MIRT517393	hsa-miR-4533	PAR-CLIP	22012620
MIRT517400	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT517399	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT517398	hsa-miR-3125	PAR-CLIP	23446348
MIRT517396	hsa-miR-3916	PAR-CLIP	23446348
MIRT517397	hsa-miR-6859-5p	PAR-CLIP	23446348
MIRT517395	hsa-miR-4476	PAR-CLIP	23446348
MIRT517394	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT517393	hsa-miR-4533	PAR-CLIP	23446348
MIRT821167	hsa-miR-1273f	CLIP-seq
MIRT821168	hsa-miR-1293	CLIP-seq
MIRT821169	hsa-miR-150	CLIP-seq
MIRT821170	hsa-miR-1972	CLIP-seq
MIRT821171	hsa-miR-2278	CLIP-seq
MIRT821172	hsa-miR-326	CLIP-seq
MIRT821173	hsa-miR-330-5p	CLIP-seq
MIRT821174	hsa-miR-4483	CLIP-seq
MIRT821175	hsa-miR-4534	CLIP-seq
MIRT821176	hsa-miR-4687-3p	CLIP-seq
MIRT821177	hsa-miR-4717-5p	CLIP-seq
MIRT821178	hsa-miR-4802-5p	CLIP-seq
MIRT821179	hsa-miR-541	CLIP-seq
MIRT821180	hsa-miR-654-5p	CLIP-seq
MIRT1545734	hsa-miR-101	CLIP-seq
MIRT1545735	hsa-miR-1291	CLIP-seq
MIRT1545736	hsa-miR-296-3p	CLIP-seq
MIRT1545737	hsa-miR-296-5p	CLIP-seq
MIRT1545738	hsa-miR-3122	CLIP-seq
MIRT1545739	hsa-miR-3614-5p	CLIP-seq
MIRT1545740	hsa-miR-3689a-3p	CLIP-seq
MIRT1545741	hsa-miR-3689c	CLIP-seq
MIRT1545742	hsa-miR-3913-5p	CLIP-seq
MIRT1545743	hsa-miR-3940-5p	CLIP-seq
MIRT1545744	hsa-miR-4488	CLIP-seq
MIRT1545745	hsa-miR-4507	CLIP-seq
MIRT1545746	hsa-miR-4645-3p	CLIP-seq
MIRT1545747	hsa-miR-4649-3p	CLIP-seq
MIRT1545748	hsa-miR-4697-5p	CLIP-seq
MIRT1545749	hsa-miR-4728-5p	CLIP-seq
MIRT1545750	hsa-miR-4785	CLIP-seq
MIRT1545751	hsa-miR-488	CLIP-seq
MIRT1545752	hsa-miR-542-5p	CLIP-seq
MIRT1545753	hsa-miR-552	CLIP-seq
MIRT1545754	hsa-miR-629	CLIP-seq
MIRT1556031	hsa-miR-1915	CLIP-seq
MIRT1556032	hsa-miR-2117	CLIP-seq
MIRT1556033	hsa-miR-3117-3p	CLIP-seq
MIRT1556034	hsa-miR-3169	CLIP-seq
MIRT1556035	hsa-miR-3199	CLIP-seq
MIRT1556036	hsa-miR-4273	CLIP-seq
MIRT1556037	hsa-miR-4279	CLIP-seq
MIRT1556038	hsa-miR-4759	CLIP-seq
MIRT1942729	hsa-miR-1281	CLIP-seq
MIRT1545740	hsa-miR-3689a-3p	CLIP-seq
MIRT1545741	hsa-miR-3689c	CLIP-seq
MIRT1942730	hsa-miR-4436b-3p	CLIP-seq
MIRT1545751	hsa-miR-488	CLIP-seq
MIRT821168	hsa-miR-1293	CLIP-seq
MIRT821171	hsa-miR-2278	CLIP-seq
MIRT1545738	hsa-miR-3122	CLIP-seq
MIRT821172	hsa-miR-326	CLIP-seq
MIRT821173	hsa-miR-330-5p	CLIP-seq
MIRT1545739	hsa-miR-3614-5p	CLIP-seq
MIRT1545740	hsa-miR-3689a-3p	CLIP-seq
MIRT1545741	hsa-miR-3689c	CLIP-seq
MIRT1545742	hsa-miR-3913-5p	CLIP-seq
MIRT2181509	hsa-miR-3922-5p	CLIP-seq
MIRT1545743	hsa-miR-3940-5p	CLIP-seq
MIRT1942730	hsa-miR-4436b-3p	CLIP-seq
MIRT2181510	hsa-miR-4447	CLIP-seq
MIRT2181511	hsa-miR-4468	CLIP-seq
MIRT2181512	hsa-miR-4472	CLIP-seq
MIRT821174	hsa-miR-4483	CLIP-seq
MIRT1545745	hsa-miR-4507	CLIP-seq
MIRT821176	hsa-miR-4687-3p	CLIP-seq
MIRT2181513	hsa-miR-4691-3p	CLIP-seq
MIRT2181514	hsa-miR-4708-3p	CLIP-seq
MIRT821179	hsa-miR-541	CLIP-seq
MIRT1545754	hsa-miR-629	CLIP-seq
MIRT821180	hsa-miR-654-5p	CLIP-seq
MIRT2444789	hsa-miR-1909	CLIP-seq
MIRT821171	hsa-miR-2278	CLIP-seq
MIRT2444790	hsa-miR-4660	CLIP-seq
MIRT821176	hsa-miR-4687-3p	CLIP-seq
MIRT2444791	hsa-miR-4688	CLIP-seq
MIRT2444792	hsa-miR-486-3p	CLIP-seq
MIRT821179	hsa-miR-541	CLIP-seq
MIRT821180	hsa-miR-654-5p	CLIP-seq
MIRT2484923	hsa-miR-122	CLIP-seq
MIRT821167	hsa-miR-1273f	CLIP-seq
MIRT2484924	hsa-miR-185	CLIP-seq
MIRT821170	hsa-miR-1972	CLIP-seq
MIRT2484925	hsa-miR-298	CLIP-seq
MIRT2484926	hsa-miR-3714	CLIP-seq
MIRT2484927	hsa-miR-3911	CLIP-seq
MIRT2484928	hsa-miR-3915	CLIP-seq
MIRT2181509	hsa-miR-3922-5p	CLIP-seq
MIRT2484929	hsa-miR-3928	CLIP-seq
MIRT2484930	hsa-miR-4267	CLIP-seq
MIRT2484931	hsa-miR-4274	CLIP-seq
MIRT2484932	hsa-miR-4306	CLIP-seq
MIRT2484933	hsa-miR-4455	CLIP-seq
MIRT2484934	hsa-miR-4475	CLIP-seq
MIRT2484935	hsa-miR-4493	CLIP-seq
MIRT821175	hsa-miR-4534	CLIP-seq
MIRT2484936	hsa-miR-4644	CLIP-seq
MIRT1545747	hsa-miR-4649-3p	CLIP-seq
MIRT821177	hsa-miR-4717-5p	CLIP-seq
MIRT2484937	hsa-miR-4753-5p	CLIP-seq
MIRT2484938	hsa-miR-4786-3p	CLIP-seq
MIRT821178	hsa-miR-4802-5p	CLIP-seq
MIRT1545751	hsa-miR-488	CLIP-seq
MIRT2484923	hsa-miR-122	CLIP-seq
MIRT821167	hsa-miR-1273f	CLIP-seq
MIRT2484924	hsa-miR-185	CLIP-seq
MIRT1556031	hsa-miR-1915	CLIP-seq
MIRT821170	hsa-miR-1972	CLIP-seq
MIRT1556032	hsa-miR-2117	CLIP-seq
MIRT2484925	hsa-miR-298	CLIP-seq
MIRT1556033	hsa-miR-3117-3p	CLIP-seq
MIRT1556034	hsa-miR-3169	CLIP-seq
MIRT1556035	hsa-miR-3199	CLIP-seq
MIRT2484926	hsa-miR-3714	CLIP-seq
MIRT2484927	hsa-miR-3911	CLIP-seq
MIRT2484928	hsa-miR-3915	CLIP-seq
MIRT2181509	hsa-miR-3922-5p	CLIP-seq
MIRT2484929	hsa-miR-3928	CLIP-seq
MIRT2484930	hsa-miR-4267	CLIP-seq
MIRT1556036	hsa-miR-4273	CLIP-seq
MIRT2484931	hsa-miR-4274	CLIP-seq
MIRT1556037	hsa-miR-4279	CLIP-seq
MIRT2484932	hsa-miR-4306	CLIP-seq
MIRT2484933	hsa-miR-4455	CLIP-seq
MIRT2484934	hsa-miR-4475	CLIP-seq
MIRT2484935	hsa-miR-4493	CLIP-seq
MIRT2675962	hsa-miR-4515	CLIP-seq
MIRT821175	hsa-miR-4534	CLIP-seq
MIRT2484936	hsa-miR-4644	CLIP-seq
MIRT1545747	hsa-miR-4649-3p	CLIP-seq
MIRT821177	hsa-miR-4717-5p	CLIP-seq
MIRT2484937	hsa-miR-4753-5p	CLIP-seq
MIRT1556038	hsa-miR-4759	CLIP-seq
MIRT2484938	hsa-miR-4786-3p	CLIP-seq
MIRT821178	hsa-miR-4802-5p	CLIP-seq
MIRT1545751	hsa-miR-488	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
NFKB1	Activation	15536164
RELA	Activation	15536164

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001974	Process	Blood vessel remodeling	IEA
GO:0005201	Function	Extracellular matrix structural constituent	NAS	1860845
GO:0005515	Function	Protein binding	IPI	11598131, 32814053
GO:0005539	Function	Glycosaminoglycan binding	IEA
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005796	Component	Golgi lumen	TAS
GO:0008150	Process	Biological_process	ND
GO:0009986	Component	Cell surface	IDA	2212616
GO:0019800	Process	Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	IEA
GO:0030021	Function	Extracellular matrix structural constituent conferring compression resistance	ISS
GO:0030021	Function	Extracellular matrix structural constituent conferring compression resistance	RCA	20551380, 25037231, 27559042, 28327460, 28675934
GO:0030133	Component	Transport vesicle	IDA
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030206	Process	Chondroitin sulfate biosynthetic process	TAS
GO:0030207	Process	Chondroitin sulfate catabolic process	TAS
GO:0030208	Process	Dermatan sulfate biosynthetic process	TAS
GO:0031012	Component	Extracellular matrix	NAS	1860845
GO:0042383	Component	Sarcolemma	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0050840	Function	Extracellular matrix binding	IEA
GO:0060348	Process	Bone development	IEA
GO:0061975	Process	Articular cartilage development	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 27559042, 28327460, 28675934
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	20551380
GO:0062023	Component	Collagen-containing extracellular matrix	ISS	22261194
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
301870	1044	ENSG00000182492

Protein

UniProt ID

P21810

Protein name

Biglycan (Bone/cartilage proteoglycan I) (PG-S1)

Protein function

May be involved in collagen fiber assembly.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01462	LRRNT	62 → 89	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	90 → 150	Leucine rich repeat	Repeat
PF13855	LRR_8	159 → 220	Leucine rich repeat	Repeat
PF13855	LRR_8	229 → 289	Leucine rich repeat	Repeat

Sequence

MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYS
AMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALV
LVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNK
IQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLK
LLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLA
IQFGNYKK

Sequence length

368

Interactions

View interactions

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