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BGN (biglycan)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
633
Gene nameGene Name - the full gene name approved by the HGNC.
Biglycan
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
BGN
SynonymsGene synonyms aliases
DSPG1, MRLS, PG-S1, PGI, SEMDX, SLRR1A
ChromosomeChromosome number
X
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq28
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
SNPsSNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs879255604 A>G Pathogenic Missense variant, coding sequence variant
rs879255605 G>T Pathogenic Missense variant, coding sequence variant
rs886037823 G>A Pathogenic Stop gained, coding sequence variant
rs886037824 A>C Pathogenic Missense variant, coding sequence variant
rs886037825 G>A Pathogenic Missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT517393 hsa-miR-4533 PAR-CLIP 23446348
MIRT517393 hsa-miR-4533 PAR-CLIP 22012620
MIRT517393 hsa-miR-4533 PAR-CLIP 27292025
MIRT517393 hsa-miR-4533 HITS-CLIP 27418678
MIRT517394 hsa-miR-6876-5p PAR-CLIP 23446348
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
NFKB1 Activation 15536164
RELA Activation 15536164
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0001974 Process Blood vessel remodeling IEA
GO:0005201 Function Extracellular matrix structural constituent NAS 1860845
GO:0005515 Function Protein binding IPI 11598131, 32814053
GO:0005539 Function Glycosaminoglycan binding IEA
GO:0005576 Component Extracellular region HDA 27068509
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P21810
Protein name Biglycan (Bone/cartilage proteoglycan I) (PG-S1)
Protein function May be involved in collagen fiber assembly.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01462 LRRNT
62 → 89
Leucine rich repeat N-terminal domain
 Family
PF13855 LRR_8
90 → 150
Leucine rich repeat
 Repeat
PF13855 LRR_8
159 → 220
Leucine rich repeat
 Repeat
PF13855 LRR_8
229 → 289
Leucine rich repeat
 Repeat
Sequence 
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYS
AMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALV
LVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNK
IQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLK
LLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLA
IQFGNYKK
Sequence length 368
Interactions View interactions

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