BCAT2 (branched chain amino acid transaminase 2)

Gene

• Entrez ID: 587
• Gene name: Branched chain amino acid transaminase 2
• Gene symbol: BCAT2
• Synonyms: BCAM, BCATM, BCT2, HVLI, PP18
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants en

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028382	hsa-miR-32-5p	Sequencing	20371350
MIRT041917	hsa-miR-484	CLASH	23622248
MIRT040021	hsa-miR-615-3p	CLASH	23622248
MIRT728218	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT728217	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT028382	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT817824	hsa-miR-185	CLIP-seq
MIRT817825	hsa-miR-1912	CLIP-seq
MIRT817826	hsa-miR-29a	CLIP-seq
MIRT817827	hsa-miR-29b	CLIP-seq
MIRT817828	hsa-miR-29c	CLIP-seq
MIRT817829	hsa-miR-3065-3p	CLIP-seq
MIRT817830	hsa-miR-3176	CLIP-seq
MIRT817831	hsa-miR-362-5p	CLIP-seq
MIRT817832	hsa-miR-3713	CLIP-seq
MIRT817833	hsa-miR-3922-3p	CLIP-seq
MIRT817834	hsa-miR-4306	CLIP-seq
MIRT817835	hsa-miR-4488	CLIP-seq
MIRT817836	hsa-miR-4506	CLIP-seq
MIRT817837	hsa-miR-4508	CLIP-seq
MIRT817838	hsa-miR-4632	CLIP-seq
MIRT817839	hsa-miR-4644	CLIP-seq
MIRT817840	hsa-miR-4697-5p	CLIP-seq
MIRT817841	hsa-miR-4717-3p	CLIP-seq
MIRT817842	hsa-miR-4733-3p	CLIP-seq
MIRT817843	hsa-miR-4761-5p	CLIP-seq
MIRT817844	hsa-miR-500b	CLIP-seq
MIRT817845	hsa-miR-501-5p	CLIP-seq
MIRT817846	hsa-miR-548c-3p	CLIP-seq
MIRT817847	hsa-miR-95	CLIP-seq
MIRT817848	hsa-miR-1254	CLIP-seq
MIRT817849	hsa-miR-1256	CLIP-seq
MIRT817850	hsa-miR-125a-3p	CLIP-seq
MIRT817851	hsa-miR-1271	CLIP-seq
MIRT817852	hsa-miR-146a	CLIP-seq
MIRT817853	hsa-miR-146b-5p	CLIP-seq
MIRT817854	hsa-miR-182	CLIP-seq
MIRT817824	hsa-miR-185	CLIP-seq
MIRT817825	hsa-miR-1912	CLIP-seq
MIRT817855	hsa-miR-2116	CLIP-seq
MIRT817856	hsa-miR-25	CLIP-seq
MIRT817826	hsa-miR-29a	CLIP-seq
MIRT817827	hsa-miR-29b	CLIP-seq
MIRT817828	hsa-miR-29c	CLIP-seq
MIRT817829	hsa-miR-3065-3p	CLIP-seq
MIRT817857	hsa-miR-3116	CLIP-seq
MIRT817830	hsa-miR-3176	CLIP-seq
MIRT817858	hsa-miR-3184	CLIP-seq
MIRT817859	hsa-miR-32	CLIP-seq
MIRT817860	hsa-miR-363	CLIP-seq
MIRT817861	hsa-miR-367	CLIP-seq
MIRT817833	hsa-miR-3922-3p	CLIP-seq
MIRT817862	hsa-miR-3934	CLIP-seq
MIRT817863	hsa-miR-423-5p	CLIP-seq
MIRT817864	hsa-miR-4251	CLIP-seq
MIRT817834	hsa-miR-4306	CLIP-seq
MIRT817865	hsa-miR-4324	CLIP-seq
MIRT817866	hsa-miR-4325	CLIP-seq
MIRT817835	hsa-miR-4488	CLIP-seq
MIRT817867	hsa-miR-4492	CLIP-seq
MIRT817868	hsa-miR-4498	CLIP-seq
MIRT817869	hsa-miR-4505	CLIP-seq
MIRT817838	hsa-miR-4632	CLIP-seq
MIRT817870	hsa-miR-4642	CLIP-seq
MIRT817839	hsa-miR-4644	CLIP-seq
MIRT817871	hsa-miR-4677-5p	CLIP-seq
MIRT817840	hsa-miR-4697-5p	CLIP-seq
MIRT817872	hsa-miR-4731-5p	CLIP-seq
MIRT817842	hsa-miR-4733-3p	CLIP-seq
MIRT817873	hsa-miR-589	CLIP-seq
MIRT817874	hsa-miR-616	CLIP-seq
MIRT817875	hsa-miR-637	CLIP-seq
MIRT817876	hsa-miR-661	CLIP-seq
MIRT817877	hsa-miR-762	CLIP-seq
MIRT817878	hsa-miR-764	CLIP-seq
MIRT817879	hsa-miR-9	CLIP-seq
MIRT817880	hsa-miR-92a	CLIP-seq
MIRT817881	hsa-miR-92b	CLIP-seq
MIRT817882	hsa-miR-96	CLIP-seq
MIRT817826	hsa-miR-29a	CLIP-seq
MIRT817827	hsa-miR-29b	CLIP-seq
MIRT817828	hsa-miR-29c	CLIP-seq
MIRT817829	hsa-miR-3065-3p	CLIP-seq
MIRT817830	hsa-miR-3176	CLIP-seq
MIRT1941766	hsa-miR-3919	CLIP-seq
MIRT817833	hsa-miR-3922-3p	CLIP-seq
MIRT817842	hsa-miR-4733-3p	CLIP-seq
MIRT817846	hsa-miR-548c-3p	CLIP-seq
MIRT817847	hsa-miR-95	CLIP-seq
MIRT2180671	hsa-miR-122	CLIP-seq
MIRT817848	hsa-miR-1254	CLIP-seq
MIRT817850	hsa-miR-125a-3p	CLIP-seq
MIRT2180672	hsa-miR-1301	CLIP-seq
MIRT2180673	hsa-miR-1321	CLIP-seq
MIRT817852	hsa-miR-146a	CLIP-seq
MIRT817853	hsa-miR-146b-5p	CLIP-seq
MIRT817824	hsa-miR-185	CLIP-seq
MIRT817825	hsa-miR-1912	CLIP-seq
MIRT817826	hsa-miR-29a	CLIP-seq
MIRT817827	hsa-miR-29b	CLIP-seq
MIRT817828	hsa-miR-29c	CLIP-seq
MIRT817829	hsa-miR-3065-3p	CLIP-seq
MIRT817857	hsa-miR-3116	CLIP-seq
MIRT2180674	hsa-miR-3122	CLIP-seq
MIRT2180675	hsa-miR-3162-5p	CLIP-seq
MIRT817830	hsa-miR-3176	CLIP-seq
MIRT2180676	hsa-miR-3689a-3p	CLIP-seq
MIRT2180677	hsa-miR-3689c	CLIP-seq
MIRT2180678	hsa-miR-3913-5p	CLIP-seq
MIRT1941766	hsa-miR-3919	CLIP-seq
MIRT817833	hsa-miR-3922-3p	CLIP-seq
MIRT817862	hsa-miR-3934	CLIP-seq
MIRT817864	hsa-miR-4251	CLIP-seq
MIRT817834	hsa-miR-4306	CLIP-seq
MIRT817865	hsa-miR-4324	CLIP-seq
MIRT817866	hsa-miR-4325	CLIP-seq
MIRT817838	hsa-miR-4632	CLIP-seq
MIRT817839	hsa-miR-4644	CLIP-seq
MIRT817841	hsa-miR-4717-3p	CLIP-seq
MIRT817842	hsa-miR-4733-3p	CLIP-seq
MIRT2180679	hsa-miR-4739	CLIP-seq
MIRT2180680	hsa-miR-4756-5p	CLIP-seq
MIRT2180681	hsa-miR-5047	CLIP-seq
MIRT817846	hsa-miR-548c-3p	CLIP-seq
MIRT817873	hsa-miR-589	CLIP-seq
MIRT817874	hsa-miR-616	CLIP-seq
MIRT817876	hsa-miR-661	CLIP-seq
MIRT817878	hsa-miR-764	CLIP-seq
MIRT2180682	hsa-miR-938	CLIP-seq
MIRT817847	hsa-miR-95	CLIP-seq
MIRT817850	hsa-miR-125a-3p	CLIP-seq
MIRT817856	hsa-miR-25	CLIP-seq
MIRT817830	hsa-miR-3176	CLIP-seq
MIRT817859	hsa-miR-32	CLIP-seq
MIRT817860	hsa-miR-363	CLIP-seq
MIRT817861	hsa-miR-367	CLIP-seq
MIRT817833	hsa-miR-3922-3p	CLIP-seq
MIRT817862	hsa-miR-3934	CLIP-seq
MIRT817866	hsa-miR-4325	CLIP-seq
MIRT817841	hsa-miR-4717-3p	CLIP-seq
MIRT817878	hsa-miR-764	CLIP-seq
MIRT817880	hsa-miR-92a	CLIP-seq
MIRT817881	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004084	Function	Branched-chain-amino-acid transaminase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	28514442, 29568061
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0009082	Process	Branched-chain amino acid biosynthetic process	IEA
GO:0009083	Process	Branched-chain amino acid catabolic process	TAS
GO:0009098	Process	Leucine biosynthetic process	IBA	21873635
GO:0009099	Process	Valine biosynthetic process	IBA	21873635
GO:0052654	Function	L-leucine transaminase activity	IEA
GO:0052655	Function	L-valine transaminase activity	IEA
GO:0052656	Function	L-isoleucine transaminase activity	IEA

Other IDs

• MIM: 113530
• HGNC: 977
• e!Ensembl: ENSG00000105552

Protein

• UniProt ID: O15382
• Protein name: Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18)
• Protein function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:17050531, PubMed:25653144, PubMed:8702755). May also function as a transporter of branched chain alpha-keto acids
• PDB: 1EKF, 1EKP, 1EKV, 1KT8, 1KTA, 2A1H, 2HDK, 2HG8, 2HGW, 2HGX, 2HHF, 5BWR, 5BWT, 5BWU, 5BWV, 5BWW, 5BWX, 5CR5, 5HNE, 5I5S, 5I5T, 5I5U, 5I5V, 5I5W, 5I5X, 5I5Y, 5I60, 5MPR, 6PRX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01063	Aminotran_4	100 → 350	Amino-transferase class IV	Domain

• Sequence:

  MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
  FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
  WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
  GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
  QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
  LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
  TMENGPELILRFQKELKEIQYGIRAHEWMFPV

• Sequence length: 392