BANF1 (barrier to autointegration nuclear assembly factor 1)

Gene

• Entrez ID: 8815
• Gene name: Barrier to autointegration nuclear assembly factor 1
• Gene symbol: BANF1
• Synonyms: BAF, BCRP1, D14S1460, NGPS
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815730	hsa-miR-1255a	CLIP-seq
MIRT815731	hsa-miR-1255b	CLIP-seq
MIRT815732	hsa-miR-1289	CLIP-seq
MIRT815733	hsa-miR-150	CLIP-seq
MIRT815734	hsa-miR-2114	CLIP-seq
MIRT815735	hsa-miR-31	CLIP-seq
MIRT815736	hsa-miR-3125	CLIP-seq
MIRT815737	hsa-miR-3126-5p	CLIP-seq
MIRT815738	hsa-miR-3128	CLIP-seq
MIRT815739	hsa-miR-3148	CLIP-seq
MIRT815740	hsa-miR-3162-3p	CLIP-seq
MIRT815741	hsa-miR-3175	CLIP-seq
MIRT815742	hsa-miR-320a	CLIP-seq
MIRT815743	hsa-miR-320b	CLIP-seq
MIRT815744	hsa-miR-320c	CLIP-seq
MIRT815745	hsa-miR-320d	CLIP-seq
MIRT815746	hsa-miR-320e	CLIP-seq
MIRT815747	hsa-miR-3609	CLIP-seq
MIRT815748	hsa-miR-3613-3p	CLIP-seq
MIRT815749	hsa-miR-3616-3p	CLIP-seq
MIRT815750	hsa-miR-3667-5p	CLIP-seq
MIRT815751	hsa-miR-3675-5p	CLIP-seq
MIRT815752	hsa-miR-3916	CLIP-seq
MIRT815753	hsa-miR-4278	CLIP-seq
MIRT815754	hsa-miR-4419a	CLIP-seq
MIRT815755	hsa-miR-4429	CLIP-seq
MIRT815756	hsa-miR-4447	CLIP-seq
MIRT815757	hsa-miR-4471	CLIP-seq
MIRT815758	hsa-miR-4472	CLIP-seq
MIRT815759	hsa-miR-4490	CLIP-seq
MIRT815760	hsa-miR-4510	CLIP-seq
MIRT815761	hsa-miR-4638-5p	CLIP-seq
MIRT815762	hsa-miR-4668-5p	CLIP-seq
MIRT815763	hsa-miR-4710	CLIP-seq
MIRT815764	hsa-miR-4721	CLIP-seq
MIRT815765	hsa-miR-4727-5p	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815767	hsa-miR-4769-3p	CLIP-seq
MIRT815768	hsa-miR-4782-5p	CLIP-seq
MIRT815769	hsa-miR-488	CLIP-seq
MIRT815770	hsa-miR-522	CLIP-seq
MIRT815771	hsa-miR-548ah	CLIP-seq
MIRT815772	hsa-miR-765	CLIP-seq
MIRT815773	hsa-miR-873	CLIP-seq
MIRT815774	hsa-miR-877	CLIP-seq
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815730	hsa-miR-1255a	CLIP-seq
MIRT815731	hsa-miR-1255b	CLIP-seq
MIRT815732	hsa-miR-1289	CLIP-seq
MIRT815775	hsa-miR-134	CLIP-seq
MIRT815776	hsa-miR-1911	CLIP-seq
MIRT815734	hsa-miR-2114	CLIP-seq
MIRT815735	hsa-miR-31	CLIP-seq
MIRT815777	hsa-miR-3118	CLIP-seq
MIRT815736	hsa-miR-3125	CLIP-seq
MIRT815737	hsa-miR-3126-5p	CLIP-seq
MIRT815738	hsa-miR-3128	CLIP-seq
MIRT815739	hsa-miR-3148	CLIP-seq
MIRT815740	hsa-miR-3162-3p	CLIP-seq
MIRT815747	hsa-miR-3609	CLIP-seq
MIRT815748	hsa-miR-3613-3p	CLIP-seq
MIRT815749	hsa-miR-3616-3p	CLIP-seq
MIRT815778	hsa-miR-3908	CLIP-seq
MIRT815752	hsa-miR-3916	CLIP-seq
MIRT815779	hsa-miR-3942-5p	CLIP-seq
MIRT815754	hsa-miR-4419a	CLIP-seq
MIRT815780	hsa-miR-4446-3p	CLIP-seq
MIRT815756	hsa-miR-4447	CLIP-seq
MIRT815781	hsa-miR-4450	CLIP-seq
MIRT815782	hsa-miR-4461	CLIP-seq
MIRT815757	hsa-miR-4471	CLIP-seq
MIRT815758	hsa-miR-4472	CLIP-seq
MIRT815783	hsa-miR-4492	CLIP-seq
MIRT815784	hsa-miR-4498	CLIP-seq
MIRT815785	hsa-miR-4505	CLIP-seq
MIRT815760	hsa-miR-4510	CLIP-seq
MIRT815761	hsa-miR-4638-5p	CLIP-seq
MIRT815786	hsa-miR-4667-5p	CLIP-seq
MIRT815762	hsa-miR-4668-5p	CLIP-seq
MIRT815787	hsa-miR-4700-5p	CLIP-seq
MIRT815788	hsa-miR-4703-5p	CLIP-seq
MIRT815763	hsa-miR-4710	CLIP-seq
MIRT815764	hsa-miR-4721	CLIP-seq
MIRT815765	hsa-miR-4727-5p	CLIP-seq
MIRT815789	hsa-miR-4731-5p	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815790	hsa-miR-4766-3p	CLIP-seq
MIRT815767	hsa-miR-4769-3p	CLIP-seq
MIRT815768	hsa-miR-4782-5p	CLIP-seq
MIRT815769	hsa-miR-488	CLIP-seq
MIRT815770	hsa-miR-522	CLIP-seq
MIRT815791	hsa-miR-548ae	CLIP-seq
MIRT815771	hsa-miR-548ah	CLIP-seq
MIRT815792	hsa-miR-548aj	CLIP-seq
MIRT815793	hsa-miR-548am	CLIP-seq
MIRT815794	hsa-miR-548x	CLIP-seq
MIRT815795	hsa-miR-624	CLIP-seq
MIRT815796	hsa-miR-762	CLIP-seq
MIRT815772	hsa-miR-765	CLIP-seq
MIRT815774	hsa-miR-877	CLIP-seq
MIRT815797	hsa-miR-943	CLIP-seq
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815732	hsa-miR-1289	CLIP-seq
MIRT815775	hsa-miR-134	CLIP-seq
MIRT815733	hsa-miR-150	CLIP-seq
MIRT815776	hsa-miR-1911	CLIP-seq
MIRT1941313	hsa-miR-203	CLIP-seq
MIRT815734	hsa-miR-2114	CLIP-seq
MIRT815735	hsa-miR-31	CLIP-seq
MIRT815777	hsa-miR-3118	CLIP-seq
MIRT815736	hsa-miR-3125	CLIP-seq
MIRT815737	hsa-miR-3126-5p	CLIP-seq
MIRT815738	hsa-miR-3128	CLIP-seq
MIRT815739	hsa-miR-3148	CLIP-seq
MIRT815740	hsa-miR-3162-3p	CLIP-seq
MIRT1941314	hsa-miR-335	CLIP-seq
MIRT815747	hsa-miR-3609	CLIP-seq
MIRT1941315	hsa-miR-3612	CLIP-seq
MIRT815748	hsa-miR-3613-3p	CLIP-seq
MIRT815750	hsa-miR-3667-5p	CLIP-seq
MIRT1941316	hsa-miR-3689d	CLIP-seq
MIRT815778	hsa-miR-3908	CLIP-seq
MIRT815752	hsa-miR-3916	CLIP-seq
MIRT815779	hsa-miR-3942-5p	CLIP-seq
MIRT815754	hsa-miR-4419a	CLIP-seq
MIRT815756	hsa-miR-4447	CLIP-seq
MIRT815757	hsa-miR-4471	CLIP-seq
MIRT815758	hsa-miR-4472	CLIP-seq
MIRT815760	hsa-miR-4510	CLIP-seq
MIRT815761	hsa-miR-4638-5p	CLIP-seq
MIRT815762	hsa-miR-4668-5p	CLIP-seq
MIRT1941317	hsa-miR-4696	CLIP-seq
MIRT815788	hsa-miR-4703-5p	CLIP-seq
MIRT815763	hsa-miR-4710	CLIP-seq
MIRT1941318	hsa-miR-4723-5p	CLIP-seq
MIRT815765	hsa-miR-4727-5p	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815790	hsa-miR-4766-3p	CLIP-seq
MIRT815767	hsa-miR-4769-3p	CLIP-seq
MIRT815769	hsa-miR-488	CLIP-seq
MIRT815770	hsa-miR-522	CLIP-seq
MIRT815791	hsa-miR-548ae	CLIP-seq
MIRT815771	hsa-miR-548ah	CLIP-seq
MIRT815792	hsa-miR-548aj	CLIP-seq
MIRT815793	hsa-miR-548am	CLIP-seq
MIRT815794	hsa-miR-548x	CLIP-seq
MIRT815795	hsa-miR-624	CLIP-seq
MIRT1941319	hsa-miR-650	CLIP-seq
MIRT815772	hsa-miR-765	CLIP-seq
MIRT815774	hsa-miR-877	CLIP-seq
MIRT815797	hsa-miR-943	CLIP-seq
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815735	hsa-miR-31	CLIP-seq
MIRT815737	hsa-miR-3126-5p	CLIP-seq
MIRT815738	hsa-miR-3128	CLIP-seq
MIRT815742	hsa-miR-320a	CLIP-seq
MIRT815743	hsa-miR-320b	CLIP-seq
MIRT815744	hsa-miR-320c	CLIP-seq
MIRT815745	hsa-miR-320d	CLIP-seq
MIRT815746	hsa-miR-320e	CLIP-seq
MIRT815747	hsa-miR-3609	CLIP-seq
MIRT815751	hsa-miR-3675-5p	CLIP-seq
MIRT815754	hsa-miR-4419a	CLIP-seq
MIRT815755	hsa-miR-4429	CLIP-seq
MIRT815756	hsa-miR-4447	CLIP-seq
MIRT815757	hsa-miR-4471	CLIP-seq
MIRT815758	hsa-miR-4472	CLIP-seq
MIRT815760	hsa-miR-4510	CLIP-seq
MIRT815762	hsa-miR-4668-5p	CLIP-seq
MIRT815763	hsa-miR-4710	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815769	hsa-miR-488	CLIP-seq
MIRT815770	hsa-miR-522	CLIP-seq
MIRT815771	hsa-miR-548ah	CLIP-seq
MIRT815773	hsa-miR-873	CLIP-seq
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815776	hsa-miR-1911	CLIP-seq
MIRT815737	hsa-miR-3126-5p	CLIP-seq
MIRT815742	hsa-miR-320a	CLIP-seq
MIRT815743	hsa-miR-320b	CLIP-seq
MIRT815744	hsa-miR-320c	CLIP-seq
MIRT815745	hsa-miR-320d	CLIP-seq
MIRT815746	hsa-miR-320e	CLIP-seq
MIRT815751	hsa-miR-3675-5p	CLIP-seq
MIRT1941316	hsa-miR-3689d	CLIP-seq
MIRT815754	hsa-miR-4419a	CLIP-seq
MIRT815755	hsa-miR-4429	CLIP-seq
MIRT815759	hsa-miR-4490	CLIP-seq
MIRT815760	hsa-miR-4510	CLIP-seq
MIRT815763	hsa-miR-4710	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815773	hsa-miR-873	CLIP-seq
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815733	hsa-miR-150	CLIP-seq
MIRT815776	hsa-miR-1911	CLIP-seq
MIRT1941313	hsa-miR-203	CLIP-seq
MIRT815735	hsa-miR-31	CLIP-seq
MIRT815738	hsa-miR-3128	CLIP-seq
MIRT815739	hsa-miR-3148	CLIP-seq
MIRT815741	hsa-miR-3175	CLIP-seq
MIRT1941314	hsa-miR-335	CLIP-seq
MIRT1941315	hsa-miR-3612	CLIP-seq
MIRT815748	hsa-miR-3613-3p	CLIP-seq
MIRT815750	hsa-miR-3667-5p	CLIP-seq
MIRT1941316	hsa-miR-3689d	CLIP-seq
MIRT815778	hsa-miR-3908	CLIP-seq
MIRT815779	hsa-miR-3942-5p	CLIP-seq
MIRT815753	hsa-miR-4278	CLIP-seq
MIRT815757	hsa-miR-4471	CLIP-seq
MIRT815762	hsa-miR-4668-5p	CLIP-seq
MIRT1941317	hsa-miR-4696	CLIP-seq
MIRT815788	hsa-miR-4703-5p	CLIP-seq
MIRT1941318	hsa-miR-4723-5p	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815790	hsa-miR-4766-3p	CLIP-seq
MIRT815770	hsa-miR-522	CLIP-seq
MIRT1941319	hsa-miR-650	CLIP-seq
MIRT815729	hsa-miR-1226	CLIP-seq
MIRT815733	hsa-miR-150	CLIP-seq
MIRT815776	hsa-miR-1911	CLIP-seq
MIRT1941313	hsa-miR-203	CLIP-seq
MIRT815735	hsa-miR-31	CLIP-seq
MIRT815738	hsa-miR-3128	CLIP-seq
MIRT815739	hsa-miR-3148	CLIP-seq
MIRT815741	hsa-miR-3175	CLIP-seq
MIRT1941314	hsa-miR-335	CLIP-seq
MIRT1941315	hsa-miR-3612	CLIP-seq
MIRT815748	hsa-miR-3613-3p	CLIP-seq
MIRT815750	hsa-miR-3667-5p	CLIP-seq
MIRT1941316	hsa-miR-3689d	CLIP-seq
MIRT815778	hsa-miR-3908	CLIP-seq
MIRT815779	hsa-miR-3942-5p	CLIP-seq
MIRT815753	hsa-miR-4278	CLIP-seq
MIRT815757	hsa-miR-4471	CLIP-seq
MIRT815762	hsa-miR-4668-5p	CLIP-seq
MIRT1941317	hsa-miR-4696	CLIP-seq
MIRT815788	hsa-miR-4703-5p	CLIP-seq
MIRT1941318	hsa-miR-4723-5p	CLIP-seq
MIRT815766	hsa-miR-4733-3p	CLIP-seq
MIRT815790	hsa-miR-4766-3p	CLIP-seq
MIRT815770	hsa-miR-522	CLIP-seq
MIRT1941319	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000793	Component	Condensed chromosome	IEA
GO:0003677	Function	DNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	12163176, 22399800, 22770216, 25502805, 25910212, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	18005698, 22194607
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	18005698, 22194607
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	IBA	21873635
GO:0007084	Process	Mitotic nuclear envelope reassembly	TAS
GO:0008022	Function	Protein C-terminus binding	IMP	22399800
GO:0009615	Process	Response to virus	TAS	9465049
GO:0015074	Process	DNA integration	IEA
GO:0019899	Function	Enzyme binding	IPI	22399800
GO:0030261	Process	Chromosome condensation	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	16155580
GO:0042803	Function	Protein homodimerization activity	IPI	22399800
GO:0045071	Process	Negative regulation of viral genome replication	IDA	18005698
GO:0047485	Function	Protein N-terminus binding	IPI	22399800
GO:0051169	Process	Nuclear transport	TAS
GO:0075713	Process	Establishment of integrated proviral latency	TAS
GO:0097726	Function	LEM domain binding	IMP	22399800

Other IDs

• MIM: 603811
• HGNC: 17397
• e!Ensembl: ENSG00000175334

Protein

• UniProt ID: O75531
• Protein name: Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]
• Protein function: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubM
• PDB: 1CI4, 1QCK, 2BZF, 2EZX, 2EZY, 2EZZ, 2ODG, 6GHD, 6RPR, 6UNT, 6URE, 6URJ, 6URK, 6URL, 6URN, 6URR, 6URZ, 6US0, 6US1, 6US7, 6USB, 6USD, 6USI, 7ABM, 7NDY, 7Z21, 9J8M, 9J8N, 9J8O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02961	BAF	1 → 88	Barrier to autointegration factor	Domain

• Sequence:

  MTTSQKHRDFVAEPMGEKPVGSLAGIGEVLGKKLEERGFDKAYVVLGQFLVLKKDEDLFR
  EWLKDTCGANAKQSRDCFGCLREWCDAFL

• Sequence length: 89