BAIAP2 (BAR/IMD domain containing adaptor protein 2)

Gene

• Entrez ID: 10458
• Gene name: BAR/IMD domain containing adaptor protein 2
• Gene symbol: BAIAP2
• Synonyms: BAP2, FLAF3, IRSP53, WAML
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor ty

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037874	hsa-miR-455-3p	CLASH	23622248
MIRT815462	hsa-miR-1237	CLIP-seq
MIRT815463	hsa-miR-15a	CLIP-seq
MIRT815464	hsa-miR-15b	CLIP-seq
MIRT815465	hsa-miR-16	CLIP-seq
MIRT815466	hsa-miR-195	CLIP-seq
MIRT815467	hsa-miR-214	CLIP-seq
MIRT815468	hsa-miR-2355-5p	CLIP-seq
MIRT815469	hsa-miR-3135b	CLIP-seq
MIRT815470	hsa-miR-3187-3p	CLIP-seq
MIRT815471	hsa-miR-3619-5p	CLIP-seq
MIRT815472	hsa-miR-424	CLIP-seq
MIRT815473	hsa-miR-4434	CLIP-seq
MIRT815474	hsa-miR-4436b-3p	CLIP-seq
MIRT815475	hsa-miR-4516	CLIP-seq
MIRT815476	hsa-miR-4529-5p	CLIP-seq
MIRT815477	hsa-miR-4722-5p	CLIP-seq
MIRT815478	hsa-miR-4755-3p	CLIP-seq
MIRT815479	hsa-miR-4768-3p	CLIP-seq
MIRT815480	hsa-miR-497	CLIP-seq
MIRT815481	hsa-miR-761	CLIP-seq
MIRT815482	hsa-miR-938	CLIP-seq
MIRT815483	hsa-miR-1268	CLIP-seq
MIRT815484	hsa-miR-1268b	CLIP-seq
MIRT815485	hsa-miR-361-3p	CLIP-seq
MIRT815486	hsa-miR-4447	CLIP-seq
MIRT815487	hsa-miR-4466	CLIP-seq
MIRT815488	hsa-miR-4472	CLIP-seq
MIRT815489	hsa-miR-4488	CLIP-seq
MIRT815490	hsa-miR-4697-5p	CLIP-seq
MIRT815491	hsa-miR-4726-3p	CLIP-seq
MIRT815492	hsa-miR-675	CLIP-seq
MIRT815493	hsa-miR-1193	CLIP-seq
MIRT815494	hsa-miR-1287	CLIP-seq
MIRT815495	hsa-miR-1827	CLIP-seq
MIRT815496	hsa-miR-219-1-3p	CLIP-seq
MIRT815468	hsa-miR-2355-5p	CLIP-seq
MIRT815497	hsa-miR-3126-5p	CLIP-seq
MIRT815469	hsa-miR-3135b	CLIP-seq
MIRT815498	hsa-miR-3150a-3p	CLIP-seq
MIRT815499	hsa-miR-3175	CLIP-seq
MIRT815500	hsa-miR-3190	CLIP-seq
MIRT815501	hsa-miR-3194-3p	CLIP-seq
MIRT815502	hsa-miR-3202	CLIP-seq
MIRT815503	hsa-miR-3612	CLIP-seq
MIRT815504	hsa-miR-3622b-5p	CLIP-seq
MIRT815505	hsa-miR-3663-3p	CLIP-seq
MIRT815506	hsa-miR-3670	CLIP-seq
MIRT815507	hsa-miR-4533	CLIP-seq
MIRT815508	hsa-miR-4694-5p	CLIP-seq
MIRT815477	hsa-miR-4722-5p	CLIP-seq
MIRT815509	hsa-miR-4728-5p	CLIP-seq
MIRT815510	hsa-miR-4758-3p	CLIP-seq
MIRT815479	hsa-miR-4768-3p	CLIP-seq
MIRT815511	hsa-miR-4783-3p	CLIP-seq
MIRT815512	hsa-miR-650	CLIP-seq
MIRT815513	hsa-miR-658	CLIP-seq
MIRT815514	hsa-miR-939	CLIP-seq
MIRT815515	hsa-miR-940	CLIP-seq
MIRT1941247	hsa-miR-3065-3p	CLIP-seq
MIRT1941248	hsa-miR-3689d	CLIP-seq
MIRT2180004	hsa-miR-1293	CLIP-seq
MIRT2180005	hsa-miR-146b-3p	CLIP-seq
MIRT2180006	hsa-miR-181a	CLIP-seq
MIRT2180007	hsa-miR-181b	CLIP-seq
MIRT2180008	hsa-miR-181c	CLIP-seq
MIRT2180009	hsa-miR-181d	CLIP-seq
MIRT2180010	hsa-miR-2113	CLIP-seq
MIRT2180011	hsa-miR-3173-5p	CLIP-seq
MIRT2180012	hsa-miR-323-5p	CLIP-seq
MIRT2180013	hsa-miR-342-5p	CLIP-seq
MIRT2180014	hsa-miR-3618	CLIP-seq
MIRT2180015	hsa-miR-4262	CLIP-seq
MIRT815486	hsa-miR-4447	CLIP-seq
MIRT815488	hsa-miR-4472	CLIP-seq
MIRT2180016	hsa-miR-4483	CLIP-seq
MIRT2180017	hsa-miR-4651	CLIP-seq
MIRT2180018	hsa-miR-4664-5p	CLIP-seq
MIRT2180019	hsa-miR-4675	CLIP-seq
MIRT2180020	hsa-miR-4711-3p	CLIP-seq
MIRT2180021	hsa-miR-4741	CLIP-seq
MIRT2180022	hsa-miR-4793-3p	CLIP-seq
MIRT2180023	hsa-miR-592	CLIP-seq
MIRT2180024	hsa-miR-593	CLIP-seq
MIRT2180025	hsa-miR-599	CLIP-seq
MIRT2180026	hsa-miR-608	CLIP-seq
MIRT2180027	hsa-miR-874	CLIP-seq
MIRT2180028	hsa-miR-934	CLIP-seq
MIRT815485	hsa-miR-361-3p	CLIP-seq
MIRT815495	hsa-miR-1827	CLIP-seq
MIRT815496	hsa-miR-219-1-3p	CLIP-seq
MIRT815503	hsa-miR-3612	CLIP-seq
MIRT815505	hsa-miR-3663-3p	CLIP-seq
MIRT815477	hsa-miR-4722-5p	CLIP-seq
MIRT815479	hsa-miR-4768-3p	CLIP-seq
MIRT815512	hsa-miR-650	CLIP-seq
MIRT815513	hsa-miR-658	CLIP-seq
MIRT815515	hsa-miR-940	CLIP-seq
MIRT2483421	hsa-miR-125a-3p	CLIP-seq
MIRT2483422	hsa-miR-3934	CLIP-seq
MIRT2483423	hsa-miR-4419a	CLIP-seq
MIRT815473	hsa-miR-4434	CLIP-seq
MIRT2483424	hsa-miR-4510	CLIP-seq
MIRT815475	hsa-miR-4516	CLIP-seq
MIRT2483425	hsa-miR-4687-5p	CLIP-seq
MIRT2483426	hsa-miR-764	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0005515	Function	Protein binding	IPI	11157984, 11696321, 12598619, 15289329, 16189514, 17003044, 18448434, 19171758, 19460367, 19564905, 19933840, 20936779, 21311754, 24189400, 24658140, 25416956, 25519916, 25814554, 28514442, 31980649
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	TAS	10343108
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	19366662
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0007009	Process	Plasma membrane organization	IEA
GO:0007409	Process	Axonogenesis	TAS	10343108
GO:0008022	Function	Protein C-terminus binding	TAS	10343108
GO:0008093	Function	Cytoskeletal anchor activity	IEA
GO:0008286	Process	Insulin receptor signaling pathway	TAS	10343108
GO:0008360	Process	Regulation of cell shape	ISS
GO:0009617	Process	Response to bacterium	IMP	19366662
GO:0015629	Component	Actin cytoskeleton	IDA	19366662
GO:0030175	Component	Filopodium	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA	21873635
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	19366662
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0042802	Function	Identical protein binding	IPI	11696321, 14752106, 25416956
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0051017	Process	Actin filament bundle assembly	IBA	21873635
GO:0051017	Process	Actin filament bundle assembly	ISS
GO:0051764	Process	Actin crosslink formation	IBA	21873635
GO:0051764	Process	Actin crosslink formation	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070064	Function	Proline-rich region binding	IDA	19366662
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:2000251	Process	Positive regulation of actin cytoskeleton reorganization	IBA	21873635

Other IDs

• MIM: 605475
• HGNC: 947
• e!Ensembl: ENSG00000175866

Protein

• UniProt ID: Q9UQB8
• Protein name: BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58)
• Protein function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin c
• PDB: 1WDZ, 1Y2O, 2YKT, 3RNJ, 4JS0, 6BCR, 6BCY, 6BD1, 6BD2, 6BQT, 6ZEG, 6ZEI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08397	IMD	17 → 237	IRSp53/MIM homology domain	Family
  PF07653	SH3_2	378 → 435	Variant SH3 domain	Domain

• Sequence:

  MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG
  ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL
  KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS
  DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA
  VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN
  GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT
  LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK
  TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA
  QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE
  HGDGSARTLAGR

• Sequence length: 552