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B3GAT3 (beta-1,3-glucuronyltransferase 3)

Gene

26229

Beta-1,3-glucuronyltransferase 3

B3GAT3

GLCATI, JDSCD, glcUAT-I

11q12.3

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the

Show/Hide all(7)

SNP ID	Visualize variation	Clinical significance	Consequence
rs372487178	C>T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs377340567	G>A	Likely-pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs387906937	C>G,T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs535206047	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs753781915	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs879255269	G>A	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1085307917	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

Show/Hide all(119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT813146	hsa-let-7a	CLIP-seq
MIRT813147	hsa-let-7b	CLIP-seq
MIRT813148	hsa-let-7c	CLIP-seq
MIRT813149	hsa-let-7d	CLIP-seq
MIRT813150	hsa-let-7e	CLIP-seq
MIRT813151	hsa-let-7f	CLIP-seq
MIRT813152	hsa-let-7g	CLIP-seq
MIRT813153	hsa-let-7i	CLIP-seq
MIRT813154	hsa-miR-1299	CLIP-seq
MIRT813155	hsa-miR-3179	CLIP-seq
MIRT813156	hsa-miR-3202	CLIP-seq
MIRT813157	hsa-miR-3689d	CLIP-seq
MIRT813158	hsa-miR-4458	CLIP-seq
MIRT813159	hsa-miR-4476	CLIP-seq
MIRT813160	hsa-miR-4500	CLIP-seq
MIRT813161	hsa-miR-4778-5p	CLIP-seq
MIRT813162	hsa-miR-4782-5p	CLIP-seq
MIRT813163	hsa-miR-516b	CLIP-seq
MIRT813164	hsa-miR-98	CLIP-seq
MIRT1940379	hsa-miR-2355-5p	CLIP-seq
MIRT1940380	hsa-miR-4446-3p	CLIP-seq
MIRT1940381	hsa-miR-4457	CLIP-seq
MIRT1940382	hsa-miR-4646-3p	CLIP-seq
MIRT1940383	hsa-miR-4731-3p	CLIP-seq
MIRT1940384	hsa-miR-4801	CLIP-seq
MIRT2179294	hsa-miR-149	CLIP-seq
MIRT2179295	hsa-miR-3064-5p	CLIP-seq
MIRT2179296	hsa-miR-4794	CLIP-seq
MIRT2482865	hsa-miR-1227	CLIP-seq
MIRT2482866	hsa-miR-1254	CLIP-seq
MIRT2482867	hsa-miR-1286	CLIP-seq
MIRT2482868	hsa-miR-146b-3p	CLIP-seq
MIRT2179294	hsa-miR-149	CLIP-seq
MIRT2482869	hsa-miR-15a	CLIP-seq
MIRT2482870	hsa-miR-15b	CLIP-seq
MIRT2482871	hsa-miR-16	CLIP-seq
MIRT2482872	hsa-miR-195	CLIP-seq
MIRT2482873	hsa-miR-214	CLIP-seq
MIRT1940379	hsa-miR-2355-5p	CLIP-seq
MIRT2482874	hsa-miR-2467-3p	CLIP-seq
MIRT2482875	hsa-miR-2861	CLIP-seq
MIRT2482876	hsa-miR-3064-3p	CLIP-seq
MIRT2179295	hsa-miR-3064-5p	CLIP-seq
MIRT2482877	hsa-miR-3116	CLIP-seq
MIRT2482878	hsa-miR-3173-5p	CLIP-seq
MIRT2482879	hsa-miR-3184	CLIP-seq
MIRT2482880	hsa-miR-34a	CLIP-seq
MIRT2482881	hsa-miR-34c-5p	CLIP-seq
MIRT2482882	hsa-miR-3619-3p	CLIP-seq
MIRT2482883	hsa-miR-3619-5p	CLIP-seq
MIRT2482884	hsa-miR-423-5p	CLIP-seq
MIRT2482885	hsa-miR-424	CLIP-seq
MIRT2482886	hsa-miR-4254	CLIP-seq
MIRT2482887	hsa-miR-4265	CLIP-seq
MIRT2482888	hsa-miR-4292	CLIP-seq
MIRT2482889	hsa-miR-4296	CLIP-seq
MIRT2482890	hsa-miR-4322	CLIP-seq
MIRT2482891	hsa-miR-4417	CLIP-seq
MIRT2482892	hsa-miR-4436a	CLIP-seq
MIRT1940380	hsa-miR-4446-3p	CLIP-seq
MIRT1940381	hsa-miR-4457	CLIP-seq
MIRT2482893	hsa-miR-449a	CLIP-seq
MIRT2482894	hsa-miR-449b	CLIP-seq
MIRT1940382	hsa-miR-4646-3p	CLIP-seq
MIRT2482895	hsa-miR-4688	CLIP-seq
MIRT2482896	hsa-miR-4728-5p	CLIP-seq
MIRT1940383	hsa-miR-4731-3p	CLIP-seq
MIRT2179296	hsa-miR-4794	CLIP-seq
MIRT1940384	hsa-miR-4801	CLIP-seq
MIRT2482897	hsa-miR-486-3p	CLIP-seq
MIRT2482898	hsa-miR-497	CLIP-seq
MIRT2482899	hsa-miR-591	CLIP-seq
MIRT2482900	hsa-miR-761	CLIP-seq
MIRT2482901	hsa-miR-874	CLIP-seq
MIRT2482865	hsa-miR-1227	CLIP-seq
MIRT2482866	hsa-miR-1254	CLIP-seq
MIRT2482867	hsa-miR-1286	CLIP-seq
MIRT2482868	hsa-miR-146b-3p	CLIP-seq
MIRT2179294	hsa-miR-149	CLIP-seq
MIRT2482869	hsa-miR-15a	CLIP-seq
MIRT2482870	hsa-miR-15b	CLIP-seq
MIRT2482871	hsa-miR-16	CLIP-seq
MIRT2482872	hsa-miR-195	CLIP-seq
MIRT2482873	hsa-miR-214	CLIP-seq
MIRT1940379	hsa-miR-2355-5p	CLIP-seq
MIRT2482874	hsa-miR-2467-3p	CLIP-seq
MIRT2482875	hsa-miR-2861	CLIP-seq
MIRT2482876	hsa-miR-3064-3p	CLIP-seq
MIRT2179295	hsa-miR-3064-5p	CLIP-seq
MIRT2482877	hsa-miR-3116	CLIP-seq
MIRT2482878	hsa-miR-3173-5p	CLIP-seq
MIRT2482879	hsa-miR-3184	CLIP-seq
MIRT2482880	hsa-miR-34a	CLIP-seq
MIRT2482881	hsa-miR-34c-5p	CLIP-seq
MIRT2482882	hsa-miR-3619-3p	CLIP-seq
MIRT2482883	hsa-miR-3619-5p	CLIP-seq
MIRT2482884	hsa-miR-423-5p	CLIP-seq
MIRT2482885	hsa-miR-424	CLIP-seq
MIRT2482886	hsa-miR-4254	CLIP-seq
MIRT2482887	hsa-miR-4265	CLIP-seq
MIRT2482888	hsa-miR-4292	CLIP-seq
MIRT2482889	hsa-miR-4296	CLIP-seq
MIRT2482890	hsa-miR-4322	CLIP-seq
MIRT2482891	hsa-miR-4417	CLIP-seq
MIRT1940380	hsa-miR-4446-3p	CLIP-seq
MIRT1940381	hsa-miR-4457	CLIP-seq
MIRT2482893	hsa-miR-449a	CLIP-seq
MIRT2482894	hsa-miR-449b	CLIP-seq
MIRT1940382	hsa-miR-4646-3p	CLIP-seq
MIRT2482895	hsa-miR-4688	CLIP-seq
MIRT2482896	hsa-miR-4728-5p	CLIP-seq
MIRT1940383	hsa-miR-4731-3p	CLIP-seq
MIRT2179296	hsa-miR-4794	CLIP-seq
MIRT1940384	hsa-miR-4801	CLIP-seq
MIRT2482897	hsa-miR-486-3p	CLIP-seq
MIRT2482898	hsa-miR-497	CLIP-seq
MIRT2482899	hsa-miR-591	CLIP-seq
MIRT2482900	hsa-miR-761	CLIP-seq
MIRT2482901	hsa-miR-874	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	24425863
GO:0005794	Component	Golgi apparatus	IDA	21763480
GO:0005801	Component	Cis-Golgi network	IDA	21763480, 25893793
GO:0005975	Process	Carbohydrate metabolic process	IBA	21873635
GO:0006024	Process	Glycosaminoglycan biosynthetic process	IDA	24425863
GO:0006024	Process	Glycosaminoglycan biosynthetic process	IMP	25893793
GO:0006024	Process	Glycosaminoglycan biosynthetic process	NAS	10842173
GO:0006486	Process	Protein glycosylation	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IDA	21763480
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IMP	25893793
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA	21873635
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	NAS	10842173
GO:0015020	Function	Glucuronosyltransferase activity	IDA	25893793
GO:0015020	Function	Glucuronosyltransferase activity	IMP	21763480
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	NAS	10842173
GO:0030203	Process	Glycosaminoglycan metabolic process	TAS
GO:0043085	Process	Positive regulation of catalytic activity	IDA	24425863
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA	21873635
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IDA	21763480
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IMP	25893793
GO:0050651	Process	Dermatan sulfate proteoglycan biosynthetic process	IDA	21763480
GO:0050651	Process	Dermatan sulfate proteoglycan biosynthetic process	IMP	25893793
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0072542	Function	Protein phosphatase activator activity	IDA	24425863
GO:0090316	Process	Positive regulation of intracellular protein transport	IMP	24425863

MIM	HGNC	e!Ensembl
606374	923	ENSG00000149541

Protein

UniProt ID

O94766

Protein name

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)

Protein function

Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to

PDB

1FGG , 1KWS , 3CU0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03360	Glyco_transf_43	96 → 312	Glycosyltransferase family 43	Family

Sequence

MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRR
PPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPL
VSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKD
PPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFH
TAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAAN
CTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV

Sequence length

335

Interactions

View interactions

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