B3GAT2 (beta-1,3-glucuronyltransferase 2)

Gene

• Entrez ID: 135152
• Gene name: Beta-1,3-glucuronyltransferase 2
• Gene symbol: B3GAT2
• Synonyms: GLCATS
• Chromosome: 6
• Chromosome location: 6q13
• Summary: The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT783086	hsa-miR-1178-5p	HITS-CLIP	27418678
MIRT783091	hsa-miR-1182	HITS-CLIP	27418678
MIRT783755	hsa-miR-135a-3p	HITS-CLIP	27418678
MIRT786084	hsa-miR-4517	HITS-CLIP	27418678
MIRT787557	hsa-miR-548l	HITS-CLIP	27418678
MIRT787558	hsa-miR-548n	HITS-CLIP	27418678
MIRT787671	hsa-miR-5583-3p	HITS-CLIP	27418678
MIRT787782	hsa-miR-5692b	HITS-CLIP	27418678
MIRT787785	hsa-miR-5692c	HITS-CLIP	27418678

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IBA	21873635
GO:0006486	Process	Protein glycosylation	IEA
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA	21873635
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0030203	Process	Glycosaminoglycan metabolic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA	21873635

Other IDs

• MIM: 607497
• HGNC: 922
• e!Ensembl: ENSG00000112309

Protein

• UniProt ID: Q9NPZ5
• Protein name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)
• Protein function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.
• PDB: 2D0J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03360	Glyco_transf_43	101 → 304	Glycosyltransferase family 43	Family

• Sequence:

  MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
  HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
  ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
  LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
  AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
  TRTEKVNLANEPKYHLDTVKIEV

• Sequence length: 323