ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)

Gene

• Entrez ID: 489
• Gene name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
• Gene symbol: ATP2A3
• Synonyms: SERCA3
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT441153	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT489847	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT489848	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489849	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489850	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489851	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489852	hsa-miR-8085	PAR-CLIP	23592263
MIRT489853	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489854	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489855	hsa-miR-3656	PAR-CLIP	23592263
MIRT489856	hsa-miR-6886-3p	PAR-CLIP	23592263
MIRT489857	hsa-miR-938	PAR-CLIP	23592263
MIRT489858	hsa-miR-6133	PAR-CLIP	23592263
MIRT489859	hsa-miR-6130	PAR-CLIP	23592263
MIRT489860	hsa-miR-6129	PAR-CLIP	23592263
MIRT489861	hsa-miR-6127	PAR-CLIP	23592263
MIRT489862	hsa-miR-4510	PAR-CLIP	23592263
MIRT489863	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489864	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT489865	hsa-miR-4270	PAR-CLIP	23592263
MIRT489866	hsa-miR-4441	PAR-CLIP	23592263
MIRT489867	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489868	hsa-miR-4739	PAR-CLIP	23592263
MIRT489869	hsa-miR-1321	PAR-CLIP	23592263
MIRT489870	hsa-miR-6760-5p	PAR-CLIP	23592263

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	22851172

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005388	Function	Calcium transmembrane transporter activity, phosphorylative mechanism	IBA	21873635
GO:0005388	Function	Calcium transmembrane transporter activity, phosphorylative mechanism	IDA	9843705
GO:0005524	Function	ATP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	8809064
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006816	Process	Calcium ion transport	TAS	8809064
GO:0006874	Process	Cellular calcium ion homeostasis	IBA	21873635
GO:0006874	Process	Cellular calcium ion homeostasis	IMP	18068335
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	16725111
GO:0008553	Function	Proton-exporting ATPase activity, phosphorylative mechanism	IBA	21873635
GO:0008656	Function	Cysteine-type endopeptidase activator activity involved in apoptotic process	IDA	16725111
GO:0015085	Function	Calcium ion transmembrane transporter activity	IDA	11956212, 15028735
GO:0016021	Component	Integral component of membrane	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IDA	8809064
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0030899	Function	Calcium-dependent ATPase activity	IDA	9843705
GO:0031090	Component	Organelle membrane	IDA	15028735
GO:0031095	Component	Platelet dense tubular network membrane	TAS
GO:0031965	Component	Nuclear membrane	IEA
GO:0033017	Component	Sarcoplasmic reticulum membrane	IBA	21873635
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0044325	Function	Ion channel binding	IPI	18068335
GO:0046872	Function	Metal ion binding	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	16725111
GO:0070588	Process	Calcium ion transmembrane transport	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IDA	9843705, 11956212
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653
GO:1900121	Process	Negative regulation of receptor binding	IMP	18068335
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1903515	Process	Calcium ion transport from cytosol to endoplasmic reticulum	IDA	15028735
GO:1903779	Process	Regulation of cardiac conduction	TAS

Other IDs

• MIM: 601929
• HGNC: 813
• e!Ensembl: ENSG00000074370

Protein

• UniProt ID: Q93084
• Protein name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3)
• Protein function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00690	Cation_ATPase_N	4 → 72	Cation transporter/ATPase, N-terminus	Domain
  PF00122	E1-E2_ATPase	121 → 329		Family
  PF13246	Cation_ATPase	418 → 528		Family
  PF00689	Cation_ATPase_C	784 → 987	Cation transporting ATPase, C-terminus	Family

• Sequence:

  MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDL
  LVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALK
  EYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSIL
  TGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA
  AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAV
  ALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
  MSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC
  NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMR
  KEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPT
  SREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGML
  DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDD
  LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAM
  GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI
  LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI
  GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMA
  LSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVT
  PLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK

• Sequence length: 999