ATP1B4 (ATPase Na+/K+ transporting family member beta 4)

Gene

• Entrez ID: 23439
• Gene name: ATPase Na+/K+ transporting family member beta 4
• Gene symbol: ATP1B4
• Synonyms: -
• Chromosome: X
• Chromosome location: Xq24
• Summary: This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT496071	hsa-miR-4701-5p	PAR-CLIP	22291592
MIRT496072	hsa-miR-4715-3p	PAR-CLIP	22291592
MIRT496073	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT496074	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496075	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496076	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496077	hsa-miR-940	PAR-CLIP	22291592
MIRT496077	hsa-miR-940	HITS-CLIP	23824327
MIRT496078	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT496078	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT496079	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT496079	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT496080	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT496081	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT496082	hsa-miR-941	PAR-CLIP	22291592
MIRT660436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT660437	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT660438	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT660439	hsa-miR-4736	HITS-CLIP	23824327
MIRT660440	hsa-miR-657	HITS-CLIP	23824327
MIRT660441	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT660442	hsa-miR-3919	HITS-CLIP	23824327
MIRT660443	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT675851	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT675852	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT675853	hsa-miR-3689c	HITS-CLIP	23824327
MIRT675854	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT675855	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT675856	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT675857	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT675858	hsa-miR-7977	HITS-CLIP	23824327
MIRT675859	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT675860	hsa-miR-4654	HITS-CLIP	23824327
MIRT675861	hsa-miR-6778-5p	HITS-CLIP	23824327
MIRT675862	hsa-miR-1233-5p	HITS-CLIP	23824327
MIRT675863	hsa-miR-4648	HITS-CLIP	23824327
MIRT675864	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT675865	hsa-miR-4466	HITS-CLIP	23824327
MIRT675866	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT675867	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT675868	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT675869	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT675870	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT675871	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT675872	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT675873	hsa-miR-4284	HITS-CLIP	23824327
MIRT675874	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT675875	hsa-miR-134-3p	HITS-CLIP	23824327
MIRT675876	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT675877	hsa-miR-4318	HITS-CLIP	23824327
MIRT680475	hsa-miR-548s	HITS-CLIP	23824327
MIRT680476	hsa-miR-6084	HITS-CLIP	23824327
MIRT680477	hsa-miR-3926	HITS-CLIP	23824327
MIRT680478	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT680479	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT680480	hsa-miR-4421	HITS-CLIP	23824327
MIRT680481	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT680482	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT680483	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT680484	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT680485	hsa-miR-6732-3p	HITS-CLIP	23824327
MIRT761419	hsa-miR-1228-3p	PAR-CLIP	27292025
MIRT765770	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT767049	hsa-miR-3689d	PAR-CLIP	27292025
MIRT767358	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT769741	hsa-miR-4497	PAR-CLIP	27292025
MIRT770125	hsa-miR-4537	PAR-CLIP	27292025
MIRT770270	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT775489	hsa-miR-6086	PAR-CLIP	27292025
MIRT775924	hsa-miR-6134	PAR-CLIP	27292025
MIRT776200	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT777065	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT780387	hsa-miR-6851-5p	PAR-CLIP	27292025
MIRT780812	hsa-miR-6880-5p	PAR-CLIP	27292025
MIRT782130	hsa-miR-7847-3p	PAR-CLIP	27292025

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17592128, 32296183
GO:0005635	Component	Nuclear envelope	TAS
GO:0005637	Component	Nuclear inner membrane	IBA	21873635
GO:0005637	Component	Nuclear inner membrane	IDA	17592128
GO:0005887	Component	Integral component of plasma membrane	TAS	10456317
GO:0005890	Component	Sodium:potassium-exchanging ATPase complex	IEA
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	IDA	17592128
GO:0022890	Function	Inorganic cation transmembrane transporter activity	TAS	10456317
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS
GO:0098662	Process	Inorganic cation transmembrane transport	IDA	17592128

Other IDs

• MIM: HGNC

Protein

• UniProt ID: Q9UN42
• Protein name: Protein ATP1B4 (X,K-ATPase subunit beta-m) (X/potassium-transporting ATPase subunit beta-m)
• Protein function: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00287	Na_K-ATPase	80 → 351	Sodium / potassium ATPase beta chain	Family

• Sequence:

  MRRQLRSRRAPSFPYSYRYRLDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEK
  EEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFY
  ASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVI
  SLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGY
  STGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYG
  KLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNIET

• Sequence length: 357