ATP1B3 (ATPase Na+/K+ transporting subunit beta 3)

Gene

• Entrez ID: 483
• Gene name: ATPase Na+/K+ transporting subunit beta 3
• Gene symbol: ATP1B3
• Synonyms: ATPB-3, CD298
• Chromosome: 3
• Chromosome location: 3q23
• Summary: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025733	hsa-miR-7-5p	Microarray	19073608
MIRT036767	hsa-miR-760	CLASH	23622248
MIRT045107	hsa-miR-186-5p	CLASH	23622248
MIRT048487	hsa-miR-100-5p	CLASH	23622248
MIRT305201	hsa-miR-1272	HITS-CLIP	23313552
MIRT305202	hsa-miR-1322	HITS-CLIP	23313552
MIRT305203	hsa-miR-6079	HITS-CLIP	23313552
MIRT305204	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT705334	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT705335	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT705336	hsa-miR-5095	HITS-CLIP	23313552
MIRT705337	hsa-miR-365b-5p	HITS-CLIP	23313552
MIRT705338	hsa-miR-365a-5p	HITS-CLIP	23313552
MIRT705339	hsa-miR-8052	HITS-CLIP	23313552
MIRT705340	hsa-miR-3199	HITS-CLIP	23313552
MIRT705341	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT705342	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT705343	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT705344	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT705345	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT705346	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT705347	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT705348	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT705349	hsa-miR-520h	HITS-CLIP	23313552
MIRT705350	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT705351	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT705352	hsa-miR-4438	HITS-CLIP	23313552
MIRT705353	hsa-miR-520e	HITS-CLIP	23313552
MIRT705354	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT705355	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT705356	hsa-miR-520b	HITS-CLIP	23313552
MIRT705357	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT705358	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT705359	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT705360	hsa-miR-302e	HITS-CLIP	23313552
MIRT705361	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT705362	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT705363	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT705364	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT705365	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT705366	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT705367	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT705368	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT705369	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT705370	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT705371	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT705372	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT705373	hsa-miR-4688	HITS-CLIP	23313552
MIRT705374	hsa-miR-629-3p	HITS-CLIP	23313552
MIRT705375	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT705376	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT705377	hsa-miR-1299	HITS-CLIP	23313552
MIRT705378	hsa-miR-519e-5p	HITS-CLIP	23313552
MIRT705379	hsa-miR-515-5p	HITS-CLIP	23313552
MIRT705380	hsa-miR-6516-3p	HITS-CLIP	23313552
MIRT705381	hsa-miR-3682-5p	HITS-CLIP	23313552
MIRT705382	hsa-miR-323a-5p	HITS-CLIP	23313552
MIRT705383	hsa-miR-548au-3p	HITS-CLIP	23313552
MIRT705384	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT705385	hsa-miR-671-5p	HITS-CLIP	23313552
MIRT705386	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT705387	hsa-miR-3171	HITS-CLIP	23313552
MIRT705388	hsa-miR-6128	HITS-CLIP	23313552
MIRT705389	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT705390	hsa-miR-5695	HITS-CLIP	23313552
MIRT705391	hsa-miR-519d-5p	HITS-CLIP	23313552
MIRT705392	hsa-miR-935	HITS-CLIP	23313552
MIRT705393	hsa-miR-4692	HITS-CLIP	23313552
MIRT705394	hsa-miR-4514	HITS-CLIP	23313552
MIRT705395	hsa-miR-922	HITS-CLIP	23313552
MIRT705396	hsa-miR-4257	HITS-CLIP	23313552
MIRT705397	hsa-miR-6847-5p	HITS-CLIP	23313552
MIRT705398	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT705399	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT705400	hsa-miR-411-3p	HITS-CLIP	23313552
MIRT705401	hsa-miR-379-3p	HITS-CLIP	23313552
MIRT705402	hsa-miR-7843-5p	HITS-CLIP	23313552
MIRT705403	hsa-miR-6879-5p	HITS-CLIP	23313552
MIRT705404	hsa-miR-6735-5p	HITS-CLIP	23313552
MIRT705405	hsa-miR-4632-5p	HITS-CLIP	23313552
MIRT705406	hsa-miR-4436b-3p	HITS-CLIP	23313552
MIRT705407	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT705408	hsa-miR-6757-3p	HITS-CLIP	23313552
MIRT705409	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT705410	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT705411	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT705412	hsa-miR-513b-3p	HITS-CLIP	23313552
MIRT705413	hsa-miR-1273d	HITS-CLIP	23313552
MIRT705414	hsa-miR-1197	HITS-CLIP	23313552

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001671	Function	ATPase activator activity	IBA	21873635
GO:0001671	Function	ATPase activator activity	IDA	10636900, 19542013
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IDA	18522992
GO:0005886	Component	Plasma membrane	TAS
GO:0005890	Component	Sodium:potassium-exchanging ATPase complex	IBA	21873635
GO:0005890	Component	Sodium:potassium-exchanging ATPase complex	IDA	10636900, 19542013
GO:0005890	Component	Sodium:potassium-exchanging ATPase complex	IPI	16861705
GO:0005901	Component	Caveola	IEA
GO:0006883	Process	Cellular sodium ion homeostasis	IBA	21873635
GO:0006883	Process	Cellular sodium ion homeostasis	IDA	10636900, 19542013
GO:0010248	Process	Establishment or maintenance of transmembrane electrochemical gradient	IEA
GO:0030007	Process	Cellular potassium ion homeostasis	IBA	21873635
GO:0030007	Process	Cellular potassium ion homeostasis	IDA	10636900, 19542013
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	10636900, 19542013
GO:0030674	Function	Protein-macromolecule adaptor activity	IGI	16861705
GO:0032781	Process	Positive regulation of ATPase activity	IDA	10636900
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0035725	Process	Sodium ion transmembrane transport	IGI	16861705
GO:0036126	Component	Sperm flagellum	IDA	16861705
GO:0036376	Process	Sodium ion export across plasma membrane	IBA	21873635
GO:0036376	Process	Sodium ion export across plasma membrane	IDA	10636900, 19542013
GO:0042470	Component	Melanosome	IEA
GO:0050821	Process	Protein stabilization	IDA	10636900
GO:0050900	Process	Leukocyte migration	TAS
GO:0051117	Function	ATPase binding	IPI	10636900, 16861705
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071805	Process	Potassium ion transmembrane transport	IGI	16861705
GO:0072659	Process	Protein localization to plasma membrane	IDA	18522992
GO:0086009	Process	Membrane repolarization	IDA	19542013
GO:1901018	Process	Positive regulation of potassium ion transmembrane transporter activity	IDA	10636900
GO:1903278	Process	Positive regulation of sodium ion export across plasma membrane	IDA	10636900
GO:1903288	Process	Positive regulation of potassium ion import across plasma membrane	IDA	10636900
GO:1903779	Process	Regulation of cardiac conduction	TAS
GO:1990573	Process	Potassium ion import across plasma membrane	IBA	21873635
GO:1990573	Process	Potassium ion import across plasma membrane	IDA	10636900, 19542013

Other IDs

• MIM: 601867
• HGNC: 806
• e!Ensembl: ENSG00000069849

Protein

• UniProt ID: P54709
• Protein name: Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)
• Protein function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00287	Na_K-ATPase	6 → 273	Sodium / potassium ATPase beta chain	Family

• Sequence:

  MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
  MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
  EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
  LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
  NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA

• Sequence length: 279