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ATF6B (activating transcription factor 6 beta)

Gene

1388

Activating transcription factor 6 beta

ATF6B

ATF6beta, CREB-RP, CREBL1, G13

6p21.32

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting

Show/Hide all(117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004191	hsa-miR-197-3p	Microarray	16822819
MIRT645450	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT645449	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT645448	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT645447	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT645446	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT645445	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT645444	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT645442	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT645443	hsa-miR-3662	HITS-CLIP	23824327
MIRT645441	hsa-miR-3646	HITS-CLIP	23824327
MIRT645440	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT645439	hsa-miR-4780	HITS-CLIP	23824327
MIRT645438	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT645437	hsa-miR-4433a-5p	HITS-CLIP	23824327
MIRT645436	hsa-miR-1260a	HITS-CLIP	23824327
MIRT645435	hsa-miR-1260b	HITS-CLIP	23824327
MIRT645434	hsa-miR-623	HITS-CLIP	23824327
MIRT645433	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT645432	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT645431	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT645430	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645428	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645429	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT645450	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT645449	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT645448	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT645447	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT645446	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT645445	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT645444	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT645442	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT645443	hsa-miR-3662	HITS-CLIP	23824327
MIRT645441	hsa-miR-3646	HITS-CLIP	23824327
MIRT645440	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT645439	hsa-miR-4780	HITS-CLIP	23824327
MIRT645438	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT645437	hsa-miR-4433a-5p	HITS-CLIP	23824327
MIRT645436	hsa-miR-1260a	HITS-CLIP	23824327
MIRT645435	hsa-miR-1260b	HITS-CLIP	23824327
MIRT645434	hsa-miR-623	HITS-CLIP	23824327
MIRT645433	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT645432	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT645431	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT645430	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645428	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645429	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT804398	hsa-miR-103a	CLIP-seq
MIRT804399	hsa-miR-107	CLIP-seq
MIRT804400	hsa-miR-1257	CLIP-seq
MIRT804401	hsa-miR-1260	CLIP-seq
MIRT804402	hsa-miR-1280	CLIP-seq
MIRT804403	hsa-miR-132	CLIP-seq
MIRT804404	hsa-miR-141	CLIP-seq
MIRT804405	hsa-miR-197	CLIP-seq
MIRT804406	hsa-miR-200a	CLIP-seq
MIRT804407	hsa-miR-212	CLIP-seq
MIRT804408	hsa-miR-224	CLIP-seq
MIRT804409	hsa-miR-3123	CLIP-seq
MIRT804410	hsa-miR-3925-5p	CLIP-seq
MIRT804411	hsa-miR-4263	CLIP-seq
MIRT804412	hsa-miR-4270	CLIP-seq
MIRT804413	hsa-miR-4302	CLIP-seq
MIRT804414	hsa-miR-4441	CLIP-seq
MIRT804415	hsa-miR-4660	CLIP-seq
MIRT804416	hsa-miR-4697-3p	CLIP-seq
MIRT804417	hsa-miR-4704-5p	CLIP-seq
MIRT804418	hsa-miR-4790-3p	CLIP-seq
MIRT804419	hsa-miR-494	CLIP-seq
MIRT804420	hsa-miR-646	CLIP-seq
MIRT804401	hsa-miR-1260	CLIP-seq
MIRT804402	hsa-miR-1280	CLIP-seq
MIRT804404	hsa-miR-141	CLIP-seq
MIRT804406	hsa-miR-200a	CLIP-seq
MIRT1937532	hsa-miR-4667-5p	CLIP-seq
MIRT1937533	hsa-miR-4700-5p	CLIP-seq
MIRT804417	hsa-miR-4704-5p	CLIP-seq
MIRT804419	hsa-miR-494	CLIP-seq
MIRT804401	hsa-miR-1260	CLIP-seq
MIRT804402	hsa-miR-1280	CLIP-seq
MIRT804400	hsa-miR-1257	CLIP-seq
MIRT2384546	hsa-miR-2467-3p	CLIP-seq
MIRT804413	hsa-miR-4302	CLIP-seq
MIRT804416	hsa-miR-4697-3p	CLIP-seq
MIRT804418	hsa-miR-4790-3p	CLIP-seq
MIRT2480470	hsa-miR-1233	CLIP-seq
MIRT2480471	hsa-miR-1253	CLIP-seq
MIRT2480472	hsa-miR-1255a	CLIP-seq
MIRT2480473	hsa-miR-1255b	CLIP-seq
MIRT2480474	hsa-miR-27a	CLIP-seq
MIRT2480475	hsa-miR-27b	CLIP-seq
MIRT2480476	hsa-miR-3169	CLIP-seq
MIRT2480477	hsa-miR-371-5p	CLIP-seq
MIRT2480478	hsa-miR-377	CLIP-seq
MIRT2480479	hsa-miR-4515	CLIP-seq
MIRT2480480	hsa-miR-4712-3p	CLIP-seq
MIRT2480481	hsa-miR-4766-5p	CLIP-seq
MIRT2480482	hsa-miR-4778-5p	CLIP-seq
MIRT2480483	hsa-miR-4786-3p	CLIP-seq
MIRT2480484	hsa-miR-513a-5p	CLIP-seq
MIRT2480485	hsa-miR-637	CLIP-seq
MIRT2480470	hsa-miR-1233	CLIP-seq
MIRT2480471	hsa-miR-1253	CLIP-seq
MIRT2480472	hsa-miR-1255a	CLIP-seq
MIRT2480473	hsa-miR-1255b	CLIP-seq
MIRT2480474	hsa-miR-27a	CLIP-seq
MIRT2480475	hsa-miR-27b	CLIP-seq
MIRT2480476	hsa-miR-3169	CLIP-seq
MIRT2480477	hsa-miR-371-5p	CLIP-seq
MIRT2480478	hsa-miR-377	CLIP-seq
MIRT2480479	hsa-miR-4515	CLIP-seq
MIRT2480480	hsa-miR-4712-3p	CLIP-seq
MIRT2480481	hsa-miR-4766-5p	CLIP-seq
MIRT2480482	hsa-miR-4778-5p	CLIP-seq
MIRT2480483	hsa-miR-4786-3p	CLIP-seq
MIRT2480484	hsa-miR-513a-5p	CLIP-seq
MIRT2480485	hsa-miR-637	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription regulatory region sequence-specific DNA binding	IDA	11256944
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	11256944
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	14973138
GO:0003700	Function	DNA-binding transcription factor activity	IDA	11256944
GO:0005515	Function	Protein binding	IPI	12445808
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	11256944
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	11256944
GO:0005794	Component	Golgi apparatus	TAS	22013210
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	8586413
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	NAS	11256944
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	TAS	22013210
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA	21873635
GO:0032993	Component	Protein-DNA complex	IDA	11256944
GO:0035497	Function	CAMP response element binding	IEA
GO:0036500	Process	ATF6-mediated unfolded protein response	TAS	22013210
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	14973138
GO:0090575	Component	RNA polymerase II transcription regulator complex	IDA	11256944
GO:1903892	Process	Negative regulation of ATF6-mediated unfolded protein response	IDA	9837962
GO:1990440	Process	Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IDA	11256944
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
600984	2349	ENSG00000213676

Protein

UniProt ID

Q99941

Protein name

Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive ele

Protein function

[Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endop

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00170	bZIP_1	323 → 389	bZIP transcription factor	Coiled-coil

Sequence

MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDG
SSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGE
VLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASL
LSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTR
KPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLP
RPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAV
LADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPP
SAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAF
PGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKS
QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRD
HLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTS
TVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP

Sequence length

703

Interactions

View interactions

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