ASPA (aspartoacylase)

Gene

• Entrez ID: 443
• Gene name: Aspartoacylase
• Gene symbol: ASPA
• Synonyms: ACY2, ASP
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052301	hsa-let-7b-5p	CLASH	23622248
MIRT447681	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447682	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447683	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT711575	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT711576	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711577	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT711578	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT711579	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT711580	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT762019	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT762767	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT763009	hsa-miR-1827	PAR-CLIP	27292025
MIRT764204	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT764557	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT765407	hsa-miR-3192-5p	PAR-CLIP	27292025
MIRT766158	hsa-miR-3622b-5p	PAR-CLIP	27292025
MIRT766785	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT766873	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT766961	hsa-miR-3689c	PAR-CLIP	27292025
MIRT768660	hsa-miR-4327	PAR-CLIP	27292025
MIRT770124	hsa-miR-4537	PAR-CLIP	27292025
MIRT770267	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT770612	hsa-miR-4649-3p	PAR-CLIP	27292025
MIRT771529	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT771682	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT772056	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT772693	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT773659	hsa-miR-5197-5p	PAR-CLIP	27292025
MIRT775644	hsa-miR-6087	PAR-CLIP	27292025
MIRT776197	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT777062	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT778862	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT778953	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT779092	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT779383	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT779642	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT780888	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT781175	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT781319	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT782189	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT782869	hsa-miR-940	PAR-CLIP	27292025

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004046	Function	Aminoacylase activity	TAS	8252036
GO:0005515	Function	Protein binding	IPI	22284616, 25416956, 25910212, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006533	Process	Aspartate catabolic process	TAS	8252036
GO:0008652	Process	Cellular amino acid biosynthetic process	TAS
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0016811	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IBA	21873635
GO:0019807	Function	Aspartoacylase activity	IEA
GO:0022010	Process	Central nervous system myelination	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 17194761
GO:0046872	Function	Metal ion binding	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA

Other IDs

• MIM: 608034
• HGNC: 756
• e!Ensembl: ENSG00000108381

Protein

• UniProt ID: P45381
• Protein name: Aspartoacylase (EC 3.5.1.15) (Aminoacylase-2) (ACY-2)
• Protein function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
• PDB: 2I3C, 2O4H, 2O53, 2Q51, 4MRI, 4MXU, 4NFR, 4TNU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04952	AstE_AspA	10 → 301	Succinylglutamate desuccinylase / Aspartoacylase family	Domain

• Sequence:

  MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
  CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
  NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
  PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
  AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
  LTLNAKSIRCCLH

• Sequence length: 313