GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

APOA1 (apolipoprotein A1)

Gene

335

Apolipoprotein A1

APOA1

AMYLD3, HPALP2, apo(a)

11q23.3

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues t

Show/Hide all(63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT483217	hsa-miR-3179	PAR-CLIP	20371350
MIRT483216	hsa-miR-3202	PAR-CLIP	20371350
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT483217	hsa-miR-3179	PAR-CLIP	20371350
MIRT483216	hsa-miR-3202	PAR-CLIP	20371350
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT528210	hsa-miR-627-3p	PAR-CLIP	22012620
MIRT528209	hsa-miR-1305	PAR-CLIP	22012620
MIRT528208	hsa-miR-6722-5p	PAR-CLIP	22012620
MIRT499158	hsa-miR-181d-3p	PAR-CLIP	24398324
MIRT483217	hsa-miR-3179	PAR-CLIP	24398324
MIRT499157	hsa-miR-3663-3p	PAR-CLIP	24398324
MIRT483216	hsa-miR-3202	PAR-CLIP	24398324
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	24398324
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	24398324
MIRT483217	hsa-miR-3179	PAR-CLIP	23592263
MIRT483216	hsa-miR-3202	PAR-CLIP	23592263
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483217	hsa-miR-3179	PAR-CLIP	23592263
MIRT483216	hsa-miR-3202	PAR-CLIP	23592263
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT449578	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT449577	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT449576	hsa-miR-4740-3p	PAR-CLIP	22100165
MIRT449575	hsa-miR-3158-5p	PAR-CLIP	22100165
MIRT449574	hsa-miR-558	PAR-CLIP	22100165
MIRT449573	hsa-miR-6869-5p	PAR-CLIP	22100165
MIRT483217	hsa-miR-3179	PAR-CLIP	20371350
MIRT483216	hsa-miR-3202	PAR-CLIP	20371350
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT483217	hsa-miR-3179	PAR-CLIP	20371350
MIRT483216	hsa-miR-3202	PAR-CLIP	20371350
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT528210	hsa-miR-627-3p	PAR-CLIP	22012620
MIRT528209	hsa-miR-1305	PAR-CLIP	22012620
MIRT528208	hsa-miR-6722-5p	PAR-CLIP	22012620
MIRT499158	hsa-miR-181d-3p	PAR-CLIP	24398324
MIRT483217	hsa-miR-3179	PAR-CLIP	24398324
MIRT499157	hsa-miR-3663-3p	PAR-CLIP	24398324
MIRT483216	hsa-miR-3202	PAR-CLIP	24398324
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	24398324
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	24398324
MIRT483217	hsa-miR-3179	PAR-CLIP	23592263
MIRT483216	hsa-miR-3202	PAR-CLIP	23592263
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483217	hsa-miR-3179	PAR-CLIP	23592263
MIRT483216	hsa-miR-3202	PAR-CLIP	23592263
MIRT483214	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483215	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT449578	hsa-miR-135a-5p	PAR-CLIP	22100165
MIRT449577	hsa-miR-135b-5p	PAR-CLIP	22100165
MIRT449576	hsa-miR-4740-3p	PAR-CLIP	22100165
MIRT449575	hsa-miR-3158-5p	PAR-CLIP	22100165
MIRT449574	hsa-miR-558	PAR-CLIP	22100165
MIRT449573	hsa-miR-6869-5p	PAR-CLIP	22100165
MIRT756031	hsa-miR-520h	Luciferase reporter assay, qRT-PCR	34555726

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
FOXA2	Unknown	7961760
GATA6	Unknown	14659877
HNF4A	Unknown	7961760
SP1	Unknown	10829013

Show/Hide all(135)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0001540	Function	Amyloid-beta binding	IDA	11297421
GO:0001540	Function	Amyloid-beta binding	IPI	9211985
GO:0001932	Process	Regulation of protein phosphorylation	IEA
GO:0001935	Process	Endothelial cell proliferation	IEA
GO:0002576	Process	Platelet degranulation	TAS
GO:0002719	Process	Negative regulation of cytokine production involved in immune response	IDA	12458630
GO:0005102	Function	Signaling receptor binding	IPI	27477018
GO:0005515	Function	Protein binding	IPI	1587806, 11297421, 11991719, 12084722, 12917409, 15174051, 17676061, 17786215, 19758344, 23719382, 25241761, 25416956, 25910212, 28565870, 28887769, 30458687, 31270237, 32296183, 32814053
GO:0005543	Function	Phospholipid binding	IBA	21873635
GO:0005543	Function	Phospholipid binding	IDA	12810715
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 20551380, 22664934
GO:0005615	Component	Extracellular space	IDA	19433579
GO:0005615	Component	Extracellular space	ISS	22261194
GO:0005634	Component	Nucleus	IEA
GO:0005769	Component	Early endosome	TAS
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IDA	4335615
GO:0006695	Process	Cholesterol biosynthetic process	IBA	21873635
GO:0006898	Process	Receptor-mediated endocytosis	TAS
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IDA	23726972
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	16443932
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	23726972
GO:0007584	Process	Response to nutrient	IEA
GO:0008035	Function	High-density lipoprotein particle binding	IEA
GO:0008203	Process	Cholesterol metabolic process	IMP	15464323
GO:0008211	Process	Glucocorticoid metabolic process	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IDA	21571275
GO:0010873	Process	Positive regulation of cholesterol esterification	IBA	21873635
GO:0010873	Process	Positive regulation of cholesterol esterification	IDA	4335615
GO:0010875	Process	Positive regulation of cholesterol efflux	IDA	27472885
GO:0010898	Process	Positive regulation of triglyceride catabolic process	IBA	21873635
GO:0010903	Process	Negative regulation of very-low-density lipoprotein particle remodeling	IDA	14967812
GO:0014012	Process	Peripheral nervous system axon regeneration	IEA
GO:0015485	Function	Cholesterol binding	IBA	21873635
GO:0015485	Function	Cholesterol binding	IDA	15464323
GO:0018158	Process	Protein oxidation	IDA	12576517
GO:0018206	Process	Peptidyl-methionine modification	IDA	12576517
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0019899	Function	Enzyme binding	IPI	1587806
GO:0019915	Process	Lipid storage	IEA
GO:0030139	Component	Endocytic vesicle	IDA	14747463
GO:0030300	Process	Regulation of intestinal cholesterol absorption	IBA	21873635
GO:0030301	Process	Cholesterol transport	IDA	10559507
GO:0030325	Process	Adrenal gland development	IEA
GO:0031072	Function	Heat shock protein binding	IPI	11027668
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031210	Function	Phosphatidylcholine binding	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IDA	14703508
GO:0032489	Process	Regulation of Cdc42 protein signal transduction	IDA	16443932
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IDA	12458630
GO:0033344	Process	Cholesterol efflux	IBA	21873635
GO:0033344	Process	Cholesterol efflux	IDA	11162594, 14703508, 15358760, 16443932, 21481393
GO:0033344	Process	Cholesterol efflux	IMP	12202492
GO:0033700	Process	Phospholipid efflux	IBA	21873635
GO:0033700	Process	Phospholipid efflux	IDA	11162594, 14703508
GO:0034115	Process	Negative regulation of heterotypic cell-cell adhesion	IDA	21571275
GO:0034190	Function	Apolipoprotein receptor binding	IPI	11162594
GO:0034191	Function	Apolipoprotein A-I receptor binding	IPI	16443932
GO:0034361	Component	Very-low-density lipoprotein particle	IDA	17154273
GO:0034362	Component	Low-density lipoprotein particle	IEA
GO:0034363	Component	Intermediate-density lipoprotein particle	IEA
GO:0034364	Component	High-density lipoprotein particle	IBA	21873635
GO:0034364	Component	High-density lipoprotein particle	IDA	210174, 3104518, 9211985, 15464323, 21571275
GO:0034364	Component	High-density lipoprotein particle	TAS	27477018
GO:0034365	Component	Discoidal high-density lipoprotein particle	IEA
GO:0034366	Component	Spherical high-density lipoprotein particle	IDA	16682745
GO:0034371	Process	Chylomicron remodeling	TAS
GO:0034372	Process	Very-low-density lipoprotein particle remodeling	IBA	21873635
GO:0034375	Process	High-density lipoprotein particle remodeling	IC	4335615
GO:0034375	Process	High-density lipoprotein particle remodeling	IDA	21481393
GO:0034375	Process	High-density lipoprotein particle remodeling	TAS
GO:0034378	Process	Chylomicron assembly	TAS
GO:0034380	Process	High-density lipoprotein particle assembly	IBA	21873635
GO:0034380	Process	High-density lipoprotein particle assembly	IDA	190223
GO:0034380	Process	High-density lipoprotein particle assembly	TAS
GO:0034384	Process	High-density lipoprotein particle clearance	IC	12651854
GO:0034384	Process	High-density lipoprotein particle clearance	TAS
GO:0034774	Component	Secretory granule lumen	TAS
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IDA	23726972
GO:0042157	Process	Lipoprotein metabolic process	IBA	21873635
GO:0042158	Process	Lipoprotein biosynthetic process	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042627	Component	Chylomicron	IBA	21873635
GO:0042632	Process	Cholesterol homeostasis	IBA	21873635
GO:0042632	Process	Cholesterol homeostasis	IDA	21571275
GO:0042632	Process	Cholesterol homeostasis	IMP	15464323
GO:0042802	Function	Identical protein binding	IPI	8049247, 17676061, 18719128, 20133843, 20884842, 22184756, 22609356, 24316228, 24702826
GO:0043534	Process	Blood vessel endothelial cell migration	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0043691	Process	Reverse cholesterol transport	IBA	21873635
GO:0043691	Process	Reverse cholesterol transport	IMP	15464323
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045499	Function	Chemorepellent activity	IDA	23726972
GO:0045723	Process	Positive regulation of fatty acid biosynthetic process	IBA	21873635
GO:0046470	Process	Phosphatidylcholine metabolic process	IBA	21873635
GO:0046889	Process	Positive regulation of lipid biosynthetic process	IBA	21873635
GO:0050728	Process	Negative regulation of inflammatory response	IDA	21571275
GO:0050766	Process	Positive regulation of phagocytosis	IDA	20495215
GO:0050821	Process	Protein stabilization	IDA	17655203, 20495215
GO:0050919	Process	Negative chemotaxis	IDA	23726972
GO:0051006	Process	Positive regulation of lipoprotein lipase activity	IBA	21873635
GO:0051180	Process	Vitamin transport	IMP	15140193
GO:0051345	Process	Positive regulation of hydrolase activity	IDA	7638166
GO:0051496	Process	Positive regulation of stress fiber assembly	IDA	23726972
GO:0055085	Process	Transmembrane transport	TAS
GO:0055091	Process	Phospholipid homeostasis	IDA	21571275
GO:0055102	Function	Lipase inhibitor activity	IEA
GO:0060192	Process	Negative regulation of lipase activity	IEA
GO:0060228	Function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IBA	21873635
GO:0060228	Function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IDA	4335615
GO:0060354	Process	Negative regulation of cell adhesion molecule production	IDA	21571275
GO:0060761	Process	Negative regulation of response to cytokine stimulus	IDA	21571275
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27559042
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0070328	Process	Triglyceride homeostasis	IBA	21873635
GO:0070328	Process	Triglyceride homeostasis	IDA	21571275
GO:0070371	Process	ERK1 and ERK2 cascade	IDA	23726972
GO:0070508	Process	Cholesterol import	IMP	14718538
GO:0070653	Function	High-density lipoprotein particle receptor binding	IBA	21873635
GO:0070653	Function	High-density lipoprotein particle receptor binding	IPI	10764676, 12651854
GO:0071682	Component	Endocytic vesicle lumen	TAS
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0120020	Function	Cholesterol transfer activity	IDA	9651324
GO:0120020	Function	Cholesterol transfer activity	IMP	15464323
GO:1900026	Process	Positive regulation of substrate adhesion-dependent cell spreading	IDA	23726972
GO:1902995	Process	Positive regulation of phospholipid efflux	IDA	27472885
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
107680	600	ENSG00000118137

Protein

UniProt ID

P02647

Protein name

Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]

Protein function

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP comple

PDB

1AV1 , 1GW3 , 1GW4 , 1ODP , 1ODQ , 1ODR , 2MSC , 2MSD , 2MSE , 2N5E , 3K2S , 3R2P , 4V6M , 6CC9 , 6CCH , 6CCX , 6CLZ , 6CM1 , 6PTS , 6PTW , 6W4E , 6W4F , 7KJR , 7RSC , 7RSE , 8EQS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01442	Apolipoprotein	69 → 259	Apolipoprotein A1/A4/E domain	Domain

Sequence

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ

Sequence length

267

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412