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ALDH9A1 (aldehyde dehydrogenase 9 family member A1)

Gene

223

Aldehyde dehydrogenase 9 family member A1

ALDH9A1

ALDH4, ALDH7, ALDH9, E3, TMABA-DH, TMABADH, TMABALDH

1q24.1

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs121908986	C>G,T	Affects	Missense variant, coding sequence variant

Show/Hide all(128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002631	hsa-miR-124-3p	Microarray	15685193
MIRT002631	hsa-miR-124-3p	Microarray	18668037
MIRT020624	hsa-miR-155-5p	Proteomics	18668040
MIRT024328	hsa-miR-215-5p	Microarray	19074876
MIRT025249	hsa-miR-34a-5p	Proteomics	21566225
MIRT026254	hsa-miR-192-5p	Microarray	19074876
MIRT028704	hsa-miR-27a-3p	Sequencing	20371350
MIRT041186	hsa-miR-497-5p	CLASH	23622248
MIRT045873	hsa-miR-128-3p	CLASH	23622248
MIRT048479	hsa-miR-100-5p	CLASH	23622248
MIRT049809	hsa-miR-92a-3p	CLASH	23622248
MIRT111738	hsa-miR-802	PAR-CLIP	23592263
MIRT181987	hsa-miR-1250-3p	PAR-CLIP	23592263
MIRT441235	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441236	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT457259	hsa-miR-8070	PAR-CLIP	23592263
MIRT457259	hsa-miR-8070	PAR-CLIP	24398324
MIRT457259	hsa-miR-8070	PAR-CLIP	23446348
MIRT457259	hsa-miR-8070	PAR-CLIP	21572407
MIRT457259	hsa-miR-8070	PAR-CLIP	20371350
MIRT457259	hsa-miR-8070	HITS-CLIP	27418678
MIRT457260	hsa-miR-494-5p	PAR-CLIP	23592263
MIRT457260	hsa-miR-494-5p	PAR-CLIP	24398324
MIRT457260	hsa-miR-494-5p	PAR-CLIP	23446348
MIRT457260	hsa-miR-494-5p	PAR-CLIP	21572407
MIRT457260	hsa-miR-494-5p	PAR-CLIP	20371350
MIRT457260	hsa-miR-494-5p	HITS-CLIP	27418678
MIRT457261	hsa-miR-410-5p	PAR-CLIP	23592263
MIRT457261	hsa-miR-410-5p	PAR-CLIP	24398324
MIRT457261	hsa-miR-410-5p	PAR-CLIP	23446348
MIRT457261	hsa-miR-410-5p	PAR-CLIP	21572407
MIRT457261	hsa-miR-410-5p	PAR-CLIP	20371350
MIRT457261	hsa-miR-410-5p	HITS-CLIP	27418678
MIRT457262	hsa-miR-323b-5p	PAR-CLIP	23592263
MIRT457262	hsa-miR-323b-5p	PAR-CLIP	24398324
MIRT457262	hsa-miR-323b-5p	PAR-CLIP	23446348
MIRT457262	hsa-miR-323b-5p	PAR-CLIP	21572407
MIRT457262	hsa-miR-323b-5p	PAR-CLIP	20371350
MIRT457262	hsa-miR-323b-5p	HITS-CLIP	27418678
MIRT457263	hsa-miR-1283	PAR-CLIP	23592263
MIRT457263	hsa-miR-1283	PAR-CLIP	23446348
MIRT457263	hsa-miR-1283	PAR-CLIP	20371350
MIRT457263	hsa-miR-1283	PAR-CLIP	26701625
MIRT457263	hsa-miR-1283	HITS-CLIP	27418678
MIRT457264	hsa-miR-4275	PAR-CLIP	23592263
MIRT457264	hsa-miR-4275	PAR-CLIP	24398324
MIRT457264	hsa-miR-4275	PAR-CLIP	23446348
MIRT457264	hsa-miR-4275	PAR-CLIP	21572407
MIRT457264	hsa-miR-4275	PAR-CLIP	20371350
MIRT457264	hsa-miR-4275	HITS-CLIP	27418678
MIRT457265	hsa-miR-1255b-2-3p	PAR-CLIP	23592263
MIRT457265	hsa-miR-1255b-2-3p	PAR-CLIP	23446348
MIRT457265	hsa-miR-1255b-2-3p	PAR-CLIP	21572407
MIRT457265	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT457265	hsa-miR-1255b-2-3p	HITS-CLIP	27418678
MIRT457266	hsa-miR-582-3p	PAR-CLIP	23592263
MIRT457266	hsa-miR-582-3p	PAR-CLIP	24398324
MIRT457266	hsa-miR-582-3p	PAR-CLIP	23446348
MIRT457266	hsa-miR-582-3p	PAR-CLIP	21572407
MIRT457266	hsa-miR-582-3p	PAR-CLIP	20371350
MIRT457266	hsa-miR-582-3p	HITS-CLIP	27418678
MIRT457267	hsa-miR-30e-3p	PAR-CLIP	23592263
MIRT457268	hsa-miR-30d-3p	PAR-CLIP	23592263
MIRT457269	hsa-miR-4276	PAR-CLIP	23592263
MIRT457270	hsa-miR-30a-3p	PAR-CLIP	23592263
MIRT457271	hsa-miR-5192	PAR-CLIP	23592263
MIRT457272	hsa-miR-4644	PAR-CLIP	23592263
MIRT457273	hsa-miR-4306	PAR-CLIP	23592263
MIRT457274	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT457275	hsa-miR-8075	PAR-CLIP	23592263
MIRT457276	hsa-miR-8082	PAR-CLIP	23592263
MIRT457277	hsa-miR-3134	PAR-CLIP	23592263
MIRT457278	hsa-miR-4534	PAR-CLIP	23592263
MIRT457279	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT457280	hsa-miR-5190	PAR-CLIP	23592263
MIRT483741	hsa-miR-561-5p	PAR-CLIP	23592263
MIRT483742	hsa-miR-3162-5p	PAR-CLIP	23592263
MIRT483743	hsa-miR-4703-3p	PAR-CLIP	23592263
MIRT483744	hsa-miR-711	PAR-CLIP	23592263
MIRT483745	hsa-miR-20b-3p	PAR-CLIP	23592263
MIRT483746	hsa-miR-6830-5p	PAR-CLIP	23592263
MIRT483747	hsa-miR-135a-3p	PAR-CLIP	23592263
MIRT483748	hsa-miR-5000-5p	PAR-CLIP	23592263
MIRT483749	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT483750	hsa-miR-4739	PAR-CLIP	23592263
MIRT483751	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT483752	hsa-miR-1321	PAR-CLIP	23592263
MIRT483753	hsa-miR-4690-5p	PAR-CLIP	23592263
MIRT483754	hsa-miR-6816-3p	PAR-CLIP	23592263
MIRT483755	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT509348	hsa-miR-4325	PAR-CLIP	23446348
MIRT509348	hsa-miR-4325	PAR-CLIP	21572407
MIRT509348	hsa-miR-4325	PAR-CLIP	20371350
MIRT509348	hsa-miR-4325	HITS-CLIP	27418678
MIRT509349	hsa-miR-4793-3p	PAR-CLIP	23446348
MIRT509349	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT509349	hsa-miR-4793-3p	PAR-CLIP	20371350
MIRT509349	hsa-miR-4793-3p	HITS-CLIP	27418678
MIRT509350	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT509350	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT509350	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT509350	hsa-miR-1273g-3p	HITS-CLIP	27418678
MIRT509351	hsa-miR-3614-5p	PAR-CLIP	23446348
MIRT509351	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT509351	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT509351	hsa-miR-3614-5p	HITS-CLIP	27418678
MIRT509352	hsa-miR-890	PAR-CLIP	23446348
MIRT509352	hsa-miR-890	PAR-CLIP	21572407
MIRT509352	hsa-miR-890	PAR-CLIP	20371350
MIRT509352	hsa-miR-890	HITS-CLIP	27418678
MIRT728357	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT728358	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT728359	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT728360	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT728361	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT728362	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT728363	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT728364	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT736510	hsa-miR-1252-5p	PAR-CLIP	26701625
MIRT738582	hsa-miR-194-3p	PAR-CLIP	26701625
MIRT744390	hsa-miR-4434	PAR-CLIP	26701625
MIRT745743	hsa-miR-4516	PAR-CLIP	26701625
MIRT745782	hsa-miR-4519	PAR-CLIP	26701625
MIRT745977	hsa-miR-4531	PAR-CLIP	26701625
MIRT751346	hsa-miR-5703	PAR-CLIP	26701625
MIRT753716	hsa-miR-6716-5p	PAR-CLIP	26701625
MIRT755270	hsa-miR-6770-5p	PAR-CLIP	26701625
MIRT760042	hsa-miR-8060	PAR-CLIP	26701625

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IBA	21873635
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IDA	2925663, 30914451
GO:0005737	Component	Cytoplasm	TAS	2925663
GO:0005829	Component	Cytosol	TAS
GO:0006081	Process	Cellular aldehyde metabolic process	IDA	8645224, 30914451
GO:0019145	Function	Aminobutyraldehyde dehydrogenase activity	IBA	21873635
GO:0019145	Function	Aminobutyraldehyde dehydrogenase activity	IDA	2925663, 8645224
GO:0033737	Function	1-pyrroline dehydrogenase activity	IEA
GO:0042136	Process	Neurotransmitter biosynthetic process	IDA	2925663
GO:0042445	Process	Hormone metabolic process	TAS	2925663
GO:0043878	Function	Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA
GO:0045329	Process	Carnitine biosynthetic process	IEA
GO:0045329	Process	Carnitine biosynthetic process	TAS
GO:0047105	Function	4-trimethylammoniobutyraldehyde dehydrogenase activity	IBA	21873635
GO:0047105	Function	4-trimethylammoniobutyraldehyde dehydrogenase activity	IDA	30914451
GO:0051289	Process	Protein homotetramerization	IDA	30914451
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
602733	412	ENSG00000143149

Protein

UniProt ID

P49189

Protein name

4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]

Protein function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.

PDB

6QAK , 6QAO , 6QAP , 6VR6 , 6VWF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00171	Aldedh	21 → 483	Aldehyde dehydrogenase family	Family

Sequence

MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

Sequence length

494

Interactions

View interactions

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