ALDH2 (aldehyde dehydrogenase 2 family member)

Gene

• Entrez ID: 217
• Gene name: Aldehyde dehydrogenase 2 family member
• Gene symbol: ALDH2
• Synonyms: ALDH-E2, ALDHI, ALDM
• Chromosome: 12
• Chromosome location: 12q24.12
• Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can b

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs671	G>A	Drug-response, protective, risk-factor	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016754	hsa-miR-335-5p	Microarray	18185580
MIRT023536	hsa-miR-1-3p	Proteomics	18668040
MIRT031438	hsa-miR-16-5p	Proteomics	18668040
MIRT039939	hsa-miR-615-3p	CLASH	23622248
MIRT519128	hsa-miR-1245a	PAR-CLIP	23446348
MIRT519127	hsa-miR-8079	PAR-CLIP	23446348
MIRT519126	hsa-miR-4638-5p	PAR-CLIP	23446348
MIRT519125	hsa-miR-6790-3p	PAR-CLIP	23446348
MIRT519124	hsa-miR-6821-3p	PAR-CLIP	23446348
MIRT519123	hsa-miR-4765	PAR-CLIP	23446348
MIRT519122	hsa-miR-640	PAR-CLIP	23446348
MIRT519128	hsa-miR-1245a	PAR-CLIP	23446348
MIRT519127	hsa-miR-8079	PAR-CLIP	23446348
MIRT519126	hsa-miR-4638-5p	PAR-CLIP	23446348
MIRT519125	hsa-miR-6790-3p	PAR-CLIP	23446348
MIRT519124	hsa-miR-6821-3p	PAR-CLIP	23446348
MIRT519123	hsa-miR-4765	PAR-CLIP	23446348
MIRT519122	hsa-miR-640	PAR-CLIP	23446348
MIRT777131	hsa-miR-30a	CLIP-seq
MIRT777132	hsa-miR-30b	CLIP-seq
MIRT777133	hsa-miR-30c	CLIP-seq
MIRT777134	hsa-miR-30d	CLIP-seq
MIRT777135	hsa-miR-30e	CLIP-seq
MIRT777136	hsa-miR-3689a-5p	CLIP-seq
MIRT777137	hsa-miR-3689b	CLIP-seq
MIRT777138	hsa-miR-3689e	CLIP-seq
MIRT777139	hsa-miR-3689f	CLIP-seq
MIRT777140	hsa-miR-4274	CLIP-seq
MIRT777141	hsa-miR-4423-5p	CLIP-seq
MIRT777142	hsa-miR-4519	CLIP-seq
MIRT2170127	hsa-miR-1185	CLIP-seq
MIRT2170128	hsa-miR-3065-3p	CLIP-seq
MIRT2170129	hsa-miR-3140-5p	CLIP-seq
MIRT2170130	hsa-miR-330-3p	CLIP-seq
MIRT2170131	hsa-miR-3679-5p	CLIP-seq
MIRT777136	hsa-miR-3689a-5p	CLIP-seq
MIRT777137	hsa-miR-3689b	CLIP-seq
MIRT777138	hsa-miR-3689e	CLIP-seq
MIRT777139	hsa-miR-3689f	CLIP-seq
MIRT2170132	hsa-miR-3919	CLIP-seq
MIRT2170133	hsa-miR-3942-3p	CLIP-seq
MIRT777140	hsa-miR-4274	CLIP-seq
MIRT2170134	hsa-miR-4282	CLIP-seq
MIRT2170135	hsa-miR-4291	CLIP-seq
MIRT2170136	hsa-miR-4326	CLIP-seq
MIRT777141	hsa-miR-4423-5p	CLIP-seq
MIRT2170137	hsa-miR-4476	CLIP-seq
MIRT777142	hsa-miR-4519	CLIP-seq
MIRT2170138	hsa-miR-4753-3p	CLIP-seq
MIRT2170139	hsa-miR-4756-3p	CLIP-seq
MIRT2170140	hsa-miR-4766-5p	CLIP-seq
MIRT2170141	hsa-miR-4768-5p	CLIP-seq
MIRT2170142	hsa-miR-4793-5p	CLIP-seq
MIRT2170143	hsa-miR-513a-3p	CLIP-seq
MIRT2170144	hsa-miR-520d-5p	CLIP-seq
MIRT2170145	hsa-miR-524-5p	CLIP-seq
MIRT2170146	hsa-miR-548c-3p	CLIP-seq
MIRT2170147	hsa-miR-621	CLIP-seq
MIRT2384067	hsa-miR-578	CLIP-seq
MIRT2170128	hsa-miR-3065-3p	CLIP-seq
MIRT2473006	hsa-miR-3148	CLIP-seq
MIRT2473007	hsa-miR-3674	CLIP-seq
MIRT2170133	hsa-miR-3942-3p	CLIP-seq
MIRT2170134	hsa-miR-4282	CLIP-seq
MIRT2170135	hsa-miR-4291	CLIP-seq
MIRT2473008	hsa-miR-4496	CLIP-seq
MIRT2170138	hsa-miR-4753-3p	CLIP-seq
MIRT2170141	hsa-miR-4768-5p	CLIP-seq
MIRT2170143	hsa-miR-513a-3p	CLIP-seq
MIRT2170128	hsa-miR-3065-3p	CLIP-seq
MIRT2473006	hsa-miR-3148	CLIP-seq
MIRT2473007	hsa-miR-3674	CLIP-seq
MIRT2170133	hsa-miR-3942-3p	CLIP-seq
MIRT2170134	hsa-miR-4282	CLIP-seq
MIRT2170135	hsa-miR-4291	CLIP-seq
MIRT2473008	hsa-miR-4496	CLIP-seq
MIRT2170138	hsa-miR-4753-3p	CLIP-seq
MIRT2170141	hsa-miR-4768-5p	CLIP-seq
MIRT2170143	hsa-miR-513a-3p	CLIP-seq
MIRT2384067	hsa-miR-578	CLIP-seq
MIRT2674900	hsa-miR-628-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IBA	21873635
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IDA	4015840
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	TAS	8903321
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005975	Process	Carbohydrate metabolic process	TAS	8903321
GO:0006066	Process	Alcohol metabolic process	TAS	1306115
GO:0006068	Process	Ethanol catabolic process	IEA
GO:0006069	Process	Ethanol oxidation	TAS
GO:0009055	Function	Electron transfer activity	TAS	8903321
GO:0022900	Process	Electron transport chain	IEA
GO:0043878	Function	Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA
GO:0051287	Function	NAD binding	ISS	12693930
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 100650
• HGNC: 404
• e!Ensembl: ENSG00000111275

Protein

• UniProt ID: P05091
• Protein name: Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)
• Protein function: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
• PDB: 1CW3, 1NZW, 1NZX, 1NZZ, 1O00, 1O01, 1O02, 1O04, 1O05, 1ZUM, 2ONM, 2ONN, 2ONO, 2ONP, 2VLE, 3INJ, 3INL, 3N80, 3N81, 3N82, 3N83, 3SZ9, 4FQF, 4FR8, 4KWF, 4KWG, 5L13, 8DR9, 8SHS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00171	Aldedh	45 → 508	Aldehyde dehydrogenase family	Family

• Sequence:

  MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
  TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
  ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
  QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
  FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
  DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
  QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
  VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
  PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

• Sequence length: 517