GediPNet logo

AKT3 (AKT serine/threonine kinase 3)
Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10000
Gene nameGene Name - the full gene name approved by the HGNC.
AKT serine/threonine kinase 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
AKT3
SynonymsGene synonyms aliases
MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q43-q44
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
SNPsSNP information provided by dbSNP.
Gene SNPs Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs397514605 T>C Pathogenic Coding sequence variant, missense variant, genic upstream transcript variant
rs397514606 C>T Pathogenic Coding sequence variant, 5 prime UTR variant, missense variant, genic upstream transcript variant
rs587776935 G>A Likely-pathogenic, pathogenic Genic downstream transcript variant, coding sequence variant, missense variant, intron variant
rs886041100 A>T Likely-pathogenic Missense variant, coding sequence variant, genic upstream transcript variant
rs1064795602 C>T Pathogenic Genic downstream transcript variant, missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT003099 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003099 hsa-miR-122-5p Immunoblot, Luciferase reporter assay, qRT-PCR 24244539
MIRT003329 hsa-miR-16-5p Luciferase reporter assay 23233752
MIRT003329 hsa-miR-16-5p PAR-CLIP 23592263
MIRT003329 hsa-miR-16-5p PAR-CLIP 21572407
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000002 Process Mitochondrial genome maintenance IMP 18524868
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 25323119
GO:0004672 Function Protein kinase activity TAS 10092583
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 16540465
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Other IDs
UniProt ID Q9Y243
Protein name RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Protein function AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
PDB 2X18
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH
6 → 107
PH domain
 Domain
PF00069 Pkinase
148 → 405
Protein kinase domain
 Domain
PF00433 Pkinase_C
426 → 473
Protein kinase C terminal domain
 Family
Sequence
Sequence length 479
Interactions View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412