AGTR1 (angiotensin II receptor type 1)

Gene

• Entrez ID: 185
• Gene name: Angiotensin II receptor type 1
• Gene symbol: AGTR1
• Synonyms: AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
• Chromosome: 3
• Chromosome location: 3q24
• Summary: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs5186	A>C	Risk-factor, benign	3 prime UTR variant
rs104893677	C>T	Pathogenic	Missense variant, coding sequence variant
rs387906577	->T	Pathogenic	Coding sequence variant, frameshift variant
rs397514687	C>G,T	Pathogenic	Missense variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	19177201
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR, Reporter assay	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Quantitative proteomic approach, Western blot	20735984
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot, Reporter assay	16675453
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	22664914
MIRT023107	hsa-miR-124-3p	Microarray	18668037
MIRT030131	hsa-miR-26b-5p	Microarray	19088304
MIRT731253	hsa-miR-410-3p	Luciferase reporter assay, Western blot	25646808
MIRT735042	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28073349

Transcription factors

Transcription factor	Regulation	Reference
ETV4	Activation	8206588
HIF1A	Activation	15718424
SND1	Activation	18603592
SP1	Activation	22282354
SP1	Repression	22282354
SP1	Unknown	11072083;15507319
SP3	Unknown	15507319

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	17159080
GO:0001596	Function	Angiotensin type I receptor activity	IBA	21873635
GO:0001596	Function	Angiotensin type I receptor activity	IDA	10993080
GO:0001596	Function	Angiotensin type I receptor activity	IPI	1378723
GO:0001822	Process	Kidney development	IMP	16116425
GO:0002018	Process	Renin-angiotensin regulation of aldosterone production	NAS	17159080
GO:0002034	Process	Maintenance of blood vessel diameter homeostasis by renin-angiotensin	IC	10993080
GO:0003081	Process	Regulation of systemic arterial blood pressure by renin-angiotensin	IC	1378723
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004945	Function	Angiotensin type II receptor activity	IDA	1567413, 15611106
GO:0005515	Function	Protein binding	IPI	1378723, 15611106, 19023134, 21412239, 22935142, 23597562, 26460884, 28298427
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	19023134
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IC	1378723
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	1378723
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	NAS	17159080
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	1567413
GO:0007266	Process	Rho protein signal transduction	IDA	15611106
GO:0010744	Process	Positive regulation of macrophage derived foam cell differentiation	IC	18971559
GO:0010873	Process	Positive regulation of cholesterol esterification	IMP	18971559
GO:0016021	Component	Integral component of membrane	NAS	8135787
GO:0019229	Process	Regulation of vasoconstriction	IC	1378723
GO:0019229	Process	Regulation of vasoconstriction	IDA	15117835
GO:0019229	Process	Regulation of vasoconstriction	NAS	17159080
GO:0019722	Process	Calcium-mediated signaling	IDA	1567413
GO:0031711	Function	Bradykinin receptor binding	IPI	10993080
GO:0032270	Process	Positive regulation of cellular protein metabolic process	IMP	18971559
GO:0032430	Process	Positive regulation of phospholipase A2 activity	IMP	17069818
GO:0033864	Process	Positive regulation of NAD(P)H oxidase activity	TAS	17159080
GO:0034374	Process	Low-density lipoprotein particle remodeling	NAS	17069818
GO:0035813	Process	Regulation of renal sodium excretion	NAS	17159080
GO:0038166	Process	Angiotensin-activated signaling pathway	IDA	1567413
GO:0042127	Process	Regulation of cell population proliferation	NAS	17159080
GO:0046982	Function	Protein heterodimerization activity	IPI	10993080
GO:0050727	Process	Regulation of inflammatory response	IC	1378723
GO:0050729	Process	Positive regulation of inflammatory response	TAS	17159080
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IDA	1567413
GO:0060326	Process	Cell chemotaxis	IDA	15635042
GO:0086097	Process	Phospholipase C-activating angiotensin-activated signaling pathway	IDA	1378723
GO:0097746	Process	Blood vessel diameter maintenance	IC	1378723
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	25850724
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	TAS	17159080

Other IDs

• MIM: 106165
• HGNC: 336
• e!Ensembl: ENSG00000144891

Protein

• UniProt ID: P30556
• Protein name: Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1)
• Protein function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
• PDB: 1ZV0, 4YAY, 4ZUD, 6DO1, 6OS0, 6OS1, 6OS2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	45 → 302	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
  TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
  CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
  AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
  IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
  FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

• Sequence length: 359