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AGTR1 (angiotensin II receptor type 1)

Gene

185

Angiotensin II receptor type 1

AGTR1

AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R

3q24

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene enc

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs5186	A>C	Risk-factor, benign	3 prime UTR variant
rs104893677	C>T	Pathogenic	Missense variant, coding sequence variant
rs387906577	->T	Pathogenic	Coding sequence variant, frameshift variant
rs397514687	C>G,T	Pathogenic	Missense variant, coding sequence variant, stop gained

Show/Hide all(130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	19177201
MIRT002006	hsa-miR-155-5p	Review	20026422
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Quantitative proteomic approach, Western blot	20735984
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot	16675453
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot	16675453
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Western blot	21310411
MIRT002006	hsa-miR-155-5p	Reporter assay	17588946
MIRT002006	hsa-miR-155-5p	Reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Reporter assay	16675453
MIRT023107	hsa-miR-124-3p	Microarray	18668037
MIRT030131	hsa-miR-26b-5p	Microarray	19088304
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	22664914
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT733624	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28073349
MIRT733624	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28073349
MIRT733063	hsa-miR-155-3p	Luciferase reporter assay, qRT-PCR, Western blotting	32896760
MIRT733063	hsa-miR-155-3p	Luciferase reporter assay, qRT-PCR, Western blotting	32896760
MIRT733624	hsa-miR-34a-5p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	33650673
MIRT773122	hsa-miR-1	CLIP-seq
MIRT773123	hsa-miR-1321	CLIP-seq
MIRT773124	hsa-miR-206	CLIP-seq
MIRT773125	hsa-miR-2117	CLIP-seq
MIRT773126	hsa-miR-2467-3p	CLIP-seq
MIRT773127	hsa-miR-3125	CLIP-seq
MIRT773128	hsa-miR-3158-5p	CLIP-seq
MIRT773129	hsa-miR-3162-5p	CLIP-seq
MIRT773130	hsa-miR-3678-3p	CLIP-seq
MIRT773131	hsa-miR-3916	CLIP-seq
MIRT773132	hsa-miR-4268	CLIP-seq
MIRT773133	hsa-miR-4273	CLIP-seq
MIRT773134	hsa-miR-4448	CLIP-seq
MIRT773135	hsa-miR-4690-5p	CLIP-seq
MIRT773136	hsa-miR-4739	CLIP-seq
MIRT773137	hsa-miR-4753-3p	CLIP-seq
MIRT773138	hsa-miR-4756-5p	CLIP-seq
MIRT773139	hsa-miR-613	CLIP-seq
MIRT773140	hsa-miR-302a	CLIP-seq
MIRT773141	hsa-miR-302b	CLIP-seq
MIRT773142	hsa-miR-302c	CLIP-seq
MIRT773143	hsa-miR-302d	CLIP-seq
MIRT773144	hsa-miR-302e	CLIP-seq
MIRT773145	hsa-miR-3606	CLIP-seq
MIRT773146	hsa-miR-3616-5p	CLIP-seq
MIRT773147	hsa-miR-3647-5p	CLIP-seq
MIRT773148	hsa-miR-372	CLIP-seq
MIRT773149	hsa-miR-373	CLIP-seq
MIRT773150	hsa-miR-4795-5p	CLIP-seq
MIRT773151	hsa-miR-512-3p	CLIP-seq
MIRT773152	hsa-miR-520a-3p	CLIP-seq
MIRT773153	hsa-miR-520b	CLIP-seq
MIRT773154	hsa-miR-520c-3p	CLIP-seq
MIRT773155	hsa-miR-520d-3p	CLIP-seq
MIRT773156	hsa-miR-520e	CLIP-seq
MIRT773157	hsa-miR-573	CLIP-seq
MIRT773158	hsa-miR-579	CLIP-seq
MIRT773123	hsa-miR-1321	CLIP-seq
MIRT773129	hsa-miR-3162-5p	CLIP-seq
MIRT773135	hsa-miR-4690-5p	CLIP-seq
MIRT773136	hsa-miR-4739	CLIP-seq
MIRT773138	hsa-miR-4756-5p	CLIP-seq
MIRT1928223	hsa-miR-3944-5p	CLIP-seq
MIRT1928224	hsa-miR-431	CLIP-seq
MIRT1928225	hsa-miR-4684-3p	CLIP-seq
MIRT1928226	hsa-miR-511	CLIP-seq
MIRT1928227	hsa-miR-518a-5p	CLIP-seq
MIRT1928228	hsa-miR-527	CLIP-seq
MIRT2471548	hsa-miR-1299	CLIP-seq
MIRT2471549	hsa-miR-1976	CLIP-seq
MIRT2471550	hsa-miR-2116	CLIP-seq
MIRT2471551	hsa-miR-3120-5p	CLIP-seq
MIRT2471552	hsa-miR-3654	CLIP-seq
MIRT1928223	hsa-miR-3944-5p	CLIP-seq
MIRT2471553	hsa-miR-3978	CLIP-seq
MIRT2471554	hsa-miR-4261	CLIP-seq
MIRT773132	hsa-miR-4268	CLIP-seq
MIRT773133	hsa-miR-4273	CLIP-seq
MIRT773134	hsa-miR-4448	CLIP-seq
MIRT2471555	hsa-miR-4520a-3p	CLIP-seq
MIRT2471556	hsa-miR-4638-3p	CLIP-seq
MIRT2471557	hsa-miR-4677-5p	CLIP-seq
MIRT2471558	hsa-miR-4680-5p	CLIP-seq
MIRT2471559	hsa-miR-4738-3p	CLIP-seq
MIRT2471560	hsa-miR-764	CLIP-seq
MIRT2471561	hsa-miR-875-3p	CLIP-seq
MIRT2471562	hsa-miR-938	CLIP-seq
MIRT2471548	hsa-miR-1299	CLIP-seq
MIRT2471549	hsa-miR-1976	CLIP-seq
MIRT2471550	hsa-miR-2116	CLIP-seq
MIRT2674753	hsa-miR-3119	CLIP-seq
MIRT2471551	hsa-miR-3120-5p	CLIP-seq
MIRT2674754	hsa-miR-3140-3p	CLIP-seq
MIRT2471552	hsa-miR-3654	CLIP-seq
MIRT2674755	hsa-miR-375	CLIP-seq
MIRT1928223	hsa-miR-3944-5p	CLIP-seq
MIRT2471553	hsa-miR-3978	CLIP-seq
MIRT2471554	hsa-miR-4261	CLIP-seq
MIRT773132	hsa-miR-4268	CLIP-seq
MIRT773133	hsa-miR-4273	CLIP-seq
MIRT1928224	hsa-miR-431	CLIP-seq
MIRT773134	hsa-miR-4448	CLIP-seq
MIRT2674756	hsa-miR-4474-3p	CLIP-seq
MIRT2471555	hsa-miR-4520a-3p	CLIP-seq
MIRT2471556	hsa-miR-4638-3p	CLIP-seq
MIRT2471557	hsa-miR-4677-5p	CLIP-seq
MIRT2471558	hsa-miR-4680-5p	CLIP-seq
MIRT1928225	hsa-miR-4684-3p	CLIP-seq
MIRT2674757	hsa-miR-4698	CLIP-seq
MIRT2471559	hsa-miR-4738-3p	CLIP-seq
MIRT1928226	hsa-miR-511	CLIP-seq
MIRT1928227	hsa-miR-518a-5p	CLIP-seq
MIRT1928228	hsa-miR-527	CLIP-seq
MIRT2471560	hsa-miR-764	CLIP-seq
MIRT2471561	hsa-miR-875-3p	CLIP-seq
MIRT2674758	hsa-miR-889	CLIP-seq
MIRT2471562	hsa-miR-938	CLIP-seq

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
ETV4	Activation	8206588
HIF1A	Activation	15718424
SND1	Activation	18603592
SP1	Activation	22282354
SP1	Repression	22282354
SP1	Unknown	11072083;15507319
SP3	Unknown	15507319

Show/Hide all(47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	17159080
GO:0001596	Function	Angiotensin type I receptor activity	IBA	21873635
GO:0001596	Function	Angiotensin type I receptor activity	IDA	10993080
GO:0001596	Function	Angiotensin type I receptor activity	IPI	1378723
GO:0001822	Process	Kidney development	IMP	16116425
GO:0002018	Process	Renin-angiotensin regulation of aldosterone production	NAS	17159080
GO:0002034	Process	Maintenance of blood vessel diameter homeostasis by renin-angiotensin	IC	10993080
GO:0003081	Process	Regulation of systemic arterial blood pressure by renin-angiotensin	IC	1378723
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004945	Function	Angiotensin type II receptor activity	IDA	1567413, 15611106
GO:0005515	Function	Protein binding	IPI	1378723, 15611106, 19023134, 21412239, 22935142, 23597562, 26460884, 28298427
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	19023134
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IC	1378723
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	1378723
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	NAS	17159080
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	1567413
GO:0007266	Process	Rho protein signal transduction	IDA	15611106
GO:0010744	Process	Positive regulation of macrophage derived foam cell differentiation	IC	18971559
GO:0010873	Process	Positive regulation of cholesterol esterification	IMP	18971559
GO:0016021	Component	Integral component of membrane	NAS	8135787
GO:0019229	Process	Regulation of vasoconstriction	IC	1378723
GO:0019229	Process	Regulation of vasoconstriction	IDA	15117835
GO:0019229	Process	Regulation of vasoconstriction	NAS	17159080
GO:0019722	Process	Calcium-mediated signaling	IDA	1567413
GO:0031711	Function	Bradykinin receptor binding	IPI	10993080
GO:0032270	Process	Positive regulation of cellular protein metabolic process	IMP	18971559
GO:0032430	Process	Positive regulation of phospholipase A2 activity	IMP	17069818
GO:0033864	Process	Positive regulation of NAD(P)H oxidase activity	TAS	17159080
GO:0034374	Process	Low-density lipoprotein particle remodeling	NAS	17069818
GO:0035813	Process	Regulation of renal sodium excretion	NAS	17159080
GO:0038166	Process	Angiotensin-activated signaling pathway	IDA	1567413
GO:0042127	Process	Regulation of cell population proliferation	NAS	17159080
GO:0046982	Function	Protein heterodimerization activity	IPI	10993080
GO:0050727	Process	Regulation of inflammatory response	IC	1378723
GO:0050729	Process	Positive regulation of inflammatory response	TAS	17159080
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IDA	1567413
GO:0060326	Process	Cell chemotaxis	IDA	15635042
GO:0086097	Process	Phospholipase C-activating angiotensin-activated signaling pathway	IDA	1378723
GO:0097746	Process	Blood vessel diameter maintenance	IC	1378723
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	25850724
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	TAS	17159080

MIM	HGNC	e!Ensembl
106165	336	ENSG00000144891

Protein

UniProt ID

P30556

Protein name

Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)

Protein function

Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, Pub

PDB

4YAY , 4ZUD , 6DO1 , 6OS0 , 6OS1 , 6OS2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	45 → 302	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

Sequence length

359

Interactions

View interactions

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