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ADSS2 (adenylosuccinate synthase 2)

Gene

159

Adenylosuccinate synthase 2

ADSS2

ADEH, ADSS, ADSS 2

1q44

This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

Show/Hide all(98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001480	hsa-miR-16-5p	pSILAC, Proteomics;Other	18668040
MIRT027907	hsa-miR-96-5p	Sequencing	20371350
MIRT050584	hsa-miR-20a-5p	CLASH	23622248
MIRT064982	hsa-miR-548aw	PAR-CLIP	22012620
MIRT064982	hsa-miR-548aw	PAR-CLIP	21572407
MIRT064982	hsa-miR-548aw	PAR-CLIP	20371350
MIRT135019	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT135019	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT135019	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT135022	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT135022	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT135022	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT135023	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT135023	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT135023	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT135026	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT135026	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT135026	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT135029	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT135029	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT135029	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT135054	hsa-miR-2116-5p	PAR-CLIP	21572407
MIRT135054	hsa-miR-2116-5p	PAR-CLIP	20371350
MIRT135056	hsa-miR-4273	PAR-CLIP	21572407
MIRT135056	hsa-miR-4273	PAR-CLIP	20371350
MIRT135057	hsa-miR-4677-5p	PAR-CLIP	21572407
MIRT135057	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT135061	hsa-miR-7156-5p	PAR-CLIP	21572407
MIRT135061	hsa-miR-7156-5p	PAR-CLIP	20371350
MIRT539365	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT539365	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT539365	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT539366	hsa-miR-2113	PAR-CLIP	22012620
MIRT539366	hsa-miR-2113	PAR-CLIP	21572407
MIRT539366	hsa-miR-2113	PAR-CLIP	20371350
MIRT539367	hsa-miR-4772-5p	PAR-CLIP	22012620
MIRT539367	hsa-miR-4772-5p	PAR-CLIP	21572407
MIRT539368	hsa-miR-20a-3p	PAR-CLIP	22012620
MIRT539368	hsa-miR-20a-3p	PAR-CLIP	21572407
MIRT539368	hsa-miR-20a-3p	PAR-CLIP	20371350
MIRT539369	hsa-miR-548o-3p	PAR-CLIP	22012620
MIRT539369	hsa-miR-548o-3p	PAR-CLIP	21572407
MIRT539369	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT539370	hsa-miR-1323	PAR-CLIP	22012620
MIRT539370	hsa-miR-1323	PAR-CLIP	21572407
MIRT539370	hsa-miR-1323	PAR-CLIP	20371350
MIRT539371	hsa-miR-4495	PAR-CLIP	22012620
MIRT539371	hsa-miR-4495	PAR-CLIP	21572407
MIRT539371	hsa-miR-4495	PAR-CLIP	20371350
MIRT539372	hsa-miR-2115-3p	PAR-CLIP	22012620
MIRT539372	hsa-miR-2115-3p	PAR-CLIP	21572407
MIRT539372	hsa-miR-2115-3p	PAR-CLIP	20371350
MIRT539373	hsa-miR-548av-3p	PAR-CLIP	22012620
MIRT539373	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT539373	hsa-miR-548av-3p	PAR-CLIP	20371350
MIRT539374	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT539374	hsa-miR-548f-3p	PAR-CLIP	21572407
MIRT539374	hsa-miR-548f-3p	PAR-CLIP	20371350
MIRT539375	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT539375	hsa-miR-548e-3p	PAR-CLIP	21572407
MIRT539375	hsa-miR-548e-3p	PAR-CLIP	20371350
MIRT539376	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT539376	hsa-miR-548az-3p	PAR-CLIP	21572407
MIRT539376	hsa-miR-548az-3p	PAR-CLIP	20371350
MIRT539377	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT539377	hsa-miR-548ar-3p	PAR-CLIP	21572407
MIRT539377	hsa-miR-548ar-3p	PAR-CLIP	20371350
MIRT539378	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT539378	hsa-miR-548a-3p	PAR-CLIP	21572407
MIRT539378	hsa-miR-548a-3p	PAR-CLIP	20371350
MIRT539379	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT539379	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT539379	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT539380	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT539380	hsa-miR-383-5p	PAR-CLIP	21572407
MIRT539380	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT539381	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT539381	hsa-miR-19b-3p	PAR-CLIP	22012620
MIRT539381	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT539381	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT539382	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT539382	hsa-miR-19a-3p	PAR-CLIP	22012620
MIRT539382	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT539382	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT539383	hsa-miR-6807-3p	PAR-CLIP	22012620
MIRT539383	hsa-miR-6807-3p	PAR-CLIP	21572407
MIRT539383	hsa-miR-6807-3p	PAR-CLIP	20371350
MIRT539384	hsa-miR-217	PAR-CLIP	22012620
MIRT539384	hsa-miR-217	PAR-CLIP	21572407
MIRT539384	hsa-miR-217	PAR-CLIP	20371350
MIRT559712	hsa-miR-6739-3p	PAR-CLIP	21572407
MIRT559712	hsa-miR-6739-3p	PAR-CLIP	20371350
MIRT559713	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT559713	hsa-miR-22-5p	PAR-CLIP	20371350
MIRT559714	hsa-miR-6881-5p	PAR-CLIP	21572407
MIRT559715	hsa-miR-6782-5p	PAR-CLIP	21572407
MIRT559716	hsa-miR-181c-3p	PAR-CLIP	21572407
MIRT559717	hsa-miR-5582-3p	PAR-CLIP	21572407

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002376	Process	Immune system process	NAS	15786719
GO:0004019	Function	Adenylosuccinate synthase activity	IBA	21873635
GO:0004019	Function	Adenylosuccinate synthase activity	IDA	2004783
GO:0004019	Function	Adenylosuccinate synthase activity	NAS	1592113
GO:0005515	Function	Protein binding	IPI	23455924, 24981860, 28514442
GO:0005525	Function	GTP binding	NAS	1592113, 15786719
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006167	Process	AMP biosynthetic process	IDA	2004783
GO:0006167	Process	AMP biosynthetic process	NAS	1592113, 15786719
GO:0006531	Process	Aspartate metabolic process	IEA
GO:0009168	Process	Purine ribonucleoside monophosphate biosynthetic process	TAS
GO:0014074	Process	Response to purine-containing compound	IEA
GO:0042301	Function	Phosphate ion binding	NAS	1592113, 15786719
GO:0044208	Process	'de novo' AMP biosynthetic process	IBA	21873635
GO:0044208	Process	'de novo' AMP biosynthetic process	IEA
GO:0046040	Process	IMP metabolic process	IBA	21873635
GO:0060359	Process	Response to ammonium ion	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071257	Process	Cellular response to electrical stimulus	IEA

MIM	HGNC	e!Ensembl
103060	292	ENSG00000035687

Protein

UniProt ID

P30520

Protein name

Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2)

Protein function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

PDB

2V40

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00709	Adenylsucc_synt	31 → 453	Adenylosuccinate synthetase	Domain

Sequence

MAFAETYPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRC
QGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGL
EGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLR
MCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYE
ALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAY
TTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALAL
TKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKE
LPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF

Sequence length

456

Interactions

View interactions

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