ADRB2 (adrenoceptor beta 2)

Gene

• Entrez ID: 154
• Gene name: Adrenoceptor beta 2
• Gene symbol: ADRB2
• Synonyms: ADRB2R, ADRBR, B2AR, BAR, BETA2AR
• Chromosome: 5
• Chromosome location: 5q32
• Summary: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson`s Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1042713	G>A,C	Risk-factor, benign, drug-response	Coding sequence variant, missense variant
rs1800888	C>T	Drug-response	Coding sequence variant, missense variant

Transcription factors

Transcription factor	Regulation	Reference
EZH2	Repression	17996646

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IDA	20395454
GO:0002024	Process	Diet induced thermogenesis	IEA
GO:0002025	Process	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	21873635
GO:0002028	Process	Regulation of sodium ion transport	IEA
GO:0002032	Process	Desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA	15123695
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004941	Function	Beta2-adrenergic receptor activity	IBA	21873635
GO:0004941	Function	Beta2-adrenergic receptor activity	IDA	15123695, 19710023
GO:0004941	Function	Beta2-adrenergic receptor activity	NAS	20395454
GO:0005515	Function	Protein binding	IPI	9560162, 9671706, 15123695, 15518545, 17148612, 17170700, 19424180, 19584355, 20353789, 20590567, 20733053, 23208550, 23236378, 23291003, 24405750, 28298427, 30157263, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005764	Component	Lysosome	TAS	9507004
GO:0005768	Component	Endosome	TAS	10734107
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA	27481942
GO:0005886	Component	Plasma membrane	IDA	9235896, 27481942
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	12297500, 19710023
GO:0006898	Process	Receptor-mediated endocytosis	IDA	15123695
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	1371121
GO:0007171	Process	Activation of transmembrane receptor protein tyrosine kinase activity	TAS	10734107
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	2823249
GO:0007190	Process	Activation of adenylate cyclase activity	IDA	15123695
GO:0008179	Function	Adenylate cyclase binding	IEA
GO:0008333	Process	Endosome to lysosome transport	TAS	9507004
GO:0009409	Process	Response to cold	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0010739	Process	Positive regulation of protein kinase A signaling	IGI	20395454
GO:0015459	Function	Potassium channel regulator activity	IDA	12297500
GO:0016020	Component	Membrane	NAS	20395454
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0030501	Process	Positive regulation of bone mineralization	IEA
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0031649	Process	Heat generation	IEA
GO:0040015	Process	Negative regulation of multicellular organism growth	IEA
GO:0042802	Function	Identical protein binding	IPI	15518545, 19763081, 20590567
GO:0042803	Function	Protein homodimerization activity	IDA	15123695
GO:0043235	Component	Receptor complex	IDA	15123695, 23382219
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	15123695
GO:0044877	Function	Protein-containing complex binding	IPI	20395454
GO:0045453	Process	Bone resorption	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045986	Process	Negative regulation of smooth muscle contraction	IBA	21873635
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0051380	Function	Norepinephrine binding	IBA	21873635
GO:0051380	Function	Norepinephrine binding	IDA	15123695
GO:0061024	Process	Membrane organization	TAS
GO:0061885	Process	Positive regulation of mini excitatory postsynaptic potential	IEA
GO:0071875	Process	Adrenergic receptor signaling pathway	IDA	19710023
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	21873635
GO:0071902	Process	Positive regulation of protein serine/threonine kinase activity	IGI	20395454
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	12387862
GO:1901098	Process	Positive regulation of autophagosome maturation	IDA	23708524
GO:1904504	Process	Positive regulation of lipophagy	IDA	23708524
GO:1904646	Process	Cellular response to amyloid-beta	IGI	20395454
GO:1990911	Process	Response to psychosocial stress	TAS	20395454
GO:2000481	Process	Positive regulation of cAMP-dependent protein kinase activity	TAS	20395454
GO:2000969	Process	Positive regulation of AMPA receptor activity	IGI	20395454

Other IDs

• MIM: 109690
• HGNC: 286
• e!Ensembl: ENSG00000169252

Protein

• UniProt ID: P07550
• Protein name: Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
• Protein function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
• PDB: 1GQ4, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 4QKX, 5D5A, 5D5B, 5D6L, 5JQH, 5X7D, 6E67, 6KR8, 6MXT, 6N48, 6NI3, 6OBA, 6PRZ, 6PS0, 6PS1, 6PS2, 6PS3, 6PS4, 6PS5, 6PS6, 7BZ2, 7DHI, 7DHR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	50 → 326	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
  FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
  IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
  AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
  HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
  NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
  GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

• Sequence length: 413