ADIPOR1 (adiponectin receptor 1)

Gene

• Entrez ID: 51094
• Gene name: Adiponectin receptor 1
• Gene symbol: ADIPOR1
• Synonyms: ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048047	hsa-miR-197-3p	CLASH	23622248
MIRT441261	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT441261	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT768907	hsa-miR-1254	CLIP-seq
MIRT768908	hsa-miR-127-5p	CLIP-seq
MIRT768909	hsa-miR-1278	CLIP-seq
MIRT768910	hsa-miR-1294	CLIP-seq
MIRT768911	hsa-miR-221	CLIP-seq
MIRT768912	hsa-miR-222	CLIP-seq
MIRT768913	hsa-miR-3116	CLIP-seq
MIRT768914	hsa-miR-3119	CLIP-seq
MIRT768915	hsa-miR-3184	CLIP-seq
MIRT768916	hsa-miR-3649	CLIP-seq
MIRT768917	hsa-miR-3690	CLIP-seq
MIRT768918	hsa-miR-3973	CLIP-seq
MIRT768919	hsa-miR-410	CLIP-seq
MIRT768920	hsa-miR-423-5p	CLIP-seq
MIRT768921	hsa-miR-4316	CLIP-seq
MIRT768922	hsa-miR-4426	CLIP-seq
MIRT768923	hsa-miR-4635	CLIP-seq
MIRT768924	hsa-miR-4638-3p	CLIP-seq
MIRT768925	hsa-miR-4647	CLIP-seq
MIRT768926	hsa-miR-4662b	CLIP-seq
MIRT768927	hsa-miR-4677-3p	CLIP-seq
MIRT768928	hsa-miR-4679	CLIP-seq
MIRT768929	hsa-miR-4786-3p	CLIP-seq
MIRT768930	hsa-miR-520g	CLIP-seq
MIRT768931	hsa-miR-520h	CLIP-seq
MIRT768932	hsa-miR-532-5p	CLIP-seq
MIRT768933	hsa-miR-548k	CLIP-seq
MIRT768934	hsa-miR-548n	CLIP-seq
MIRT768935	hsa-miR-548t	CLIP-seq
MIRT768936	hsa-miR-548v	CLIP-seq
MIRT768937	hsa-miR-593	CLIP-seq
MIRT768938	hsa-miR-595	CLIP-seq
MIRT768939	hsa-miR-603	CLIP-seq
MIRT768940	hsa-miR-607	CLIP-seq
MIRT768941	hsa-miR-648	CLIP-seq
MIRT768907	hsa-miR-1254	CLIP-seq
MIRT768908	hsa-miR-127-5p	CLIP-seq
MIRT768909	hsa-miR-1278	CLIP-seq
MIRT768910	hsa-miR-1294	CLIP-seq
MIRT768913	hsa-miR-3116	CLIP-seq
MIRT768942	hsa-miR-3143	CLIP-seq
MIRT768943	hsa-miR-3150b-3p	CLIP-seq
MIRT768944	hsa-miR-3180-5p	CLIP-seq
MIRT768945	hsa-miR-3182	CLIP-seq
MIRT768915	hsa-miR-3184	CLIP-seq
MIRT768946	hsa-miR-320a	CLIP-seq
MIRT768947	hsa-miR-320b	CLIP-seq
MIRT768948	hsa-miR-320c	CLIP-seq
MIRT768949	hsa-miR-320d	CLIP-seq
MIRT768916	hsa-miR-3649	CLIP-seq
MIRT768950	hsa-miR-3686	CLIP-seq
MIRT768917	hsa-miR-3690	CLIP-seq
MIRT768951	hsa-miR-376c	CLIP-seq
MIRT768920	hsa-miR-423-5p	CLIP-seq
MIRT768921	hsa-miR-4316	CLIP-seq
MIRT768922	hsa-miR-4426	CLIP-seq
MIRT768952	hsa-miR-4429	CLIP-seq
MIRT768953	hsa-miR-4443	CLIP-seq
MIRT768954	hsa-miR-4446-5p	CLIP-seq
MIRT768955	hsa-miR-4452	CLIP-seq
MIRT768956	hsa-miR-4477a	CLIP-seq
MIRT768957	hsa-miR-4480	CLIP-seq
MIRT768958	hsa-miR-455-3p	CLIP-seq
MIRT768923	hsa-miR-4635	CLIP-seq
MIRT768924	hsa-miR-4638-3p	CLIP-seq
MIRT768959	hsa-miR-4645-5p	CLIP-seq
MIRT768925	hsa-miR-4647	CLIP-seq
MIRT768960	hsa-miR-4659a-3p	CLIP-seq
MIRT768961	hsa-miR-4659b-3p	CLIP-seq
MIRT768926	hsa-miR-4662b	CLIP-seq
MIRT768962	hsa-miR-4673	CLIP-seq
MIRT768927	hsa-miR-4677-3p	CLIP-seq
MIRT768928	hsa-miR-4679	CLIP-seq
MIRT768963	hsa-miR-4684-5p	CLIP-seq
MIRT768964	hsa-miR-4698	CLIP-seq
MIRT768965	hsa-miR-4709-3p	CLIP-seq
MIRT768966	hsa-miR-4711-3p	CLIP-seq
MIRT768967	hsa-miR-4711-5p	CLIP-seq
MIRT768968	hsa-miR-4762-3p	CLIP-seq
MIRT768969	hsa-miR-4775	CLIP-seq
MIRT768970	hsa-miR-4777-5p	CLIP-seq
MIRT768971	hsa-miR-4784	CLIP-seq
MIRT768929	hsa-miR-4786-3p	CLIP-seq
MIRT768972	hsa-miR-518d-5p	CLIP-seq
MIRT768973	hsa-miR-519b-5p	CLIP-seq
MIRT768974	hsa-miR-519c-5p	CLIP-seq
MIRT768975	hsa-miR-520a-5p	CLIP-seq
MIRT768976	hsa-miR-520c-5p	CLIP-seq
MIRT768977	hsa-miR-522	CLIP-seq
MIRT768978	hsa-miR-525-5p	CLIP-seq
MIRT768979	hsa-miR-526a	CLIP-seq
MIRT768980	hsa-miR-590-3p	CLIP-seq
MIRT768937	hsa-miR-593	CLIP-seq
MIRT768939	hsa-miR-603	CLIP-seq
MIRT768981	hsa-miR-765	CLIP-seq
MIRT768908	hsa-miR-127-5p	CLIP-seq
MIRT1926738	hsa-miR-137	CLIP-seq
MIRT1926739	hsa-miR-1587	CLIP-seq
MIRT1926740	hsa-miR-2355-5p	CLIP-seq
MIRT768943	hsa-miR-3150b-3p	CLIP-seq
MIRT1926741	hsa-miR-3189-5p	CLIP-seq
MIRT1926742	hsa-miR-4312	CLIP-seq
MIRT1926743	hsa-miR-4417	CLIP-seq
MIRT1926744	hsa-miR-4453	CLIP-seq
MIRT1926745	hsa-miR-4455	CLIP-seq
MIRT1926746	hsa-miR-4492	CLIP-seq
MIRT1926747	hsa-miR-4498	CLIP-seq
MIRT1926748	hsa-miR-4538	CLIP-seq
MIRT1926749	hsa-miR-4656	CLIP-seq
MIRT768960	hsa-miR-4659a-3p	CLIP-seq
MIRT768961	hsa-miR-4659b-3p	CLIP-seq
MIRT1926750	hsa-miR-4663	CLIP-seq
MIRT1926751	hsa-miR-4675	CLIP-seq
MIRT1926752	hsa-miR-4689	CLIP-seq
MIRT1926753	hsa-miR-4741	CLIP-seq
MIRT1926754	hsa-miR-4758-3p	CLIP-seq
MIRT1926755	hsa-miR-4779	CLIP-seq
MIRT768971	hsa-miR-4784	CLIP-seq
MIRT1926756	hsa-miR-4796-3p	CLIP-seq
MIRT768932	hsa-miR-532-5p	CLIP-seq
MIRT1926757	hsa-miR-591	CLIP-seq
MIRT1926758	hsa-miR-609	CLIP-seq
MIRT1926759	hsa-miR-628-5p	CLIP-seq
MIRT1926760	hsa-miR-762	CLIP-seq
MIRT768909	hsa-miR-1278	CLIP-seq
MIRT768910	hsa-miR-1294	CLIP-seq
MIRT2167719	hsa-miR-3074-5p	CLIP-seq
MIRT768942	hsa-miR-3143	CLIP-seq
MIRT768943	hsa-miR-3150b-3p	CLIP-seq
MIRT768944	hsa-miR-3180-5p	CLIP-seq
MIRT768945	hsa-miR-3182	CLIP-seq
MIRT2167720	hsa-miR-3183	CLIP-seq
MIRT768915	hsa-miR-3184	CLIP-seq
MIRT768916	hsa-miR-3649	CLIP-seq
MIRT768950	hsa-miR-3686	CLIP-seq
MIRT2167721	hsa-miR-370	CLIP-seq
MIRT768951	hsa-miR-376c	CLIP-seq
MIRT768918	hsa-miR-3973	CLIP-seq
MIRT768919	hsa-miR-410	CLIP-seq
MIRT768920	hsa-miR-423-5p	CLIP-seq
MIRT768921	hsa-miR-4316	CLIP-seq
MIRT768922	hsa-miR-4426	CLIP-seq
MIRT768956	hsa-miR-4477a	CLIP-seq
MIRT768959	hsa-miR-4645-5p	CLIP-seq
MIRT768925	hsa-miR-4647	CLIP-seq
MIRT768960	hsa-miR-4659a-3p	CLIP-seq
MIRT768961	hsa-miR-4659b-3p	CLIP-seq
MIRT768926	hsa-miR-4662b	CLIP-seq
MIRT768962	hsa-miR-4673	CLIP-seq
MIRT768927	hsa-miR-4677-3p	CLIP-seq
MIRT768928	hsa-miR-4679	CLIP-seq
MIRT768967	hsa-miR-4711-5p	CLIP-seq
MIRT2167722	hsa-miR-4723-3p	CLIP-seq
MIRT768968	hsa-miR-4762-3p	CLIP-seq
MIRT768971	hsa-miR-4784	CLIP-seq
MIRT768975	hsa-miR-520a-5p	CLIP-seq
MIRT768930	hsa-miR-520g	CLIP-seq
MIRT768931	hsa-miR-520h	CLIP-seq
MIRT768978	hsa-miR-525-5p	CLIP-seq
MIRT768932	hsa-miR-532-5p	CLIP-seq
MIRT768933	hsa-miR-548k	CLIP-seq
MIRT768937	hsa-miR-593	CLIP-seq
MIRT1926740	hsa-miR-2355-5p	CLIP-seq
MIRT768943	hsa-miR-3150b-3p	CLIP-seq
MIRT1926741	hsa-miR-3189-5p	CLIP-seq
MIRT1926742	hsa-miR-4312	CLIP-seq
MIRT1926750	hsa-miR-4663	CLIP-seq
MIRT1926752	hsa-miR-4689	CLIP-seq
MIRT1926754	hsa-miR-4758-3p	CLIP-seq
MIRT1926755	hsa-miR-4779	CLIP-seq
MIRT768971	hsa-miR-4784	CLIP-seq
MIRT768932	hsa-miR-532-5p	CLIP-seq
MIRT1926757	hsa-miR-591	CLIP-seq
MIRT1926759	hsa-miR-628-5p	CLIP-seq
MIRT2470379	hsa-miR-1236	CLIP-seq
MIRT2470380	hsa-miR-1263	CLIP-seq
MIRT768908	hsa-miR-127-5p	CLIP-seq
MIRT768910	hsa-miR-1294	CLIP-seq
MIRT1926738	hsa-miR-137	CLIP-seq
MIRT1926739	hsa-miR-1587	CLIP-seq
MIRT1926740	hsa-miR-2355-5p	CLIP-seq
MIRT768943	hsa-miR-3150b-3p	CLIP-seq
MIRT2167720	hsa-miR-3183	CLIP-seq
MIRT768915	hsa-miR-3184	CLIP-seq
MIRT1926741	hsa-miR-3189-5p	CLIP-seq
MIRT2470381	hsa-miR-3688-3p	CLIP-seq
MIRT2470382	hsa-miR-3978	CLIP-seq
MIRT768920	hsa-miR-423-5p	CLIP-seq
MIRT2470383	hsa-miR-4291	CLIP-seq
MIRT1926742	hsa-miR-4312	CLIP-seq
MIRT768921	hsa-miR-4316	CLIP-seq
MIRT1926743	hsa-miR-4417	CLIP-seq
MIRT1926744	hsa-miR-4453	CLIP-seq
MIRT1926745	hsa-miR-4455	CLIP-seq
MIRT1926746	hsa-miR-4492	CLIP-seq
MIRT2470384	hsa-miR-4494	CLIP-seq
MIRT1926747	hsa-miR-4498	CLIP-seq
MIRT1926748	hsa-miR-4538	CLIP-seq
MIRT1926749	hsa-miR-4656	CLIP-seq
MIRT1926750	hsa-miR-4663	CLIP-seq
MIRT2470385	hsa-miR-4670-3p	CLIP-seq
MIRT1926751	hsa-miR-4675	CLIP-seq
MIRT768927	hsa-miR-4677-3p	CLIP-seq
MIRT768928	hsa-miR-4679	CLIP-seq
MIRT1926752	hsa-miR-4689	CLIP-seq
MIRT2470386	hsa-miR-4694-3p	CLIP-seq
MIRT2167722	hsa-miR-4723-3p	CLIP-seq
MIRT1926753	hsa-miR-4741	CLIP-seq
MIRT1926754	hsa-miR-4758-3p	CLIP-seq
MIRT1926755	hsa-miR-4779	CLIP-seq
MIRT768971	hsa-miR-4784	CLIP-seq
MIRT1926756	hsa-miR-4796-3p	CLIP-seq
MIRT2470387	hsa-miR-499a-5p	CLIP-seq
MIRT768932	hsa-miR-532-5p	CLIP-seq
MIRT2470388	hsa-miR-545	CLIP-seq
MIRT2470389	hsa-miR-561	CLIP-seq
MIRT1926757	hsa-miR-591	CLIP-seq
MIRT768937	hsa-miR-593	CLIP-seq
MIRT1926758	hsa-miR-609	CLIP-seq
MIRT1926759	hsa-miR-628-5p	CLIP-seq
MIRT1926760	hsa-miR-762	CLIP-seq
MIRT768910	hsa-miR-1294	CLIP-seq
MIRT1926738	hsa-miR-137	CLIP-seq
MIRT1926739	hsa-miR-1587	CLIP-seq
MIRT1926740	hsa-miR-2355-5p	CLIP-seq
MIRT768943	hsa-miR-3150b-3p	CLIP-seq
MIRT768915	hsa-miR-3184	CLIP-seq
MIRT1926741	hsa-miR-3189-5p	CLIP-seq
MIRT2470381	hsa-miR-3688-3p	CLIP-seq
MIRT2470382	hsa-miR-3978	CLIP-seq
MIRT768920	hsa-miR-423-5p	CLIP-seq
MIRT1926742	hsa-miR-4312	CLIP-seq
MIRT768921	hsa-miR-4316	CLIP-seq
MIRT1926743	hsa-miR-4417	CLIP-seq
MIRT1926745	hsa-miR-4455	CLIP-seq
MIRT1926746	hsa-miR-4492	CLIP-seq
MIRT1926747	hsa-miR-4498	CLIP-seq
MIRT1926749	hsa-miR-4656	CLIP-seq
MIRT1926750	hsa-miR-4663	CLIP-seq
MIRT1926751	hsa-miR-4675	CLIP-seq
MIRT768927	hsa-miR-4677-3p	CLIP-seq
MIRT768928	hsa-miR-4679	CLIP-seq
MIRT1926752	hsa-miR-4689	CLIP-seq
MIRT2470386	hsa-miR-4694-3p	CLIP-seq
MIRT1926753	hsa-miR-4741	CLIP-seq
MIRT1926754	hsa-miR-4758-3p	CLIP-seq
MIRT1926755	hsa-miR-4779	CLIP-seq
MIRT768971	hsa-miR-4784	CLIP-seq
MIRT1926756	hsa-miR-4796-3p	CLIP-seq
MIRT768932	hsa-miR-532-5p	CLIP-seq
MIRT2470389	hsa-miR-561	CLIP-seq
MIRT1926757	hsa-miR-591	CLIP-seq
MIRT768937	hsa-miR-593	CLIP-seq
MIRT1926758	hsa-miR-609	CLIP-seq
MIRT1926759	hsa-miR-628-5p	CLIP-seq
MIRT1926760	hsa-miR-762	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF3	Repression	20696134
FOXO1	Activation	20125105

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	19233263
GO:0005886	Component	Plasma membrane	TAS
GO:0009755	Process	Hormone-mediated signaling pathway	IDA	12802337
GO:0010633	Process	Negative regulation of epithelial cell migration	IMP	23776679
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IMP	23776679
GO:0010906	Process	Regulation of glucose metabolic process	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0019216	Process	Regulation of lipid metabolic process	ISS
GO:0019395	Process	Fatty acid oxidation	IDA	12802337
GO:0019901	Function	Protein kinase binding	IPI	19233263
GO:0030308	Process	Negative regulation of cell growth	IEA
GO:0031226	Component	Intrinsic component of plasma membrane	IDA	12802337
GO:0033210	Process	Leptin-mediated signaling pathway	IEA
GO:0033211	Process	Adiponectin-activated signaling pathway	IBA	21873635
GO:0033211	Process	Adiponectin-activated signaling pathway	IDA	12802337
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0042304	Process	Regulation of fatty acid biosynthetic process	TAS
GO:0042593	Process	Glucose homeostasis	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IMP	23776679
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	IEA
GO:0046628	Process	Positive regulation of insulin receptor signaling pathway	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0055100	Function	Adiponectin binding	IDA	12802337
GO:0097003	Function	Adipokinetic hormone receptor activity	IDA	12802337
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24531262
GO:1901223	Process	Negative regulation of NIK/NF-kappaB signaling	IMP	23776679

Other IDs

• MIM: 607945
• HGNC: 24040
• e!Ensembl: ENSG00000159346

Protein

• UniProt ID: Q96A54
• Protein name: Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I)
• Protein function: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-bin
• PDB: 5LXG, 6KRZ, 6KS0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03006	HlyIII	129 → 352	Haemolysin-III related	Family

• Sequence:

  MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEE
  EEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPS
  FRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
  VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLS
  IVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQM
  GWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQE
  FRYGLEGGCTDDTLL

• Sequence length: 375