ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)

Gene

• Entrez ID: 125
• Gene name: Alcohol dehydrogenase 1B (class I), beta polypeptide
• Gene symbol: ADH1B
• Synonyms: ADH2, HEL-S-117
• Chromosome: 4
• Chromosome location: 4q23
• Summary: The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT551507	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551506	hsa-miR-567	HITS-CLIP	21572407
MIRT551505	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551504	hsa-miR-3924	HITS-CLIP	21572407
MIRT551503	hsa-miR-568	HITS-CLIP	21572407
MIRT551502	hsa-miR-297	HITS-CLIP	21572407
MIRT551501	hsa-miR-3149	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	21572407
MIRT518107	hsa-miR-381-3p	HITS-CLIP	21572407
MIRT504589	hsa-miR-4280	HITS-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	HITS-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	HITS-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	HITS-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518103	hsa-miR-4705	HITS-CLIP	21572407
MIRT518102	hsa-let-7a-3p	HITS-CLIP	21572407
MIRT518101	hsa-let-7b-3p	HITS-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	21572407
MIRT518099	hsa-miR-98-3p	HITS-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	23313552
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT551507	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551506	hsa-miR-567	PAR-CLIP	21572407
MIRT551505	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551504	hsa-miR-3924	PAR-CLIP	21572407
MIRT551503	hsa-miR-568	PAR-CLIP	21572407
MIRT551502	hsa-miR-297	PAR-CLIP	21572407
MIRT551501	hsa-miR-3149	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	21572407
MIRT518107	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT504589	hsa-miR-4280	PAR-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	21572407
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518103	hsa-miR-4705	PAR-CLIP	21572407
MIRT518102	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT518101	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT518099	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	23446348
MIRT518107	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	23446348
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518103	hsa-miR-4705	PAR-CLIP	23446348
MIRT518102	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT518101	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT518099	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT551507	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551506	hsa-miR-567	HITS-CLIP	21572407
MIRT551505	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551504	hsa-miR-3924	HITS-CLIP	21572407
MIRT551503	hsa-miR-568	HITS-CLIP	21572407
MIRT551502	hsa-miR-297	HITS-CLIP	21572407
MIRT551501	hsa-miR-3149	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	21572407
MIRT518107	hsa-miR-381-3p	HITS-CLIP	21572407
MIRT504589	hsa-miR-4280	HITS-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	HITS-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	HITS-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	HITS-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518103	hsa-miR-4705	HITS-CLIP	21572407
MIRT518102	hsa-let-7a-3p	HITS-CLIP	21572407
MIRT518101	hsa-let-7b-3p	HITS-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	21572407
MIRT518099	hsa-miR-98-3p	HITS-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	23313552
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT551507	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551506	hsa-miR-567	PAR-CLIP	21572407
MIRT551505	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551504	hsa-miR-3924	PAR-CLIP	21572407
MIRT551503	hsa-miR-568	PAR-CLIP	21572407
MIRT551502	hsa-miR-297	PAR-CLIP	21572407
MIRT551501	hsa-miR-3149	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	21572407
MIRT518107	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT504589	hsa-miR-4280	PAR-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	21572407
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	21572407
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518103	hsa-miR-4705	PAR-CLIP	21572407
MIRT518102	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT518101	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT518099	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518108	hsa-miR-300	PAR-CLIP	23446348
MIRT518107	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	23446348
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518103	hsa-miR-4705	PAR-CLIP	23446348
MIRT518102	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT518101	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT518099	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT768618	hsa-miR-4686	CLIP-seq
MIRT768619	hsa-miR-4795-3p	CLIP-seq
MIRT768620	hsa-miR-4797-5p	CLIP-seq
MIRT768621	hsa-miR-548c-3p	CLIP-seq
MIRT1926688	hsa-miR-1303	CLIP-seq
MIRT1926689	hsa-miR-23a	CLIP-seq
MIRT1926690	hsa-miR-23b	CLIP-seq
MIRT1926691	hsa-miR-23c	CLIP-seq
MIRT1926692	hsa-miR-4422	CLIP-seq
MIRT1926693	hsa-miR-4699-5p	CLIP-seq
MIRT1926692	hsa-miR-4422	CLIP-seq
MIRT2167642	hsa-miR-4699-3p	CLIP-seq
MIRT2470328	hsa-miR-2355-5p	CLIP-seq
MIRT2674553	hsa-miR-1183	CLIP-seq
MIRT2674554	hsa-miR-1200	CLIP-seq
MIRT2674555	hsa-miR-1229	CLIP-seq
MIRT2674556	hsa-miR-1252	CLIP-seq
MIRT2674557	hsa-miR-224	CLIP-seq
MIRT2470328	hsa-miR-2355-5p	CLIP-seq
MIRT2674558	hsa-miR-299-3p	CLIP-seq
MIRT2674559	hsa-miR-3074-5p	CLIP-seq
MIRT2674560	hsa-miR-3127-5p	CLIP-seq
MIRT2674561	hsa-miR-3136-3p	CLIP-seq
MIRT2674562	hsa-miR-3140-5p	CLIP-seq
MIRT2674563	hsa-miR-3151	CLIP-seq
MIRT2674564	hsa-miR-338-3p	CLIP-seq
MIRT2674565	hsa-miR-3614-5p	CLIP-seq
MIRT2674566	hsa-miR-3653	CLIP-seq
MIRT2674567	hsa-miR-3658	CLIP-seq
MIRT2674568	hsa-miR-3662	CLIP-seq
MIRT2674569	hsa-miR-3682-5p	CLIP-seq
MIRT2674570	hsa-miR-3918	CLIP-seq
MIRT2674571	hsa-miR-3978	CLIP-seq
MIRT2674572	hsa-miR-421	CLIP-seq
MIRT2674573	hsa-miR-432	CLIP-seq
MIRT2674574	hsa-miR-4447	CLIP-seq
MIRT2674575	hsa-miR-4452	CLIP-seq
MIRT2674576	hsa-miR-4464	CLIP-seq
MIRT2674577	hsa-miR-4472	CLIP-seq
MIRT2674578	hsa-miR-4476	CLIP-seq
MIRT2674579	hsa-miR-4535	CLIP-seq
MIRT2674580	hsa-miR-4680-5p	CLIP-seq
MIRT2674581	hsa-miR-4693-5p	CLIP-seq
MIRT2674582	hsa-miR-4696	CLIP-seq
MIRT2167642	hsa-miR-4699-3p	CLIP-seq
MIRT1926693	hsa-miR-4699-5p	CLIP-seq
MIRT2674583	hsa-miR-4742-3p	CLIP-seq
MIRT2674584	hsa-miR-4744	CLIP-seq
MIRT2674585	hsa-miR-4748	CLIP-seq
MIRT2674586	hsa-miR-4776-5p	CLIP-seq
MIRT2674587	hsa-miR-4790-3p	CLIP-seq
MIRT768620	hsa-miR-4797-5p	CLIP-seq
MIRT2674588	hsa-miR-486-3p	CLIP-seq
MIRT2674589	hsa-miR-486-5p	CLIP-seq
MIRT2674590	hsa-miR-491-5p	CLIP-seq
MIRT2674591	hsa-miR-492	CLIP-seq
MIRT2674592	hsa-miR-513a-3p	CLIP-seq
MIRT2674593	hsa-miR-513a-5p	CLIP-seq
MIRT2674594	hsa-miR-587	CLIP-seq
MIRT2674595	hsa-miR-590-3p	CLIP-seq
MIRT2674596	hsa-miR-642b	CLIP-seq
MIRT2674597	hsa-miR-9	CLIP-seq
MIRT2674598	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820, 16787387
GO:0004024	Function	Alcohol dehydrogenase activity, zinc-dependent	IBA	21873635
GO:0004024	Function	Alcohol dehydrogenase activity, zinc-dependent	IDA	9982
GO:0004745	Function	Retinol dehydrogenase activity	IBA	21873635
GO:0004745	Function	Retinol dehydrogenase activity	IDA	15369820
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006069	Process	Ethanol oxidation	IBA	21873635
GO:0006069	Process	Ethanol oxidation	IDA	2398055
GO:0006069	Process	Ethanol oxidation	TAS
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	9982
GO:0042572	Process	Retinol metabolic process	IBA	21873635
GO:0042573	Process	Retinoic acid metabolic process	IBA	21873635

Other IDs

• MIM: 103720
• HGNC: 250
• e!Ensembl: ENSG00000196616

Protein

• UniProt ID: P00325
• Protein name: All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
• Protein function: Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyze the NADH-dependent reduct
• PDB: 1DEH, 1HDX, 1HDY, 1HDZ, 1HSZ, 1HTB, 1U3U, 1U3V, 3HUD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08240	ADH_N	34 → 161	Alcohol dehydrogenase GroES-like domain	Domain
  PF00107	ADH_zinc_N	203 → 339	Zinc-binding dehydrogenase	Family

• Sequence:

  MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
  PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNP
  RGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
  YGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATE
  CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ
  NLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGF
  DLLHSGKSIRTVLTF

• Sequence length: 375