ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)

Gene

• Entrez ID: 125
• Gene name: Alcohol dehydrogenase 1B (class I), beta polypeptide
• Gene symbol: ADH1B
• Synonyms: ADH2, HEL-S-117
• Chromosome: 4
• Chromosome location: 4q23
• Summary: The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT504583	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504583	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504583	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT504584	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504584	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT504584	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT504585	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT504585	hsa-miR-4758-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT504586	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT504586	hsa-miR-3189-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504587	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT504587	hsa-miR-5699-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504588	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT504588	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT504589	hsa-miR-4280	PAR-CLIP	23446348
MIRT504589	hsa-miR-4280	PAR-CLIP, HITS-CLIP	21572407
MIRT518099	hsa-miR-98-3p	PAR-CLIP	23446348
MIRT518099	hsa-miR-98-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518099	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP	23446348
MIRT518100	hsa-let-7f-1-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518100	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT518101	hsa-let-7b-3p	PAR-CLIP	23446348
MIRT518101	hsa-let-7b-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518101	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT518102	hsa-let-7a-3p	PAR-CLIP	23446348
MIRT518102	hsa-let-7a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518102	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT518103	hsa-miR-4705	PAR-CLIP	23446348
MIRT518103	hsa-miR-4705	PAR-CLIP, HITS-CLIP	21572407
MIRT518103	hsa-miR-4705	HITS-CLIP	23824327
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP	23446348
MIRT518104	hsa-miR-4666a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518104	hsa-miR-4666a-3p	HITS-CLIP	23824327
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT518105	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	PAR-CLIP	23446348
MIRT518106	hsa-miR-34b-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518106	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	PAR-CLIP	23446348
MIRT518107	hsa-miR-381-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23824327
MIRT518107	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT518108	hsa-miR-300	PAR-CLIP	23446348
MIRT518108	hsa-miR-300	PAR-CLIP, HITS-CLIP	21572407
MIRT518108	hsa-miR-300	HITS-CLIP	23824327
MIRT518108	hsa-miR-300	HITS-CLIP	23313552
MIRT551501	hsa-miR-3149	PAR-CLIP, HITS-CLIP	21572407
MIRT551502	hsa-miR-297	PAR-CLIP, HITS-CLIP	21572407
MIRT551503	hsa-miR-568	PAR-CLIP, HITS-CLIP	21572407
MIRT551504	hsa-miR-3924	PAR-CLIP, HITS-CLIP	21572407
MIRT551505	hsa-miR-223-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT551506	hsa-miR-567	PAR-CLIP, HITS-CLIP	21572407
MIRT551507	hsa-miR-511-3p	PAR-CLIP, HITS-CLIP	21572407

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820, 16787387
GO:0004024	Function	Alcohol dehydrogenase activity, zinc-dependent	IBA	21873635
GO:0004024	Function	Alcohol dehydrogenase activity, zinc-dependent	IDA	9982
GO:0004745	Function	Retinol dehydrogenase activity	IBA	21873635
GO:0004745	Function	Retinol dehydrogenase activity	IDA	15369820
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006069	Process	Ethanol oxidation	IBA	21873635
GO:0006069	Process	Ethanol oxidation	IDA	2398055
GO:0006069	Process	Ethanol oxidation	TAS
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	9982
GO:0042572	Process	Retinol metabolic process	IBA	21873635
GO:0042573	Process	Retinoic acid metabolic process	IBA	21873635

Other IDs

• MIM: 103720
• HGNC: 250
• e!Ensembl: ENSG00000196616

Protein

• UniProt ID: P00325
• Protein name: All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
• Protein function: Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).
• PDB: 1DEH, 1HDX, 1HDY, 1HDZ, 1HSZ, 1HTB, 1U3U, 1U3V, 3HUD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08240	ADH_N	34 → 161	Alcohol dehydrogenase GroES-like domain	Domain
  PF00107	ADH_zinc_N	203 → 339	Zinc-binding dehydrogenase	Family

• Sequence:

  MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
  PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNP
  RGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
  YGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATE
  CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ
  NLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGF
  DLLHSGKSIRTVLTF

• Sequence length: 375