ADCY9 (adenylate cyclase 9)

Gene

• Entrez ID: 115
• Gene name: Adenylate cyclase 9
• Gene symbol: ADCY9
• Synonyms: AC9, ACIX
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016333	hsa-miR-193b-3p	Microarray	20304954
MIRT022222	hsa-miR-124-3p	Microarray	18668037
MIRT025695	hsa-miR-7-5p	Microarray	19073608
MIRT027498	hsa-miR-98-5p	Microarray	19088304
MIRT032153	hsa-let-7d-5p	Sequencing	20371350
MIRT037005	hsa-miR-877-3p	CLASH	23622248
MIRT037595	hsa-miR-744-5p	CLASH	23622248
MIRT039580	hsa-miR-33b-5p	CLASH	23622248
MIRT043559	hsa-miR-331-3p	CLASH	23622248
MIRT047729	hsa-miR-10a-5p	CLASH	23622248
MIRT048684	hsa-miR-99a-5p	CLASH	23622248
MIRT054648	hsa-miR-181b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24269684
MIRT054648	hsa-miR-181b-5p	PAR-CLIP	26701625
MIRT494822	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT494823	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT494824	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT494825	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT494826	hsa-miR-5698	PAR-CLIP	23592263
MIRT494827	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT494828	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT494829	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT494830	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT494831	hsa-miR-3656	PAR-CLIP	23592263
MIRT494832	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT494833	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT494834	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT494835	hsa-miR-6132	PAR-CLIP	23592263
MIRT494836	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT494837	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT494838	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT494839	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT494840	hsa-miR-3943	PAR-CLIP	23592263
MIRT512308	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512308	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT512308	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT512308	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT512309	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512309	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT512309	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT512309	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT512310	hsa-miR-3201	PAR-CLIP	23446348
MIRT512310	hsa-miR-3201	PAR-CLIP, HITS-CLIP	21572407
MIRT512310	hsa-miR-3201	PAR-CLIP	20371350
MIRT512311	hsa-miR-4791	PAR-CLIP	23446348
MIRT512311	hsa-miR-4791	PAR-CLIP, HITS-CLIP	21572407
MIRT512311	hsa-miR-4791	PAR-CLIP	20371350
MIRT512312	hsa-miR-8076	PAR-CLIP	23446348
MIRT512312	hsa-miR-8076	PAR-CLIP, HITS-CLIP	21572407
MIRT512312	hsa-miR-8076	PAR-CLIP	20371350
MIRT512313	hsa-miR-1246	PAR-CLIP	23446348
MIRT512313	hsa-miR-1246	PAR-CLIP, HITS-CLIP	21572407
MIRT512313	hsa-miR-1246	PAR-CLIP	20371350
MIRT512314	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512314	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT512314	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT512314	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT512315	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT512315	hsa-miR-410-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT512315	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT705887	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT705888	hsa-miR-29b-2-5p	HITS-CLIP	23313552
MIRT705889	hsa-miR-5047	HITS-CLIP	23313552
MIRT705890	hsa-miR-1301-3p	HITS-CLIP	23313552
MIRT705891	hsa-miR-7156-3p	HITS-CLIP	23313552
MIRT705892	hsa-miR-4436b-5p	HITS-CLIP	23313552
MIRT705893	hsa-miR-185-3p	HITS-CLIP	23313552
MIRT705894	hsa-miR-4656	HITS-CLIP	23313552
MIRT705895	hsa-miR-4448	HITS-CLIP	23313552
MIRT705896	hsa-miR-4660	HITS-CLIP	23313552
MIRT705897	hsa-miR-3177-3p	HITS-CLIP	23313552
MIRT705898	hsa-miR-4508	HITS-CLIP	23313552
MIRT705899	hsa-miR-3189-3p	HITS-CLIP	23313552
MIRT705900	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT705901	hsa-miR-6736-3p	HITS-CLIP	23313552
MIRT738024	hsa-miR-181a-5p	PAR-CLIP	26701625
MIRT738039	hsa-miR-181c-5p	PAR-CLIP	26701625
MIRT738047	hsa-miR-181d-5p	PAR-CLIP	26701625
MIRT742093	hsa-miR-3671	PAR-CLIP	26701625
MIRT743481	hsa-miR-4262	PAR-CLIP	26701625
MIRT748898	hsa-miR-4789-5p	PAR-CLIP	26701625
MIRT749394	hsa-miR-5004-5p	PAR-CLIP	26701625
MIRT751744	hsa-miR-607	PAR-CLIP	26701625
MIRT756952	hsa-miR-6825-5p	PAR-CLIP	26701625
MIRT758825	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT759210	hsa-miR-7154-3p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0003091	Process	Renal water homeostasis	TAS
GO:0004016	Function	Adenylate cyclase activity	IBA	21873635
GO:0004016	Function	Adenylate cyclase activity	IDA	9628827
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	10987815
GO:0006171	Process	CAMP biosynthetic process	IDA	9628827, 10987815
GO:0007165	Process	Signal transduction	TAS	9628827
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	9628827
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS
GO:0007190	Process	Activation of adenylate cyclase activity	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS
GO:0016021	Component	Integral component of membrane	IDA	9628827
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0034199	Process	Activation of protein kinase A activity	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0071377	Process	Cellular response to glucagon stimulus	TAS
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IMP	9628827

Other IDs

• MIM: 603302
• HGNC: 240
• e!Ensembl: ENSG00000162104

Protein

• UniProt ID: O60503
• Protein name: Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9)
• Protein function: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00211	Guanylate_cyc	385 → 573	Adenylate and Guanylate cyclase catalytic domain	Domain
  PF00211	Guanylate_cyc	1049 → 1243	Adenylate and Guanylate cyclase catalytic domain	Domain

• Sequence:

  MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
  GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
  FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
  LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
  PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
  MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
  HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
  DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
  KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
  DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
  SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
  STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
  REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF
  ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR
  MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS
  AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER
  NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK
  IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE
  CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE
  FAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT
  GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP
  DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE
  RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV

• Sequence length: 1353