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ADCY7 (adenylate cyclase 7)

Gene

Adenylate cyclase 7

ADCY7

AC7

16

16q12.1

This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characteriz

Show/Hide all(194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018909	hsa-miR-335-5p	Microarray	18185580
MIRT527570	hsa-miR-302f	PAR-CLIP	22012620
MIRT527571	hsa-miR-634	PAR-CLIP	22012620
MIRT527569	hsa-miR-4310	PAR-CLIP	22012620
MIRT527568	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT527567	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT527566	hsa-miR-938	PAR-CLIP	22012620
MIRT527565	hsa-miR-6886-3p	PAR-CLIP	22012620
MIRT527564	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT527563	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT527562	hsa-miR-5590-5p	PAR-CLIP	22012620
MIRT527560	hsa-miR-4659a-5p	PAR-CLIP	22012620
MIRT527561	hsa-miR-4659b-5p	PAR-CLIP	22012620
MIRT527559	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT527558	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT527557	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT527556	hsa-miR-4776-3p	PAR-CLIP	22012620
MIRT527570	hsa-miR-302f	PAR-CLIP	22012620
MIRT527571	hsa-miR-634	PAR-CLIP	22012620
MIRT527569	hsa-miR-4310	PAR-CLIP	22012620
MIRT527568	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT527567	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT527566	hsa-miR-938	PAR-CLIP	22012620
MIRT527565	hsa-miR-6886-3p	PAR-CLIP	22012620
MIRT527564	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT527563	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT527562	hsa-miR-5590-5p	PAR-CLIP	22012620
MIRT527560	hsa-miR-4659a-5p	PAR-CLIP	22012620
MIRT527561	hsa-miR-4659b-5p	PAR-CLIP	22012620
MIRT527559	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT527558	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT527557	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT527556	hsa-miR-4776-3p	PAR-CLIP	22012620
MIRT768122	hsa-miR-103a	CLIP-seq
MIRT768123	hsa-miR-107	CLIP-seq
MIRT768124	hsa-miR-1202	CLIP-seq
MIRT768125	hsa-miR-1207-5p	CLIP-seq
MIRT768126	hsa-miR-1225-3p	CLIP-seq
MIRT768127	hsa-miR-127-5p	CLIP-seq
MIRT768128	hsa-miR-1279	CLIP-seq
MIRT768129	hsa-miR-135a	CLIP-seq
MIRT768130	hsa-miR-135b	CLIP-seq
MIRT768131	hsa-miR-147b	CLIP-seq
MIRT768132	hsa-miR-1539	CLIP-seq
MIRT768133	hsa-miR-1909	CLIP-seq
MIRT768134	hsa-miR-210	CLIP-seq
MIRT768135	hsa-miR-24	CLIP-seq
MIRT768136	hsa-miR-3120-3p	CLIP-seq
MIRT768137	hsa-miR-3175	CLIP-seq
MIRT768138	hsa-miR-3614-5p	CLIP-seq
MIRT768139	hsa-miR-3617	CLIP-seq
MIRT768140	hsa-miR-3669	CLIP-seq
MIRT768141	hsa-miR-3943	CLIP-seq
MIRT768142	hsa-miR-3944-5p	CLIP-seq
MIRT768143	hsa-miR-3972	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768145	hsa-miR-4284	CLIP-seq
MIRT768146	hsa-miR-4436b-5p	CLIP-seq
MIRT768147	hsa-miR-4530	CLIP-seq
MIRT768148	hsa-miR-455-5p	CLIP-seq
MIRT768149	hsa-miR-4659a-3p	CLIP-seq
MIRT768150	hsa-miR-4659b-3p	CLIP-seq
MIRT768151	hsa-miR-4712-3p	CLIP-seq
MIRT768152	hsa-miR-4729	CLIP-seq
MIRT768153	hsa-miR-4755-3p	CLIP-seq
MIRT768154	hsa-miR-4762-5p	CLIP-seq
MIRT768155	hsa-miR-4763-3p	CLIP-seq
MIRT768156	hsa-miR-4768-3p	CLIP-seq
MIRT768157	hsa-miR-4789-5p	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768159	hsa-miR-548ac	CLIP-seq
MIRT768160	hsa-miR-548ae	CLIP-seq
MIRT768161	hsa-miR-548aj	CLIP-seq
MIRT768162	hsa-miR-548am	CLIP-seq
MIRT768163	hsa-miR-548d-3p	CLIP-seq
MIRT768164	hsa-miR-548x	CLIP-seq
MIRT768165	hsa-miR-548z	CLIP-seq
MIRT768166	hsa-miR-558	CLIP-seq
MIRT768167	hsa-miR-579	CLIP-seq
MIRT768168	hsa-miR-604	CLIP-seq
MIRT768169	hsa-miR-641	CLIP-seq
MIRT768170	hsa-miR-642b	CLIP-seq
MIRT768171	hsa-miR-647	CLIP-seq
MIRT768172	hsa-miR-665	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT1926578	hsa-miR-539	CLIP-seq
MIRT2167569	hsa-miR-128	CLIP-seq
MIRT2167570	hsa-miR-3144-5p	CLIP-seq
MIRT2167571	hsa-miR-3191	CLIP-seq
MIRT2167572	hsa-miR-3200-5p	CLIP-seq
MIRT2167573	hsa-miR-3663-3p	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT2167574	hsa-miR-4269	CLIP-seq
MIRT2167575	hsa-miR-4303	CLIP-seq
MIRT2167576	hsa-miR-4645-5p	CLIP-seq
MIRT2167577	hsa-miR-4652-5p	CLIP-seq
MIRT2167578	hsa-miR-4673	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT2443241	hsa-miR-10a	CLIP-seq
MIRT2443242	hsa-miR-10b	CLIP-seq
MIRT2443243	hsa-miR-2276	CLIP-seq
MIRT2443244	hsa-miR-4704-3p	CLIP-seq
MIRT2443245	hsa-miR-4772-3p	CLIP-seq
MIRT2470134	hsa-miR-1207-3p	CLIP-seq
MIRT2470135	hsa-miR-1254	CLIP-seq
MIRT2470136	hsa-miR-1266	CLIP-seq
MIRT2470137	hsa-miR-129-3p	CLIP-seq
MIRT2470138	hsa-miR-1912	CLIP-seq
MIRT2470139	hsa-miR-1915	CLIP-seq
MIRT2470140	hsa-miR-19a	CLIP-seq
MIRT2470141	hsa-miR-19b	CLIP-seq
MIRT2470142	hsa-miR-205	CLIP-seq
MIRT2470143	hsa-miR-2113	CLIP-seq
MIRT768135	hsa-miR-24	CLIP-seq
MIRT2470144	hsa-miR-3065-3p	CLIP-seq
MIRT2470145	hsa-miR-3116	CLIP-seq
MIRT2470146	hsa-miR-3130-5p	CLIP-seq
MIRT2470147	hsa-miR-3156-5p	CLIP-seq
MIRT2470148	hsa-miR-3176	CLIP-seq
MIRT2470149	hsa-miR-337-5p	CLIP-seq
MIRT2470150	hsa-miR-3650	CLIP-seq
MIRT2470151	hsa-miR-371-5p	CLIP-seq
MIRT2470152	hsa-miR-371b-5p	CLIP-seq
MIRT2470153	hsa-miR-3922-3p	CLIP-seq
MIRT2470154	hsa-miR-3925-3p	CLIP-seq
MIRT2470155	hsa-miR-3942-3p	CLIP-seq
MIRT2470156	hsa-miR-3973	CLIP-seq
MIRT2470157	hsa-miR-4252	CLIP-seq
MIRT2470158	hsa-miR-4261	CLIP-seq
MIRT2470159	hsa-miR-4267	CLIP-seq
MIRT2167574	hsa-miR-4269	CLIP-seq
MIRT2470160	hsa-miR-4270	CLIP-seq
MIRT2470161	hsa-miR-4441	CLIP-seq
MIRT2470162	hsa-miR-4482	CLIP-seq
MIRT2470163	hsa-miR-4495	CLIP-seq
MIRT2470164	hsa-miR-4518	CLIP-seq
MIRT2470165	hsa-miR-451b	CLIP-seq
MIRT2167576	hsa-miR-4645-5p	CLIP-seq
MIRT2167578	hsa-miR-4673	CLIP-seq
MIRT2470166	hsa-miR-4690-3p	CLIP-seq
MIRT2470167	hsa-miR-4695-3p	CLIP-seq
MIRT2470168	hsa-miR-4726-3p	CLIP-seq
MIRT2470169	hsa-miR-4738-3p	CLIP-seq
MIRT2470170	hsa-miR-515-5p	CLIP-seq
MIRT2470171	hsa-miR-520g	CLIP-seq
MIRT2470172	hsa-miR-520h	CLIP-seq
MIRT2470173	hsa-miR-543	CLIP-seq
MIRT2470174	hsa-miR-548g	CLIP-seq
MIRT2470175	hsa-miR-561	CLIP-seq
MIRT2470176	hsa-miR-766	CLIP-seq
MIRT2470177	hsa-miR-875-3p	CLIP-seq
MIRT2470136	hsa-miR-1266	CLIP-seq
MIRT2674541	hsa-miR-1294	CLIP-seq
MIRT2470139	hsa-miR-1915	CLIP-seq
MIRT768135	hsa-miR-24	CLIP-seq
MIRT2470147	hsa-miR-3156-5p	CLIP-seq
MIRT2674542	hsa-miR-3180	CLIP-seq
MIRT2674543	hsa-miR-3180-3p	CLIP-seq
MIRT2674544	hsa-miR-3184	CLIP-seq
MIRT2674545	hsa-miR-3196	CLIP-seq
MIRT2470149	hsa-miR-337-5p	CLIP-seq
MIRT2470151	hsa-miR-371-5p	CLIP-seq
MIRT2470152	hsa-miR-371b-5p	CLIP-seq
MIRT2470155	hsa-miR-3942-3p	CLIP-seq
MIRT2470156	hsa-miR-3973	CLIP-seq
MIRT2674546	hsa-miR-423-5p	CLIP-seq
MIRT2470160	hsa-miR-4270	CLIP-seq
MIRT2674547	hsa-miR-4316	CLIP-seq
MIRT2470161	hsa-miR-4441	CLIP-seq
MIRT2674548	hsa-miR-4488	CLIP-seq
MIRT2470164	hsa-miR-4518	CLIP-seq
MIRT2470165	hsa-miR-451b	CLIP-seq
MIRT2470166	hsa-miR-4690-3p	CLIP-seq
MIRT2470167	hsa-miR-4695-3p	CLIP-seq
MIRT2674549	hsa-miR-4697-5p	CLIP-seq
MIRT2470168	hsa-miR-4726-3p	CLIP-seq
MIRT2470171	hsa-miR-520g	CLIP-seq
MIRT2470172	hsa-miR-520h	CLIP-seq
MIRT768159	hsa-miR-548ac	CLIP-seq
MIRT768160	hsa-miR-548ae	CLIP-seq
MIRT768161	hsa-miR-548aj	CLIP-seq
MIRT768162	hsa-miR-548am	CLIP-seq
MIRT768163	hsa-miR-548d-3p	CLIP-seq
MIRT768164	hsa-miR-548x	CLIP-seq
MIRT768165	hsa-miR-548z	CLIP-seq
MIRT768172	hsa-miR-665	CLIP-seq
MIRT2674550	hsa-miR-758	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002819	Process	Regulation of adaptive immune response	ISS
GO:0003091	Process	Renal water homeostasis	TAS
GO:0004016	Function	Adenylate cyclase activity	IBA	21873635
GO:0004016	Function	Adenylate cyclase activity	IDA	11113152, 17760784
GO:0004016	Function	Adenylate cyclase activity	IMP	18541530, 23178822, 23229509, 23842570
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006171	Process	CAMP biosynthetic process	IDA	11113152, 17760784
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS
GO:0007190	Process	Activation of adenylate cyclase activity	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS
GO:0016021	Component	Integral component of membrane	IDA	11113152
GO:0034199	Process	Activation of protein kinase A activity	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0060135	Process	Maternal process involved in female pregnancy	IEA
GO:0071285	Process	Cellular response to lithium ion	ISS
GO:0071361	Process	Cellular response to ethanol	IDA	12454008, 17760784
GO:0071377	Process	Cellular response to glucagon stimulus	TAS
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS

MIM	HGNC	e!Ensembl
600385	238	ENSG00000121281

Protein

UniProt ID

Protein name

Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)

Protein function

Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through syner

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16214	AC_N	15 → 256	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
PF00211	Guanylate_cyc	270 → 447	Adenylate and Guanylate cyclase catalytic domain	Domain
PF06327	DUF1053	485 → 593	Domain of Unknown Function (DUF1053)	Family
PF00211	Guanylate_cyc	870 → 1069	Adenylate and Guanylate cyclase catalytic domain	Domain

Sequence

MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN

Sequence length

1080

Interactions

View interactions

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