ADCY2 (adenylate cyclase 2)

Gene

• Entrez ID: 108
• Gene name: Adenylate cyclase 2
• Gene symbol: ADCY2
• Synonyms: AC2, HBAC2
• Chromosome: 5
• Chromosome location: 5p15.31
• Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	ISS
GO:0003091	Process	Renal water homeostasis	TAS
GO:0004016	Function	Adenylate cyclase activity	IBA	21873635
GO:0004016	Function	Adenylate cyclase activity	ISS
GO:0004016	Function	Adenylate cyclase activity	NAS	1427768
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11549699
GO:0005886	Component	Plasma membrane	IDA	11549699
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006171	Process	CAMP biosynthetic process	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS
GO:0007190	Process	Activation of adenylate cyclase activity	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS
GO:0008179	Function	Adenylate cyclase binding	ISS
GO:0016020	Component	Membrane	ISS
GO:0019933	Process	CAMP-mediated signaling	ISS
GO:0030145	Function	Manganese ion binding	ISS
GO:0030425	Component	Dendrite	ISS
GO:0034199	Process	Activation of protein kinase A activity	TAS
GO:0045121	Component	Membrane raft	ISS
GO:0071377	Process	Cellular response to glucagon stimulus	TAS
GO:1904322	Process	Cellular response to forskolin	ISS

Other IDs

• MIM: 103071
• HGNC: 233
• e!Ensembl: ENSG00000078295

Protein

• UniProt ID: Q08462
• Protein name: Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)
• Protein function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16214	AC_N	28 → 266	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
  PF00211	Guanylate_cyc	281 → 465	Adenylate and Guanylate cyclase catalytic domain	Domain
  PF06327	DUF1053	495 → 600	Domain of Unknown Function (DUF1053)	Family
  PF00211	Guanylate_cyc	878 → 1078	Adenylate and Guanylate cyclase catalytic domain	Domain

• Sequence:

  MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA
  LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM
  GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
  PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ
  ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT
  RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
  MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG
  VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR
  HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
  RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF
  KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP
  LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
  ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT
  HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK
  EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY
  TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS
  QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI
  WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM
  SRSLSQSNVAS

• Sequence length: 1091