ADAL (adenosine deaminase like)

Gene

• Entrez ID: 161823
• Gene name: Adenosine deaminase like
• Gene symbol: ADAL
• Synonyms: HsMAPDA
• Chromosome: 15
• Chromosome location: 15q15.3

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004000	Function	Adenosine deaminase activity	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006154	Process	Adenosine catabolic process	IBA	21873635
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0017144	Process	Drug metabolic process	TAS
GO:0043101	Process	Purine-containing compound salvage	TAS
GO:0046103	Process	Inosine biosynthetic process	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 619346
• HGNC: 31853
• e!Ensembl: ENSG00000168803

Protein

• UniProt ID: Q6DHV7
• Protein name: Adenosine deaminase-like protein (EC 3.5.4.-) (Adenosine deaminase-like protein isoform 1) (N6-mAMP deaminase) (HsMAPDA) (N6-methyl-AMP aminohydrolase)
• Protein function: Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00962	A_deaminase	17 → 344	Adenosine/AMP deaminase	Domain

• Sequence:

  MIEAEEQQPCKTDFYSELPKVELHAHLNGSISSHTMKKLIAQKPDLKIHDQMTVIDKGKK
  RTLEECFQMFQTIHQLTSSPEDILMVTKDVIKEFADDGVKYLELRSTPRRENATGMTKKT
  YVESILEGIKQSKQENLDIDVRYLIAVDRRGGPLVAKETVKLAEEFFLSTEGTVLGLDLS
  GDPTVGQAKDFLEPLLEAKKAGLKLALHLSEIPNQKKETQILLDLLPDRIGHGTFLNSGE
  GGSLDLVDFVRQHRIPLELCLTSNVKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFAT
  HLSQEYQLAAETFNLTQSQVWDLSYESINYIFASDSTRSELRKKWNHLKPRVLHI

• Sequence length: 355