ACY1 (aminoacylase 1)

Gene

• Entrez ID: 95
• Gene name: Aminoacylase 1
• Gene symbol: ACY1
• Synonyms: ACY-1, ACY1D, HEL-S-5
• Chromosome: 3
• Chromosome location: 3p21.2
• Summary: This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gen

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT705960	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT705959	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT705958	hsa-miR-4323	HITS-CLIP	23313552
MIRT705957	hsa-miR-4688	HITS-CLIP	23313552
MIRT705956	hsa-miR-6743-5p	HITS-CLIP	23313552
MIRT705955	hsa-miR-1915-3p	HITS-CLIP	23313552
MIRT705954	hsa-miR-6764-5p	HITS-CLIP	23313552
MIRT705953	hsa-miR-3189-3p	HITS-CLIP	23313552
MIRT705952	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT705951	hsa-miR-671-5p	HITS-CLIP	23313552
MIRT705950	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT705949	hsa-miR-92a-1-5p	HITS-CLIP	23313552
MIRT705948	hsa-miR-4425	HITS-CLIP	23313552
MIRT705947	hsa-miR-6079	HITS-CLIP	23313552
MIRT705946	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT705945	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT705944	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT705943	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT705942	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT705941	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT705940	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT705960	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT705959	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT705958	hsa-miR-4323	HITS-CLIP	23313552
MIRT705957	hsa-miR-4688	HITS-CLIP	23313552
MIRT705956	hsa-miR-6743-5p	HITS-CLIP	23313552
MIRT705955	hsa-miR-1915-3p	HITS-CLIP	23313552
MIRT705954	hsa-miR-6764-5p	HITS-CLIP	23313552
MIRT705953	hsa-miR-3189-3p	HITS-CLIP	23313552
MIRT705952	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT705951	hsa-miR-671-5p	HITS-CLIP	23313552
MIRT705950	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT705949	hsa-miR-92a-1-5p	HITS-CLIP	23313552
MIRT705948	hsa-miR-4425	HITS-CLIP	23313552
MIRT705947	hsa-miR-6079	HITS-CLIP	23313552
MIRT705946	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT705945	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT705944	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT705943	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT705942	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT705941	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT705940	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT765697	hsa-miR-1915	CLIP-seq
MIRT765697	hsa-miR-1915	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004046	Function	Aminoacylase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	21044950, 28514442, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0006520	Process	Cellular amino acid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0042802	Function	Identical protein binding	IPI	16189514, 21516116, 25502805, 31515488, 32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070062	Component	Extracellular exosome	IDA	21082674

Other IDs

• MIM: 104620
• HGNC: 177
• e!Ensembl: ENSG00000243989

Protein

• UniProt ID: Q03154
• Protein name: Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase)
• Protein function: Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids.
• PDB: 1Q7L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01546	Peptidase_M20	76 → 397	Peptidase family M20/M25/M40	Family
  PF07687	M20_dimer	188 → 302	Peptidase dimerisation domain	Domain

• Sequence:

  MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVV
  TVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQ
  YLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANP
  TDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSN
  PHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEG
  VTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPAL
  GFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS

• Sequence length: 408