ACTC1 (actin alpha cardiac muscle 1)

Gene

• Entrez ID: 70
• Gene name: Actin alpha cardiac muscle 1
• Gene symbol: ACTC1
• Synonyms: ACTC, ASD5, CMD1R, CMH11, LVNC4
• Chromosome: 15
• Chromosome location: 15q14
• Summary: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023839	hsa-miR-1-3p	Proteomics	18668040
MIRT731629	hsa-miR-139-5p	Luciferase reporter assay	27139165
MIRT783026	hsa-let-7c-3p	HITS-CLIP	27418678
MIRT783791	hsa-miR-142-5p	HITS-CLIP	27418678
MIRT784317	hsa-miR-25-3p	HITS-CLIP	27418678
MIRT784400	hsa-miR-299-5p	HITS-CLIP	27418678
MIRT784406	hsa-miR-29b-1-5p	HITS-CLIP	27418678
MIRT784500	hsa-miR-30a-5p	HITS-CLIP	27418678
MIRT784513	hsa-miR-30b-5p	HITS-CLIP	27418678
MIRT784539	hsa-miR-30c-5p	HITS-CLIP	27418678
MIRT784546	hsa-miR-30d-5p	HITS-CLIP	27418678
MIRT784553	hsa-miR-30e-5p	HITS-CLIP	27418678
MIRT784558	hsa-miR-3119	HITS-CLIP	27418678
MIRT784595	hsa-miR-3126-5p	HITS-CLIP	27418678
MIRT784653	hsa-miR-3145-5p	HITS-CLIP	27418678
MIRT784763	hsa-miR-3188	HITS-CLIP	27418678
MIRT784842	hsa-miR-3202	HITS-CLIP	27418678
MIRT784852	hsa-miR-32-5p	HITS-CLIP	27418678
MIRT784897	hsa-miR-340-5p	HITS-CLIP	27418678
MIRT784983	hsa-miR-363-3p	HITS-CLIP	27418678
MIRT785064	hsa-miR-3663-5p	HITS-CLIP	27418678
MIRT785175	hsa-miR-367-3p	HITS-CLIP	27418678
MIRT785286	hsa-miR-369-3p	HITS-CLIP	27418678
MIRT785380	hsa-miR-378a-5p	HITS-CLIP	27418678
MIRT785457	hsa-miR-3927-3p	HITS-CLIP	27418678
MIRT785479	hsa-miR-3942-5p	HITS-CLIP	27418678
MIRT785781	hsa-miR-4419a	HITS-CLIP	27418678
MIRT785795	hsa-miR-4422	HITS-CLIP	27418678
MIRT785847	hsa-miR-4432	HITS-CLIP	27418678
MIRT786071	hsa-miR-4510	HITS-CLIP	27418678
MIRT786170	hsa-miR-4527	HITS-CLIP	27418678
MIRT786191	hsa-miR-4533	HITS-CLIP	27418678
MIRT786404	hsa-miR-4684-3p	HITS-CLIP	27418678
MIRT786457	hsa-miR-4703-5p	HITS-CLIP	27418678
MIRT786602	hsa-miR-4747-5p	HITS-CLIP	27418678
MIRT786804	hsa-miR-4793-5p	HITS-CLIP	27418678
MIRT786908	hsa-miR-495-3p	HITS-CLIP	27418678
MIRT787063	hsa-miR-5087	HITS-CLIP	27418678
MIRT787222	hsa-miR-5196-3p	HITS-CLIP	27418678
MIRT787223	hsa-miR-5196-5p	HITS-CLIP	27418678
MIRT787528	hsa-miR-548g-3p	HITS-CLIP	27418678
MIRT787701	hsa-miR-5590-3p	HITS-CLIP	27418678
MIRT787740	hsa-miR-5688	HITS-CLIP	27418678
MIRT787796	hsa-miR-5695	HITS-CLIP	27418678
MIRT787924	hsa-miR-580-5p	HITS-CLIP	27418678
MIRT787990	hsa-miR-6077	HITS-CLIP	27418678
MIRT787996	hsa-miR-6079	HITS-CLIP	27418678
MIRT788059	hsa-miR-6127	HITS-CLIP	27418678
MIRT788066	hsa-miR-6129	HITS-CLIP	27418678
MIRT788073	hsa-miR-6130	HITS-CLIP	27418678
MIRT788081	hsa-miR-6133	HITS-CLIP	27418678
MIRT788234	hsa-miR-6503-5p	HITS-CLIP	27418678
MIRT788566	hsa-miR-6753-3p	HITS-CLIP	27418678
MIRT788990	hsa-miR-6831-5p	HITS-CLIP	27418678
MIRT789016	hsa-miR-6834-5p	HITS-CLIP	27418678
MIRT789018	hsa-miR-6835-3p	HITS-CLIP	27418678
MIRT789031	hsa-miR-6838-3p	HITS-CLIP	27418678
MIRT789256	hsa-miR-6875-5p	HITS-CLIP	27418678
MIRT789394	hsa-miR-7107-3p	HITS-CLIP	27418678
MIRT789424	hsa-miR-7-1-3p	HITS-CLIP	27418678
MIRT789470	hsa-miR-7-2-3p	HITS-CLIP	27418678
MIRT789506	hsa-miR-7-5p	HITS-CLIP	27418678
MIRT789881	hsa-miR-876-3p	HITS-CLIP	27418678
MIRT789958	hsa-miR-92a-3p	HITS-CLIP	27418678
MIRT789960	hsa-miR-92b-3p	HITS-CLIP	27418678
MIRT790013	hsa-miR-9500	HITS-CLIP	27418678
MIRT790018	hsa-miR-95-5p	HITS-CLIP	27418678

Transcription factors

Transcription factor	Regulation	Reference
YY1	Repression	9171244

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IDA	16611632
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005737	Component	Cytoplasm	IDA	20962418
GO:0005829	Component	Cytosol	TAS
GO:0005869	Component	Dynactin complex	IBA	21873635
GO:0005884	Component	Actin filament	IBA	21873635
GO:0005884	Component	Actin filament	IDA	16611632, 19799913
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATPase activity	IDA	16611632, 17765196
GO:0017022	Function	Myosin binding	IBA	21873635
GO:0017022	Function	Myosin binding	IDA	19799913
GO:0017022	Function	Myosin binding	IPI	16611632
GO:0030017	Component	Sarcomere	IBA	21873635
GO:0030017	Component	Sarcomere	IDA	16288873
GO:0030027	Component	Lamellipodium	ISS
GO:0030048	Process	Actin filament-based movement	IDA	16611632
GO:0030049	Process	Muscle filament sliding	TAS
GO:0030175	Component	Filopodium	ISS
GO:0030240	Process	Skeletal muscle thin filament assembly	ISS
GO:0031032	Process	Actomyosin structure organization	ISS
GO:0031674	Component	I band	ISS
GO:0033275	Process	Actin-myosin filament sliding	IBA	21873635
GO:0033275	Process	Actin-myosin filament sliding	IMP	19799913
GO:0042493	Process	Response to drug	IEA
GO:0044297	Component	Cell body	ISS
GO:0045471	Process	Response to ethanol	IEA
GO:0055003	Process	Cardiac myofibril assembly	ISS
GO:0055008	Process	Cardiac muscle tissue morphogenesis	ISS
GO:0060047	Process	Heart contraction	IBA	21873635
GO:0060047	Process	Heart contraction	IMP	9563954, 17611253, 17947298
GO:0060048	Process	Cardiac muscle contraction	IEA
GO:0070062	Component	Extracellular exosome	HDA	21362503, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0090131	Process	Mesenchyme migration	ISS

Other IDs

• MIM: 102540
• HGNC: 143
• e!Ensembl: ENSG00000159251

Protein

• UniProt ID: P68032
• Protein name: Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
• Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00022	Actin	4 → 377	Actin	Family

• Sequence:

  MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
  QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
  MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
  DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
  SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
  LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
  KQEYDEAGPSIVHRKCF

• Sequence length: 377