ACTC1 (actin alpha cardiac muscle 1)

Gene

• Entrez ID: 70
• Gene name: Actin alpha cardiac muscle 1
• Gene symbol: ACTC1
• Synonyms: ACTC, ASD5, CMD1R, CMH11, LVNC4
• Chromosome: 15
• Chromosome location: 15q14
• Summary: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023839	hsa-miR-1-3p	Proteomics	18668040
MIRT731629	hsa-miR-139-5p	Luciferase reporter assay	27139165
MIRT731629	hsa-miR-139-5p	Luciferase reporter assay	27139165
MIRT763851	hsa-miR-1303	CLIP-seq
MIRT763852	hsa-miR-137	CLIP-seq
MIRT763853	hsa-miR-190	CLIP-seq
MIRT763854	hsa-miR-190b	CLIP-seq
MIRT763855	hsa-miR-25	CLIP-seq
MIRT763856	hsa-miR-3133	CLIP-seq
MIRT763857	hsa-miR-3168	CLIP-seq
MIRT763858	hsa-miR-32	CLIP-seq
MIRT763859	hsa-miR-34b	CLIP-seq
MIRT763860	hsa-miR-363	CLIP-seq
MIRT763861	hsa-miR-367	CLIP-seq
MIRT763862	hsa-miR-3688-3p	CLIP-seq
MIRT763863	hsa-miR-3978	CLIP-seq
MIRT763864	hsa-miR-4263	CLIP-seq
MIRT763865	hsa-miR-4307	CLIP-seq
MIRT763866	hsa-miR-4325	CLIP-seq
MIRT763867	hsa-miR-450b-5p	CLIP-seq
MIRT763868	hsa-miR-4536	CLIP-seq
MIRT763869	hsa-miR-4539	CLIP-seq
MIRT763870	hsa-miR-4699-5p	CLIP-seq
MIRT763871	hsa-miR-4724-5p	CLIP-seq
MIRT763872	hsa-miR-514	CLIP-seq
MIRT763873	hsa-miR-514b-3p	CLIP-seq
MIRT763874	hsa-miR-548b-3p	CLIP-seq
MIRT763875	hsa-miR-568	CLIP-seq
MIRT763876	hsa-miR-576-5p	CLIP-seq
MIRT763877	hsa-miR-877	CLIP-seq
MIRT763878	hsa-miR-92a	CLIP-seq
MIRT763879	hsa-miR-92b	CLIP-seq
MIRT763880	hsa-miR-935	CLIP-seq
MIRT1925123	hsa-miR-1290	CLIP-seq
MIRT763855	hsa-miR-25	CLIP-seq
MIRT1925124	hsa-miR-3130-3p	CLIP-seq
MIRT1925125	hsa-miR-3167	CLIP-seq
MIRT1925126	hsa-miR-3194-3p	CLIP-seq
MIRT763858	hsa-miR-32	CLIP-seq
MIRT763860	hsa-miR-363	CLIP-seq
MIRT763861	hsa-miR-367	CLIP-seq
MIRT763864	hsa-miR-4263	CLIP-seq
MIRT1925127	hsa-miR-4282	CLIP-seq
MIRT1925128	hsa-miR-4760-3p	CLIP-seq
MIRT1925129	hsa-miR-4793-3p	CLIP-seq
MIRT1925130	hsa-miR-4799-5p	CLIP-seq
MIRT763876	hsa-miR-576-5p	CLIP-seq
MIRT1925131	hsa-miR-876-5p	CLIP-seq
MIRT763878	hsa-miR-92a	CLIP-seq
MIRT763879	hsa-miR-92b	CLIP-seq
MIRT2166637	hsa-miR-1229	CLIP-seq
MIRT2166638	hsa-miR-767-3p	CLIP-seq
MIRT2166639	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
YY1	Repression	9171244

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IDA	16611632
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005737	Component	Cytoplasm	IDA	20962418
GO:0005829	Component	Cytosol	TAS
GO:0005869	Component	Dynactin complex	IBA	21873635
GO:0005884	Component	Actin filament	IBA	21873635
GO:0005884	Component	Actin filament	IDA	16611632, 19799913
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007015	Process	Actin filament organization	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATPase activity	IDA	16611632, 17765196
GO:0017022	Function	Myosin binding	IBA	21873635
GO:0017022	Function	Myosin binding	IDA	19799913
GO:0017022	Function	Myosin binding	IPI	16611632
GO:0030017	Component	Sarcomere	IBA	21873635
GO:0030017	Component	Sarcomere	IDA	16288873
GO:0030027	Component	Lamellipodium	ISS
GO:0030048	Process	Actin filament-based movement	IDA	16611632
GO:0030049	Process	Muscle filament sliding	TAS
GO:0030175	Component	Filopodium	ISS
GO:0030240	Process	Skeletal muscle thin filament assembly	ISS
GO:0031032	Process	Actomyosin structure organization	ISS
GO:0031674	Component	I band	ISS
GO:0033275	Process	Actin-myosin filament sliding	IBA	21873635
GO:0033275	Process	Actin-myosin filament sliding	IMP	19799913
GO:0042493	Process	Response to drug	IEA
GO:0044297	Component	Cell body	ISS
GO:0045471	Process	Response to ethanol	IEA
GO:0055003	Process	Cardiac myofibril assembly	ISS
GO:0055008	Process	Cardiac muscle tissue morphogenesis	ISS
GO:0060047	Process	Heart contraction	IBA	21873635
GO:0060047	Process	Heart contraction	IMP	9563954, 17611253, 17947298
GO:0060048	Process	Cardiac muscle contraction	IEA
GO:0070062	Component	Extracellular exosome	HDA	21362503, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0090131	Process	Mesenchyme migration	ISS

Other IDs

• MIM: 102540
• HGNC: 143
• e!Ensembl: ENSG00000159251

Protein

• UniProt ID: P68032
• Protein name: Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
• Protein function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
• PDB: 8GSU, 8GSW, 8GT1, 8GT2, 8GT3, 8GT4, 8GT5, 8ZB7, 8ZI9, 8ZJ1, 9B3Q, 9B3R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00022	Actin	4 → 377	Actin	Family

• Sequence:

  MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
  QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
  MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
  DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
  SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
  LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
  KQEYDEAGPSIVHRKCF

• Sequence length: 377