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ACTB (actin beta)

Gene

Actin beta

ACTB

BRWS1, PS1TP5BP1

7p22.1

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]

Show/Hide all(55)

SNP ID	Visualize variation	Clinical significance	Consequence
rs104894003	G>A	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs281875331	T>C,G	Pathogenic, not-provided	Missense variant, coding sequence variant
rs281875332	G>A,C	Pathogenic, not-provided	Missense variant, coding sequence variant
rs281875333	G>A,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs281875334	C>T	Pathogenic	Missense variant, coding sequence variant
rs368352689	C>G,T	Pathogenic	Missense variant, coding sequence variant
rs397515470	C>T	Pathogenic	Missense variant, coding sequence variant
rs587779769	G>A,T	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs587779770	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs587779771	A>G	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs587779772	C>G,T	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs587779773	A>G	Pathogenic	Coding sequence variant, missense variant
rs587779774	G>A	Pathogenic	Coding sequence variant, missense variant
rs587779775	G>A	Pathogenic	Coding sequence variant, missense variant
rs587779776	G>C	Pathogenic	Coding sequence variant, missense variant
rs587779777	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs587780273	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs755437923	C>G,T	Likely-pathogenic	Coding sequence variant, missense variant
rs765265404	C>A,T	Pathogenic	Synonymous variant, coding sequence variant, missense variant
rs768401130	G>A,C	Likely-pathogenic	Coding sequence variant, synonymous variant, missense variant
rs769182426	G>A,C	Likely-pathogenic	Coding sequence variant, synonymous variant, missense variant
rs786205585	G>A,C	Likely-pathogenic	Coding sequence variant, missense variant
rs797044950	G>A,C	Pathogenic	Coding sequence variant, missense variant, synonymous variant
rs886039472	C>T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant
rs886041266	G>C	Likely-pathogenic	Missense variant, coding sequence variant
rs886041267	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs886041270	G>C	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs886041309	G>A	Pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs886041790	C>A,G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs1057517888	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1057518071	G>C,T	Likely-pathogenic	Missense variant, coding sequence variant, synonymous variant
rs1057518073	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1057518142	->GGAGGGGCCGGACT	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1064793444	C>T	Pathogenic	Missense variant, coding sequence variant
rs1131691341	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1554329068	T>A	Pathogenic	Coding sequence variant, stop gained
rs1554329078	->C	Pathogenic, uncertain-significance	Coding sequence variant, frameshift variant
rs1554329113	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1554329182	GT>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1554329216	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1554329269	C>G	Pathogenic	Coding sequence variant, missense variant
rs1554329281	G>A	Pathogenic	Coding sequence variant, missense variant
rs1554329331	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1554329516	T>A	Pathogenic	Coding sequence variant, missense variant
rs1554329523	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554329546	AAG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1554329552	G>C	Pathogenic	Coding sequence variant, missense variant
rs1554329554	C>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1554329584	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554329646	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1562718649	->G	Pathogenic, uncertain-significance	Coding sequence variant, frameshift variant
rs1562718846	TGGTGGTGCCGCCAGACA>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1562719872	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1562720119	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1584261979	G>A	Pathogenic	Missense variant, coding sequence variant

Show/Hide all(206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007163	hsa-miR-644a	Luciferase reporter assay, qRT-PCR, Western blot	23091630
MIRT024098	hsa-miR-1-3p	Proteomics	18668040
MIRT035818	hsa-miR-1307-3p	CLASH	23622248
MIRT035877	hsa-miR-1303	CLASH	23622248
MIRT035901	hsa-miR-1295a	CLASH	23622248
MIRT037388	hsa-miR-744-5p	CLASH	23622248
MIRT037834	hsa-miR-455-3p	CLASH	23622248
MIRT038781	hsa-miR-93-3p	CLASH	23622248
MIRT041669	hsa-miR-484	CLASH	23622248
MIRT043141	hsa-miR-324-5p	CLASH	23622248
MIRT043650	hsa-miR-326	CLASH	23622248
MIRT043906	hsa-miR-378a-3p	CLASH	23622248
MIRT044755	hsa-miR-320a	CLASH	23622248
MIRT046589	hsa-miR-222-3p	CLASH	23622248
MIRT046843	hsa-miR-221-3p	CLASH	23622248
MIRT048244	hsa-miR-196a-5p	CLASH	23622248
MIRT048522	hsa-miR-100-5p	CLASH	23622248
MIRT049406	hsa-miR-92a-3p	CLASH	23622248
MIRT051251	hsa-miR-16-5p	CLASH	23622248
MIRT051732	hsa-let-7c-5p	CLASH	23622248
MIRT051913	hsa-let-7b-5p	CLASH	23622248
MIRT052403	hsa-let-7a-5p	CLASH	23622248
MIRT052797	hsa-miR-3176	CLASH	23622248
MIRT053374	hsa-miR-145-5p	qRT-PCR, Western blot	19439999
MIRT053374	hsa-miR-145-5p	PAR-CLIP	23592263
MIRT053374	hsa-miR-145-5p	PAR-CLIP	26701625
MIRT053374	hsa-miR-145-5p	PAR-CLIP	27292025
MIRT222253	hsa-miR-548t-3p	PAR-CLIP	23592263
MIRT222253	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT222253	hsa-miR-548t-3p	PAR-CLIP	26701625
MIRT222255	hsa-miR-548aa	PAR-CLIP	23592263
MIRT222255	hsa-miR-548aa	PAR-CLIP	21572407
MIRT222255	hsa-miR-548aa	PAR-CLIP	26701625
MIRT222256	hsa-miR-548ap-3p	PAR-CLIP	23592263
MIRT222256	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT222256	hsa-miR-548ap-3p	PAR-CLIP	26701625
MIRT239825	hsa-miR-4282	PAR-CLIP	20371350
MIRT239826	hsa-miR-4698	PAR-CLIP	20371350
MIRT239827	hsa-miR-8063	PAR-CLIP	20371350
MIRT258433	hsa-miR-4289	PAR-CLIP	23592263
MIRT258433	hsa-miR-4289	PAR-CLIP	21572407
MIRT441278	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT441279	hsa-miR-544a	HITS-CLIP	24374217
MIRT441279	hsa-miR-544a	PAR-CLIP	23446348
MIRT441279	hsa-miR-544a	PAR-CLIP	20371350
MIRT441279	hsa-miR-544a	PAR-CLIP	27292025
MIRT441280	hsa-miR-432-3p	HITS-CLIP	24374217
MIRT441281	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT441282	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT441283	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT441284	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT482506	hsa-miR-5572	PAR-CLIP	23592263
MIRT482507	hsa-miR-4260	PAR-CLIP	23592263
MIRT482508	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT482509	hsa-miR-3611	PAR-CLIP	23592263
MIRT482509	hsa-miR-3611	PAR-CLIP	21572407
MIRT482510	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT482511	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT482512	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT482513	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT482514	hsa-miR-1275	PAR-CLIP	23592263
MIRT482515	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT482515	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT482516	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT482516	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT482517	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT482518	hsa-miR-4525	PAR-CLIP	23592263
MIRT482519	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT482520	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT482521	hsa-miR-5698	PAR-CLIP	23592263
MIRT482522	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT482523	hsa-miR-6876-3p	PAR-CLIP	23592263
MIRT482524	hsa-miR-626	PAR-CLIP	23592263
MIRT482525	hsa-miR-520h	PAR-CLIP	23592263
MIRT482525	hsa-miR-520h	PAR-CLIP	21572407
MIRT482526	hsa-miR-520g-3p	PAR-CLIP	23592263
MIRT482526	hsa-miR-520g-3p	PAR-CLIP	21572407
MIRT482527	hsa-miR-3973	PAR-CLIP	23592263
MIRT482527	hsa-miR-3973	PAR-CLIP	21572407
MIRT482528	hsa-miR-6510-3p	PAR-CLIP	23592263
MIRT482529	hsa-miR-3529-3p	PAR-CLIP	23592263
MIRT482529	hsa-miR-3529-3p	PAR-CLIP	21572407
MIRT482530	hsa-miR-6507-3p	PAR-CLIP	23592263
MIRT482530	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT482531	hsa-miR-937-5p	PAR-CLIP	23592263
MIRT482531	hsa-miR-937-5p	PAR-CLIP	21572407
MIRT482531	hsa-miR-937-5p	PAR-CLIP	26701625
MIRT482531	hsa-miR-937-5p	PAR-CLIP	27292025
MIRT482532	hsa-miR-1200	PAR-CLIP	23592263
MIRT482532	hsa-miR-1200	PAR-CLIP	21572407
MIRT482532	hsa-miR-1200	PAR-CLIP	26701625
MIRT482532	hsa-miR-1200	PAR-CLIP	27292025
MIRT482533	hsa-miR-5702	PAR-CLIP	23592263
MIRT482533	hsa-miR-5702	PAR-CLIP	21572407
MIRT482533	hsa-miR-5702	PAR-CLIP	26701625
MIRT482533	hsa-miR-5702	PAR-CLIP	27292025
MIRT482534	hsa-miR-544b	PAR-CLIP	23592263
MIRT482534	hsa-miR-544b	PAR-CLIP	21572407
MIRT482534	hsa-miR-544b	PAR-CLIP	26701625
MIRT482534	hsa-miR-544b	PAR-CLIP	27292025
MIRT482535	hsa-miR-4324	PAR-CLIP	23592263
MIRT482535	hsa-miR-4324	PAR-CLIP	21572407
MIRT482535	hsa-miR-4324	PAR-CLIP	26701625
MIRT482535	hsa-miR-4324	PAR-CLIP	27292025
MIRT482536	hsa-miR-4328	PAR-CLIP	23592263
MIRT482536	hsa-miR-4328	PAR-CLIP	26701625
MIRT482536	hsa-miR-4328	PAR-CLIP	27292025
MIRT482537	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT482537	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT482537	hsa-miR-3613-3p	PAR-CLIP	26701625
MIRT482537	hsa-miR-3613-3p	PAR-CLIP	27292025
MIRT482538	hsa-miR-605-5p	PAR-CLIP	23592263
MIRT482538	hsa-miR-605-5p	PAR-CLIP	21572407
MIRT482538	hsa-miR-605-5p	PAR-CLIP	26701625
MIRT482538	hsa-miR-605-5p	PAR-CLIP	27292025
MIRT482539	hsa-miR-548z	PAR-CLIP	23592263
MIRT482539	hsa-miR-548z	PAR-CLIP	21572407
MIRT482539	hsa-miR-548z	PAR-CLIP	26701625
MIRT482540	hsa-miR-548h-3p	PAR-CLIP	23592263
MIRT482540	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT482540	hsa-miR-548h-3p	PAR-CLIP	26701625
MIRT482541	hsa-miR-548d-3p	PAR-CLIP	23592263
MIRT482541	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT482541	hsa-miR-548d-3p	PAR-CLIP	26701625
MIRT482542	hsa-miR-548bb-3p	PAR-CLIP	23592263
MIRT482542	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT482542	hsa-miR-548bb-3p	PAR-CLIP	26701625
MIRT482543	hsa-miR-548ac	PAR-CLIP	23592263
MIRT482543	hsa-miR-548ac	PAR-CLIP	21572407
MIRT482543	hsa-miR-548ac	PAR-CLIP	26701625
MIRT482544	hsa-miR-5195-3p	PAR-CLIP	23592263
MIRT482544	hsa-miR-5195-3p	PAR-CLIP	26701625
MIRT482544	hsa-miR-5195-3p	PAR-CLIP	27292025
MIRT503197	hsa-miR-6772-5p	PAR-CLIP	24398324
MIRT503197	hsa-miR-6772-5p	PAR-CLIP	23446348
MIRT503197	hsa-miR-6772-5p	PAR-CLIP	20371350
MIRT503197	hsa-miR-6772-5p	PAR-CLIP	26701625
MIRT503197	hsa-miR-6772-5p	PAR-CLIP	27292025
MIRT503198	hsa-let-7i-3p	PAR-CLIP	24398324
MIRT503198	hsa-let-7i-3p	PAR-CLIP	23446348
MIRT503198	hsa-let-7i-3p	PAR-CLIP	20371350
MIRT503198	hsa-let-7i-3p	PAR-CLIP	26701625
MIRT503198	hsa-let-7i-3p	PAR-CLIP	27292025
MIRT503199	hsa-miR-5681a	PAR-CLIP	24398324
MIRT503199	hsa-miR-5681a	PAR-CLIP	23446348
MIRT503199	hsa-miR-5681a	PAR-CLIP	20371350
MIRT503199	hsa-miR-5681a	PAR-CLIP	26701625
MIRT503199	hsa-miR-5681a	PAR-CLIP	27292025
MIRT503200	hsa-miR-191-3p	PAR-CLIP	24398324
MIRT503200	hsa-miR-191-3p	PAR-CLIP	23446348
MIRT503200	hsa-miR-191-3p	PAR-CLIP	20371350
MIRT503200	hsa-miR-191-3p	PAR-CLIP	26701625
MIRT503200	hsa-miR-191-3p	PAR-CLIP	27292025
MIRT503201	hsa-miR-329-5p	PAR-CLIP	24398324
MIRT503201	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT503201	hsa-miR-329-5p	PAR-CLIP	20371350
MIRT503201	hsa-miR-329-5p	PAR-CLIP	26701625
MIRT503201	hsa-miR-329-5p	PAR-CLIP	27292025
MIRT503202	hsa-miR-4464	PAR-CLIP	24398324
MIRT503202	hsa-miR-4464	PAR-CLIP	23446348
MIRT503202	hsa-miR-4464	PAR-CLIP	20371350
MIRT503202	hsa-miR-4464	PAR-CLIP	26701625
MIRT503202	hsa-miR-4464	PAR-CLIP	27292025
MIRT503203	hsa-miR-4748	PAR-CLIP	24398324
MIRT503203	hsa-miR-4748	PAR-CLIP	23446348
MIRT503203	hsa-miR-4748	PAR-CLIP	20371350
MIRT503203	hsa-miR-4748	PAR-CLIP	26701625
MIRT503203	hsa-miR-4748	PAR-CLIP	27292025
MIRT503204	hsa-miR-3912-3p	PAR-CLIP	24398324
MIRT503204	hsa-miR-3912-3p	PAR-CLIP	23446348
MIRT503204	hsa-miR-3912-3p	PAR-CLIP	20371350
MIRT503204	hsa-miR-3912-3p	PAR-CLIP	26701625
MIRT503204	hsa-miR-3912-3p	PAR-CLIP	27292025
MIRT512326	hsa-miR-4477a	PAR-CLIP	23446348
MIRT512326	hsa-miR-4477a	PAR-CLIP	20371350
MIRT512327	hsa-miR-4699-5p	PAR-CLIP	23446348
MIRT512327	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT512328	hsa-miR-525-3p	PAR-CLIP	23446348
MIRT512328	hsa-miR-525-3p	PAR-CLIP	20371350
MIRT512329	hsa-miR-524-3p	PAR-CLIP	23446348
MIRT512329	hsa-miR-524-3p	PAR-CLIP	20371350
MIRT512330	hsa-miR-548l	PAR-CLIP	23446348
MIRT512330	hsa-miR-548l	PAR-CLIP	20371350
MIRT512331	hsa-miR-548n	PAR-CLIP	23446348
MIRT512331	hsa-miR-548n	PAR-CLIP	20371350
MIRT512332	hsa-miR-506-3p	PAR-CLIP	23446348
MIRT512332	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT512333	hsa-miR-124-3p	PAR-CLIP	23446348
MIRT512333	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT513074	hsa-miR-6738-3p	PAR-CLIP	23446348
MIRT513074	hsa-miR-6738-3p	PAR-CLIP	20371350
MIRT513074	hsa-miR-6738-3p	PAR-CLIP	27292025
MIRT543082	hsa-miR-192-3p	PAR-CLIP	21572407
MIRT543083	hsa-miR-6870-3p	PAR-CLIP	21572407
MIRT543084	hsa-miR-6872-3p	PAR-CLIP	21572407
MIRT543085	hsa-miR-216a-5p	PAR-CLIP	21572407
MIRT543086	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT543087	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT568637	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT568638	hsa-miR-557	PAR-CLIP	20371350
MIRT568639	hsa-miR-507	PAR-CLIP	20371350
MIRT568640	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT568641	hsa-miR-33b-5p	PAR-CLIP	20371350
MIRT568642	hsa-miR-33a-5p	PAR-CLIP	20371350
MIRT568642	hsa-miR-33a-5p	Flow, qRT-PCR, Western blot	25544258
MIRT568643	hsa-miR-382-3p	PAR-CLIP	20371350

Show/Hide all(86)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000079	Process	Regulation of cyclin-dependent protein serine/threonine kinase activity	ISS
GO:0000785	Component	Chromatin	HDA	16217013
GO:0001738	Process	Morphogenesis of a polarized epithelium	IMP	22855531
GO:0001895	Process	Retina homeostasis	HEP	23580065
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	6202424
GO:0005515	Function	Protein binding	IPI	11687588, 14592989, 15047060, 15161933, 15328537, 16049941, 16189514, 16375898, 17192268, 17342765, 17404223, 17502619, 17599063, 17823310, 18331289, 18562541, 19000816, 19008859, 19328794, 19338310, 20473970, 20618440, 21044950, 21516116, 21555369, 21577206, 21969592, 22038833, 231
GO:0005524	Function	ATP binding	IEA
GO:0005615	Component	Extracellular space	HDA	16502470, 22664934, 23580065
GO:0005634	Component	Nucleus	IDA	11687588
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	24327345
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IDA	24327345
GO:0005856	Component	Cytoskeleton	ISS
GO:0005856	Component	Cytoskeleton	TAS	16130169
GO:0005884	Component	Actin filament	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IMP	25753039
GO:0005912	Component	Adherens junction	IDA	22855531
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007163	Process	Establishment or maintenance of cell polarity	IMP	22855531
GO:0007409	Process	Axonogenesis	IBA	21873635
GO:0015629	Component	Actin cytoskeleton	IDA	11687588
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016579	Process	Protein deubiquitination	TAS
GO:0019894	Function	Kinesin binding	IPI	18680169
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0019901	Function	Protein kinase binding	IPI	24327345
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0022898	Process	Regulation of transmembrane transporter activity	IGI	18331289
GO:0022898	Process	Regulation of transmembrane transporter activity	ISS	18331289
GO:0030027	Component	Lamellipodium	IDA	24415753
GO:0030424	Component	Axon	IBA	21873635
GO:0030957	Function	Tat protein binding	IPI	16687403
GO:0031492	Function	Nucleosomal DNA binding	HDA	16217013
GO:0031982	Component	Vesicle	HDA	19190083
GO:0032091	Process	Negative regulation of protein binding	ISS
GO:0032991	Component	Protein-containing complex	HDA	16217013
GO:0032991	Component	Protein-containing complex	IDA	11687588, 24415753
GO:0034329	Process	Cell junction assembly	TAS
GO:0034333	Process	Adherens junction assembly	IMP	22855531
GO:0035267	Component	NuA4 histone acetyltransferase complex	IBA	21873635
GO:0035267	Component	NuA4 histone acetyltransferase complex	IDA	10966108
GO:0035633	Process	Maintenance of blood-brain barrier	NAS	30280653
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	15121898
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0042802	Function	Identical protein binding	IPI	16189514, 17404223, 18234857, 19000816, 20383143, 21516116, 25416956, 25502805, 25910212, 29892012, 31515488, 32296183
GO:0043044	Process	ATP-dependent chromatin remodeling	HDA	16217013
GO:0043296	Component	Apical junction complex	IDA	22855531
GO:0045176	Process	Apical protein localization	IMP	22855531
GO:0045202	Component	Synapse	IBA	21873635
GO:0045815	Process	Positive regulation of gene expression, epigenetic	TAS
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0048870	Process	Cell motility	IBA	21873635
GO:0048870	Process	Cell motility	IMP	6202424
GO:0050998	Function	Nitric-oxide synthase binding	IPI	17502619
GO:0051621	Process	Regulation of norepinephrine uptake	IGI	18331289
GO:0051621	Process	Regulation of norepinephrine uptake	ISS	18331289
GO:0051623	Process	Positive regulation of norepinephrine uptake	TAS	18331289
GO:0061024	Process	Membrane organization	TAS
GO:0070062	Component	Extracellular exosome	HDA	11487543, 19199708, 20458337, 21362503, 23533145
GO:0070160	Component	Tight junction	IDA	22855531
GO:0070527	Process	Platelet aggregation	HMP	23382103
GO:0071896	Process	Protein localization to adherens junction	IMP	22855531
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0072749	Process	Cellular response to cytochalasin B	IMP	6202424
GO:0097433	Component	Dense body	ISS
GO:0098793	Component	Presynapse	TAS	18331289
GO:0098871	Component	Postsynaptic actin cytoskeleton	IDA	18341992
GO:0098871	Component	Postsynaptic actin cytoskeleton	IMP	18341992
GO:0098973	Function	Structural constituent of postsynaptic actin cytoskeleton	EXP	18341992
GO:0098973	Function	Structural constituent of postsynaptic actin cytoskeleton	IBA	21873635
GO:0098973	Function	Structural constituent of postsynaptic actin cytoskeleton	IDA	18341992
GO:0098973	Function	Structural constituent of postsynaptic actin cytoskeleton	IMP	18341992
GO:0098974	Process	Postsynaptic actin cytoskeleton organization	IDA	18341992
GO:0098978	Component	Glutamatergic synapse	EXP	18341992
GO:0098978	Component	Glutamatergic synapse	IDA	18341992
GO:0098978	Component	Glutamatergic synapse	IMP	18341992
GO:0150111	Process	Regulation of transepithelial transport	IMP	22855531
GO:1903076	Process	Regulation of protein localization to plasma membrane	IMP	18331289
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

MIM	HGNC	e!Ensembl
102630	132	ENSG00000075624

Protein

UniProt ID

P60709

Protein name

Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]

Protein function

Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947).

PDB

3BYH , 3D2U , 3J82 , 3LUE , 6ANU , 6ICT , 6ICV , 6LTJ , 6MBJ , 6MBK , 6MBL , 6NBW , 6OX0 , 6OX1 , 6OX2 , 6OX3 , 6OX4 , 6OX5 , 6V62 , 6V63 , 6WK1 , 6WK2 , 7AS4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00022	Actin	2 → 375	Actin	Family

Sequence

MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Sequence length

375

Interactions

View interactions

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