ACSL6 (acyl-CoA synthetase long chain family member 6)

Gene

• Entrez ID: 23305
• Gene name: Acyl-CoA synthetase long chain family member 6
• Gene symbol: ACSL6
• Synonyms: ACS2, FACL6, LACS 6, LACS2, LACS5
• Chromosome: 5
• Chromosome location: 5q31.1
• Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025504	hsa-miR-34a-5p	Proteomics	21566225
MIRT669636	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT669635	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT669634	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT669633	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT669632	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT669631	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669630	hsa-miR-1281	HITS-CLIP	23824327
MIRT669629	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT669628	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT669627	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT669626	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT669625	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT669624	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT669623	hsa-miR-4284	HITS-CLIP	23824327
MIRT669622	hsa-miR-1206	HITS-CLIP	23824327
MIRT669621	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504011	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT669636	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT669635	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT669634	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT669633	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT669632	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT669631	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669630	hsa-miR-1281	HITS-CLIP	23824327
MIRT669629	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT669628	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT669627	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT669626	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT669625	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT669624	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT669623	hsa-miR-4284	HITS-CLIP	23824327
MIRT669622	hsa-miR-1206	HITS-CLIP	23824327
MIRT669621	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504011	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT763592	hsa-miR-1321	CLIP-seq
MIRT763593	hsa-miR-1913	CLIP-seq
MIRT763594	hsa-miR-1976	CLIP-seq
MIRT763595	hsa-miR-3162-5p	CLIP-seq
MIRT763596	hsa-miR-3199	CLIP-seq
MIRT763597	hsa-miR-324-3p	CLIP-seq
MIRT763598	hsa-miR-4258	CLIP-seq
MIRT763599	hsa-miR-4279	CLIP-seq
MIRT763600	hsa-miR-4438	CLIP-seq
MIRT763601	hsa-miR-4707-3p	CLIP-seq
MIRT763602	hsa-miR-4722-3p	CLIP-seq
MIRT763603	hsa-miR-4739	CLIP-seq
MIRT763604	hsa-miR-4740-3p	CLIP-seq
MIRT763605	hsa-miR-4756-5p	CLIP-seq
MIRT763606	hsa-miR-500a	CLIP-seq
MIRT763607	hsa-miR-5095	CLIP-seq
MIRT763608	hsa-miR-617	CLIP-seq
MIRT763609	hsa-miR-10a	CLIP-seq
MIRT763610	hsa-miR-10b	CLIP-seq
MIRT763611	hsa-miR-1193	CLIP-seq
MIRT763612	hsa-miR-1208	CLIP-seq
MIRT763613	hsa-miR-1256	CLIP-seq
MIRT763614	hsa-miR-129-5p	CLIP-seq
MIRT763592	hsa-miR-1321	CLIP-seq
MIRT763615	hsa-miR-1323	CLIP-seq
MIRT763593	hsa-miR-1913	CLIP-seq
MIRT763616	hsa-miR-1915	CLIP-seq
MIRT763594	hsa-miR-1976	CLIP-seq
MIRT763617	hsa-miR-2115	CLIP-seq
MIRT763618	hsa-miR-2278	CLIP-seq
MIRT763619	hsa-miR-2392	CLIP-seq
MIRT763620	hsa-miR-3152-3p	CLIP-seq
MIRT763595	hsa-miR-3162-5p	CLIP-seq
MIRT763596	hsa-miR-3199	CLIP-seq
MIRT763597	hsa-miR-324-3p	CLIP-seq
MIRT763621	hsa-miR-339-5p	CLIP-seq
MIRT763622	hsa-miR-371-5p	CLIP-seq
MIRT763623	hsa-miR-371b-5p	CLIP-seq
MIRT763599	hsa-miR-4279	CLIP-seq
MIRT763624	hsa-miR-4282	CLIP-seq
MIRT763625	hsa-miR-4420	CLIP-seq
MIRT763626	hsa-miR-4421	CLIP-seq
MIRT763600	hsa-miR-4438	CLIP-seq
MIRT763627	hsa-miR-4468	CLIP-seq
MIRT763628	hsa-miR-450b-5p	CLIP-seq
MIRT763629	hsa-miR-4642	CLIP-seq
MIRT763630	hsa-miR-4661-3p	CLIP-seq
MIRT763631	hsa-miR-4662a-5p	CLIP-seq
MIRT763632	hsa-miR-4676-5p	CLIP-seq
MIRT763601	hsa-miR-4707-3p	CLIP-seq
MIRT763602	hsa-miR-4722-3p	CLIP-seq
MIRT763633	hsa-miR-4725-5p	CLIP-seq
MIRT763603	hsa-miR-4739	CLIP-seq
MIRT763604	hsa-miR-4740-3p	CLIP-seq
MIRT763605	hsa-miR-4756-5p	CLIP-seq
MIRT763634	hsa-miR-483-5p	CLIP-seq
MIRT763635	hsa-miR-504	CLIP-seq
MIRT763636	hsa-miR-507	CLIP-seq
MIRT763607	hsa-miR-5095	CLIP-seq
MIRT763637	hsa-miR-516a-3p	CLIP-seq
MIRT763638	hsa-miR-518a-5p	CLIP-seq
MIRT763639	hsa-miR-527	CLIP-seq
MIRT763640	hsa-miR-548aa	CLIP-seq
MIRT763641	hsa-miR-548o	CLIP-seq
MIRT763642	hsa-miR-557	CLIP-seq
MIRT763643	hsa-miR-575	CLIP-seq
MIRT763608	hsa-miR-617	CLIP-seq
MIRT763644	hsa-miR-892a	CLIP-seq
MIRT763645	hsa-let-7a	CLIP-seq
MIRT763646	hsa-let-7b	CLIP-seq
MIRT763647	hsa-let-7c	CLIP-seq
MIRT763648	hsa-let-7d	CLIP-seq
MIRT763649	hsa-let-7e	CLIP-seq
MIRT763650	hsa-let-7f	CLIP-seq
MIRT763651	hsa-let-7g	CLIP-seq
MIRT763652	hsa-let-7i	CLIP-seq
MIRT763653	hsa-miR-196a	CLIP-seq
MIRT763654	hsa-miR-196b	CLIP-seq
MIRT763655	hsa-miR-202	CLIP-seq
MIRT763656	hsa-miR-3653	CLIP-seq
MIRT763657	hsa-miR-3658	CLIP-seq
MIRT763658	hsa-miR-3926	CLIP-seq
MIRT763659	hsa-miR-4458	CLIP-seq
MIRT763660	hsa-miR-4500	CLIP-seq
MIRT763661	hsa-miR-4511	CLIP-seq
MIRT763662	hsa-miR-4699-3p	CLIP-seq
MIRT763663	hsa-miR-4724-5p	CLIP-seq
MIRT763664	hsa-miR-4753-5p	CLIP-seq
MIRT763665	hsa-miR-548b-3p	CLIP-seq
MIRT763666	hsa-miR-98	CLIP-seq
MIRT1925058	hsa-miR-3671	CLIP-seq
MIRT1925059	hsa-miR-3689a-3p	CLIP-seq
MIRT1925060	hsa-miR-3689c	CLIP-seq
MIRT1925061	hsa-miR-3689d	CLIP-seq
MIRT1925062	hsa-miR-4459	CLIP-seq
MIRT1925063	hsa-miR-4728-5p	CLIP-seq
MIRT1925064	hsa-miR-579	CLIP-seq
MIRT1925065	hsa-miR-944	CLIP-seq
MIRT2166515	hsa-miR-105	CLIP-seq
MIRT763609	hsa-miR-10a	CLIP-seq
MIRT763610	hsa-miR-10b	CLIP-seq
MIRT2166516	hsa-miR-1307	CLIP-seq
MIRT763616	hsa-miR-1915	CLIP-seq
MIRT763594	hsa-miR-1976	CLIP-seq
MIRT2166517	hsa-miR-2276	CLIP-seq
MIRT763618	hsa-miR-2278	CLIP-seq
MIRT2166518	hsa-miR-3135	CLIP-seq
MIRT763596	hsa-miR-3199	CLIP-seq
MIRT763621	hsa-miR-339-5p	CLIP-seq
MIRT2166519	hsa-miR-3646	CLIP-seq
MIRT763599	hsa-miR-4279	CLIP-seq
MIRT763626	hsa-miR-4421	CLIP-seq
MIRT763600	hsa-miR-4438	CLIP-seq
MIRT1925062	hsa-miR-4459	CLIP-seq
MIRT763627	hsa-miR-4468	CLIP-seq
MIRT763630	hsa-miR-4661-3p	CLIP-seq
MIRT763602	hsa-miR-4722-3p	CLIP-seq
MIRT763663	hsa-miR-4724-5p	CLIP-seq
MIRT763633	hsa-miR-4725-5p	CLIP-seq
MIRT763604	hsa-miR-4740-3p	CLIP-seq
MIRT2166520	hsa-miR-494	CLIP-seq
MIRT2166521	hsa-miR-499-3p	CLIP-seq
MIRT2166522	hsa-miR-499a-3p	CLIP-seq
MIRT763635	hsa-miR-504	CLIP-seq
MIRT763607	hsa-miR-5095	CLIP-seq
MIRT2166523	hsa-miR-542-3p	CLIP-seq
MIRT2166524	hsa-miR-664	CLIP-seq
MIRT2166525	hsa-miR-935	CLIP-seq
MIRT763609	hsa-miR-10a	CLIP-seq
MIRT763610	hsa-miR-10b	CLIP-seq
MIRT2674326	hsa-miR-1267	CLIP-seq
MIRT2166516	hsa-miR-1307	CLIP-seq
MIRT763615	hsa-miR-1323	CLIP-seq
MIRT2674327	hsa-miR-1908	CLIP-seq
MIRT2674328	hsa-miR-3135b	CLIP-seq
MIRT763621	hsa-miR-339-5p	CLIP-seq
MIRT2674329	hsa-miR-3652	CLIP-seq
MIRT763622	hsa-miR-371-5p	CLIP-seq
MIRT763623	hsa-miR-371b-5p	CLIP-seq
MIRT2674330	hsa-miR-4294	CLIP-seq
MIRT763626	hsa-miR-4421	CLIP-seq
MIRT2674331	hsa-miR-4423-5p	CLIP-seq
MIRT2674332	hsa-miR-4430	CLIP-seq
MIRT2674333	hsa-miR-4652-3p	CLIP-seq
MIRT763633	hsa-miR-4725-5p	CLIP-seq
MIRT763635	hsa-miR-504	CLIP-seq
MIRT763641	hsa-miR-548o	CLIP-seq
MIRT2674334	hsa-miR-663	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IBA	21873635
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	24269233
GO:0001676	Process	Long-chain fatty acid metabolic process	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	NAS	10548543
GO:0005524	Function	ATP binding	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	NAS	10548543
GO:0006637	Process	Acyl-CoA metabolic process	NAS	10548543
GO:0008610	Process	Lipid biosynthetic process	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	IBA	21873635
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042803	Function	Protein homodimerization activity	IDA	20429931
GO:0047676	Function	Arachidonate-CoA ligase activity	IBA	21873635
GO:0047676	Function	Arachidonate-CoA ligase activity	ISS

Other IDs

• MIM: 604443
• HGNC: 16496
• e!Ensembl: ENSG00000164398

Protein

• UniProt ID: Q9UKU0
• Protein name: Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6)
• Protein function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in br
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	103 → 563	AMP-binding enzyme	Family
  PF13193	AMP-binding_C	572 → 661	AMP-binding enzyme C-terminal domain	Domain

• Sequence:

  MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQ
  SEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQW
  LSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDT
  LGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQK
  CGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGF
  LKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCP
  TIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKI
  QASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHV
  GAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGD
  IGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGI
  VVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHS
  DMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

• Sequence length: 697