ACSL6 (acyl-CoA synthetase long chain family member 6)

Gene

• Entrez ID: 23305
• Gene name: Acyl-CoA synthetase long chain family member 6
• Gene symbol: ACSL6
• Synonyms: ACS2, FACL6, LACS 6, LACS2, LACS5
• Chromosome: 5
• Chromosome location: 5q31.1
• Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025504	hsa-miR-34a-5p	Proteomics	21566225
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504011	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT669621	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT669622	hsa-miR-1206	HITS-CLIP	23824327
MIRT669623	hsa-miR-4284	HITS-CLIP	23824327
MIRT669624	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT669625	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT669626	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT669627	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT669628	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT669629	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT669630	hsa-miR-1281	HITS-CLIP	23824327
MIRT669631	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669632	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT669633	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT669634	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT669635	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT669636	hsa-miR-6890-3p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IBA	21873635
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	24269233
GO:0001676	Process	Long-chain fatty acid metabolic process	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	NAS	10548543
GO:0005524	Function	ATP binding	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	NAS	10548543
GO:0006637	Process	Acyl-CoA metabolic process	NAS	10548543
GO:0008610	Process	Lipid biosynthetic process	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	IBA	21873635
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042803	Function	Protein homodimerization activity	IDA	20429931
GO:0047676	Function	Arachidonate-CoA ligase activity	IBA	21873635
GO:0047676	Function	Arachidonate-CoA ligase activity	ISS

Other IDs

• MIM: 604443
• HGNC: 16496
• e!Ensembl: ENSG00000164398

Protein

• UniProt ID: Q9UKU0
• Protein name: Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6)
• Protein function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	103 → 563	AMP-binding enzyme	Family
  PF13193	AMP-binding_C	572 → 661	AMP-binding enzyme C-terminal domain	Domain

• Sequence:

  MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQ
  SEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQW
  LSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDT
  LGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQK
  CGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGF
  LKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCP
  TIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKI
  QASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHV
  GAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGD
  IGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGI
  VVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHS
  DMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

• Sequence length: 697