ACSL4 (acyl-CoA synthetase long chain family member 4)

Gene

• Entrez ID: 2182
• Gene name: Acyl-CoA synthetase long chain family member 4
• Gene symbol: ACSL4
• Synonyms: ACS4, FACL4, LACS4, MRX63, MRX68, XLID63
• Chromosome: X
• Chromosome location: Xq23
• Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs122458138	G>T	Pathogenic	Coding sequence variant, missense variant
rs122458139	G>A	Pathogenic	Coding sequence variant, missense variant
rs183171123	T>C	Conflicting-interpretations-of-pathogenicity, benign	Intron variant
rs200451158	T>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs886042180	AT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1569423317	T>C	Pathogenic	Splice acceptor variant
rs1603401125	A>C	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020060	hsa-miR-375	Microarray	20215506
MIRT025215	hsa-miR-34a-5p	Proteomics	21566225
MIRT025215	hsa-miR-34a-5p	Proteomics	21566225
MIRT025215	hsa-miR-34a-5p	Proteomics	21566225
MIRT025215	hsa-miR-34a-5p	Reporter assay;Proteomics	21566225
MIRT028658	hsa-miR-30a-5p	Proteomics	18668040
MIRT043925	hsa-miR-378a-3p	CLASH	23622248
MIRT054569	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	24576478
MIRT054569	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	24576478
MIRT549467	hsa-miR-144-3p	HITS-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	HITS-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	HITS-CLIP	21572407
MIRT549464	hsa-miR-3666	HITS-CLIP	21572407
MIRT549463	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT549461	hsa-miR-4295	HITS-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	HITS-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	HITS-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	HITS-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	HITS-CLIP	21572407
MIRT175380	hsa-miR-93-5p	HITS-CLIP	21572407
MIRT175378	hsa-miR-17-5p	HITS-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	HITS-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	HITS-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT549457	hsa-miR-3662	HITS-CLIP	21572407
MIRT549455	hsa-miR-132-3p	HITS-CLIP	21572407
MIRT549454	hsa-miR-212-3p	HITS-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	HITS-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	HITS-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	HITS-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	HITS-CLIP	21572407
MIRT549452	hsa-miR-580-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT549450	hsa-miR-3163	HITS-CLIP	21572407
MIRT549449	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT549448	hsa-miR-586	HITS-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	HITS-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	HITS-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT175430	hsa-miR-4477a	HITS-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	HITS-CLIP	21572407
MIRT549444	hsa-miR-527	HITS-CLIP	21572407
MIRT175328	hsa-miR-448	HITS-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	HITS-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	HITS-CLIP	21572407
MIRT549441	hsa-miR-3658	HITS-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	HITS-CLIP	21572407
MIRT108449	hsa-miR-507	HITS-CLIP	21572407
MIRT108450	hsa-miR-557	HITS-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	HITS-CLIP	21572407
MIRT108438	hsa-miR-129-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	23824327
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT549448	hsa-miR-586	HITS-CLIP	23824327
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT175328	hsa-miR-448	HITS-CLIP	23824327
MIRT549467	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549464	hsa-miR-3666	PAR-CLIP	21572407
MIRT549463	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT549461	hsa-miR-4295	PAR-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT175380	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT175378	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT549457	hsa-miR-3662	PAR-CLIP	21572407
MIRT549456	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT549455	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT549454	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT549452	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT549451	hsa-miR-8485	PAR-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT549450	hsa-miR-3163	PAR-CLIP	21572407
MIRT549449	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549448	hsa-miR-586	PAR-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT175430	hsa-miR-4477a	PAR-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	PAR-CLIP	21572407
MIRT549444	hsa-miR-527	PAR-CLIP	21572407
MIRT175328	hsa-miR-448	PAR-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT549441	hsa-miR-3658	PAR-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT108449	hsa-miR-507	PAR-CLIP	21572407
MIRT108450	hsa-miR-557	PAR-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT108438	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444490	hsa-miR-1298-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT441286	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT441285	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT441286	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT441285	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT549466	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT549465	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT737243	hsa-miR-211-5p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR	32859232
MIRT549467	hsa-miR-144-3p	HITS-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	HITS-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	HITS-CLIP	21572407
MIRT549464	hsa-miR-3666	HITS-CLIP	21572407
MIRT549463	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT549461	hsa-miR-4295	HITS-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	HITS-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	HITS-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	HITS-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	HITS-CLIP	21572407
MIRT175380	hsa-miR-93-5p	HITS-CLIP	21572407
MIRT175378	hsa-miR-17-5p	HITS-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	HITS-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	HITS-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT549457	hsa-miR-3662	HITS-CLIP	21572407
MIRT549455	hsa-miR-132-3p	HITS-CLIP	21572407
MIRT549454	hsa-miR-212-3p	HITS-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	HITS-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	HITS-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	HITS-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	HITS-CLIP	21572407
MIRT549452	hsa-miR-580-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT549450	hsa-miR-3163	HITS-CLIP	21572407
MIRT549449	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT549448	hsa-miR-586	HITS-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	HITS-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	HITS-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT175430	hsa-miR-4477a	HITS-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	HITS-CLIP	21572407
MIRT549444	hsa-miR-527	HITS-CLIP	21572407
MIRT175328	hsa-miR-448	HITS-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	HITS-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	HITS-CLIP	21572407
MIRT549441	hsa-miR-3658	HITS-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	HITS-CLIP	21572407
MIRT108449	hsa-miR-507	HITS-CLIP	21572407
MIRT108450	hsa-miR-557	HITS-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	HITS-CLIP	21572407
MIRT108438	hsa-miR-129-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	23824327
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT549448	hsa-miR-586	HITS-CLIP	23824327
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT175328	hsa-miR-448	HITS-CLIP	23824327
MIRT549467	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549464	hsa-miR-3666	PAR-CLIP	21572407
MIRT549463	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT549461	hsa-miR-4295	PAR-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT175380	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT175378	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT549457	hsa-miR-3662	PAR-CLIP	21572407
MIRT549456	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT549455	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT549454	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT549452	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT549451	hsa-miR-8485	PAR-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT549450	hsa-miR-3163	PAR-CLIP	21572407
MIRT549449	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549448	hsa-miR-586	PAR-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT175430	hsa-miR-4477a	PAR-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	PAR-CLIP	21572407
MIRT549444	hsa-miR-527	PAR-CLIP	21572407
MIRT175328	hsa-miR-448	PAR-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT549441	hsa-miR-3658	PAR-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT108449	hsa-miR-507	PAR-CLIP	21572407
MIRT108450	hsa-miR-557	PAR-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT108438	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444490	hsa-miR-1298-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT054569	hsa-miR-205-5p	Microarray, qRT-PCR	35816043
MIRT763532	hsa-miR-1915	CLIP-seq
MIRT763533	hsa-miR-374a	CLIP-seq
MIRT763534	hsa-miR-374b	CLIP-seq
MIRT763535	hsa-miR-4291	CLIP-seq
MIRT763536	hsa-miR-4310	CLIP-seq
MIRT763537	hsa-miR-4726-3p	CLIP-seq
MIRT763538	hsa-miR-548an	CLIP-seq
MIRT763539	hsa-miR-1207-3p	CLIP-seq
MIRT763540	hsa-miR-1323	CLIP-seq
MIRT763541	hsa-miR-1537	CLIP-seq
MIRT763542	hsa-miR-3687	CLIP-seq
MIRT763543	hsa-miR-410	CLIP-seq
MIRT763544	hsa-miR-4442	CLIP-seq
MIRT763545	hsa-miR-4793-3p	CLIP-seq
MIRT763546	hsa-miR-548a-5p	CLIP-seq
MIRT763547	hsa-miR-548ab	CLIP-seq
MIRT763548	hsa-miR-548ak	CLIP-seq
MIRT763549	hsa-miR-548b-5p	CLIP-seq
MIRT763550	hsa-miR-548c-5p	CLIP-seq
MIRT763551	hsa-miR-548d-5p	CLIP-seq
MIRT763552	hsa-miR-548h	CLIP-seq
MIRT763553	hsa-miR-548i	CLIP-seq
MIRT763554	hsa-miR-548j	CLIP-seq
MIRT763555	hsa-miR-548k	CLIP-seq
MIRT763556	hsa-miR-548l	CLIP-seq
MIRT763557	hsa-miR-548o	CLIP-seq
MIRT763558	hsa-miR-548w	CLIP-seq
MIRT763559	hsa-miR-548y	CLIP-seq
MIRT763560	hsa-miR-559	CLIP-seq
MIRT763561	hsa-miR-590-3p	CLIP-seq
MIRT1922545	hsa-miR-1275	CLIP-seq
MIRT1922546	hsa-miR-19a	CLIP-seq
MIRT1922547	hsa-miR-19b	CLIP-seq
MIRT1922548	hsa-miR-3200-5p	CLIP-seq
MIRT1922549	hsa-miR-342-3p	CLIP-seq
MIRT1922550	hsa-miR-342-5p	CLIP-seq
MIRT1922551	hsa-miR-377	CLIP-seq
MIRT1922552	hsa-miR-4251	CLIP-seq
MIRT1922553	hsa-miR-4329	CLIP-seq
MIRT1922554	hsa-miR-4662a-3p	CLIP-seq
MIRT1922555	hsa-miR-4664-5p	CLIP-seq
MIRT1922556	hsa-miR-4665-5p	CLIP-seq
MIRT1925035	hsa-miR-101	CLIP-seq
MIRT1925036	hsa-miR-1257	CLIP-seq
MIRT1925037	hsa-miR-1297	CLIP-seq
MIRT1925038	hsa-miR-144	CLIP-seq
MIRT1925039	hsa-miR-204	CLIP-seq
MIRT1925040	hsa-miR-211	CLIP-seq
MIRT1925041	hsa-miR-26a	CLIP-seq
MIRT1925042	hsa-miR-26b	CLIP-seq
MIRT1925043	hsa-miR-33a	CLIP-seq
MIRT1925044	hsa-miR-33b	CLIP-seq
MIRT1925045	hsa-miR-4436b-3p	CLIP-seq
MIRT1925046	hsa-miR-4446-5p	CLIP-seq
MIRT1925047	hsa-miR-4465	CLIP-seq
MIRT1925048	hsa-miR-4660	CLIP-seq
MIRT1925049	hsa-miR-4755-5p	CLIP-seq
MIRT1925050	hsa-miR-582-5p	CLIP-seq
MIRT1925051	hsa-miR-584	CLIP-seq
MIRT1925052	hsa-miR-595	CLIP-seq
MIRT1925053	hsa-miR-623	CLIP-seq
MIRT1925054	hsa-miR-646	CLIP-seq
MIRT1922546	hsa-miR-19a	CLIP-seq
MIRT1922547	hsa-miR-19b	CLIP-seq
MIRT2166498	hsa-miR-205	CLIP-seq
MIRT2383830	hsa-miR-132	CLIP-seq
MIRT2383831	hsa-miR-212	CLIP-seq
MIRT2383832	hsa-miR-380	CLIP-seq
MIRT2383833	hsa-miR-4328	CLIP-seq
MIRT2435177	hsa-miR-576-5p	CLIP-seq
MIRT2443084	hsa-miR-3127-5p	CLIP-seq
MIRT2443085	hsa-miR-4270	CLIP-seq
MIRT2443086	hsa-miR-4441	CLIP-seq
MIRT2443087	hsa-miR-4668-5p	CLIP-seq
MIRT2443088	hsa-miR-4774-3p	CLIP-seq
MIRT2468948	hsa-miR-1236	CLIP-seq
MIRT2468949	hsa-miR-1279	CLIP-seq
MIRT1925037	hsa-miR-1297	CLIP-seq
MIRT2383830	hsa-miR-132	CLIP-seq
MIRT763540	hsa-miR-1323	CLIP-seq
MIRT2468950	hsa-miR-134	CLIP-seq
MIRT2468951	hsa-miR-145	CLIP-seq
MIRT2468952	hsa-miR-150	CLIP-seq
MIRT2468953	hsa-miR-1910	CLIP-seq
MIRT2468954	hsa-miR-1913	CLIP-seq
MIRT2468955	hsa-miR-199a-3p	CLIP-seq
MIRT2468956	hsa-miR-199b-3p	CLIP-seq
MIRT1925039	hsa-miR-204	CLIP-seq
MIRT1925040	hsa-miR-211	CLIP-seq
MIRT2468957	hsa-miR-2113	CLIP-seq
MIRT2468958	hsa-miR-2114	CLIP-seq
MIRT2383831	hsa-miR-212	CLIP-seq
MIRT2468959	hsa-miR-214	CLIP-seq
MIRT1925041	hsa-miR-26a	CLIP-seq
MIRT1925042	hsa-miR-26b	CLIP-seq
MIRT2468960	hsa-miR-3118	CLIP-seq
MIRT2468961	hsa-miR-3129-5p	CLIP-seq
MIRT2468962	hsa-miR-3148	CLIP-seq
MIRT2468963	hsa-miR-3153	CLIP-seq
MIRT2468964	hsa-miR-3161	CLIP-seq
MIRT2468965	hsa-miR-3164	CLIP-seq
MIRT2468966	hsa-miR-3180-5p	CLIP-seq
MIRT2468967	hsa-miR-320a	CLIP-seq
MIRT2468968	hsa-miR-320b	CLIP-seq
MIRT2468969	hsa-miR-320c	CLIP-seq
MIRT2468970	hsa-miR-320d	CLIP-seq
MIRT2468971	hsa-miR-324-3p	CLIP-seq
MIRT2468972	hsa-miR-325	CLIP-seq
MIRT2468973	hsa-miR-3619-5p	CLIP-seq
MIRT763533	hsa-miR-374a	CLIP-seq
MIRT763534	hsa-miR-374b	CLIP-seq
MIRT2468974	hsa-miR-374c	CLIP-seq
MIRT1922551	hsa-miR-377	CLIP-seq
MIRT2468975	hsa-miR-3978	CLIP-seq
MIRT2468976	hsa-miR-4263	CLIP-seq
MIRT2468977	hsa-miR-4429	CLIP-seq
MIRT1925045	hsa-miR-4436b-3p	CLIP-seq
MIRT1925047	hsa-miR-4465	CLIP-seq
MIRT2468978	hsa-miR-4475	CLIP-seq
MIRT2468979	hsa-miR-4521	CLIP-seq
MIRT2468980	hsa-miR-4522	CLIP-seq
MIRT2468981	hsa-miR-455-3p	CLIP-seq
MIRT2468982	hsa-miR-4639-3p	CLIP-seq
MIRT2468983	hsa-miR-4659a-3p	CLIP-seq
MIRT2468984	hsa-miR-4659b-3p	CLIP-seq
MIRT2468985	hsa-miR-4668-3p	CLIP-seq
MIRT2443087	hsa-miR-4668-5p	CLIP-seq
MIRT2468986	hsa-miR-4678	CLIP-seq
MIRT2468987	hsa-miR-4694-3p	CLIP-seq
MIRT2468988	hsa-miR-4713-5p	CLIP-seq
MIRT2468989	hsa-miR-4724-3p	CLIP-seq
MIRT2468990	hsa-miR-4729	CLIP-seq
MIRT2468991	hsa-miR-4742-3p	CLIP-seq
MIRT1925049	hsa-miR-4755-5p	CLIP-seq
MIRT2468992	hsa-miR-4762-3p	CLIP-seq
MIRT2468993	hsa-miR-4762-5p	CLIP-seq
MIRT2468994	hsa-miR-4766-5p	CLIP-seq
MIRT2468995	hsa-miR-4795-3p	CLIP-seq
MIRT2468996	hsa-miR-4799-5p	CLIP-seq
MIRT2468997	hsa-miR-522	CLIP-seq
MIRT2468998	hsa-miR-532-3p	CLIP-seq
MIRT2468999	hsa-miR-548ag	CLIP-seq
MIRT2469000	hsa-miR-548ai	CLIP-seq
MIRT2469001	hsa-miR-548c-3p	CLIP-seq
MIRT763557	hsa-miR-548o	CLIP-seq
MIRT2435177	hsa-miR-576-5p	CLIP-seq
MIRT2469002	hsa-miR-599	CLIP-seq
MIRT2469003	hsa-miR-618	CLIP-seq
MIRT1925053	hsa-miR-623	CLIP-seq
MIRT2469004	hsa-miR-628-3p	CLIP-seq
MIRT2469005	hsa-miR-655	CLIP-seq
MIRT2469006	hsa-miR-656	CLIP-seq
MIRT2469007	hsa-miR-761	CLIP-seq
MIRT2469008	hsa-miR-934	CLIP-seq
MIRT2469009	hsa-miR-938	CLIP-seq
MIRT2468948	hsa-miR-1236	CLIP-seq
MIRT2468949	hsa-miR-1279	CLIP-seq
MIRT1925037	hsa-miR-1297	CLIP-seq
MIRT2674316	hsa-miR-1298	CLIP-seq
MIRT2383830	hsa-miR-132	CLIP-seq
MIRT763540	hsa-miR-1323	CLIP-seq
MIRT2468950	hsa-miR-134	CLIP-seq
MIRT2468951	hsa-miR-145	CLIP-seq
MIRT2468952	hsa-miR-150	CLIP-seq
MIRT2468953	hsa-miR-1910	CLIP-seq
MIRT2468954	hsa-miR-1913	CLIP-seq
MIRT2468955	hsa-miR-199a-3p	CLIP-seq
MIRT2468956	hsa-miR-199b-3p	CLIP-seq
MIRT2674317	hsa-miR-200b	CLIP-seq
MIRT2674318	hsa-miR-200c	CLIP-seq
MIRT1925039	hsa-miR-204	CLIP-seq
MIRT2166498	hsa-miR-205	CLIP-seq
MIRT1925040	hsa-miR-211	CLIP-seq
MIRT2468957	hsa-miR-2113	CLIP-seq
MIRT2468958	hsa-miR-2114	CLIP-seq
MIRT2383831	hsa-miR-212	CLIP-seq
MIRT2468959	hsa-miR-214	CLIP-seq
MIRT1925041	hsa-miR-26a	CLIP-seq
MIRT1925042	hsa-miR-26b	CLIP-seq
MIRT2468960	hsa-miR-3118	CLIP-seq
MIRT2443084	hsa-miR-3127-5p	CLIP-seq
MIRT2468961	hsa-miR-3129-5p	CLIP-seq
MIRT2468962	hsa-miR-3148	CLIP-seq
MIRT2468963	hsa-miR-3153	CLIP-seq
MIRT2468964	hsa-miR-3161	CLIP-seq
MIRT2468965	hsa-miR-3164	CLIP-seq
MIRT2468966	hsa-miR-3180-5p	CLIP-seq
MIRT2468967	hsa-miR-320a	CLIP-seq
MIRT2468968	hsa-miR-320b	CLIP-seq
MIRT2468969	hsa-miR-320c	CLIP-seq
MIRT2468970	hsa-miR-320d	CLIP-seq
MIRT2468971	hsa-miR-324-3p	CLIP-seq
MIRT2468972	hsa-miR-325	CLIP-seq
MIRT2468973	hsa-miR-3619-5p	CLIP-seq
MIRT2674319	hsa-miR-3691-3p	CLIP-seq
MIRT763533	hsa-miR-374a	CLIP-seq
MIRT763534	hsa-miR-374b	CLIP-seq
MIRT2468974	hsa-miR-374c	CLIP-seq
MIRT1922551	hsa-miR-377	CLIP-seq
MIRT2468975	hsa-miR-3978	CLIP-seq
MIRT2468976	hsa-miR-4263	CLIP-seq
MIRT2443085	hsa-miR-4270	CLIP-seq
MIRT2674320	hsa-miR-4282	CLIP-seq
MIRT2468977	hsa-miR-4429	CLIP-seq
MIRT1925045	hsa-miR-4436b-3p	CLIP-seq
MIRT2443086	hsa-miR-4441	CLIP-seq
MIRT1925046	hsa-miR-4446-5p	CLIP-seq
MIRT1925047	hsa-miR-4465	CLIP-seq
MIRT2468978	hsa-miR-4475	CLIP-seq
MIRT2468979	hsa-miR-4521	CLIP-seq
MIRT2468980	hsa-miR-4522	CLIP-seq
MIRT2468981	hsa-miR-455-3p	CLIP-seq
MIRT2468983	hsa-miR-4659a-3p	CLIP-seq
MIRT2468984	hsa-miR-4659b-3p	CLIP-seq
MIRT2468985	hsa-miR-4668-3p	CLIP-seq
MIRT2443087	hsa-miR-4668-5p	CLIP-seq
MIRT2468986	hsa-miR-4678	CLIP-seq
MIRT2468987	hsa-miR-4694-3p	CLIP-seq
MIRT2468988	hsa-miR-4713-5p	CLIP-seq
MIRT2468989	hsa-miR-4724-3p	CLIP-seq
MIRT2468990	hsa-miR-4729	CLIP-seq
MIRT2468991	hsa-miR-4742-3p	CLIP-seq
MIRT1925049	hsa-miR-4755-5p	CLIP-seq
MIRT2468992	hsa-miR-4762-3p	CLIP-seq
MIRT2468993	hsa-miR-4762-5p	CLIP-seq
MIRT2468994	hsa-miR-4766-5p	CLIP-seq
MIRT2443088	hsa-miR-4774-3p	CLIP-seq
MIRT2468995	hsa-miR-4795-3p	CLIP-seq
MIRT2468996	hsa-miR-4799-5p	CLIP-seq
MIRT2674321	hsa-miR-520d-5p	CLIP-seq
MIRT2468997	hsa-miR-522	CLIP-seq
MIRT2674322	hsa-miR-524-5p	CLIP-seq
MIRT2468998	hsa-miR-532-3p	CLIP-seq
MIRT2674323	hsa-miR-548ac	CLIP-seq
MIRT2468999	hsa-miR-548ag	CLIP-seq
MIRT2469000	hsa-miR-548ai	CLIP-seq
MIRT2469001	hsa-miR-548c-3p	CLIP-seq
MIRT2674324	hsa-miR-548d-3p	CLIP-seq
MIRT763557	hsa-miR-548o	CLIP-seq
MIRT2674325	hsa-miR-548z	CLIP-seq
MIRT2435177	hsa-miR-576-5p	CLIP-seq
MIRT763561	hsa-miR-590-3p	CLIP-seq
MIRT2469002	hsa-miR-599	CLIP-seq
MIRT2469003	hsa-miR-618	CLIP-seq
MIRT1925053	hsa-miR-623	CLIP-seq
MIRT2469004	hsa-miR-628-3p	CLIP-seq
MIRT2469005	hsa-miR-655	CLIP-seq
MIRT2469006	hsa-miR-656	CLIP-seq
MIRT2469007	hsa-miR-761	CLIP-seq
MIRT2469008	hsa-miR-934	CLIP-seq
MIRT2469009	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001676	Process	Long-chain fatty acid metabolic process	IBA	21873635
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	24269233
GO:0001676	Process	Long-chain fatty acid metabolic process	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	10669417, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IMP	22633490
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11889465
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005811	Component	Lipid droplet	IBA	21873635
GO:0005811	Component	Lipid droplet	IDA	14741744
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006629	Process	Lipid metabolic process	IDA	9598324
GO:0007584	Process	Response to nutrient	IEA
GO:0015908	Process	Fatty acid transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IEA
GO:0030182	Process	Neuron differentiation	IBA	21873635
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IMP	11889465
GO:0032024	Process	Positive regulation of insulin secretion	ISS
GO:0035336	Process	Long-chain fatty-acyl-CoA metabolic process	IBA	21873635
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0043025	Component	Neuronal cell body	IEA
GO:0044233	Component	Mitochondria-associated endoplasmic reticulum membrane	IDA	23455425
GO:0047676	Function	Arachidonate-CoA ligase activity	IBA	21873635
GO:0047676	Function	Arachidonate-CoA ligase activity	IDA	9598324
GO:0060136	Process	Embryonic process involved in female pregnancy	IEA
GO:0060996	Process	Dendritic spine development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0070672	Process	Response to interleukin-15	IEA

Other IDs

• MIM: 300157
• HGNC: 3571
• e!Ensembl: ENSG00000068366

Protein

• UniProt ID: O60488
• Protein name: Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)
• Protein function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	103 → 578	AMP-binding enzyme	Family

• Sequence:

  MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYR
  SVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLIL
  GNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL
  YATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPE
  GFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMT
  GQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSK
  GDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLC
  NLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEV
  TDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAED
  YSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDN
  ICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAM
  KLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK

• Sequence length: 711