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ACSL3 (acyl-CoA synthetase long chain family member 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2181
Gene nameGene Name - the full gene name approved by the HGNC.
Acyl-CoA synthetase long chain family member 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ACSL3
SynonymsGene synonyms aliases
ACS3, FACL3, LACS 3, LACS3, PRO2194
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q36.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017614 hsa-miR-335-5p Microarray 18185580
MIRT019639 hsa-miR-340-5p Sequencing 20371350
MIRT019874 hsa-miR-375 Microarray 20215506
MIRT024182 hsa-miR-221-3p Sequencing 20371350
MIRT048455 hsa-miR-100-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001676 Process Long-chain fatty acid metabolic process IBA 21873635
GO:0001676 Process Long-chain fatty acid metabolic process IMP 22633490
GO:0001676 Process Long-chain fatty acid metabolic process ISS
GO:0004467 Function Long-chain fatty acid-CoA ligase activity IBA 21873635
GO:0004467 Function Long-chain fatty acid-CoA ligase activity IMP 20219900, 22633490
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O95573
Protein name Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)
Protein function Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00501 AMP-binding
113 587
AMP-binding enzyme
Family
Sequence
Sequence length 720
Interactions View interactions

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