ACSBG2 (acyl-CoA synthetase bubblegum family member 2)

Gene

• Entrez ID: 81616
• Gene name: Acyl-CoA synthetase bubblegum family member 2
• Gene symbol: ACSBG2
• Synonyms: BGR, BRGL, PRTD-NY3, PRTDNY3
• Chromosome: 19
• Chromosome location: 19p13.3

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	16371355, 16762313
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	16371355
GO:0005739	Component	Mitochondrion	IDA	16762313
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IDA	16371355, 16762313
GO:0007275	Process	Multicellular organism development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0016020	Component	Membrane	IEA
GO:0016405	Function	CoA-ligase activity	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IBA	21873635
GO:0047617	Function	Acyl-CoA hydrolase activity	IDA	16762313
GO:0047676	Function	Arachidonate-CoA ligase activity	IDA	16762313

Other IDs

• MIM: 614363
• HGNC: 24174
• e!Ensembl: ENSG00000130377

Protein

• UniProt ID: Q5FVE4
• Protein name: Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Arachidonate--CoA ligase ACSBG2) (EC 6.2.1.15) (Bubblegum-related protein) (PRTD-NY3)
• Protein function: Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:16371355, PubMed:16762313). Has increased ability to activate oleic and linoleic acid (PubMed:16371355). May play a role in spermatogenesis (PubMed:15685348).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	57 → 519	AMP-binding enzyme	Family

• Sequence:

  MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES
  VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI
  TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA
  IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV
  MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA
  LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK
  MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY
  GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET
  ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII
  SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD
  PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ
  IDHMYH

• Sequence length: 666