ACSBG1 (acyl-CoA synthetase bubblegum family member 1)

Gene

• Entrez ID: 23205
• Gene name: Acyl-CoA synthetase bubblegum family member 1
• Gene symbol: ACSBG1
• Synonyms: BG, BG1, BGM, GR-LACS, LPD
• Chromosome: 15
• Chromosome location: 15q25.1
• Summary: The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	10954726
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	10954726, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	10954726, 24269233
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	10954726
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	24269233
GO:0016405	Function	CoA-ligase activity	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IDA	10954726
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042552	Process	Myelination	NAS	10954726
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IBA	21873635
GO:0051384	Process	Response to glucocorticoid	IEA

Other IDs

• MIM: 614362
• HGNC: 29567
• e!Ensembl: ENSG00000103740

Protein

• UniProt ID: Q96GR2
• Protein name: Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin)
• Protein function: Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:12975357, PubMed:24269233, PubMed:10954726). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:10954726).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	109 → 573	AMP-binding enzyme	Family

• Sequence:

  MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA
  LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI
  ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA
  GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP
  NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT
  WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL
  VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL
  KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS
  GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI
  DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI
  GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA
  IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ
  EQKM

• Sequence length: 724