ACP1 (acid phosphatase 1)

Gene

• Entrez ID: 52
• Gene name: Acid phosphatase 1
• Gene symbol: ACP1
• Synonyms: HAAP, LMW-PTP, LMWPTP
• Chromosome: 2
• Chromosome location: 2p25.3
• Summary: The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043619	hsa-miR-151a-3p	CLASH	23622248
MIRT050258	hsa-miR-25-3p	CLASH	23622248
MIRT302322	hsa-miR-595	PAR-CLIP	21572407
MIRT302323	hsa-miR-648	PAR-CLIP	21572407
MIRT302325	hsa-miR-3115	PAR-CLIP	21572407
MIRT302326	hsa-miR-3650	PAR-CLIP	21572407
MIRT302327	hsa-miR-4455	PAR-CLIP	21572407
MIRT302329	hsa-miR-5680	PAR-CLIP	21572407
MIRT302330	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT531608	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT531609	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT531610	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT551898	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT551899	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT551900	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT551901	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT551902	hsa-miR-609	PAR-CLIP	21572407
MIRT551903	hsa-miR-6772-5p	PAR-CLIP	21572407
MIRT551904	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT551905	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT551906	hsa-miR-300	PAR-CLIP	21572407
MIRT551907	hsa-miR-6882-5p	PAR-CLIP	21572407

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003993	Function	Acid phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	9499402, 15846844, 25556234
GO:0005737	Component	Cytoplasm	IDA	10940933
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	10940933
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 171500
• HGNC: 122
• e!Ensembl: ENSG00000143727

Protein

• UniProt ID: P24666
• Protein name: Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)
• Protein function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
• PDB: 1XWW, 3N8I, 4Z99, 4Z9A, 4Z9B, 5JNR, 5JNS, 5JNT, 5KQG, 5KQL, 5KQM, 5KQP, 5PNT, 6Y2V, 6Y2W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01451	LMWPc	9 → 154	Low molecular weight phosphotyrosine protein phosphatase	Domain

• Sequence:

  MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
  QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
  DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH

• Sequence length: 158