ACOX3 (acyl-CoA oxidase 3, pristanoyl)

Gene

• Entrez ID: 8310
• Gene name: Acyl-CoA oxidase 3, pristanoyl
• Gene symbol: ACOX3
• Synonyms: -
• Chromosome: 4
• Chromosome location: 4p16.1
• Summary: Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003997	Function	Acyl-CoA oxidase activity	IBA	21873635
GO:0005504	Function	Fatty acid binding	IBA	21873635
GO:0005777	Component	Peroxisome	IBA	21873635
GO:0005777	Component	Peroxisome	IDA	8993592
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006625	Process	Protein targeting to peroxisome	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016402	Function	Pristanoyl-CoA oxidase activity	IBA	21873635
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	IBA	21873635
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	IEA
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	TAS
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA	21873635
GO:0055088	Process	Lipid homeostasis	IBA	21873635
GO:0071949	Function	FAD binding	IEA

Other IDs

• MIM: 603402
• HGNC: 121
• e!Ensembl: ENSG00000087008

Protein

• UniProt ID: O15254
• Protein name: Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)
• Protein function: Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02770	Acyl-CoA_dh_M	155 → 266	Acyl-CoA dehydrogenase, middle domain	Domain
  PF01756	ACOX	510 → 693	Acyl-CoA oxidase	Family

• Sequence:

  MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPL
  FARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAK
  YLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPAT
  EEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMP
  GVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGAS
  LGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYL
  AAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQ
  ECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFR
  SPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSG
  SSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSL
  SRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADG
  ELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL

• Sequence length: 700