Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
48 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Aconitase 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
ACO1 |
SynonymsGene synonyms aliases
|
ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1 |
ChromosomeChromosome number
|
9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
9p21.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4F |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
MTF1 |
Unknown |
16886906 |
SP1 |
Unknown |
16886906 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0003723 |
Function |
RNA binding |
IDA |
1946430 |
GO:0003723 |
Function |
RNA binding |
NAS |
1903202 |
GO:0003994 |
Function |
Aconitate hydratase activity |
IBA |
21873635 |
GO:0003994 |
Function |
Aconitate hydratase activity |
IDA |
1946430, 8041788 |
GO:0003994 |
Function |
Aconitate hydratase activity |
IMP |
1281544 |
GO:0005515 |
Function |
Protein binding |
IPI |
19762596, 19762597, 23414517 |
GO:0005737 |
Component |
Cytoplasm |
IMP |
1281544 |
GO:0005737 |
Component |
Cytoplasm |
NAS |
1738601 |
GO:0005739 |
Component |
Mitochondrion |
IBA |
21873635 |
GO:0005739 |
Component |
Mitochondrion |
IDA |
|
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
16144863 |
GO:0005794 |
Component |
Golgi apparatus |
IDA |
16144863 |
GO:0005829 |
Component |
Cytosol |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
IDA |
16527810 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006099 |
Process |
Tricarboxylic acid cycle |
IBA |
21873635 |
GO:0006101 |
Process |
Citrate metabolic process |
IBA |
21873635 |
GO:0006101 |
Process |
Citrate metabolic process |
IDA |
8041788, 16527810 |
GO:0006101 |
Process |
Citrate metabolic process |
IMP |
1281544 |
GO:0006417 |
Process |
Regulation of translation |
IEA |
|
GO:0006879 |
Process |
Cellular iron ion homeostasis |
TAS |
|
GO:0009791 |
Process |
Post-embryonic development |
IEA |
|
GO:0010040 |
Process |
Response to iron(II) ion |
IDA |
8041788 |
GO:0030350 |
Function |
Iron-responsive element binding |
IBA |
21873635 |
GO:0030350 |
Function |
Iron-responsive element binding |
IDA |
8041788 |
GO:0030350 |
Function |
Iron-responsive element binding |
IMP |
1281544, 23891004 |
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0047780 |
Function |
Citrate dehydratase activity |
IEA |
|
GO:0050892 |
Process |
Intestinal absorption |
IEA |
|
GO:0051538 |
Function |
3 iron, 4 sulfur cluster binding |
IBA |
21873635 |
GO:0051538 |
Function |
3 iron, 4 sulfur cluster binding |
IMP |
1281544 |
GO:0051539 |
Function |
4 iron, 4 sulfur cluster binding |
IBA |
21873635 |
GO:0051539 |
Function |
4 iron, 4 sulfur cluster binding |
IDA |
16407072 |
GO:0051539 |
Function |
4 iron, 4 sulfur cluster binding |
IMP |
1281544 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 23533145 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P21399 |
Protein name |
Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) |
Protein function |
Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes |
PDB |
2B3X
,
2B3Y
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00330 |
Aconitase |
59 → 564 |
Aconitase family (aconitate hydratase) |
Family |
PF00694 |
Aconitase_C |
692 → 821 |
Aconitase C-terminal domain |
Domain |
|
Sequence |
|
Sequence length |
889 |
Interactions |
View interactions |