ABCG4 (ATP binding cassette subfamily G member 4)

Gene

• Entrez ID: 64137
• Gene name: ATP binding cassette subfamily G member 4
• Gene symbol: ABCG4
• Synonyms: WHITE2
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein is a member of the White subfamily and plays an important role in cellular cholesterol homeostasis. This protein functions as either a homodimer or as a heterodimer with another ABC subfamily protein such as ABCG1. [provided by RefSeq, Jan 2017]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030047	hsa-miR-26b-5p	Microarray	19088304
MIRT733696	hsa-miR-185-5p	Luciferase reporter assay	27816548
MIRT763408	hsa-miR-1915-3p	PAR-CLIP	27292025
MIRT769108	hsa-miR-4436b-3p	PAR-CLIP	27292025
MIRT770480	hsa-miR-4632-5p	PAR-CLIP	27292025
MIRT771048	hsa-miR-4685-5p	PAR-CLIP	27292025
MIRT771060	hsa-miR-4687-3p	PAR-CLIP	27292025
MIRT774477	hsa-miR-548q	PAR-CLIP	27292025
MIRT777820	hsa-miR-6721-5p	PAR-CLIP	27292025
MIRT778026	hsa-miR-6735-5p	PAR-CLIP	27292025
MIRT778497	hsa-miR-6764-5p	PAR-CLIP	27292025
MIRT778526	hsa-miR-6765-3p	PAR-CLIP	27292025
MIRT780074	hsa-miR-6837-5p	PAR-CLIP	27292025
MIRT780798	hsa-miR-6879-5p	PAR-CLIP	27292025
MIRT782102	hsa-miR-7843-5p	PAR-CLIP	27292025

Transcription factors

Transcription factor	Regulation	Reference
NR1H2	Activation	16141411
NR1H3	Activation	16141411

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16870176, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	27228027
GO:0005886	Component	Plasma membrane	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0016887	Function	ATPase activity	IEA
GO:0033344	Process	Cholesterol efflux	IBA	21873635
GO:0033344	Process	Cholesterol efflux	TAS	16682745
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IEA
GO:0042802	Function	Identical protein binding	IDA	27228027
GO:0042803	Function	Protein homodimerization activity	IDA	16870176
GO:0046982	Function	Protein heterodimerization activity	IPI	16870176
GO:0055085	Process	Transmembrane transport	TAS
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

Other IDs

• MIM: 607784
• HGNC: 13884
• e!Ensembl: ENSG00000172350

Protein

• UniProt ID: Q9H172
• Protein name: ATP-binding cassette sub-family G member 4
• Protein function: May be involved in macrophage lipid homeostasis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00005	ABC_tran	85 → 229	ABC transporter	Domain
  PF19055	ABC2_membrane_7	258 → 328	ABC-2 type transporter	Family
  PF01061	ABC2_membrane	372 → 583	ABC-2 type transporter	Family

• Sequence:

  MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD
  IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE
  SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL
  VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV
  SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP
  TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP
  IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV
  FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV
  VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV
  TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR
  EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER

• Sequence length: 646