ABCD3 (ATP binding cassette subfamily D member 3)

Gene

• Entrez ID: 5825
• Gene name: ATP binding cassette subfamily D member 3
• Gene symbol: ABCD3
• Synonyms: ABC43, CBAS5, PMP70, PXMP1, ZWS2
• Chromosome: 1
• Chromosome location: 1p21.3
• Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030935	hsa-miR-21-5p	Microarray	18591254
MIRT758783	hsa-miR-323b-3p	CLIP-seq
MIRT758784	hsa-miR-3926	CLIP-seq
MIRT758785	hsa-miR-4438	CLIP-seq
MIRT758786	hsa-miR-5095	CLIP-seq
MIRT758787	hsa-miR-548s	CLIP-seq
MIRT758788	hsa-miR-1272	CLIP-seq
MIRT758789	hsa-miR-1297	CLIP-seq
MIRT758790	hsa-miR-1305	CLIP-seq
MIRT758791	hsa-miR-219-5p	CLIP-seq
MIRT758792	hsa-miR-26a	CLIP-seq
MIRT758793	hsa-miR-26b	CLIP-seq
MIRT758794	hsa-miR-296-3p	CLIP-seq
MIRT758795	hsa-miR-3121-3p	CLIP-seq
MIRT758796	hsa-miR-3130-5p	CLIP-seq
MIRT758797	hsa-miR-365	CLIP-seq
MIRT758798	hsa-miR-3682-5p	CLIP-seq
MIRT758799	hsa-miR-4307	CLIP-seq
MIRT758800	hsa-miR-4328	CLIP-seq
MIRT758801	hsa-miR-4445	CLIP-seq
MIRT758802	hsa-miR-4465	CLIP-seq
MIRT758803	hsa-miR-4482	CLIP-seq
MIRT758804	hsa-miR-4676-5p	CLIP-seq
MIRT758805	hsa-miR-4698	CLIP-seq
MIRT758806	hsa-miR-4749-3p	CLIP-seq
MIRT758807	hsa-miR-4762-3p	CLIP-seq
MIRT758808	hsa-miR-4782-3p	CLIP-seq
MIRT758809	hsa-miR-4798-5p	CLIP-seq
MIRT758810	hsa-miR-498	CLIP-seq
MIRT758811	hsa-miR-499-3p	CLIP-seq
MIRT758812	hsa-miR-499a-3p	CLIP-seq
MIRT758813	hsa-miR-508-3p	CLIP-seq
MIRT758814	hsa-miR-575	CLIP-seq
MIRT1923721	hsa-miR-135a	CLIP-seq
MIRT1923722	hsa-miR-135b	CLIP-seq
MIRT1923723	hsa-miR-1915	CLIP-seq
MIRT758799	hsa-miR-4307	CLIP-seq
MIRT1923724	hsa-miR-4726-3p	CLIP-seq
MIRT2467143	hsa-miR-105	CLIP-seq
MIRT2467144	hsa-miR-1252	CLIP-seq
MIRT2467145	hsa-miR-1273d	CLIP-seq
MIRT2467146	hsa-miR-1289	CLIP-seq
MIRT2467147	hsa-miR-1343	CLIP-seq
MIRT1923721	hsa-miR-135a	CLIP-seq
MIRT1923722	hsa-miR-135b	CLIP-seq
MIRT2467148	hsa-miR-140-3p	CLIP-seq
MIRT1923723	hsa-miR-1915	CLIP-seq
MIRT2467149	hsa-miR-2682	CLIP-seq
MIRT2467150	hsa-miR-27a	CLIP-seq
MIRT2467151	hsa-miR-27b	CLIP-seq
MIRT758794	hsa-miR-296-3p	CLIP-seq
MIRT2467152	hsa-miR-299-5p	CLIP-seq
MIRT2467153	hsa-miR-3074-5p	CLIP-seq
MIRT2467154	hsa-miR-3119	CLIP-seq
MIRT758795	hsa-miR-3121-3p	CLIP-seq
MIRT758796	hsa-miR-3130-5p	CLIP-seq
MIRT2467155	hsa-miR-3163	CLIP-seq
MIRT2467156	hsa-miR-3198	CLIP-seq
MIRT2467157	hsa-miR-323-3p	CLIP-seq
MIRT2467158	hsa-miR-337-3p	CLIP-seq
MIRT2467159	hsa-miR-3622b-5p	CLIP-seq
MIRT2467160	hsa-miR-3646	CLIP-seq
MIRT2467161	hsa-miR-3662	CLIP-seq
MIRT2467162	hsa-miR-3667-5p	CLIP-seq
MIRT2467163	hsa-miR-3689a-5p	CLIP-seq
MIRT2467164	hsa-miR-3689b	CLIP-seq
MIRT2467165	hsa-miR-3689e	CLIP-seq
MIRT2467166	hsa-miR-3689f	CLIP-seq
MIRT2467167	hsa-miR-3690	CLIP-seq
MIRT2467168	hsa-miR-369-3p	CLIP-seq
MIRT2467169	hsa-miR-374a	CLIP-seq
MIRT2467170	hsa-miR-374b	CLIP-seq
MIRT2467171	hsa-miR-374c	CLIP-seq
MIRT2467172	hsa-miR-3908	CLIP-seq
MIRT2467173	hsa-miR-3913-3p	CLIP-seq
MIRT2467174	hsa-miR-3942-5p	CLIP-seq
MIRT2467175	hsa-miR-410	CLIP-seq
MIRT2467176	hsa-miR-412	CLIP-seq
MIRT2467177	hsa-miR-4252	CLIP-seq
MIRT2467178	hsa-miR-4254	CLIP-seq
MIRT2467179	hsa-miR-4261	CLIP-seq
MIRT2467180	hsa-miR-4272	CLIP-seq
MIRT2467181	hsa-miR-4294	CLIP-seq
MIRT2467182	hsa-miR-4309	CLIP-seq
MIRT758800	hsa-miR-4328	CLIP-seq
MIRT2467183	hsa-miR-4420	CLIP-seq
MIRT2467184	hsa-miR-4423-3p	CLIP-seq
MIRT2467185	hsa-miR-4436a	CLIP-seq
MIRT2467186	hsa-miR-4477a	CLIP-seq
MIRT2467187	hsa-miR-4477b	CLIP-seq
MIRT758803	hsa-miR-4482	CLIP-seq
MIRT2467188	hsa-miR-449c	CLIP-seq
MIRT2467189	hsa-miR-451b	CLIP-seq
MIRT2467190	hsa-miR-4662a-3p	CLIP-seq
MIRT2467191	hsa-miR-4667-3p	CLIP-seq
MIRT2467192	hsa-miR-4680-5p	CLIP-seq
MIRT2467193	hsa-miR-4696	CLIP-seq
MIRT758805	hsa-miR-4698	CLIP-seq
MIRT2467194	hsa-miR-4699-5p	CLIP-seq
MIRT2467195	hsa-miR-4700-3p	CLIP-seq
MIRT2467196	hsa-miR-4703-5p	CLIP-seq
MIRT2467197	hsa-miR-4719	CLIP-seq
MIRT2467198	hsa-miR-4720-5p	CLIP-seq
MIRT1923724	hsa-miR-4726-3p	CLIP-seq
MIRT2467199	hsa-miR-4729	CLIP-seq
MIRT2467200	hsa-miR-4731-3p	CLIP-seq
MIRT2467201	hsa-miR-4733-5p	CLIP-seq
MIRT2467202	hsa-miR-4735-5p	CLIP-seq
MIRT2467203	hsa-miR-4736	CLIP-seq
MIRT2467204	hsa-miR-4738-3p	CLIP-seq
MIRT2467205	hsa-miR-4747-5p	CLIP-seq
MIRT2467206	hsa-miR-4753-3p	CLIP-seq
MIRT2467207	hsa-miR-4756-3p	CLIP-seq
MIRT2467208	hsa-miR-4760-3p	CLIP-seq
MIRT2467209	hsa-miR-4766-3p	CLIP-seq
MIRT2467210	hsa-miR-4773	CLIP-seq
MIRT2467211	hsa-miR-4775	CLIP-seq
MIRT2467212	hsa-miR-4786-3p	CLIP-seq
MIRT2467213	hsa-miR-4789-5p	CLIP-seq
MIRT2467214	hsa-miR-4790-3p	CLIP-seq
MIRT2467215	hsa-miR-4795-3p	CLIP-seq
MIRT2467216	hsa-miR-4799-3p	CLIP-seq
MIRT2467217	hsa-miR-4801	CLIP-seq
MIRT2467218	hsa-miR-4802-3p	CLIP-seq
MIRT2467219	hsa-miR-4803	CLIP-seq
MIRT2467220	hsa-miR-489	CLIP-seq
MIRT2467221	hsa-miR-491-3p	CLIP-seq
MIRT2467222	hsa-miR-494	CLIP-seq
MIRT2467223	hsa-miR-513a-5p	CLIP-seq
MIRT2467224	hsa-miR-515-3p	CLIP-seq
MIRT2467225	hsa-miR-519e	CLIP-seq
MIRT2467226	hsa-miR-548aa	CLIP-seq
MIRT2467227	hsa-miR-548c-3p	CLIP-seq
MIRT2467228	hsa-miR-548n	CLIP-seq
MIRT2467229	hsa-miR-548t	CLIP-seq
MIRT2467230	hsa-miR-568	CLIP-seq
MIRT2467231	hsa-miR-577	CLIP-seq
MIRT2467232	hsa-miR-590-3p	CLIP-seq
MIRT2467233	hsa-miR-599	CLIP-seq
MIRT2467234	hsa-miR-617	CLIP-seq
MIRT2467235	hsa-miR-655	CLIP-seq
MIRT2467236	hsa-miR-656	CLIP-seq
MIRT2467237	hsa-miR-657	CLIP-seq
MIRT2467238	hsa-miR-889	CLIP-seq
MIRT2467239	hsa-miR-940	CLIP-seq
MIRT2467143	hsa-miR-105	CLIP-seq
MIRT2467144	hsa-miR-1252	CLIP-seq
MIRT2467145	hsa-miR-1273d	CLIP-seq
MIRT2467146	hsa-miR-1289	CLIP-seq
MIRT2467147	hsa-miR-1343	CLIP-seq
MIRT1923721	hsa-miR-135a	CLIP-seq
MIRT1923722	hsa-miR-135b	CLIP-seq
MIRT2467148	hsa-miR-140-3p	CLIP-seq
MIRT2467149	hsa-miR-2682	CLIP-seq
MIRT2467150	hsa-miR-27a	CLIP-seq
MIRT2467151	hsa-miR-27b	CLIP-seq
MIRT758794	hsa-miR-296-3p	CLIP-seq
MIRT2467152	hsa-miR-299-5p	CLIP-seq
MIRT2467153	hsa-miR-3074-5p	CLIP-seq
MIRT2467154	hsa-miR-3119	CLIP-seq
MIRT758795	hsa-miR-3121-3p	CLIP-seq
MIRT758796	hsa-miR-3130-5p	CLIP-seq
MIRT2467155	hsa-miR-3163	CLIP-seq
MIRT2467156	hsa-miR-3198	CLIP-seq
MIRT2467157	hsa-miR-323-3p	CLIP-seq
MIRT2467159	hsa-miR-3622b-5p	CLIP-seq
MIRT2467160	hsa-miR-3646	CLIP-seq
MIRT2467161	hsa-miR-3662	CLIP-seq
MIRT2467162	hsa-miR-3667-5p	CLIP-seq
MIRT2467163	hsa-miR-3689a-5p	CLIP-seq
MIRT2467164	hsa-miR-3689b	CLIP-seq
MIRT2467165	hsa-miR-3689e	CLIP-seq
MIRT2467166	hsa-miR-3689f	CLIP-seq
MIRT2467167	hsa-miR-3690	CLIP-seq
MIRT2467168	hsa-miR-369-3p	CLIP-seq
MIRT2467169	hsa-miR-374a	CLIP-seq
MIRT2467170	hsa-miR-374b	CLIP-seq
MIRT2467171	hsa-miR-374c	CLIP-seq
MIRT2467172	hsa-miR-3908	CLIP-seq
MIRT2467173	hsa-miR-3913-3p	CLIP-seq
MIRT2467174	hsa-miR-3942-5p	CLIP-seq
MIRT2467175	hsa-miR-410	CLIP-seq
MIRT2467176	hsa-miR-412	CLIP-seq
MIRT2467177	hsa-miR-4252	CLIP-seq
MIRT2467178	hsa-miR-4254	CLIP-seq
MIRT2467179	hsa-miR-4261	CLIP-seq
MIRT2467180	hsa-miR-4272	CLIP-seq
MIRT2467181	hsa-miR-4294	CLIP-seq
MIRT2467182	hsa-miR-4309	CLIP-seq
MIRT758800	hsa-miR-4328	CLIP-seq
MIRT2467183	hsa-miR-4420	CLIP-seq
MIRT2467184	hsa-miR-4423-3p	CLIP-seq
MIRT2467185	hsa-miR-4436a	CLIP-seq
MIRT2467186	hsa-miR-4477a	CLIP-seq
MIRT2467187	hsa-miR-4477b	CLIP-seq
MIRT758803	hsa-miR-4482	CLIP-seq
MIRT2467188	hsa-miR-449c	CLIP-seq
MIRT2467189	hsa-miR-451b	CLIP-seq
MIRT2467190	hsa-miR-4662a-3p	CLIP-seq
MIRT2467191	hsa-miR-4667-3p	CLIP-seq
MIRT2467192	hsa-miR-4680-5p	CLIP-seq
MIRT2467193	hsa-miR-4696	CLIP-seq
MIRT758805	hsa-miR-4698	CLIP-seq
MIRT2467194	hsa-miR-4699-5p	CLIP-seq
MIRT2467195	hsa-miR-4700-3p	CLIP-seq
MIRT2467196	hsa-miR-4703-5p	CLIP-seq
MIRT2467197	hsa-miR-4719	CLIP-seq
MIRT2467198	hsa-miR-4720-5p	CLIP-seq
MIRT2467199	hsa-miR-4729	CLIP-seq
MIRT2467200	hsa-miR-4731-3p	CLIP-seq
MIRT2467201	hsa-miR-4733-5p	CLIP-seq
MIRT2467202	hsa-miR-4735-5p	CLIP-seq
MIRT2467203	hsa-miR-4736	CLIP-seq
MIRT2467204	hsa-miR-4738-3p	CLIP-seq
MIRT2467205	hsa-miR-4747-5p	CLIP-seq
MIRT2467206	hsa-miR-4753-3p	CLIP-seq
MIRT2467207	hsa-miR-4756-3p	CLIP-seq
MIRT2467208	hsa-miR-4760-3p	CLIP-seq
MIRT2467209	hsa-miR-4766-3p	CLIP-seq
MIRT2467210	hsa-miR-4773	CLIP-seq
MIRT2467211	hsa-miR-4775	CLIP-seq
MIRT2467212	hsa-miR-4786-3p	CLIP-seq
MIRT2467213	hsa-miR-4789-5p	CLIP-seq
MIRT2467214	hsa-miR-4790-3p	CLIP-seq
MIRT2467215	hsa-miR-4795-3p	CLIP-seq
MIRT2467216	hsa-miR-4799-3p	CLIP-seq
MIRT2467217	hsa-miR-4801	CLIP-seq
MIRT2467218	hsa-miR-4802-3p	CLIP-seq
MIRT2467219	hsa-miR-4803	CLIP-seq
MIRT2467220	hsa-miR-489	CLIP-seq
MIRT2467221	hsa-miR-491-3p	CLIP-seq
MIRT2467222	hsa-miR-494	CLIP-seq
MIRT2467223	hsa-miR-513a-5p	CLIP-seq
MIRT2467224	hsa-miR-515-3p	CLIP-seq
MIRT2467225	hsa-miR-519e	CLIP-seq
MIRT2467226	hsa-miR-548aa	CLIP-seq
MIRT2467227	hsa-miR-548c-3p	CLIP-seq
MIRT2467228	hsa-miR-548n	CLIP-seq
MIRT2467229	hsa-miR-548t	CLIP-seq
MIRT2467230	hsa-miR-568	CLIP-seq
MIRT2467231	hsa-miR-577	CLIP-seq
MIRT2467232	hsa-miR-590-3p	CLIP-seq
MIRT2467233	hsa-miR-599	CLIP-seq
MIRT2467234	hsa-miR-617	CLIP-seq
MIRT2467235	hsa-miR-655	CLIP-seq
MIRT2467236	hsa-miR-656	CLIP-seq
MIRT2467237	hsa-miR-657	CLIP-seq
MIRT2467238	hsa-miR-889	CLIP-seq
MIRT2467239	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005324	Function	Long-chain fatty acid transporter activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10551832, 10704444, 10777694, 11453642, 11590176, 11883941, 14709540, 16344115, 17609205, 21102411
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	IDA	11248239
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IDA	9425230, 9922452, 10704444, 11453642, 16344115, 17542813, 19479899, 20007743
GO:0005778	Component	Peroxisomal membrane	IBA	21873635
GO:0005778	Component	Peroxisomal membrane	IDA	17609205
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0005782	Component	Peroxisomal matrix	IDA	9765053
GO:0005829	Component	Cytosol	TAS
GO:0006633	Process	Fatty acid biosynthetic process	IMP	25168382
GO:0006635	Process	Fatty acid beta-oxidation	IBA	21873635
GO:0006635	Process	Fatty acid beta-oxidation	IGI	9425230
GO:0007031	Process	Peroxisome organization	IBA	21873635
GO:0007031	Process	Peroxisome organization	IDA	9425230
GO:0007031	Process	Peroxisome organization	IMP	9765053
GO:0014070	Process	Response to organic cyclic compound	IEA
GO:0015910	Process	Long-chain fatty acid import into peroxisome	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0016887	Function	ATPase activity	IDA	11248239
GO:0042493	Process	Response to drug	IEA
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042760	Process	Very long-chain fatty acid catabolic process	IBA	21873635
GO:0042760	Process	Very long-chain fatty acid catabolic process	IGI	9425230
GO:0042803	Function	Protein homodimerization activity	IDA	17609205
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043621	Function	Protein self-association	IEA
GO:0055085	Process	Transmembrane transport	TAS

Other IDs

• MIM: 170995
• HGNC: 67
• e!Ensembl: ENSG00000117528

Protein

• UniProt ID: P28288
• Protein name: ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70)
• Protein function: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the
• PDB: 8Z0F, 8Z9X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06472	ABC_membrane_2	70 → 338	ABC transporter transmembrane region 2	Family
  PF00005	ABC_tran	456 → 599	ABC transporter	Domain

• Sequence:

  MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD
  KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK
  DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
  RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVS
  GLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLV
  EHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
  GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEG
  VQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKS
  SLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL
  VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSA
  VSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS

• Sequence length: 659