ABCC5 (ATP binding cassette subfamily C member 5)

Gene

• Entrez ID: 10057
• Gene name: ATP binding cassette subfamily C member 5
• Gene symbol: ABCC5
• Synonyms: ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11
• Chromosome: 3
• Chromosome location: 3q27.1
• Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027512	hsa-miR-98-5p	Microarray	19088304
MIRT036328	hsa-miR-1229-3p	CLASH	23622248
MIRT036666	hsa-miR-935	CLASH	23622248
MIRT038057	hsa-miR-423-5p	CLASH	23622248
MIRT038057	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT038057	hsa-miR-423-5p	PAR-CLIP	24398324
MIRT044899	hsa-miR-188-5p	CLASH	23622248
MIRT054153	hsa-miR-129-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	25344911
MIRT306301	hsa-miR-4308	PAR-CLIP	23592263
MIRT306302	hsa-miR-4254	PAR-CLIP	23592263
MIRT457943	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT457943	hsa-miR-6510-5p	PAR-CLIP	24398324
MIRT457944	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT457944	hsa-miR-1304-5p	PAR-CLIP	24398324
MIRT457945	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT457945	hsa-miR-1273h-3p	PAR-CLIP	24398324
MIRT457946	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT457946	hsa-miR-6734-5p	PAR-CLIP	24398324
MIRT457947	hsa-miR-1226-5p	PAR-CLIP	23592263
MIRT457947	hsa-miR-1226-5p	PAR-CLIP	24398324
MIRT457948	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT457948	hsa-miR-6834-5p	PAR-CLIP	24398324
MIRT457949	hsa-miR-3175	PAR-CLIP	23592263
MIRT457949	hsa-miR-3175	PAR-CLIP	24398324
MIRT457949	hsa-miR-3175	PAR-CLIP	20371350
MIRT457949	hsa-miR-3175	PAR-CLIP	26701625
MIRT457950	hsa-miR-8085	PAR-CLIP	23592263
MIRT457950	hsa-miR-8085	PAR-CLIP	24398324
MIRT457951	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT457951	hsa-miR-6731-5p	PAR-CLIP	24398324
MIRT457952	hsa-miR-4644	PAR-CLIP	23592263
MIRT457952	hsa-miR-4644	PAR-CLIP	24398324
MIRT457953	hsa-miR-4306	PAR-CLIP	23592263
MIRT457953	hsa-miR-4306	PAR-CLIP	24398324
MIRT457954	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT457954	hsa-miR-185-5p	PAR-CLIP	24398324
MIRT457955	hsa-miR-4771	PAR-CLIP	23592263
MIRT457955	hsa-miR-4771	PAR-CLIP	24398324
MIRT457956	hsa-miR-3166	PAR-CLIP	23592263
MIRT457956	hsa-miR-3166	PAR-CLIP	24398324
MIRT457957	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT457957	hsa-miR-6738-5p	PAR-CLIP	24398324
MIRT457958	hsa-miR-5194	PAR-CLIP	23592263
MIRT457958	hsa-miR-5194	PAR-CLIP	24398324
MIRT457959	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT457959	hsa-miR-1914-3p	PAR-CLIP	24398324
MIRT457960	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT457960	hsa-miR-3184-5p	PAR-CLIP	24398324
MIRT457961	hsa-miR-873-3p	PAR-CLIP	23592263
MIRT457961	hsa-miR-873-3p	PAR-CLIP	24398324
MIRT457962	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT457962	hsa-miR-499b-5p	PAR-CLIP	24398324
MIRT489094	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT489094	hsa-miR-6763-5p	PAR-CLIP	20371350
MIRT489094	hsa-miR-6763-5p	PAR-CLIP	26701625
MIRT489095	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT489095	hsa-miR-3150a-3p	PAR-CLIP	20371350
MIRT489095	hsa-miR-3150a-3p	PAR-CLIP	26701625
MIRT489096	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT489096	hsa-miR-491-5p	PAR-CLIP	20371350
MIRT489096	hsa-miR-491-5p	PAR-CLIP	26701625
MIRT489097	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT489097	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT489097	hsa-miR-6848-5p	PAR-CLIP	26701625
MIRT489098	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT489098	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT489098	hsa-miR-6846-5p	PAR-CLIP	26701625
MIRT489099	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT489099	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT489099	hsa-miR-185-3p	PAR-CLIP	26701625
MIRT489100	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT489100	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT489100	hsa-miR-6825-5p	PAR-CLIP	26701625
MIRT489101	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT489101	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT489101	hsa-miR-939-5p	PAR-CLIP	26701625
MIRT489102	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT489102	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT489102	hsa-miR-1343-5p	PAR-CLIP	26701625
MIRT489103	hsa-miR-4741	PAR-CLIP	23592263
MIRT489103	hsa-miR-4741	PAR-CLIP	20371350
MIRT489103	hsa-miR-4741	PAR-CLIP	26701625
MIRT489104	hsa-miR-4675	PAR-CLIP	23592263
MIRT489104	hsa-miR-4675	PAR-CLIP	20371350
MIRT489104	hsa-miR-4675	PAR-CLIP	26701625
MIRT489105	hsa-miR-1199-3p	PAR-CLIP	23592263
MIRT489106	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT489106	hsa-miR-2467-3p	PAR-CLIP	20371350
MIRT489106	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT489107	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT489107	hsa-miR-6820-5p	PAR-CLIP	20371350
MIRT489107	hsa-miR-6820-5p	PAR-CLIP	26701625
MIRT489108	hsa-miR-6087	PAR-CLIP	23592263
MIRT489108	hsa-miR-6087	PAR-CLIP	20371350
MIRT489108	hsa-miR-6087	PAR-CLIP	26701625
MIRT489109	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT489109	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT489109	hsa-miR-6805-5p	PAR-CLIP	26701625
MIRT508158	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT508158	hsa-miR-4758-3p	PAR-CLIP	22012620
MIRT508158	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT508158	hsa-miR-4758-3p	PAR-CLIP	20371350
MIRT508159	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT508159	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT508159	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT508159	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT508160	hsa-miR-610	PAR-CLIP	23446348
MIRT508160	hsa-miR-610	PAR-CLIP	22012620
MIRT508160	hsa-miR-610	PAR-CLIP	21572407
MIRT508160	hsa-miR-610	PAR-CLIP	20371350
MIRT508161	hsa-miR-1224-3p	PAR-CLIP	23446348
MIRT508161	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT508161	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT508161	hsa-miR-1224-3p	PAR-CLIP	20371350
MIRT508162	hsa-miR-3622b-3p	PAR-CLIP	23446348
MIRT508162	hsa-miR-3622b-3p	PAR-CLIP	22012620
MIRT508162	hsa-miR-3622b-3p	PAR-CLIP	21572407
MIRT508162	hsa-miR-3622b-3p	PAR-CLIP	20371350
MIRT508163	hsa-miR-3622a-3p	PAR-CLIP	23446348
MIRT508163	hsa-miR-3622a-3p	PAR-CLIP	22012620
MIRT508163	hsa-miR-3622a-3p	PAR-CLIP	21572407
MIRT508163	hsa-miR-3622a-3p	PAR-CLIP	20371350
MIRT508164	hsa-miR-4323	PAR-CLIP	23446348
MIRT508164	hsa-miR-4323	PAR-CLIP	22012620
MIRT508164	hsa-miR-4323	PAR-CLIP	21572407
MIRT508164	hsa-miR-4323	PAR-CLIP	20371350
MIRT508165	hsa-miR-634	PAR-CLIP	23446348
MIRT508165	hsa-miR-634	PAR-CLIP	22012620
MIRT508165	hsa-miR-634	PAR-CLIP	21572407
MIRT508165	hsa-miR-634	PAR-CLIP	20371350

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IEA
GO:0005796	Component	Golgi lumen	IEA
GO:0005886	Component	Plasma membrane	IDA	18619525, 28112518
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	9827529
GO:0008514	Function	Organic anion transmembrane transporter activity	TAS
GO:0010008	Component	Endosome membrane	IEA
GO:0015216	Function	Purine nucleotide transmembrane transporter activity	IDA	10840050
GO:0015562	Function	Efflux transmembrane transporter activity	IDA	10840050
GO:0015865	Process	Purine nucleotide transport	IDA	10840050
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	15297306
GO:0016323	Component	Basolateral plasma membrane	IDA	10840050, 31791063
GO:0016323	Component	Basolateral plasma membrane	ISS	18619525
GO:0016324	Component	Apical plasma membrane	IDA	31791063
GO:0016887	Function	ATPase activity	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	TAS
GO:0034634	Function	Glutathione transmembrane transporter activity	IDA	10840050
GO:0034775	Process	Glutathione transmembrane transport	IDA	10840050
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042908	Process	Xenobiotic transport	IDA	10840050
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IDA	10840050
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:0055085	Process	Transmembrane transport	TAS
GO:0140115	Process	Export across plasma membrane	IDA	10840050
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653

Other IDs

• MIM: 605251
• HGNC: 56
• e!Ensembl: ENSG00000114770

Protein

• UniProt ID: O15440
• Protein name: Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11)
• Protein function: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00664	ABC_membrane	179 → 447	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	578 → 713	ABC transporter	Domain
  PF00664	ABC_membrane	859 → 1143	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	1210 → 1358	ABC transporter	Domain

• Sequence:

  MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS
  LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR
  VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
  LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW
  ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG
  PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE
  VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV
  HMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK
  NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA
  VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG
  KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS
  CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG
  NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI
  FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS
  VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS
  VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM
  KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP
  LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL
  LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT
  GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM
  RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD
  IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE
  SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCT
  MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG

• Sequence length: 1437