ABCC12 (ATP binding cassette subfamily C member 12)

Gene

• Entrez ID: 94160
• Gene name: ATP binding cassette subfamily C member 12
• Gene symbol: ABCC12
• Synonyms: MRP9
• Chromosome: 16
• Chromosome location: 16q12.1
• Summary: This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT613375	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613376	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT613377	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT613378	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT613379	hsa-miR-4291	HITS-CLIP	23824327
MIRT613380	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613381	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT613382	hsa-miR-761	HITS-CLIP	23824327
MIRT613383	hsa-miR-3619-5p	HITS-CLIP	23824327
MIRT613384	hsa-miR-214-3p	HITS-CLIP	23824327
MIRT613385	hsa-miR-922	HITS-CLIP	23824327
MIRT613386	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT615337	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT615338	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT615339	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT615340	hsa-miR-3183	HITS-CLIP	23824327
MIRT617018	hsa-miR-6510-5p	HITS-CLIP	23824327
MIRT624874	hsa-miR-505-5p	HITS-CLIP	23824327
MIRT624875	hsa-miR-4254	HITS-CLIP	23824327
MIRT624876	hsa-miR-3690	HITS-CLIP	23824327
MIRT640180	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT640181	hsa-miR-557	HITS-CLIP	23824327
MIRT640182	hsa-miR-507	HITS-CLIP	23824327
MIRT640183	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT640184	hsa-miR-448	HITS-CLIP	23824327
MIRT640185	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT640186	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT640187	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT640188	hsa-miR-1257	HITS-CLIP	23824327
MIRT640189	hsa-miR-15b-3p	HITS-CLIP	23824327
MIRT640190	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT640191	hsa-miR-4328	HITS-CLIP	23824327
MIRT640192	hsa-miR-153-3p	HITS-CLIP	23824327
MIRT643790	hsa-miR-587	HITS-CLIP	23824327
MIRT643791	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT643792	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT643793	hsa-miR-4705	HITS-CLIP	23824327
MIRT643794	hsa-miR-6864-5p	HITS-CLIP	23824327
MIRT643795	hsa-miR-6126	HITS-CLIP	23824327
MIRT643796	hsa-miR-6836-5p	HITS-CLIP	23824327
MIRT643797	hsa-miR-6132	HITS-CLIP	23824327
MIRT643798	hsa-miR-4635	HITS-CLIP	23824327
MIRT643799	hsa-miR-5088-5p	HITS-CLIP	23824327
MIRT643800	hsa-miR-5096	HITS-CLIP	23824327
MIRT643801	hsa-miR-576-5p	HITS-CLIP	23824327
MIRT643802	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT643803	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643804	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT643805	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT643806	hsa-miR-623	HITS-CLIP	23824327
MIRT643807	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT643808	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT643809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT643810	hsa-miR-4719	HITS-CLIP	23824327
MIRT643811	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT643812	hsa-miR-3163	HITS-CLIP	23824327
MIRT643813	hsa-miR-216b-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	17472575
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016887	Function	ATPase activity	IEA
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0055085	Process	Transmembrane transport	IBA	21873635

Other IDs

• MIM: 607041
• HGNC: 14640
• e!Ensembl: ENSG00000140798

Protein

• UniProt ID: Q96J65
• Protein name: ATP-binding cassette sub-family C member 12 (Multidrug resistance-associated protein 9)
• Protein function: Probable transporter, its substrate specificity is unknown.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00664	ABC_membrane	123 → 391	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	496 → 631	ABC transporter	Domain
  PF00664	ABC_membrane	795 → 1070	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	1137 → 1285	ABC transporter	Domain

• Sequence:

  MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWL
  TPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQR
  TRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFW
  ALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPL
  PATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQ
  TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVL
  TLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSP
  PSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK
  GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVN
  GTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG
  LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH
  QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVE
  AFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWK
  TYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVG
  AVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFF
  DTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAV
  GFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNC
  ALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTET
  QAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL
  NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI
  PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG
  ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLN
  CDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL

• Sequence length: 1359