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ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group))

Gene

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

ABCC1

ABC29, ABCC, DFNA77, GS-X, MRP, MRP1

16

16p13.11

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MD

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs60782127	G>T	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant

Show/Hide all(202)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004494	hsa-miR-134-5p	qRT-PCR, Western blot, Northern blot	20371173
MIRT003199	hsa-miR-7-5p	Luciferase reporter assay, Western blot	20099276
MIRT003199	hsa-miR-7-5p	Luciferase reporter assay, Western blot	20099276
MIRT003198	hsa-miR-345-5p	Luciferase reporter assay, Western blot	20099276
MIRT003198	hsa-miR-345-5p	Luciferase reporter assay, Western blot	20099276
MIRT021440	hsa-miR-9-5p	Microarray	17612493
MIRT024051	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT003199	hsa-miR-7-5p	Microarray	19073608
MIRT027818	hsa-miR-98-5p	Microarray	19088304
MIRT032483	hsa-let-7b-5p	Proteomics	18668040
MIRT051224	hsa-miR-16-5p	CLASH	23622248
MIRT046316	hsa-miR-23b-3p	CLASH	23622248
MIRT046005	hsa-miR-125b-5p	CLASH	23622248
MIRT042744	hsa-miR-339-5p	CLASH	23622248
MIRT040354	hsa-miR-615-3p	CLASH	23622248
MIRT053213	hsa-miR-1291	Luciferase reporter assay, Western blot	23686318
MIRT053213	hsa-miR-1291	Luciferase reporter assay, Western blot	23686318
MIRT053213	hsa-miR-1291	Luciferase reporter assay, Western blot	23686318
MIRT053213	hsa-miR-1291	Luciferase reporter assay, Western blot	23686318
MIRT706013	hsa-miR-224-5p	HITS-CLIP	23313552
MIRT706012	hsa-miR-199b-5p	HITS-CLIP	23313552
MIRT706011	hsa-miR-199a-5p	HITS-CLIP	23313552
MIRT706010	hsa-miR-145-5p	HITS-CLIP	23313552
MIRT706008	hsa-miR-5195-3p	HITS-CLIP	23313552
MIRT706009	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT706007	hsa-miR-1323	HITS-CLIP	23313552
MIRT706006	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT706005	hsa-miR-1825	HITS-CLIP	23313552
MIRT706004	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT706003	hsa-miR-520d-5p	HITS-CLIP	23313552
MIRT706002	hsa-miR-524-5p	HITS-CLIP	23313552
MIRT706001	hsa-miR-3180-5p	HITS-CLIP	23313552
MIRT706010	hsa-miR-145-5p	Luciferase reporter assay	25354783
MIRT021440	hsa-miR-9-5p	Luciferase reporter assay, qRT-PCR, Western blot	28098912
MIRT021440	hsa-miR-9-5p	Luciferase reporter assay, qRT-PCR, Western blot	28098912
MIRT003199	hsa-miR-7-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR	26108539
MIRT734736	hsa-miR-139-5p	Luciferase reporter assay, Western blotting, qRT-PCR	31750616
MIRT706013	hsa-miR-224-5p	HITS-CLIP	23313552
MIRT706012	hsa-miR-199b-5p	HITS-CLIP	23313552
MIRT706011	hsa-miR-199a-5p	HITS-CLIP	23313552
MIRT706010	hsa-miR-145-5p	HITS-CLIP	23313552
MIRT706008	hsa-miR-5195-3p	HITS-CLIP	23313552
MIRT706009	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT706007	hsa-miR-1323	HITS-CLIP	23313552
MIRT706006	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT706005	hsa-miR-1825	HITS-CLIP	23313552
MIRT706004	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT706003	hsa-miR-520d-5p	HITS-CLIP	23313552
MIRT706002	hsa-miR-524-5p	HITS-CLIP	23313552
MIRT706001	hsa-miR-3180-5p	HITS-CLIP	23313552
MIRT755758	hsa-miR-1254	Western blotting, qRT-PCR	37190912
MIRT758296	hsa-miR-145	CLIP-seq
MIRT758297	hsa-miR-149	CLIP-seq
MIRT758298	hsa-miR-2116	CLIP-seq
MIRT758299	hsa-miR-217	CLIP-seq
MIRT758300	hsa-miR-219-5p	CLIP-seq
MIRT758301	hsa-miR-224	CLIP-seq
MIRT758302	hsa-miR-3064-5p	CLIP-seq
MIRT758303	hsa-miR-409-3p	CLIP-seq
MIRT758304	hsa-miR-4273	CLIP-seq
MIRT758305	hsa-miR-4297	CLIP-seq
MIRT758306	hsa-miR-4310	CLIP-seq
MIRT758307	hsa-miR-4418	CLIP-seq
MIRT758308	hsa-miR-4445	CLIP-seq
MIRT758309	hsa-miR-4661-3p	CLIP-seq
MIRT758310	hsa-miR-4677-5p	CLIP-seq
MIRT758311	hsa-miR-4782-3p	CLIP-seq
MIRT758312	hsa-miR-4794	CLIP-seq
MIRT758313	hsa-miR-508-3p	CLIP-seq
MIRT758314	hsa-miR-509-3-5p	CLIP-seq
MIRT758315	hsa-miR-509-5p	CLIP-seq
MIRT758316	hsa-miR-600	CLIP-seq
MIRT758317	hsa-miR-604	CLIP-seq
MIRT758318	hsa-miR-647	CLIP-seq
MIRT758319	hsa-miR-653	CLIP-seq
MIRT758320	hsa-miR-1231	CLIP-seq
MIRT758321	hsa-miR-1265	CLIP-seq
MIRT758322	hsa-miR-1912	CLIP-seq
MIRT758323	hsa-miR-2052	CLIP-seq
MIRT758324	hsa-miR-3173-5p	CLIP-seq
MIRT758325	hsa-miR-3178	CLIP-seq
MIRT758326	hsa-miR-323b-5p	CLIP-seq
MIRT758327	hsa-miR-326	CLIP-seq
MIRT758328	hsa-miR-330-5p	CLIP-seq
MIRT758329	hsa-miR-4256	CLIP-seq
MIRT758330	hsa-miR-4277	CLIP-seq
MIRT758331	hsa-miR-4288	CLIP-seq
MIRT758332	hsa-miR-4292	CLIP-seq
MIRT758333	hsa-miR-4307	CLIP-seq
MIRT758334	hsa-miR-4308	CLIP-seq
MIRT758335	hsa-miR-4486	CLIP-seq
MIRT758336	hsa-miR-4720-5p	CLIP-seq
MIRT758337	hsa-miR-4747-3p	CLIP-seq
MIRT758338	hsa-miR-4799-3p	CLIP-seq
MIRT758339	hsa-miR-629	CLIP-seq
MIRT758340	hsa-miR-632	CLIP-seq
MIRT758341	hsa-miR-659	CLIP-seq
MIRT758342	hsa-miR-877	CLIP-seq
MIRT1923652	hsa-miR-1292	CLIP-seq
MIRT1923653	hsa-miR-141	CLIP-seq
MIRT1923654	hsa-miR-200a	CLIP-seq
MIRT758325	hsa-miR-3178	CLIP-seq
MIRT1923655	hsa-miR-345	CLIP-seq
MIRT758332	hsa-miR-4292	CLIP-seq
MIRT758334	hsa-miR-4308	CLIP-seq
MIRT1923656	hsa-miR-4471	CLIP-seq
MIRT758335	hsa-miR-4486	CLIP-seq
MIRT1923657	hsa-miR-4640-5p	CLIP-seq
MIRT1923658	hsa-miR-4726-5p	CLIP-seq
MIRT1923659	hsa-miR-4755-3p	CLIP-seq
MIRT1923660	hsa-miR-541	CLIP-seq
MIRT1923661	hsa-miR-654-5p	CLIP-seq
MIRT758318	hsa-miR-647	CLIP-seq
MIRT2165168	hsa-miR-101	CLIP-seq
MIRT1923653	hsa-miR-141	CLIP-seq
MIRT1923654	hsa-miR-200a	CLIP-seq
MIRT2165169	hsa-miR-29a	CLIP-seq
MIRT2165170	hsa-miR-29b	CLIP-seq
MIRT2165171	hsa-miR-29c	CLIP-seq
MIRT2165172	hsa-miR-3605-3p	CLIP-seq
MIRT2165173	hsa-miR-3918	CLIP-seq
MIRT2165174	hsa-miR-4529-5p	CLIP-seq
MIRT2165175	hsa-miR-4645-5p	CLIP-seq
MIRT2165176	hsa-miR-4673	CLIP-seq
MIRT2165177	hsa-miR-4699-3p	CLIP-seq
MIRT2165178	hsa-miR-4705	CLIP-seq
MIRT2165179	hsa-miR-4707-5p	CLIP-seq
MIRT2165180	hsa-miR-4713-5p	CLIP-seq
MIRT2165181	hsa-miR-4733-3p	CLIP-seq
MIRT2165182	hsa-miR-4747-5p	CLIP-seq
MIRT1923660	hsa-miR-541	CLIP-seq
MIRT1923661	hsa-miR-654-5p	CLIP-seq
MIRT2165183	hsa-miR-889	CLIP-seq
MIRT2383744	hsa-miR-1207-5p	CLIP-seq
MIRT2383745	hsa-miR-1343	CLIP-seq
MIRT2383746	hsa-miR-1909	CLIP-seq
MIRT2383747	hsa-miR-3144-5p	CLIP-seq
MIRT758325	hsa-miR-3178	CLIP-seq
MIRT2383748	hsa-miR-3188	CLIP-seq
MIRT1923655	hsa-miR-345	CLIP-seq
MIRT758332	hsa-miR-4292	CLIP-seq
MIRT758334	hsa-miR-4308	CLIP-seq
MIRT758335	hsa-miR-4486	CLIP-seq
MIRT2383749	hsa-miR-4514	CLIP-seq
MIRT2165175	hsa-miR-4645-5p	CLIP-seq
MIRT2165176	hsa-miR-4673	CLIP-seq
MIRT2383750	hsa-miR-4692	CLIP-seq
MIRT2383751	hsa-miR-4763-3p	CLIP-seq
MIRT2383752	hsa-miR-940	CLIP-seq
MIRT2435146	hsa-miR-328	CLIP-seq
MIRT2435147	hsa-miR-331-3p	CLIP-seq
MIRT2435148	hsa-miR-582-5p	CLIP-seq
MIRT2467031	hsa-miR-1	CLIP-seq
MIRT2165168	hsa-miR-101	CLIP-seq
MIRT2467032	hsa-miR-1229	CLIP-seq
MIRT2467033	hsa-miR-1297	CLIP-seq
MIRT2383745	hsa-miR-1343	CLIP-seq
MIRT2467034	hsa-miR-146a	CLIP-seq
MIRT2467035	hsa-miR-146b-5p	CLIP-seq
MIRT2467036	hsa-miR-206	CLIP-seq
MIRT2467037	hsa-miR-2467-3p	CLIP-seq
MIRT2467038	hsa-miR-26a	CLIP-seq
MIRT2467039	hsa-miR-26b	CLIP-seq
MIRT2467040	hsa-miR-3074-5p	CLIP-seq
MIRT2467041	hsa-miR-3136-3p	CLIP-seq
MIRT2467042	hsa-miR-3176	CLIP-seq
MIRT2435146	hsa-miR-328	CLIP-seq
MIRT2435147	hsa-miR-331-3p	CLIP-seq
MIRT2467043	hsa-miR-3672	CLIP-seq
MIRT2467044	hsa-miR-3678-3p	CLIP-seq
MIRT2467045	hsa-miR-3682-5p	CLIP-seq
MIRT2467046	hsa-miR-3922-3p	CLIP-seq
MIRT2467047	hsa-miR-3938	CLIP-seq
MIRT2467048	hsa-miR-4459	CLIP-seq
MIRT2467049	hsa-miR-4465	CLIP-seq
MIRT2467050	hsa-miR-4540	CLIP-seq
MIRT2467051	hsa-miR-4646-5p	CLIP-seq
MIRT2467052	hsa-miR-4649-5p	CLIP-seq
MIRT2467053	hsa-miR-4690-3p	CLIP-seq
MIRT2467054	hsa-miR-485-5p	CLIP-seq
MIRT2467055	hsa-miR-548ad	CLIP-seq
MIRT2435148	hsa-miR-582-5p	CLIP-seq
MIRT2467056	hsa-miR-607	CLIP-seq
MIRT2467057	hsa-miR-613	CLIP-seq
MIRT2467058	hsa-miR-665	CLIP-seq
MIRT2467031	hsa-miR-1	CLIP-seq
MIRT2467032	hsa-miR-1229	CLIP-seq
MIRT2383745	hsa-miR-1343	CLIP-seq
MIRT2467036	hsa-miR-206	CLIP-seq
MIRT2467040	hsa-miR-3074-5p	CLIP-seq
MIRT2435146	hsa-miR-328	CLIP-seq
MIRT2435147	hsa-miR-331-3p	CLIP-seq
MIRT2467045	hsa-miR-3682-5p	CLIP-seq
MIRT2467048	hsa-miR-4459	CLIP-seq
MIRT2467050	hsa-miR-4540	CLIP-seq
MIRT2467051	hsa-miR-4646-5p	CLIP-seq
MIRT2467052	hsa-miR-4649-5p	CLIP-seq
MIRT2467053	hsa-miR-4690-3p	CLIP-seq
MIRT2435148	hsa-miR-582-5p	CLIP-seq
MIRT2467056	hsa-miR-607	CLIP-seq
MIRT2467057	hsa-miR-613	CLIP-seq
MIRT2467058	hsa-miR-665	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
MYCN	Activation	10348353;14737110;7923112
MYCN	Unknown	9516823
SP1	Repression	23765166

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IDA	17050692, 23137377, 28112518
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	1360704
GO:0006691	Process	Leukotriene metabolic process	TAS
GO:0008559	Function	ABC-type xenobiotic transporter activity	IBA	21873635
GO:0009235	Process	Cobalamin metabolic process	TAS
GO:0009925	Component	Basal plasma membrane	IDA	18619525
GO:0015420	Function	ABC-type vitamin B12 transporter activity	TAS
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	ISS
GO:0015562	Function	Efflux transmembrane transporter activity	IMP	25986174
GO:0015562	Function	Efflux transmembrane transporter activity	ISS	26200696
GO:0015889	Process	Cobalamin transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016323	Component	Basolateral plasma membrane	IBA	21873635
GO:0016323	Component	Basolateral plasma membrane	IDA	24130369, 31791063
GO:0016323	Component	Basolateral plasma membrane	ISS	18619525
GO:0016324	Component	Apical plasma membrane	IDA	31791063
GO:0016328	Component	Lateral plasma membrane	IDA	31791063
GO:0016887	Function	ATPase activity	IDA	15999530
GO:0034040	Function	ATPase-coupled lipid transmembrane transporter activity	IMP	17050692
GO:0034634	Function	Glutathione transmembrane transporter activity	IBA	21873635
GO:0034634	Function	Glutathione transmembrane transporter activity	ISS	26200696
GO:0034775	Process	Glutathione transmembrane transport	IBA	21873635
GO:0042493	Process	Response to drug	ISS
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	TAS
GO:0042908	Process	Xenobiotic transport	IBA	21873635
GO:0042908	Process	Xenobiotic transport	ISS
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IDA	7961706, 9281595
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IMP	25986174
GO:0042910	Function	Xenobiotic transmembrane transporter activity	ISS	26200696
GO:0045332	Process	Phospholipid translocation	IMP	17050692
GO:0046943	Function	Carboxylic acid transmembrane transporter activity	IMP	25986174
GO:0050729	Process	Positive regulation of inflammatory response	ISS
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:0055085	Process	Transmembrane transport	TAS
GO:0060326	Process	Cell chemotaxis	ISS	17050692
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070633	Process	Transepithelial transport	IMP	25986174
GO:0071716	Process	Leukotriene transport	ISS
GO:0099039	Process	Sphingolipid translocation	IMP	17050692
GO:0140115	Process	Export across plasma membrane	IMP	25986174
GO:0140115	Process	Export across plasma membrane	ISS	26200696
GO:0140359	Function	ABC-type transporter activity	IDA	7961706, 9281595
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1904646	Process	Cellular response to amyloid-beta	ISS	26200696
GO:1905039	Process	Carboxylic acid transmembrane transport	IMP	25986174

MIM	HGNC	e!Ensembl
158343	51	ENSG00000103222

Protein

UniProt ID

Protein name

Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)

Protein function

Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estra

PDB

2CBZ , 4C3Z , 8VT4 , 8VUX , 8VVC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	325 → 596	ABC transporter transmembrane region	Family
PF00005	ABC_tran	661 → 796	ABC transporter	Domain
PF00664	ABC_membrane	975 → 1244	ABC transporter transmembrane region	Family
PF00005	ABC_tran	1310 → 1458	ABC transporter	Domain

Sequence

MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL
ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL
DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV

Sequence length

1531

Interactions

View interactions

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