ABCB5 (ATP binding cassette subfamily B member 5)

Gene

• Entrez ID: 340273
• Gene name: ATP binding cassette subfamily B member 5
• Gene symbol: ABCB5
• Synonyms: ABCB5alpha, ABCB5beta, EST422562
• Chromosome: 7
• Chromosome location: 7p21.1
• Summary: ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023509	hsa-miR-1-3p	Microarray	18668037
MIRT441597	hsa-miR-4480	PAR-CLIP	22100165
MIRT441597	hsa-miR-4480	PAR-CLIP	23708386
MIRT441597	hsa-miR-4480	PAR-CLIP	22291592
MIRT441598	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT441598	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT441598	hsa-miR-192-3p	PAR-CLIP	22291592
MIRT441599	hsa-miR-330-3p	PAR-CLIP	22100165
MIRT441599	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT441599	hsa-miR-330-3p	PAR-CLIP	22291592
MIRT441600	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT441600	hsa-miR-100-3p	PAR-CLIP	23708386
MIRT441600	hsa-miR-100-3p	PAR-CLIP	22291592
MIRT441601	hsa-miR-4311	PAR-CLIP	22100165
MIRT441601	hsa-miR-4311	PAR-CLIP	23708386
MIRT441601	hsa-miR-4311	PAR-CLIP	22291592
MIRT631235	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT631236	hsa-miR-607	HITS-CLIP	23824327
MIRT631237	hsa-miR-7855-5p	HITS-CLIP	23824327
MIRT631238	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT631239	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631240	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT631241	hsa-miR-3671	HITS-CLIP	23824327
MIRT631242	hsa-miR-4710	HITS-CLIP	23824327
MIRT631243	hsa-miR-4792	HITS-CLIP	23824327
MIRT631244	hsa-miR-4284	HITS-CLIP	23824327
MIRT631245	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631246	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631247	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631248	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631249	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631250	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631251	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631252	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631253	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631254	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT631255	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT631256	hsa-miR-580-5p	HITS-CLIP	23824327
MIRT734383	hsa-miR-522-5p	Flow, GFP reporter assay, qRT-PCR, Western blot	26043974

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001654	Process	Eye development	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	12960149
GO:0015562	Function	Efflux transmembrane transporter activity	IDA	12960149
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0016887	Function	ATPase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0042391	Process	Regulation of membrane potential	IDA	12960149
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:0055085	Process	Transmembrane transport	IDA	12960149
GO:0055085	Process	Transmembrane transport	TAS

Other IDs

• MIM: 611785
• HGNC: 46
• e!Ensembl: ENSG00000004846

Protein

• UniProt ID: Q2M3G0
• Protein name: ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) (EC 7.6.2.2)
• Protein function: Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:22306008, PubMed:15899824, PubMed:15205344). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00664	ABC_membrane	48 → 337	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	404 → 553	ABC transporter	Domain
  PF00664	ABC_membrane	692 → 966	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	1033 → 1184	ABC transporter	Domain

• Sequence:

  MENSERAEEMQENYQRNGTAEEQPKLRKEAVGSIEIFRFADGLDITLMILGILASLVNGA
  CLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAALIF
  GYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGD
  KIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYS
  KAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVYFFMNG
  TYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIF
  QVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALV
  GLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISN
  NIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALV
  RNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGML
  AEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFID
  KAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMF
  GNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQD
  IAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFL
  ILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMY
  EEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTA
  IAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREV
  SFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVD
  AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEG
  LPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDK
  ARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ

• Sequence length: 1257