ABCB10 (ATP binding cassette subfamily B member 10)

Gene

• Entrez ID: 23456
• Gene name: ATP binding cassette subfamily B member 10
• Gene symbol: ABCB10
• Synonyms: EST20237, M-ABC2, MTABC2
• Chromosome: 1
• Chromosome location: 1q42.13
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024476	hsa-miR-215-5p	Microarray	19074876
MIRT026891	hsa-miR-192-5p	Microarray	19074876
MIRT028616	hsa-miR-30a-5p	Proteomics	18668040
MIRT030557	hsa-miR-24-3p	Microarray	19748357
MIRT032488	hsa-let-7b-5p	Proteomics	18668040
MIRT758067	hsa-miR-1206	CLIP-seq
MIRT758068	hsa-miR-1208	CLIP-seq
MIRT758069	hsa-miR-1238	CLIP-seq
MIRT758070	hsa-miR-1267	CLIP-seq
MIRT758071	hsa-miR-1279	CLIP-seq
MIRT758072	hsa-miR-1323	CLIP-seq
MIRT758073	hsa-miR-141	CLIP-seq
MIRT758074	hsa-miR-146a	CLIP-seq
MIRT758075	hsa-miR-146b-5p	CLIP-seq
MIRT758076	hsa-miR-200a	CLIP-seq
MIRT758077	hsa-miR-203	CLIP-seq
MIRT758078	hsa-miR-2052	CLIP-seq
MIRT758079	hsa-miR-2276	CLIP-seq
MIRT758080	hsa-miR-3148	CLIP-seq
MIRT758081	hsa-miR-3153	CLIP-seq
MIRT758082	hsa-miR-3156-5p	CLIP-seq
MIRT758083	hsa-miR-3159	CLIP-seq
MIRT758084	hsa-miR-329	CLIP-seq
MIRT758085	hsa-miR-33a	CLIP-seq
MIRT758086	hsa-miR-33b	CLIP-seq
MIRT758087	hsa-miR-362-3p	CLIP-seq
MIRT758088	hsa-miR-3662	CLIP-seq
MIRT758089	hsa-miR-3941	CLIP-seq
MIRT758090	hsa-miR-3978	CLIP-seq
MIRT758091	hsa-miR-4330	CLIP-seq
MIRT758092	hsa-miR-4434	CLIP-seq
MIRT758093	hsa-miR-4457	CLIP-seq
MIRT758094	hsa-miR-450b-5p	CLIP-seq
MIRT758095	hsa-miR-4516	CLIP-seq
MIRT758096	hsa-miR-451b	CLIP-seq
MIRT758097	hsa-miR-452	CLIP-seq
MIRT758098	hsa-miR-4531	CLIP-seq
MIRT758099	hsa-miR-4652-3p	CLIP-seq
MIRT758100	hsa-miR-4659a-5p	CLIP-seq
MIRT758101	hsa-miR-4659b-5p	CLIP-seq
MIRT758102	hsa-miR-466	CLIP-seq
MIRT758103	hsa-miR-4668-5p	CLIP-seq
MIRT758104	hsa-miR-4672	CLIP-seq
MIRT758105	hsa-miR-4676-3p	CLIP-seq
MIRT758106	hsa-miR-4772-3p	CLIP-seq
MIRT758107	hsa-miR-4773	CLIP-seq
MIRT758108	hsa-miR-4778-5p	CLIP-seq
MIRT758109	hsa-miR-507	CLIP-seq
MIRT758110	hsa-miR-526b	CLIP-seq
MIRT758111	hsa-miR-544	CLIP-seq
MIRT758112	hsa-miR-548o	CLIP-seq
MIRT758113	hsa-miR-557	CLIP-seq
MIRT758114	hsa-miR-578	CLIP-seq
MIRT758115	hsa-miR-580	CLIP-seq
MIRT758116	hsa-miR-589	CLIP-seq
MIRT758117	hsa-miR-603	CLIP-seq
MIRT758118	hsa-miR-607	CLIP-seq
MIRT758119	hsa-miR-653	CLIP-seq
MIRT758120	hsa-miR-656	CLIP-seq
MIRT1923580	hsa-miR-1304	CLIP-seq
MIRT1923581	hsa-miR-1827	CLIP-seq
MIRT1923582	hsa-miR-183	CLIP-seq
MIRT1923583	hsa-miR-2054	CLIP-seq
MIRT1923584	hsa-miR-3120-3p	CLIP-seq
MIRT1923585	hsa-miR-3133	CLIP-seq
MIRT758083	hsa-miR-3159	CLIP-seq
MIRT1923586	hsa-miR-3682-5p	CLIP-seq
MIRT758093	hsa-miR-4457	CLIP-seq
MIRT758097	hsa-miR-452	CLIP-seq
MIRT758105	hsa-miR-4676-3p	CLIP-seq
MIRT1923587	hsa-miR-4760-3p	CLIP-seq
MIRT1923588	hsa-miR-513a-3p	CLIP-seq
MIRT758110	hsa-miR-526b	CLIP-seq
MIRT1923589	hsa-miR-545	CLIP-seq
MIRT758114	hsa-miR-578	CLIP-seq
MIRT758068	hsa-miR-1208	CLIP-seq
MIRT758069	hsa-miR-1238	CLIP-seq
MIRT758070	hsa-miR-1267	CLIP-seq
MIRT2165043	hsa-miR-128	CLIP-seq
MIRT758073	hsa-miR-141	CLIP-seq
MIRT2165044	hsa-miR-193a-3p	CLIP-seq
MIRT2165045	hsa-miR-193b	CLIP-seq
MIRT758076	hsa-miR-200a	CLIP-seq
MIRT758078	hsa-miR-2052	CLIP-seq
MIRT2165046	hsa-miR-214	CLIP-seq
MIRT758079	hsa-miR-2276	CLIP-seq
MIRT2165047	hsa-miR-3163	CLIP-seq
MIRT2165048	hsa-miR-3176	CLIP-seq
MIRT2165049	hsa-miR-3619-5p	CLIP-seq
MIRT758088	hsa-miR-3662	CLIP-seq
MIRT2165050	hsa-miR-3921	CLIP-seq
MIRT2165051	hsa-miR-3922-3p	CLIP-seq
MIRT758089	hsa-miR-3941	CLIP-seq
MIRT2165052	hsa-miR-4272	CLIP-seq
MIRT758091	hsa-miR-4330	CLIP-seq
MIRT2165053	hsa-miR-4474-5p	CLIP-seq
MIRT758097	hsa-miR-452	CLIP-seq
MIRT758099	hsa-miR-4652-3p	CLIP-seq
MIRT2165054	hsa-miR-4653-5p	CLIP-seq
MIRT758102	hsa-miR-466	CLIP-seq
MIRT758104	hsa-miR-4672	CLIP-seq
MIRT758105	hsa-miR-4676-3p	CLIP-seq
MIRT2165055	hsa-miR-4682	CLIP-seq
MIRT2165056	hsa-miR-4690-5p	CLIP-seq
MIRT2165057	hsa-miR-4714-3p	CLIP-seq
MIRT2165058	hsa-miR-4742-5p	CLIP-seq
MIRT758106	hsa-miR-4772-3p	CLIP-seq
MIRT758108	hsa-miR-4778-5p	CLIP-seq
MIRT2165059	hsa-miR-509-3p	CLIP-seq
MIRT758111	hsa-miR-544	CLIP-seq
MIRT2165060	hsa-miR-548g	CLIP-seq
MIRT758114	hsa-miR-578	CLIP-seq
MIRT2165061	hsa-miR-593	CLIP-seq
MIRT2165062	hsa-miR-761	CLIP-seq
MIRT2383740	hsa-miR-1257	CLIP-seq
MIRT2383741	hsa-miR-3607-5p	CLIP-seq
MIRT2383742	hsa-miR-485-3p	CLIP-seq
MIRT2383743	hsa-miR-548k	CLIP-seq
MIRT2425876	hsa-miR-4477a	CLIP-seq
MIRT2425877	hsa-miR-944	CLIP-seq
MIRT2467006	hsa-miR-1179	CLIP-seq
MIRT758070	hsa-miR-1267	CLIP-seq
MIRT2467007	hsa-miR-181a	CLIP-seq
MIRT2467008	hsa-miR-181b	CLIP-seq
MIRT2467009	hsa-miR-181c	CLIP-seq
MIRT2467010	hsa-miR-181d	CLIP-seq
MIRT1923582	hsa-miR-183	CLIP-seq
MIRT2467011	hsa-miR-323b-5p	CLIP-seq
MIRT2467012	hsa-miR-3672	CLIP-seq
MIRT2467013	hsa-miR-4262	CLIP-seq
MIRT2467014	hsa-miR-4470	CLIP-seq
MIRT758099	hsa-miR-4652-3p	CLIP-seq
MIRT2467015	hsa-miR-4670-3p	CLIP-seq
MIRT758108	hsa-miR-4778-5p	CLIP-seq
MIRT758114	hsa-miR-578	CLIP-seq
MIRT2467016	hsa-miR-651	CLIP-seq
MIRT758119	hsa-miR-653	CLIP-seq
MIRT2467006	hsa-miR-1179	CLIP-seq
MIRT1923582	hsa-miR-183	CLIP-seq
MIRT2467011	hsa-miR-323b-5p	CLIP-seq
MIRT2467014	hsa-miR-4470	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25063848
GO:0005524	Function	ATP binding	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006839	Process	Mitochondrial transport	NAS	10922475
GO:0016887	Function	ATPase activity	IEA
GO:0032592	Component	Integral component of mitochondrial membrane	IDA	10922475
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 605454
• HGNC: 41
• e!Ensembl: ENSG00000135776

Protein

• UniProt ID: Q9NRK6
• Protein name: ATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (EC 7.6.2.-) (Mitochondrial ATP-binding cassette 2) (M-ABC2)
• Protein function: ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315
• PDB: 3ZDQ, 4AYT, 4AYW, 4AYX, 7Y48, 7Y49
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00664	ABC_membrane	171 → 442	ABC transporter transmembrane region	Family
  PF00005	ABC_tran	510 → 662	ABC transporter	Domain

• Sequence:

  MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW
  GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG
  GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM
  SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG
  QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA
  SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN
  VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL
  MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG
  VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL
  LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA
  EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA
  TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS
  KPNGIYRKLMNKQSFISA

• Sequence length: 738